L-AP4 (L-2-amino-4-phosphonobutyric acid) is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]
^Thomsen C (August 1997). "The L-AP4 receptor". General Pharmacology. 29 (2): 151–8. doi:10.1016/S0306-3623(96)00417-X. PMID 9251893.
^Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (June 2007). "Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease". The Journal of Neuroscience. 27 (25): 6701–11. doi:10.1523/JNEUROSCI.0299-07.2007. PMC6672706. PMID 17581957.
^Macinnes N, Duty S (February 2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo". European Journal of Pharmacology. 580 (1–2): 95–9. doi:10.1016/j.ejphar.2007.10.030. PMID 18035348.
^Zhang HM, Chen SR, Pan HL (January 2009). "Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain". Neuroscience. 158 (2): 875–84. doi:10.1016/j.neuroscience.2008.10.042. PMC2649787. PMID 19017536.
^Maciejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, et al. (July 2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration". Brain Research. 1282: 20–7. doi:10.1016/j.brainres.2009.05.049. PMID 19481536. S2CID 20844494.
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.
amino, phosphonobutyric, acid, drug, used, scientific, research, which, acts, group, selective, agonist, group, metabotropic, glutamate, receptors, mglur4, first, ligand, found, agonist, selective, this, group, mglu, receptors, does, show, selectivity, between. L AP4 L 2 amino 4 phosphonobutyric acid is a drug used in scientific research which acts as a group selective agonist for the group III metabotropic glutamate receptors mGluR4 6 7 8 It was the first ligand found to act as an agonist selective for this group of mGlu receptors 1 but does not show selectivity between the different mGluR Group III subtypes It is widely used in the study of this receptor family and their various functions 2 3 4 5 L AP4Clinical dataOther namesL 2 Amino 4 phosphonobutyric acidIdentifiersIUPAC name 2S 2 Amino 4 phosphonobutanoic acidCAS Number23052 81 5 YPubChem CID179394IUPHAR BPS1410ChemSpider156157 YUNIIC8M58SS68HCompTox Dashboard EPA DTXSID30945733ECHA InfoCard100 164 384Chemical and physical dataFormulaC 4H 10N O 5PMolar mass183 100 g mol 13D model JSmol Interactive imageSMILES C CP O O O C H C O O NInChI InChI 1S C4H10NO5P c5 3 4 6 7 1 2 11 8 9 10 h3H 1 2 5H2 H 6 7 H2 8 9 10 t3 m0 s1 NKey DDOQBQRIEWHWBT VKHMYHEASA N N N Y what is this verify References Edit Thomsen C August 1997 The L AP4 receptor General Pharmacology 29 2 151 8 doi 10 1016 S0306 3623 96 00417 X PMID 9251893 Lopez S Turle Lorenzo N Acher F De Leonibus E Mele A Amalric M June 2007 Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson s disease The Journal of Neuroscience 27 25 6701 11 doi 10 1523 JNEUROSCI 0299 07 2007 PMC 6672706 PMID 17581957 Macinnes N Duty S February 2008 Group III metabotropic glutamate receptors act as hetero receptors modulating evoked GABA release in the globus pallidus in vivo European Journal of Pharmacology 580 1 2 95 9 doi 10 1016 j ejphar 2007 10 030 PMID 18035348 Zhang HM Chen SR Pan HL January 2009 Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain Neuroscience 158 2 875 84 doi 10 1016 j neuroscience 2008 10 042 PMC 2649787 PMID 19017536 Maciejak P Szyndler J Turzynska D Sobolewska A Taracha E Skorzewska A et al July 2009 The effects of group III mGluR ligands on pentylenetetrazol induced kindling of seizures and hippocampal amino acids concentration Brain Research 1282 20 7 doi 10 1016 j brainres 2009 05 049 PMID 19481536 S2CID 20844494 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title L AP4 amp oldid 1175817150, wikipedia, wiki, book, books, library,
