It has completed a phase I clinical trial for nasal decolonisation of MRSA—being tested against 5 bacterial strains. It seems unlikely to cause MRSA to develop resistance to it.[1][6]
In 2014, a phase 1 clinical trial for nasal administration was run.[7]
As of June 2022[update], another phase 1 clinical trial (for nasal administration) completed recruiting in 2016 but no results have been posted.[8]
ReferencesEdit
^ abNeka Sehgal (20 September 2010). "Promising new drug XF-73 kills superbugs within 5 minutes". from the original on 21 July 2011.
^"XF-73". Destiny Pharma. 29 July 2016. (Shows molecular structure.)
^Miller, K.; Ooi, N.; Hobbs, J. K.; Rhys-Williams, W.; Love, W. G.; Hayter, I.; Katila, M.; Chopra, I. (19 April 2008). "XF-73, a novel anti-staphylococcal antimicrobial with very rapid bactericidal activity". European Society of Clinical Microbiology and Infectious Diseases. {{cite journal}}: Cite journal requires |journal= (help)
^Mary Dejevsky (18 May 2008). "Scientists 'on brink of cure' for superbug". The Independent. Archived from the original on 7 May 2022.
exeporfinium, chloride, experimental, drug, candidate, anti, microbial, that, works, weakening, bacteria, cell, walls, potential, treatment, methicillin, resistant, staphylococcus, aureus, mrsa, possibly, clostridium, difficile, being, developed, destiny, phar. XF 73 Exeporfinium chloride is an experimental drug candidate It is an anti microbial that works via weakening bacteria cell walls 1 It is a potential treatment for methicillin resistant Staphylococcus aureus MRSA and possibly Clostridium difficile It is being developed by Destiny Pharma Ltd 2 3 4 XF 73 IdentifiersCAS Number 718638 68 7 Y3D model JSmol Interactive imageChemSpider 8094227PubChem CID 9918582UNII 1912L54M2V YCompTox Dashboard EPA DTXSID20992574InChI InChI 1S C44H50N6O2 2ClH c1 49 2 3 25 7 27 51 37 17 9 31 10 18 37 43 39 21 13 33 45 39 29 35 15 23 41 47 35 44 42 24 16 36 48 42 30 34 14 22 40 43 46 34 32 11 19 38 20 12 32 52 28 8 26 50 4 5 6 h9 24 29 30 45 46H 7 8 25 28H2 1 6H3 2 1H q 2 p 2 b33 29 34 30 35 29 36 30 43 39 43 40 44 41 44 42 Key BXHQXSXRVAELBC XRFOENPRSA LInChI 1 C44H50N6O2 2ClH c1 49 2 3 25 7 27 51 37 17 9 31 10 18 37 43 39 21 13 33 45 39 29 35 15 23 41 47 35 44 42 24 16 36 48 42 30 34 14 22 40 43 46 34 32 11 19 38 20 12 32 52 28 8 26 50 4 5 6 h9 24 29 30 45 46H 7 8 25 28H2 1 6H3 2 1H q 2 p 2 b33 29 34 30 35 29 36 30 43 39 43 40 44 41 44 42 Key BXHQXSXRVAELBC NDLTUMITBESMILES C N C C CCCOC C C1 CC C1 C C2 CC C C C3C CC C C4 CC C OCCC N C C C C C4 C N 5 C CC5 C 6 N 3 N2 C7N C6C C 7 Cl Cl PropertiesChemical formula C 44H 50Cl 2N 6O 2Molar mass 765 82 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox references Structurally it is a dicationic porphyrin 5 It has completed a phase I clinical trial for nasal decolonisation of MRSA being tested against 5 bacterial strains It seems unlikely to cause MRSA to develop resistance to it 1 6 In 2014 a phase 1 clinical trial for nasal administration was run 7 As of June 2022 update another phase 1 clinical trial for nasal administration completed recruiting in 2016 but no results have been posted 8 References Edit a b Neka Sehgal 20 September 2010 Promising new drug XF 73 kills superbugs within 5 minutes Archived from the original on 21 July 2011 XF 73 Destiny Pharma 29 July 2016 Shows molecular structure Miller K Ooi N Hobbs J K Rhys Williams W Love W G Hayter I Katila M Chopra I 19 April 2008 XF 73 a novel anti staphylococcal antimicrobial with very rapid bactericidal activity European Society of Clinical Microbiology and Infectious Diseases a href Template Cite journal html title Template Cite journal cite journal a Cite journal requires journal help Mary Dejevsky 18 May 2008 Scientists on brink of cure for superbug The Independent Archived from the original on 7 May 2022 XF series Destiny Pharma 29 July 2016 Tom Chivers 18 May 2008 MRSA UK scientists close to a treatment The Daily Telegraph Archived from the original on 21 April 2013 Study of the Nasal Decolonisation of Staphylococcus Aureus SA and the Safety and Tolerability of XF 73 Nasal Gel in Healthy Subjects Study of the Safety and Local Tolerability of Intranasal Gel Formulations of XF 73 This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title XF 73 amp oldid 1096369934, wikipedia, wiki, book, books, library,
