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Wikipedia

Nolatrexed

Nolatrexed is a thymidylate synthase inhibitor.[1][2]

Nolatrexed
Names
Preferred IUPAC name
2-Amino-6-methyl-5-[(pyridin-4-yl)sulfanyl]quinazolin-4(1H)-one
Identifiers
  • 147149-76-6 Y
3D model (JSmol)
  • Interactive image
ChemSpider
  • 97268 N
  • 108189
UNII
  • K75ZUN743Q Y
  • DTXSID3048281
  • InChI=1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19) N
    Key: XHWRWCSCBDLOLM-UHFFFAOYSA-N N
  • InChI=1/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)
    Key: XHWRWCSCBDLOLM-UHFFFAOYAK
  • CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3
Properties
C14H12N4OS
Molar mass 284.34 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)

References edit

  1. ^ Hughes AN, Rafi I, Griffin MJ, et al. (January 1999). "Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days". Clin. Cancer Res. 5 (1): 111–8. PMID 9918208.
  2. ^ "Nolatrexed". PubChem.gov. Pub Chem. Retrieved 12 August 2014.


nolatrexed, thymidylate, synthase, inhibitor, names, preferred, iupac, name, amino, methyl, pyridin, sulfanyl, quinazolin, identifiers, number, 147149, model, jsmol, interactive, image, chemspider, 97268, pubchem, 108189, unii, k75zun743q, comptox, dashboard, . Nolatrexed is a thymidylate synthase inhibitor 1 2 Nolatrexed Names Preferred IUPAC name 2 Amino 6 methyl 5 pyridin 4 yl sulfanyl quinazolin 4 1H one Identifiers CAS Number 147149 76 6 Y 3D model JSmol Interactive image ChemSpider 97268 N PubChem CID 108189 UNII K75ZUN743Q Y CompTox Dashboard EPA DTXSID3048281 InChI InChI 1S C14H12N4OS c1 8 2 3 10 11 13 19 18 14 15 17 10 12 8 20 9 4 6 16 7 5 9 h2 7H 1H3 H3 15 17 18 19 NKey XHWRWCSCBDLOLM UHFFFAOYSA N NInChI 1 C14H12N4OS c1 8 2 3 10 11 13 19 18 14 15 17 10 12 8 20 9 4 6 16 7 5 9 h2 7H 1H3 H3 15 17 18 19 Key XHWRWCSCBDLOLM UHFFFAOYAK SMILES CC1 C C2 C C C1 NC NC2 O N SC3 CC NC C3 Properties Chemical formula C14H12N4OS Molar mass 284 34 g mol Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox referencesReferences edit Hughes AN Rafi I Griffin MJ et al January 1999 Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride AG337 THYMITAQ administered orally for 5 days Clin Cancer Res 5 1 111 8 PMID 9918208 Nolatrexed PubChem gov Pub Chem Retrieved 12 August 2014 nbsp This article about an organic compound is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Nolatrexed amp oldid 1120554762, wikipedia, wiki, book, books, library,

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