The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000179841 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021057 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem. 267 (24): 16816–23. doi:10.1016/S0021-9258(18)41856-X. PMID 1512224.
^Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem. 267 (19): 13376–82. doi:10.1016/S0021-9258(18)42221-1. PMID 1618839.
^ ab"Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5".
^Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
^Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1): 87–97. doi:10.1016/s1044-7431(02)00017-9. PMID 12595241. S2CID 6172436.
External linksedit
Human AKAP5 genome location and AKAP5 gene details page in the UCSC Genome Browser.
Further readingedit
Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta". J. Biol. Chem. 267 (4): 2131–4. doi:10.1016/S0021-9258(18)45852-8. PMID 1733921.
Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. doi:10.1016/S0021-9258(18)98665-5. PMID 1860836.
Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108–11. Bibcode:1995Sci...267..108C. doi:10.1126/science.7528941. PMID 7528941.
Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton". J. Biol. Chem. 268 (17): 12796–804. doi:10.1016/S0021-9258(18)31458-3. PMID 8509414.
Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin". J. Biol. Chem. 272 (27): 17038–44. doi:10.1074/jbc.272.27.17038. PMID 9202019.
Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells". J. Biol. Chem. 274 (10): 6546–52. doi:10.1074/jbc.274.10.6546. PMID 10037748.
Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover". Endocrinology. 140 (11): 5165–70. doi:10.1210/endo.140.11.7133. PMID 10537145.
Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409–12. doi:10.1016/S0960-9822(00)00419-X. PMID 10753752.
Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci. 12 (4): 1155–64. doi:10.1046/j.1460-9568.2000.00002.x. PMID 10762347. S2CID 40933732.
Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107–19. doi:10.1016/S0896-6273(00)00013-1. PMID 10939335.
Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals". Circ. Res. 88 (3): 319–24. doi:10.1161/01.res.88.3.319. PMID 11179200.
Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem. 276 (23): 20499–505. doi:10.1074/jbc.M101425200. PMID 11287423.
Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (4): G1051–8. doi:10.1152/ajpgi.2001.281.4.G1051. PMID 11557526. S2CID 20939022.
This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.
akap5, kinase, anchor, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2h9r, 3ll8identifiersaliases, akap75, akap79, kinase, anchoring, protein, 5external, idsomim, 604688, 2685104, homologene, 1585. A kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene 5 6 7 AKAP5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2H9R 3LL8IdentifiersAliasesAKAP5 AKAP75 AKAP79 H21 A kinase anchoring protein 5External IDsOMIM 604688 MGI 2685104 HomoloGene 15854 GeneCards AKAP5Gene location Human Chr Chromosome 14 human 1 Band14q23 3Start64 465 499 bp 1 End64 474 503 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 12 C3Start76 371 665 bp 2 End76 380 927 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmiddle temporal gyrusBrodmann area 23entorhinal cortexsuperior frontal gyruspostcentral gyrusnucleus accumbensendothelial cellcaudate nucleusprefrontal cortexdorsolateral prefrontal cortexTop expressed inleft lung lobeolfactory tuberclenucleus accumbensright lungright lung lobeglobus pallidustemporal lobeRegion I of hippocampus properamygdalapiriform cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein kinase A binding calmodulin binding protein binding protein kinase A regulatory subunit binding adenylate cyclase binding SH3 domain binding protein phosphatase 2B binding beta 2 adrenergic receptor binding molecular adaptor activity glutamate receptor binding GABA receptor binding scaffold protein bindingCellular componentcytosol membrane plasma membrane cytoplasmic side of plasma membrane postsynaptic density dendrite membrane dendritic spine membrane raft excitatory synapse intracellular anatomical structureBiological processprotein targeting signal transduction positive regulation of protein kinase A signaling chemical synaptic transmission adenylate cyclase inhibiting G protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity regulation of protein kinase A signaling positive regulation of adenylate cyclase activity positive regulation of protein localization to plasma membraneSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez9495238276EnsemblENSG00000179841ENSMUSG00000021057UniProtP24588Q6PG46D3YVF0RefSeq mRNA NM 004857NM 001101471RefSeq protein NP 004848NP 004848 3NP 001094941Location UCSC Chr 14 64 47 64 47 MbChr 12 76 37 76 38 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 External links 5 Further readingFunction editThe A kinase anchor proteins AKAPs are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A PKA and confining the holoenzyme to discrete locations within the cell This gene is intronless and encodes a member of the AKAP family The encoded protein binds to the RII beta regulatory subunit of PKA and also to protein kinase C and the phosphatase calcineurin It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities PSD and be involved in the regulation of postsynaptic events It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin dependent dephosphorylation of NFAT 7 Interactions editAKAP5 has been shown to interact with Calcineurin 8 and GABRB3 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000179841 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021057 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Carr DW Stofko Hahn RE Fraser ID Cone RD Scott JD Sep 1992 Localization of the cAMP dependent protein kinase to the postsynaptic densities by A kinase anchoring proteins Characterization of AKAP 79 J Biol Chem 267 24 16816 23 doi 10 1016 S0021 9258 18 41856 X PMID 1512224 Carr DW Hausken ZE Fraser ID Stofko Hahn RE Scott JD Aug 1992 Association of the type II cAMP dependent protein kinase with a human thyroid RII anchoring protein Cloning and characterization of the RII binding domain J Biol Chem 267 19 13376 82 doi 10 1016 S0021 9258 18 42221 1 PMID 1618839 a b Entrez Gene AKAP5 A kinase PRKA anchor protein 5 Kashishian A Howard M Loh C Gallatin WM Hoekstra MF Lai Y Oct 1998 AKAP79 inhibits calcineurin through a site distinct from the immunophilin binding region J Biol Chem 273 42 27412 9 doi 10 1074 jbc 273 42 27412 PMID 9765270 Brandon NJ Jovanovic JN Colledge M Kittler JT Brandon JM Scott JD Moss SJ Jan 2003 A kinase anchoring protein 79 150 facilitates the phosphorylation of GABA A receptors by cAMP dependent protein kinase via selective interaction with receptor beta subunits Mol Cell Neurosci 22 1 87 97 doi 10 1016 s1044 7431 02 00017 9 PMID 12595241 S2CID 6172436 External links editHuman AKAP5 genome location and AKAP5 gene details page in the UCSC Genome Browser Further reading editLester LB Scott JD 1997 Anchoring and scaffold proteins for kinases and phosphatases Recent Prog Horm Res 52 409 29 discussion 429 30 PMID 9238861 Michel JJ Scott JD 2002 AKAP mediated signal transduction Annu Rev Pharmacol Toxicol 42 235 57 doi 10 1146 annurev pharmtox 42 083101 135801 PMID 11807172 Hirsch AH Glantz SB Li Y et al 1992 Cloning and expression of an intron less gene for AKAP 75 an anchor protein for the regulatory subunit of cAMP dependent protein kinase II beta J Biol Chem 267 4 2131 4 doi 10 1016 S0021 9258 18 45852 8 PMID 1733921 Carr DW Stofko Hahn RE Fraser ID et al 1991 Interaction of the regulatory subunit RII of cAMP dependent protein kinase with RII anchoring proteins occurs through an amphipathic helix binding motif J Biol Chem 266 22 14188 92 doi 10 1016 S0021 9258 18 98665 5 PMID 1860836 Coghlan VM Perrino BA Howard M et al 1995 Association of protein kinase A and protein phosphatase 2B with a common anchoring protein Science 267 5194 108 11 Bibcode 1995Sci 267 108C doi 10 1126 science 7528941 PMID 7528941 Glantz SB Li Y Rubin CS 1993 Characterization of distinct tethering and intracellular targeting domains in AKAP75 a protein that links cAMP dependent protein kinase II beta to the cytoskeleton J Biol Chem 268 17 12796 804 doi 10 1016 S0021 9258 18 31458 3 PMID 8509414 Faux MC Scott JD 1997 Regulation of the AKAP79 protein kinase C interaction by Ca2 Calmodulin J Biol Chem 272 27 17038 44 doi 10 1074 jbc 272 27 17038 PMID 9202019 Kashishian A Howard M Loh C et al 1998 AKAP79 inhibits calcineurin through a site distinct from the immunophilin binding region J Biol Chem 273 42 27412 9 doi 10 1074 jbc 273 42 27412 PMID 9765270 Paolillo M Feliciello A Porcellini A et al 1999 The type and the localization of cAMP dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells J Biol Chem 274 10 6546 52 doi 10 1074 jbc 274 10 6546 PMID 10037748 Dodge KL Carr DW Sanborn BM 1999 Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3 5 monophosphate regulation of phosphatidylinositide turnover Endocrinology 140 11 5165 70 doi 10 1210 endo 140 11 7133 PMID 10537145 Fraser ID Cong M Kim J et al 2000 Assembly of an A kinase anchoring protein beta 2 adrenergic receptor complex facilitates receptor phosphorylation and signaling Curr Biol 10 7 409 12 doi 10 1016 S0960 9822 00 00419 X PMID 10753752 Sik A Gulacsi A Lai Y et al 2000 Localization of the A kinase anchoring protein AKAP79 in the human hippocampus Eur J Neurosci 12 4 1155 64 doi 10 1046 j 1460 9568 2000 00002 x PMID 10762347 S2CID 40933732 Colledge M Dean RA Scott GK et al 2000 Targeting of PKA to glutamate receptors through a MAGUK AKAP complex Neuron 27 1 107 19 doi 10 1016 S0896 6273 00 00013 1 PMID 10939335 Indolfi C Stabile E Coppola C et al 2001 Membrane bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP protein kinase A signals Circ Res 88 3 319 24 doi 10 1161 01 res 88 3 319 PMID 11179200 Dart C Leyland ML 2001 Targeting of an A kinase anchoring protein AKAP79 to an inwardly rectifying potassium channel Kir2 1 J Biol Chem 276 23 20499 505 doi 10 1074 jbc M101425200 PMID 11287423 Xie G Raufman JP 2001 Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells Am J Physiol Gastrointest Liver Physiol 281 4 G1051 8 doi 10 1152 ajpgi 2001 281 4 G1051 PMID 11557526 S2CID 20939022 nbsp This article on a gene on human chromosome 14 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AKAP5 amp oldid 1205236191, wikipedia, wiki, book, books, library,
