Pethidine intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioidanalgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,[2] so pethidine intermediate A might also show opioid effects. It is scheduled by UNSingle Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use).[3]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). from the original on 2023-08-03. Retrieved 2023-08-16.
^Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML (March 2005). "Synthesis and biological evaluation of meperidine analogues at monoamine transporters". Journal of Medicinal Chemistry. 48 (5): 1336–43. doi:10.1021/jm0401614. PMID 15743177.
^"Conversion Factors for Controlled Substances". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.
December 18, 2023
pethidine, intermediate, phenylpiperidine, derivative, that, precursor, opioid, analgesic, drug, pethidine, meperidine, known, have, analgesic, activity, right, however, other, derivatives, pethidine, with, cyano, group, place, carboxylate, ethyl, ester, have,. Pethidine intermediate A is a 4 phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine meperidine It is not known to have any analgesic activity in its own right however other derivatives of pethidine with a 4 cyano group in place of the carboxylate ethyl ester have been found to be active 2 so pethidine intermediate A might also show opioid effects It is scheduled by UN Single Convention on Narcotic Drugs It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232 The 2014 annual manufacturing quota was 6 grammes as an end product presumably for research use 3 Pethidine intermediate AClinical dataRoutes ofadministrationN AATC codenoneLegal statusLegal statusBR Class A1 Narcotic drugs 1 DE Anlage II Authorized trade only not prescriptible US Schedule II UN Narcotic Schedule IIdentifiersIUPAC name 1 methyl 4 phenylpiperidine 4 carbonitrileCAS Number3627 62 1PubChem CID62513ChemSpider56289UNIIEL4L2474TYKEGGC22687CompTox Dashboard EPA DTXSID50189814ECHA InfoCard100 020 771Chemical and physical dataFormulaC 13H 16N 2Molar mass200 285 g mol 13D model JSmol Interactive imageSMILES CN1CCC CC1 C N c2ccccc2InChI InChI 1S C13H16N2 c1 15 9 7 13 11 14 8 10 15 12 5 3 2 4 6 12 h2 6H 7 10H2 1H3Key ZLFQTZYFXYOGLS UHFFFAOYSA N verify See also editMoramide intermediate Methadone intermediate Pethidine intermediate B norpethidine Pethidine intermediate C pethidinic acid References edit Anvisa 2023 03 31 RDC Nº 784 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 784 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 2023 04 04 Archived from the original on 2023 08 03 Retrieved 2023 08 16 Lomenzo SA Rhoden JB Izenwasser S Wade D Kopajtic T Katz JL Trudell ML March 2005 Synthesis and biological evaluation of meperidine analogues at monoamine transporters Journal of Medicinal Chemistry 48 5 1336 43 doi 10 1021 jm0401614 PMID 15743177 Conversion Factors for Controlled Substances Diversion Control Division Drug Enforcement Agency U S Department of Justice Retrieved from https en wikipedia org w index php title Pethidine intermediate A amp oldid 1180984925, wikipedia, wiki, book, books, library,
