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William Shell

January 01, 1970

William Elson Shell, M.D. (September 8, 1942 – March 28, 2017)[1][2] was an American cardiologist and inventor of several quack weight-loss products which were cited for false advertising by the Federal Trade Commission.[3] He owned several U.S. patents.[4] Shell was banned from the securities industry for life as a result of a federal SEC conviction (see below).

Career edit

Shell was a graduate of the University of Michigan Medical School. Following medical school he did an internship and residency at University Hospital in Ann Arbor, Michigan. He then completed a three-year fellowship in cardiovascular medicine under Eugene Braunwald at the University of California, San Diego. He then served two years as the Chief of the Coronary Care Unit at Keesler Air Force Base. Shell has been certified in cardiovascular disease and internal medicine by the American Board of Internal Medicine since 1974. He was the founder, former chairman of the board, CEO and chief scientific officer at Targeted Medical Pharma, Inc. in Los Angeles, California, a specialty pharmaceutical company that develops and distributes medical food products.

He led the team that discovered the cardio specific enzyme CK-MB.

From 1982 to 1995, Shell was a member of the cardiology staff at Cedars of Lebanon Hospital and Mount Sinai Hospital. During his tenure, he planned, directed and implemented the merger of the coronary care unit at Cedars of Lebanon and Mount Sinai Hospital to what is now known as Cedars-Sinai Medical Center in Los Angeles, California. In addition he directed the Cardiac Cath Lab and Cardiac Rehabilitation Center at Cedar-Sinai Medical Center. Dr. Shell was also director of the Cardiac Catheterization Laboratory and director of Cardiac Rehabilitation. He was a member of the research team at the Myocardial Infarction Research Unit, a $5 million per year research grant from the National Institute of Health. Under that program he was a national leader in the definitions and recognition of silent heart disease. He also published seminal papers of the implication of prostaglandins in heart disease. In addition, he participated in the planning, funding and administration of NIH grants and managed a biochemistry research laboratory at Cedars-Sinai Medical Center. Ultimately, he left Cedars-Sinai Medical Center in a patent dispute to enter private practice in Beverly Hills. He was a founder in Beverly Glen Medical Systems that developed techniques for transtelephonic monitoring of cardiac rhythm disturbances and autonomic nervous system function using 24-hour electrocardiographic recordings for which he published the first American paper on prolapsed mitral valve syndrome. In 1967, he was the first American physician on the American Soviet Exchange Program for which he received a presidential citation from President Richard Nixon, one of the only presidential citations given to an American physician. He has published numerous peer reviewed articles in significant medical journals. He has been granted 27 American patents on various aspects of cardiovascular disease and has more than 12 new patent applications pending at the U.S. Patent Office.

He recently (2012, 2014) published new data regarding the nutritional management of pain using the amino acid based medical food Theramine in the American Journal of Therapeutics,[5][6] in addition to new data regarding the nutritional management of sleep disorders[7] and the nutritional management of PTSD.[8]

Commercial activity edit

As an entrepreneur, Shell developed multiple patents for Targeted Medical Pharma governing the processes involved in amino acid based medical food products. Dr. Shell the former CEO of Physician Therapeutics created the following products: Theracodophen-650 Convenience Pack (Hydrocodone 10 mg, Acetaminophen 650 mg, and Theramine); Strazepam Convenience Pack (Temazepam 15 mg and Sentra PM); Gabazolamine-0.5 Convenience Pack (Alprazolam 0.5 mg and GABAdone); Gaboxetine Convenience Pack (Fluoxetine 10 mg and GABAdone); Trazamine Convenience Pack (Tradazone 50 mg and Sentra PM); Senophylline Convenience Pack (Theophylline 100 mg and Sentra PM); Therapentin-60 (Gabapentin 200 mg and Theramine); Prazolamine (Carisoprodol 350 mg and Theramine); Sentradine (Ranitidine 150 mg and Sentra PM); and Therafeldamine (Piroxicam 20 mg and Theramine)[9] Dr. Shell successfully defended these products listed in the warning letter and subsequently worked with FDA to register these products in their database as well as the NIH Dailymed database.[10] Previous products include the Fat Magnet (Lipitrol), a product that uses cellulose to trap fat and bind with it.[11] Fat Magnet was banned from making and advertising false claims by the Federal Trade Commission.[3]

Shell also formulated SeQuester, a pill which he promoted as a "natural nutritional fat sequestrant". SeQuester added bile to the fibrous matter, claiming to trap fat and allow it to pass through the digestive system without being absorbed by the body.[12] The Federal Trade Commission also banned SeQuester from making and advertising false claims.[3]

Federal conviction and lifetime ban from the securities industry edit

In 1991, Dr. Shell founded and served as chairman and chief executive officer of SeeShell Biotechnology, a company he started with Dr Jackie Ray See, a Fullerton California doctor, which merged with a company called Interactive Principals, which in turn merged into Interactive Medical Technologies Ltd ("IMT"), whose stock was quoted on the Over the Counter Bulletin Board (the so-called "pink sheets"). Dr. Shell relinquished the daily CEO role and retained the title of chairman of the board of directors until 1995. Shell and Clark Martin "Buzz" Holcomb, a Westlake Village California promoter, were sued by the Securities and Exchange Commission for an illegal unregistered distribution of IMT shares. Both Shell and Holcomb were convicted and permanently barred from the U.S. securities industry as a result, and Shell was additionally fined $35,000. Shell and Holcomb were prosecuted by SEC Enforcement Division prosecutors Alan Rubinstein and Jason Sabot, assisted by SEC Enforcement Division investigator Stanley Skubina. The enforcement action was agreed and signed on August 13, 1997. IMT signed a consent decree in June 1997.[13][14]

References edit

  1. ^ . FamilySearch. Archived from the original on 2016-05-09. Retrieved 2014-06-13.
  2. ^ "William Elson Shell Obituary - Los Angeles, CA". Dignity Memorial.
  3. ^ a b c "FTC proposed orders bar diet claims for Fat Burners, SeQuester, Lipitrol, Svelt-Patch". The Tan Sheet. Pink Sheet. 31 March 1997. Retrieved 3 September 2021.
  4. ^ Including:US application 7674482, William E. Shell, "Method and compositions for potentiating pharmaceuticals with amino acid based medical foods", published 2010-09-10, assigned to Targeted Medical Pharma, Inc.  and US application 7585523, William E. Shell, "Composition and Method to Augment and Sustain Neurotransmitter Production", published 2004-03-04, assigned to Targeted Medical Pharma, Inc. 
  5. ^ Shell, William E.; Charuvastra, Elizabeth H.; DeWood, Marcus A.; May, Lawrence A.; Bullias, Debora H.; Silver, David S (March 2012). "A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain". American Journal of Therapeutics. 19 (2): 108–114. doi:10.1097/MJT.0b013e3181f4b297. PMID 20861716. S2CID 11501257.[non-primary source needed]
  6. ^ Shell, William E.; Pavlik, Stephanie; Roth, Brandon; Silver, Michael; Breitstein, Mira L.; May, Lawrence; Silver, David (November 2016). "Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine". American Journal of Therapeutics. 23 (6): e1353–e1362. doi:10.1097/MJT.0000000000000068. PMC 5102273. PMID 25237981.[non-primary source needed]
  7. ^ Shell, William E.; May, Lawrence A.; Bullias, Debora H.; Pavlik, Stephanie L.; Silver, David S. (23 April 2012). "Sentra PM (a Medical Food) and Trazodone in the Management of Sleep Disorders". Journal of Central Nervous System Disease. 4: 65–72. doi:10.4137/JCNSD.S9381. PMC 3619436. PMID 23650468.[non-primary source needed]
  8. ^ Shell, William E; Charuvastra, Marcus; Breitstein, Mira; Pavlik, Stephanie L.; Charuvastra, Anthony; May, Lawrence; Silver, David S. (January 2014). "Administration of an Amino Acid–Based Regimen for the Management of Autonomic Nervous System Dysfunction Related to Combat-Induced Illness". Journal of Central Nervous System Disease. 6: 93–98. doi:10.4137/JCNSD.S13793. PMC 4197905. PMID 25336998.[non-primary source needed]
  9. ^ . Food and Drug Administration. Archived from the original on 2014-02-21. Retrieved 2014-02-11.
  10. ^ "DailyMed - THERACODOPHEN-650 - hydrocodone bitartrate, acetaminophen, .gamma.-aminobutyric acid". dailymed.nlm.nih.gov.
  11. ^ NCAHF (July–August 1989). "Fat Magnet Trial". National Council Against Health Fraud Newsletter.
  12. ^ "Living - Nonfat Pills -- The Jury Is Still Out On Sequester - Seattle Times Newspaper". community.seattletimes.nwsource.com.
  13. ^ "SEC News Digest, 08-14-1997" (PDF). Retrieved 2019-05-28.
  14. ^ "Form S-1". www.sec.gov. Retrieved 2019-05-28.

External links edit

  • William Shell M.D. Biography
  • Effectiveness of Theramine on Chronic Back Pain 11/05/11
  • Clinical Trial: A Randomized, Placebo-Controlled Trial of an Amino Acid Preparation on Timing and Quality of Sleep 2009
  • The American Journal of Cardiology: Phenylephrine-induced atypical chest pain in patients with prolapsing mitral valve leaflets 01/03/74

January 01, 1970
william, shell, william, elson, shell, september, 1942, march, 2017, american, cardiologist, inventor, several, quack, weight, loss, products, which, were, cited, false, advertising, federal, trade, commission, owned, several, patents, shell, banned, from, sec. William Elson Shell M D September 8 1942 March 28 2017 1 2 was an American cardiologist and inventor of several quack weight loss products which were cited for false advertising by the Federal Trade Commission 3 He owned several U S patents 4 Shell was banned from the securities industry for life as a result of a federal SEC conviction see below Contents 1 Career 2 Commercial activity 3 Federal conviction and lifetime ban from the securities industry 4 References 5 External linksCareer editThis article needs additional citations for verification Relevant discussion may be found on the talk page Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources William Shell news newspapers books scholar JSTOR February 2023 Learn how and when to remove this message Shell was a graduate of the University of Michigan Medical School Following medical school he did an internship and residency at University Hospital in Ann Arbor Michigan He then completed a three year fellowship in cardiovascular medicine under Eugene Braunwald at the University of California San Diego He then served two years as the Chief of the Coronary Care Unit at Keesler Air Force Base Shell has been certified in cardiovascular disease and internal medicine by the American Board of Internal Medicine since 1974 He was the founder former chairman of the board CEO and chief scientific officer at Targeted Medical Pharma Inc in Los Angeles California a specialty pharmaceutical company that develops and distributes medical food products He led the team that discovered the cardio specific enzyme CK MB From 1982 to 1995 Shell was a member of the cardiology staff at Cedars of Lebanon Hospital and Mount Sinai Hospital During his tenure he planned directed and implemented the merger of the coronary care unit at Cedars of Lebanon and Mount Sinai Hospital to what is now known as Cedars Sinai Medical Center in Los Angeles California In addition he directed the Cardiac Cath Lab and Cardiac Rehabilitation Center at Cedar Sinai Medical Center Dr Shell was also director of the Cardiac Catheterization Laboratory and director of Cardiac Rehabilitation He was a member of the research team at the Myocardial Infarction Research Unit a 5 million per year research grant from the National Institute of Health Under that program he was a national leader in the definitions and recognition of silent heart disease He also published seminal papers of the implication of prostaglandins in heart disease In addition he participated in the planning funding and administration of NIH grants and managed a biochemistry research laboratory at Cedars Sinai Medical Center Ultimately he left Cedars Sinai Medical Center in a patent dispute to enter private practice in Beverly Hills He was a founder in Beverly Glen Medical Systems that developed techniques for transtelephonic monitoring of cardiac rhythm disturbances and autonomic nervous system function using 24 hour electrocardiographic recordings for which he published the first American paper on prolapsed mitral valve syndrome In 1967 he was the first American physician on the American Soviet Exchange Program for which he received a presidential citation from President Richard Nixon one of the only presidential citations given to an American physician He has published numerous peer reviewed articles in significant medical journals He has been granted 27 American patents on various aspects of cardiovascular disease and has more than 12 new patent applications pending at the U S Patent Office He recently 2012 2014 published new data regarding the nutritional management of pain using the amino acid based medical food Theramine in the American Journal of Therapeutics 5 6 in addition to new data regarding the nutritional management of sleep disorders 7 and the nutritional management of PTSD 8 Commercial activity editAs an entrepreneur Shell developed multiple patents for Targeted Medical Pharma governing the processes involved in amino acid based medical food products Dr Shell the former CEO of Physician Therapeutics created the following products Theracodophen 650 Convenience Pack Hydrocodone 10 mg Acetaminophen 650 mg and Theramine Strazepam Convenience Pack Temazepam 15 mg and Sentra PM Gabazolamine 0 5 Convenience Pack Alprazolam 0 5 mg and GABAdone Gaboxetine Convenience Pack Fluoxetine 10 mg and GABAdone Trazamine Convenience Pack Tradazone 50 mg and Sentra PM Senophylline Convenience Pack Theophylline 100 mg and Sentra PM Therapentin 60 Gabapentin 200 mg and Theramine Prazolamine Carisoprodol 350 mg and Theramine Sentradine Ranitidine 150 mg and Sentra PM and Therafeldamine Piroxicam 20 mg and Theramine 9 Dr Shell successfully defended these products listed in the warning letter and subsequently worked with FDA to register these products in their database as well as the NIH Dailymed database 10 Previous products include the Fat Magnet Lipitrol a product that uses cellulose to trap fat and bind with it 11 Fat Magnet was banned from making and advertising false claims by the Federal Trade Commission 3 Shell also formulated SeQuester a pill which he promoted as a natural nutritional fat sequestrant SeQuester added bile to the fibrous matter claiming to trap fat and allow it to pass through the digestive system without being absorbed by the body 12 The Federal Trade Commission also banned SeQuester from making and advertising false claims 3 Federal conviction and lifetime ban from the securities industry editIn 1991 Dr Shell founded and served as chairman and chief executive officer of SeeShell Biotechnology a company he started with Dr Jackie Ray See a Fullerton California doctor which merged with a company called Interactive Principals which in turn merged into Interactive Medical Technologies Ltd IMT whose stock was quoted on the Over the Counter Bulletin Board the so called pink sheets Dr Shell relinquished the daily CEO role and retained the title of chairman of the board of directors until 1995 Shell and Clark Martin Buzz Holcomb a Westlake Village California promoter were sued by the Securities and Exchange Commission for an illegal unregistered distribution of IMT shares Both Shell and Holcomb were convicted and permanently barred from the U S securities industry as a result and Shell was additionally fined 35 000 Shell and Holcomb were prosecuted by SEC Enforcement Division prosecutors Alan Rubinstein and Jason Sabot assisted by SEC Enforcement Division investigator Stanley Skubina The enforcement action was agreed and signed on August 13 1997 IMT signed a consent decree in June 1997 13 14 References edit Person Details for William D Shell United States Public Records 1970 2009 FamilySearch Archived from the original on 2016 05 09 Retrieved 2014 06 13 William Elson Shell Obituary Los Angeles CA Dignity Memorial a b c FTC proposed orders bar diet claims for Fat Burners SeQuester Lipitrol Svelt Patch The Tan Sheet Pink Sheet 31 March 1997 Retrieved 3 September 2021 Including US application 7674482 William E Shell Method and compositions for potentiating pharmaceuticals with amino acid based medical foods published 2010 09 10 assigned to Targeted Medical Pharma Inc and US application 7585523 William E Shell Composition and Method to Augment and Sustain Neurotransmitter Production published 2004 03 04 assigned to Targeted Medical Pharma Inc Shell William E Charuvastra Elizabeth H DeWood Marcus A May Lawrence A Bullias Debora H Silver David S March 2012 A Double Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain American Journal of Therapeutics 19 2 108 114 doi 10 1097 MJT 0b013e3181f4b297 PMID 20861716 S2CID 11501257 non primary source needed Shell William E Pavlik Stephanie Roth Brandon Silver Michael Breitstein Mira L May Lawrence Silver David November 2016 Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine American Journal of Therapeutics 23 6 e1353 e1362 doi 10 1097 MJT 0000000000000068 PMC 5102273 PMID 25237981 non primary source needed Shell William E May Lawrence A Bullias Debora H Pavlik Stephanie L Silver David S 23 April 2012 Sentra PM a Medical Food and Trazodone in the Management of Sleep Disorders Journal of Central Nervous System Disease 4 65 72 doi 10 4137 JCNSD S9381 PMC 3619436 PMID 23650468 non primary source needed Shell William E Charuvastra Marcus Breitstein Mira Pavlik Stephanie L Charuvastra Anthony May Lawrence Silver David S January 2014 Administration of an Amino Acid Based Regimen for the Management of Autonomic Nervous System Dysfunction Related to Combat Induced Illness Journal of Central Nervous System Disease 6 93 98 doi 10 4137 JCNSD S13793 PMC 4197905 PMID 25336998 non primary source needed Warning Letters gt Physician Therapeutics LLC 4 8 10 Food and Drug Administration Archived from the original on 2014 02 21 Retrieved 2014 02 11 DailyMed THERACODOPHEN 650 hydrocodone bitartrate acetaminophen gamma aminobutyric acid dailymed nlm nih gov NCAHF July August 1989 Fat Magnet Trial National Council Against Health Fraud Newsletter Living Nonfat Pills The Jury Is Still Out On Sequester Seattle Times Newspaper community seattletimes nwsource com SEC News Digest 08 14 1997 PDF Retrieved 2019 05 28 Form S 1 www sec gov Retrieved 2019 05 28 External links editWilliam Shell M D Biography Effectiveness of Theramine on Chronic Back Pain 11 05 11 Clinical Trial A Randomized Placebo Controlled Trial of an Amino Acid Preparation on Timing and Quality of Sleep 2009 The American Journal of Cardiology Phenylephrine induced atypical chest pain in patients with prolapsing mitral valve leaflets 01 03 74 Retrieved from https en wikipedia org w index php title William Shell amp oldid 1210412679, wikipedia, wiki, book, books, library,

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