^ abcGlennon RA (2006). "Strategies for the development of selective serotonergic agents". In Roth BL (ed.). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (The Receptors). Totowa, NJ: Humana Press. p. 113. ISBN1-58829-568-0.
May 08, 2024
nbump, highly, selective, ht1a, receptor, partial, agonist, with, arylpiperazine, structure, highest, affinity, ligands, ht1a, receptor, known, displays, fold, selectivity, ht1a, over, adrenergic, receptors, respectively, clinical, dataatc, codenoneidentifiers. NBUMP is a highly selective 5 HT1A receptor partial agonist Ki 0 1 nM IA 40 with an arylpiperazine structure 1 It is one of the highest affinity ligands for the 5 HT1A receptor known 1 It displays 460 and 260 fold selectivity for 5 HT1A over the a1 adrenergic and D2 receptors respectively 1 NBUMPClinical dataATC codenoneIdentifiersIUPAC name N 4 4 2 methoxyphenyl piperazin 1 yl butyl adamantane 1 carboxamideCAS Number134390 72 0 YPubChem CID64622ChemSpider58183UNIIG184WXO36JChemical and physical dataFormulaC 26H 39N 3O 2Molar mass425 617 g mol 13D model JSmol Interactive imageSMILES COc1ccccc1N2CCN CC2 CCCCNC O C34CC5CC C3 CC C5 C4InChI InChI 1S C26H39N3O2 c1 31 24 7 3 2 6 23 24 29 12 10 28 11 13 29 9 5 4 8 27 25 30 26 17 20 14 21 18 26 16 22 15 20 19 26 h2 3 6 7 20 22H 4 5 8 19H2 1H3 H 27 30 Key PRZPXKIXNNNNCD UHFFFAOYSA N verify See also editAdatanserinReferences edit a b c Glennon RA 2006 Strategies for the development of selective serotonergic agents In Roth BL ed The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics The Receptors Totowa NJ Humana Press p 113 ISBN 1 58829 568 0 Retrieved from https en wikipedia org w index php title NBUMP amp oldid 1105896151, wikipedia, wiki, book, books, library,
