The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000071243 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029670 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.
^ ab"Entrez Gene: ING3 inhibitor of growth family, member 3".
Further readingedit
Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Nagashima M, Shiseki M, Pedeux RM, et al. (2003). "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis". Oncogene. 22 (3): 343–50. doi:10.1038/sj.onc.1206115. PMID 12545155.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC350560. PMID 14966270.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Wang Y, Dai DL, Martinka M, Li G (2007). "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma". Clin. Cancer Res. 13 (14): 4111–6. doi:10.1158/1078-0432.CCR-07-0408. PMID 17634537.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
ing3, inhibitor, growth, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1x4iidentifiersaliases, eaf4, ing2, meaf4, p47inhibitor, growth, family, member, 3external, idsomim, 607493, 1919027, homolog. Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene 5 6 ING3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1X4IIdentifiersAliasesING3 Eaf4 ING2 MEAF4 p47inhibitor of growth family member 3External IDsOMIM 607493 MGI 1919027 HomoloGene 6804 GeneCards ING3Gene location Human Chr Chromosome 7 human 1 Band7q31 31Start120 950 763 bp 1 End120 977 216 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 A3 1Start21 949 570 bp 2 End21 976 037 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytetrabecular bonemonocyteAchilles tendonbone marrowgerminal epitheliumparietal pleuravisceral pleuraoptic nervelower lobe of lungTop expressed insecondary oocytespermatidmedial ganglionic eminenceabdominal wallcumulus cellthymusneural tubeyolk sacbloodleft lung lobeMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionhistone acetyltransferase activity methylated histone binding metal ion bindingCellular componentPiccolo NuA4 histone acetyltransferase complex nucleus nucleoplasm Swr1 complex NuA4 histone acetyltransferase complexBiological processhistone H4 acetylation histone H2A acetylation regulation of growth regulation of transcription DNA templated transcription DNA templated positive regulation of apoptotic process chromatin organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5455671777EnsemblENSG00000071243ENSMUSG00000029670UniProtQ9NXR8Q8VEK6RefSeq mRNA NM 198267NM 019071NM 198266NM 023626NM 001311061RefSeq protein NP 061944NP 938008NP 001297990NP 076115Location UCSC Chr 7 120 95 120 98 MbChr 6 21 95 21 98 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene is similar to ING1 a tumor suppressor protein that can interact with TP53 inhibit cell growth and induce apoptosis This protein contains a PHD finger which is a common motif in proteins involved in chromatin remodeling This gene can activate p53 trans activated promoters including promoters of p21 waf1 and bax Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis Allelic loss and reduced expression of this gene were detected in head and neck cancers Two alternatively spliced transcript variants encoding different isoforms have been observed 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000071243 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029670 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Gunduz M Ouchida M Fukushima K Ito S Jitsumori Y Nakashima T Nagai N Nishizaki K Shimizu K Jun 2002 Allelic loss and reduced expression of the ING3 a candidate tumor suppressor gene at 7q31 in human head and neck cancers Oncogene 21 28 4462 70 doi 10 1038 sj onc 1205540 PMID 12080476 a b Entrez Gene ING3 inhibitor of growth family member 3 Further reading editDoyon Y Cote J 2004 The highly conserved and multifunctional NuA4 HAT complex Curr Opin Genet Dev 14 2 147 54 doi 10 1016 j gde 2004 02 009 PMID 15196461 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Sanger Centre The Washington University Genome Sequencing Cente The 1999 Toward a complete human genome sequence Genome Res 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Nagashima M Shiseki M Pedeux RM et al 2003 A novel PHD finger motif protein p47ING3 modulates p53 mediated transcription cell cycle control and apoptosis Oncogene 22 3 343 50 doi 10 1038 sj onc 1206115 PMID 12545155 Hillier LW Fulton RS Fulton LA et al 2003 The DNA sequence of human chromosome 7 Nature 424 6945 157 64 Bibcode 2003Natur 424 157H doi 10 1038 nature01782 PMID 12853948 Cai Y Jin J Tomomori Sato C et al 2003 Identification of new subunits of the multiprotein mammalian TRRAP TIP60 containing histone acetyltransferase complex J Biol Chem 278 44 42733 6 doi 10 1074 jbc C300389200 PMID 12963728 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Doyon Y Selleck W Lane WS et al 2004 Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans Mol Cell Biol 24 5 1884 96 doi 10 1128 MCB 24 5 1884 1896 2004 PMC 350560 PMID 14966270 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Cai Y Jin J Florens L et al 2005 The mammalian YL1 protein is a shared subunit of the TRRAP TIP60 histone acetyltransferase and SRCAP complexes J Biol Chem 280 14 13665 70 doi 10 1074 jbc M500001200 PMID 15647280 Wang Y Dai DL Martinka M Li G 2007 Prognostic significance of nuclear ING3 expression in human cutaneous melanoma Clin Cancer Res 13 14 4111 6 doi 10 1158 1078 0432 CCR 07 0408 PMID 17634537 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ING3 amp oldid 1142711053, wikipedia, wiki, book, books, library,
