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Wikipedia

FABP6

April 18, 2024

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a protein which in humans is encoded by the FABP6 gene.[5]

FABP6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP, fatty acid binding protein 6
External IDsOMIM: 600422 MGI: 96565 HomoloGene: 1108 GeneCards: FABP6
Orthologs
SpeciesHumanMouse
Entrez

2172

16204

Ensembl

ENSG00000170231

ENSMUSG00000020405

UniProt

P51161

P51162

RefSeq (mRNA)

NM_001040442
NM_001130958
NM_001445

NM_008375

RefSeq (protein)

NP_001035532
NP_001124430
NP_001436

NP_032401

Location (UCSC)Chr 5: 160.19 – 160.24 MbChr 11: 43.49 – 43.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.[5]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170231 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020405 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)".

Further reading edit

  • Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. doi:10.1016/S0952-3278(97)90496-8. PMID 9250612.
  • Fujita M, Fujii H, Kanda T, et al. (1995). "Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein". Eur. J. Biochem. 233 (2): 406–413. doi:10.1111/j.1432-1033.1995.406_2.x. PMID 7588781.
  • Oelkers P, Dawson PA (1995). "Cloning and chromosomal localization of the human ileal lipid-binding protein". Biochim. Biophys. Acta. 1257 (2): 199–202. doi:10.1016/0005-2760(95)00098-w. PMID 7619861.
  • Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1995). "Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11". Mamm. Genome. 5 (12): 805–806. doi:10.1007/BF00292019. PMID 7894165. S2CID 28184037.
  • Watanabe K, Hoshi N, Tsuura Y, et al. (1996). "Immunohistochemical distribution of intestinal 15 kDa protein in human tissues". Arch. Histol. Cytol. 58 (3): 303–306. doi:10.1679/aohc.58.303. PMID 8527237.
  • Lücke C, Zhang F, Rüterjans H, et al. (1997). "Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein". Structure. 4 (7): 785–800. doi:10.1016/S0969-2126(96)00086-X. PMID 8805562.
  • Grober J, Zaghini I, Fujii H, et al. (1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749–29754. doi:10.1074/jbc.274.42.29749. PMID 10514450.
  • Seibert C, Harteneck C, Ernst OP, et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells". Eur. J. Biochem. 266 (3): 911–916. doi:10.1046/j.1432-1327.1999.00927.x. PMID 10583385.
  • Lücke C, Zhang F, Hamilton JA, et al. (2000). "Solution structure of ileal lipid binding protein in complex with glycocholate". Eur. J. Biochem. 267 (10): 2929–2938. doi:10.1046/j.1432-1327.2000.01307.x. PMID 10806391.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kurz M, Brachvogel V, Matter H, et al. (2003). "Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures". Proteins. 50 (2): 312–328. doi:10.1002/prot.10289. PMID 12486725. S2CID 20185435.
  • Barley NF, Taylor V, Shaw-Smith CJ, et al. (2004). "Human ileal bile acid-binding protein promoter and the effects of CDX2". Biochim. Biophys. Acta. 1630 (2–3): 138–143. doi:10.1016/j.bbaexp.2003.09.008. PMID 14654244.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Landrier JF, Thomas C, Grober J, et al. (2005). "The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors". Biochim. Biophys. Acta. 1735 (1): 41–49. doi:10.1016/j.bbalip.2005.05.002. PMID 15936983.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
  • Ohmachi T, Inoue H, Mimori K, et al. (2007). "Fatty acid binding protein 6 is overexpressed in colorectal cancer". Clin. Cancer Res. 12 (17): 5090–5095. doi:10.1158/1078-0432.CCR-05-2045. PMID 16951225.
  • Fang C, Dean J, Smith JW (2007). "A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma". Cancer Res. 67 (19): 9039–9046. doi:10.1158/0008-5472.CAN-06-3690. PMID 17909007.
 

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

April 18, 2024
fabp6, fatty, acid, binding, protein, ileal, gastrotropin, also, known, protein, which, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1o1u, 1o1v, 2mm3identifiersaliases, babp, balb, ilbp, ilbp3, illbp, fatty, acid, bindi. Fatty acid binding protein 6 ileal gastrotropin also known as FABP6 is a protein which in humans is encoded by the FABP6 gene 5 FABP6Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1O1U 1O1V 2MM3IdentifiersAliasesFABP6 I 15P I BABP I BALB I BAP ILBP ILBP3 ILLBP fatty acid binding protein 6External IDsOMIM 600422 MGI 96565 HomoloGene 1108 GeneCards FABP6Gene location Human Chr Chromosome 5 human 1 Band5q33 3Start160 187 367 bp 1 End160 238 735 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 B1 1 11 25 81 cMStart43 486 876 bp 2 End43 492 367 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubebronchial epithelial cellnucleus accumbenscaudate nucleusputamenhypothalamussubstantia nigracingulate gyrusinternal globus pallidusprefrontal cortexTop expressed incrypt of lieberkuhn of small intestinePaneth cellileumintestinal villusconjunctival fornixesophaguscorneajejunumleft colonlipMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionbile acid binding lipid bindingCellular componentcytoplasm cytosol membraneBiological processlipid metabolism triglyceride catabolic process negative regulation of cell population proliferation lipid transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez217216204EnsemblENSG00000170231ENSMUSG00000020405UniProtP51161P51162RefSeq mRNA NM 001040442NM 001130958NM 001445NM 008375RefSeq protein NP 001035532NP 001124430NP 001436NP 032401Location UCSC Chr 5 160 19 160 24 MbChr 11 43 49 43 49 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editThis gene encodes the ileal fatty acid binding protein Fatty acid binding proteins are a family of small highly conserved cytoplasmic proteins that bind long chain fatty acids and other hydrophobic ligands FABP6 and FABP1 the liver fatty acid binding protein are also able to bind bile acids It is thought that FABPs roles include fatty acid uptake transport and metabolism Transcript variants generated by alternate transcription promoters and or alternate splicing have been found for this gene 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000170231 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020405 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene FABP6 fatty acid binding protein 6 ileal gastrotropin Further reading editBorchers T Hohoff C Buhlmann C Spener F 1997 Heart type fatty acid binding protein involvement in growth inhibition and differentiation Prostaglandins Leukot Essent Fatty Acids 57 1 77 84 doi 10 1016 S0952 3278 97 90496 8 PMID 9250612 Fujita M Fujii H Kanda T et al 1995 Molecular cloning expression and characterization of a human intestinal 15 kDa protein Eur J Biochem 233 2 406 413 doi 10 1111 j 1432 1033 1995 406 2 x PMID 7588781 Oelkers P Dawson PA 1995 Cloning and chromosomal localization of the human ileal lipid binding protein Biochim Biophys Acta 1257 2 199 202 doi 10 1016 0005 2760 95 00098 w PMID 7619861 Birkenmeier EH Rowe LB Crossman MW Gordon JI 1995 Ileal lipid binding protein Illbp gene maps to mouse chromosome 11 Mamm Genome 5 12 805 806 doi 10 1007 BF00292019 PMID 7894165 S2CID 28184037 Watanabe K Hoshi N Tsuura Y et al 1996 Immunohistochemical distribution of intestinal 15 kDa protein in human tissues Arch Histol Cytol 58 3 303 306 doi 10 1679 aohc 58 303 PMID 8527237 Lucke C Zhang F Ruterjans H et al 1997 Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein Structure 4 7 785 800 doi 10 1016 S0969 2126 96 00086 X PMID 8805562 Grober J Zaghini I Fujii H et al 1999 Identification of a bile acid responsive element in the human ileal bile acid binding protein gene Involvement of the farnesoid X receptor 9 cis retinoic acid receptor heterodimer J Biol Chem 274 42 29749 29754 doi 10 1074 jbc 274 42 29749 PMID 10514450 Seibert C Harteneck C Ernst OP et al 2000 Activation of the rod G protein Gt by the thrombin receptor PAR1 expressed in Sf9 cells Eur J Biochem 266 3 911 916 doi 10 1046 j 1432 1327 1999 00927 x PMID 10583385 Lucke C Zhang F Hamilton JA et al 2000 Solution structure of ileal lipid binding protein in complex with glycocholate Eur J Biochem 267 10 2929 2938 doi 10 1046 j 1432 1327 2000 01307 x PMID 10806391 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kurz M Brachvogel V Matter H et al 2003 Insights into the bile acid transportation system the human ileal lipid binding protein cholyltaurine complex and its comparison with homologous structures Proteins 50 2 312 328 doi 10 1002 prot 10289 PMID 12486725 S2CID 20185435 Barley NF Taylor V Shaw Smith CJ et al 2004 Human ileal bile acid binding protein promoter and the effects of CDX2 Biochim Biophys Acta 1630 2 3 138 143 doi 10 1016 j bbaexp 2003 09 008 PMID 14654244 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 45 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 2127 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Landrier JF Thomas C Grober J et al 2005 The gene encoding the human ileal bile acid binding protein I BABP is regulated by peroxisome proliferator activated receptors Biochim Biophys Acta 1735 1 41 49 doi 10 1016 j bbalip 2005 05 002 PMID 15936983 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 1178 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Bergheim I Harsch S Mueller O et al 2006 Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers J Lipid Res 47 1 42 50 doi 10 1194 jlr M500215 JLR200 PMID 16237211 Ohmachi T Inoue H Mimori K et al 2007 Fatty acid binding protein 6 is overexpressed in colorectal cancer Clin Cancer Res 12 17 5090 5095 doi 10 1158 1078 0432 CCR 05 2045 PMID 16951225 Fang C Dean J Smith JW 2007 A novel variant of ileal bile acid binding protein is up regulated through nuclear factor kappaB activation in colorectal adenocarcinoma Cancer Res 67 19 9039 9046 doi 10 1158 0008 5472 CAN 06 3690 PMID 17909007 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title FABP6 amp oldid 1116588054, wikipedia, wiki, book, books, library,

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