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MRC Mitochondrial Biology Unit

April 19, 2024

The MRC Mitochondrial Biology Unit (formerly the MRC Dunn Human Nutrition Unit) is a department of the School of Clinical Medicine at the University of Cambridge, funded through a strategic partnership between the Medical Research Council and the University. It is located at the Addenbrooke’s Hospital / Cambridge Biomedical Campus site in Cambridge, England. The unit is concerned with the study of the mitochondrion, as this organelle has a varied and critical role in many aspects of eukaryotic metabolism and is implicated in many metabolic, degenerative, and age-related human diseases.

MRC Mitochondrial Biology Unit
The Keith Peters Building, housing the Cambridge Institute for Medical Research and the MRC Mitochondrial Biology Unit
AbbreviationMBU
Formation1927
TypeResearch institute
Legal statusUniversity Unit
PurposeMitochondrial research
HeadquartersThe Keith Peters Building
Location
  • Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY
Director
Professor Judy Hirst
Parent organization
Medical Research Council
WebsiteMBU

History edit

The Unit was founded in 1927 using a donation from Sir William Dunn, who left £1 million to charity on his death in 1912. Part of this money was used to fund what was then called the Dunn Nutritional Laboratory, with its research supported by the Medical Research Council (MRC). Its original research focus was to investigate the role of vitamins in human health. Under the directorship of Egon Kodicek this focus changed to more general nutritional research. The Unit was restructured in 1998 under the directorship of Professor Sir John Walker to focus on mitochondrial research. The Unit was renamed in 2009 to the Mitochondrial Biology Unit to reflect its mitochondrial expertise. In March 2017 the Unit was transferred from the MRC to the University of Cambridge. The current director of the Unit is Professor Judy Hirst.

The Unit has three major scientific aims:[1]

  1. To understand the fundamental processes taking place in mitochondria
  2. To understand the involvement of these processes in human diseases
  3. To exploit knowledge of these fundamental processes for the development of new therapies to treat human diseases

Research Groups edit

The MBU is organised into nine independent research groups[2] and includes 30-40 graduate students who are members of the University of Cambridge:

  • Professor Judy Hirst FRS - Understanding the molecular mechanism of complex I and its roles in human disease
  • Professor Patrick Chinnery - Mitochondrial genomics and human diseases
  • Professor Edmund Kunji - Understanding transport processes in mitochondria
  • Dr Michal Minczuk - Discovering the genetic links between mitochondrial dysfunction and human disease
  • Professor Mike Murphy - Targeting therapeutic and probe molecules to mitochondria, mitochondrial radical production and redox signalling
  • Dr Julien Prudent - Interactions between mitochondria and the endoplasmic reticulum in cell physiology and disease
  • Dr Jelle van den Ameele - Molecular mechanisms of tissue specificity in mitochondrial disease
  • Dr Alex Whitworth - Genetic models of neurodegenerative disease
  • Professor John E. Walker FRS - Understanding the molecular mechanism of how ATP is made

Directors edit

Professor Judy Hirst FRS (2020 - ) [3]

Professor Massimo Zeviani (2013 - 2019)

Professor Sir John Walker FRS (1998 - 2013)[4][5]

Dr Roger Whitehead (1973 – 1998)

Dr Egon Kodicek CBE FRS (1963 - 1973)

Dr Leslie Harris (1929 - 1963)

Sir Frederick Gowland Hopkins (1927 - 1929)

See also edit

References edit

  1. ^ "Introduction from the Director - MRC Mitochondrial Biology Unit". www.mrc-mbu.cam.ac.uk. Retrieved 11 July 2018.
  2. ^ "Research - MRC Mitochondrial Biology Unit". www.mrc-mbu.cam.ac.uk. Retrieved 11 July 2018.
  3. ^ "News".
  4. ^ "latest news - MRC Mitochondrial Biology Unit". www.mrc-mbu.cam.ac.uk. Retrieved 11 July 2018.
  5. ^ "Staff & Students - MRC Mitochondrial Biology Unit". www.mrc-mbu.cam.ac.uk. Retrieved 11 July 2018.

External links edit

  • Official website

April 19, 2024
mitochondrial, biology, unit, formerly, dunn, human, nutrition, unit, department, school, clinical, medicine, university, cambridge, funded, through, strategic, partnership, between, medical, research, council, university, located, addenbrooke, hospital, cambr. The MRC Mitochondrial Biology Unit formerly the MRC Dunn Human Nutrition Unit is a department of the School of Clinical Medicine at the University of Cambridge funded through a strategic partnership between the Medical Research Council and the University It is located at the Addenbrooke s Hospital Cambridge Biomedical Campus site in Cambridge England The unit is concerned with the study of the mitochondrion as this organelle has a varied and critical role in many aspects of eukaryotic metabolism and is implicated in many metabolic degenerative and age related human diseases MRC Mitochondrial Biology UnitThe Keith Peters Building housing the Cambridge Institute for Medical Research and the MRC Mitochondrial Biology UnitAbbreviationMBUFormation1927TypeResearch instituteLegal statusUniversity UnitPurposeMitochondrial researchHeadquartersThe Keith Peters BuildingLocationCambridge Biomedical Campus Hills Road Cambridge CB2 0XYDirectorProfessor Judy HirstParent organizationMedical Research CouncilWebsiteMBU Contents 1 History 2 Research Groups 3 Directors 4 See also 5 References 6 External linksHistory editThe Unit was founded in 1927 using a donation from Sir William Dunn who left 1 million to charity on his death in 1912 Part of this money was used to fund what was then called the Dunn Nutritional Laboratory with its research supported by the Medical Research Council MRC Its original research focus was to investigate the role of vitamins in human health Under the directorship of Egon Kodicek this focus changed to more general nutritional research The Unit was restructured in 1998 under the directorship of Professor Sir John Walker to focus on mitochondrial research The Unit was renamed in 2009 to the Mitochondrial Biology Unit to reflect its mitochondrial expertise In March 2017 the Unit was transferred from the MRC to the University of Cambridge The current director of the Unit is Professor Judy Hirst The Unit has three major scientific aims 1 To understand the fundamental processes taking place in mitochondria To understand the involvement of these processes in human diseases To exploit knowledge of these fundamental processes for the development of new therapies to treat human diseasesResearch Groups editThe MBU is organised into nine independent research groups 2 and includes 30 40 graduate students who are members of the University of Cambridge Professor Judy Hirst FRS Understanding the molecular mechanism of complex I and its roles in human disease Professor Patrick Chinnery Mitochondrial genomics and human diseases Professor Edmund Kunji Understanding transport processes in mitochondria Dr Michal Minczuk Discovering the genetic links between mitochondrial dysfunction and human disease Professor Mike Murphy Targeting therapeutic and probe molecules to mitochondria mitochondrial radical production and redox signalling Dr Julien Prudent Interactions between mitochondria and the endoplasmic reticulum in cell physiology and disease Dr Jelle van den Ameele Molecular mechanisms of tissue specificity in mitochondrial disease Dr Alex Whitworth Genetic models of neurodegenerative disease Professor John E Walker FRS Understanding the molecular mechanism of how ATP is madeDirectors editProfessor Judy Hirst FRS 2020 3 Professor Massimo Zeviani 2013 2019 Professor Sir John Walker FRS 1998 2013 4 5 Dr Roger Whitehead 1973 1998 Dr Egon Kodicek CBE FRS 1963 1973 Dr Leslie Harris 1929 1963 Sir Frederick Gowland Hopkins 1927 1929 See also editSir William Dunn Institute of Biochemistry another beneficiary of Dunn s willReferences edit Introduction from the Director MRC Mitochondrial Biology Unit www mrc mbu cam ac uk Retrieved 11 July 2018 Research MRC Mitochondrial Biology Unit www mrc mbu cam ac uk Retrieved 11 July 2018 News latest news MRC Mitochondrial Biology Unit www mrc mbu cam ac uk Retrieved 11 July 2018 Staff amp Students MRC Mitochondrial Biology Unit www mrc mbu cam ac uk Retrieved 11 July 2018 External links editOfficial website Retrieved from https en wikipedia org w index php title MRC Mitochondrial Biology Unit amp oldid 1167409325, wikipedia, wiki, book, books, library,

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