The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000166685 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018661 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi:10.1073/pnas.96.3.915. PMC15325. PMID 9927668.
^ ab"Entrez Gene: COG1 component of oligomeric golgi complex 1".
^Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
^Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24). United States: 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.
Further readingedit
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC2173297. PMID 11980916.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ungar D, Oka T, Vasile E, et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex". J. Biol. Chem. 280 (38): 32729–35. doi:10.1074/jbc.M504590200. PMID 16020545.
Vasile E, Oka T, Ericsson M, et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex". Exp. Cell Res. 312 (16): 3132–41. doi:10.1016/j.yexcr.2006.06.005. PMID 16857184.
External linksedit
GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
Human COG1 genome location and COG1 gene details page in the UCSC Genome Browser.
This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.
cog1, conserved, oligomeric, golgi, complex, subunit, protein, that, humans, encoded, gene, identifiersaliases, cdg2g, ldlb, component, oligomeric, golgi, complex, 1external, idsomim, 606973, 1333873, homologene, 8411, genecards, gene, location, human, chromos. Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene 5 6 COG1IdentifiersAliasesCOG1 CDG2G LDLB component of oligomeric golgi complex 1External IDsOMIM 606973 MGI 1333873 HomoloGene 8411 GeneCards COG1Gene location Human Chr Chromosome 17 human 1 Band17q25 1Start73 193 055 bp 1 End73 208 507 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 E2Start113 539 995 bp 2 End113 557 880 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inanterior pituitaryBrodmann area 9nucleus accumbensprefrontal cortexcingulate gyruscaudate nucleusbody of pancreasleft ventriclegastrocnemius muscleright uterine tubeTop expressed inexternal carotid arteryinternal carotid arterymotor neuronsubstantia nigraislet of Langerhansseminiferous tubulePaneth cellright ventricleparaventricular nucleus of hypothalamussubmandibular glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein bindingCellular componentGolgi membrane Golgi apparatus membrane trans Golgi network membrane Golgi transport complexBiological processprotein transport endoplasmic reticulum to Golgi vesicle mediated transport intra Golgi vesicle mediated transport Golgi organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez938216834EnsemblENSG00000166685ENSMUSG00000018661UniProtQ8WTW3Q9Z160RefSeq mRNA NM 018714NM 013581RefSeq protein NP 061184NP 038609Location UCSC Chr 17 73 19 73 21 MbChr 11 113 54 113 56 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is one of eight proteins Cog1 8 which form a Golgi localized complex COG required for normal Golgi morphology and function It is thought that this protein is required for steps in the normal medial and trans Golgi associated processing of glycoconjugates and plays a role in the organization of the Golgi localized complex 6 Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editCOG1 has been shown to interact with COG4 7 and COG3 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000166685 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000018661 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chatterton JE Hirsch D Schwartz JJ Bickel PE Rosenberg RD Lodish HF Krieger M Mar 1999 Expression cloning of LDLB a gene essential for normal Golgi function and assembly of the ldlCp complex Proc Natl Acad Sci U S A 96 3 915 20 Bibcode 1999PNAS 96 915C doi 10 1073 pnas 96 3 915 PMC 15325 PMID 9927668 a b Entrez Gene COG1 component of oligomeric golgi complex 1 Loh Eva Hong Wanjin Jun 2004 The binary interacting network of the conserved oligomeric Golgi tethering complex J Biol Chem 279 23 United States 24640 8 doi 10 1074 jbc M400662200 ISSN 0021 9258 PMID 15047703 Loh Eva Hong Wanjin Jun 2002 Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC 90 and ldlBp J Biol Chem 277 24 United States 21955 61 doi 10 1074 jbc M202326200 ISSN 0021 9258 PMID 11929878 Further reading editNagase T Kikuno R Ishikawa KI et al 2000 Prediction of the coding sequences of unidentified human genes XVI The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro DNA Res 7 1 65 73 doi 10 1093 dnares 7 1 65 PMID 10718198 Loh E Hong W 2002 Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC 90 and ldlBp J Biol Chem 277 24 21955 61 doi 10 1074 jbc M202326200 PMID 11929878 Ungar D Oka T Brittle EE et al 2002 Characterization of a mammalian Golgi localized protein complex COG that is required for normal Golgi morphology and function J Cell Biol 157 3 405 15 doi 10 1083 jcb 200202016 PMC 2173297 PMID 11980916 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Loh E Hong W 2004 The binary interacting network of the conserved oligomeric Golgi tethering complex J Biol Chem 279 23 24640 8 doi 10 1074 jbc M400662200 PMID 15047703 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ungar D Oka T Vasile E et al 2005 Subunit architecture of the conserved oligomeric Golgi complex J Biol Chem 280 38 32729 35 doi 10 1074 jbc M504590200 PMID 16020545 Vasile E Oka T Ericsson M et al 2006 IntraGolgi distribution of the Conserved Oligomeric Golgi COG complex Exp Cell Res 312 16 3132 41 doi 10 1016 j yexcr 2006 06 005 PMID 16857184 External links editGeneReviews NCBI NIH UW entry on Congenital Disorders of Glycosylation Overview Human COG1 genome location and COG1 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title COG1 amp oldid 1115896087, wikipedia, wiki, book, books, library,
