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William Hugh Feldman

January 01, 1970

William Hugh Feldman (November 30, 1892, Glasgow, Scotland – January 15, 1974, Rochester, Minnesota)[1] was a doctor of veterinary medicine known for world-renowned achievement in two distinct fields, veterinary pathology and chemotherapy of experimental tuberculosis.[2] He also made important contributions to the treatment of leprosy.[3]

Biography edit

In 1894 he immigrated with his mother to the United States, where they settled in a small frontier town in western Colorado. There he grew up and graduated from high school. At Colorado Agricultural College (now named Colorado State University), he matriculated in 1913, graduated with a D.V.M. in 1917, joined the faculty in 1917, and received an M.Sc. in 1926. From 1917 to 1927 he taught laboratory classes in pathology and bacteriology and also directed the band at College Agricultural College, with the exception of a leave of absence when in 1920 he studied pathology under Aldred Scott Warthin at the University of Michigan Medical School.[3] In Rochester, Minnesota, from 1927 to 1944 Feldman was a veterinary research pathologist and an instructor of comparative pathology at the Mayo Foundation's Institute of Experimental Medicine. In 1944, he became a professor of pathology in the Mayo Foundation Graduate School of the University of Minnesota.[1]

He retired from the Mayo Clinic and Mayo Foundation in 1957 to accept a position in Washington, DC, with the Veterans Administration as Chief of Laboratory Services, Department of Surgery and Medicine, where he took part in cooperative studies on mycobacterial infections and other projects of the tuberculosis service. He resigned from this position in 1967, at age 75, returning to Rochester, Minnesota, where he continued to write and to pursue his avocation of photography.[2]

He expanded his M.Sc. thesis into a book with 410 pages. In 1932 he published the book[3] Neoplasms of Domesticated Animals,[4] which "was the first of its kind published in the English language"[5] and "was acclaimed by reviewers in veterinary and medical journals all over the world."[3] Feldman's second book, Avian Tuberculosis Infections, published in 1938, "is a splendid contribution to the literature on tuberculosis."[6] He was the author or co-author of approximately 300 research papers.[2]

A 1944 paper by Feldman and H. Corwin Hinshaw played an essential role in developing antibiotics to treat tuberculosis.[7]

Feldman at the Mayo Clinic suggested to Selman Waksman to search for antibiotics that could effectively treat tuberculosis. Waksman was reluctant to do research on a potentially deadly bacterium such as Mycobacterium tuberculosis, the causative pathogen of tuberculosis. When Selman's student Albert Schatz learned about this he insisted that he should be allowed to work on an anti-tuberculosis drug, to which Waksman agreed. Feldman gave Schatz H-37, the most virulent tuberculosis bacterial strain in humans.[8]

Under Waksman's direction, Schatz isolated, from the Rutgers Agriculture School's farm soil, a Streptomyces griseus strain that produced an antibiotic.[9]

The culture differed little from Dr. Waksman's many prior Actinomyces griseus isolations made over his many years of research, but the presence of an antibiotic was new. Dr. Waksman and his student Schatz named it streptomycin. A sample was given by Dr. Waksman to the Mayo Clinic's expert researchers Drs. William Feldman and Corwin Hinshaw, who were specialists in tuberculosis studies, and after testing it, they reported that it was not toxic to various animals. It was the first Rutgers antibiotic obtained that was not toxic to animals. Therefore, Schatz's culture was a very significant discovery.[10]

Dr. Feldman was the first veterinarian in the United States to hold a chair of comparative pathology in a medical institution. By the example he set, he won respect among the medical profession for the previously overlooked extent to which veterinarians could contribute in scientific research projects.[3]

More than any other researcher he developed the field of comparative pathology of tuberculosis.[11]

For one year from 1941 to 1942 Feldman was the president of the International Association of Medical Museums (renamed in 1955 the International Academy of Pathology).[1] He was the first veterinarian to be honored with that presidency.[3] For one year from 1941 to 1942 he was also the president of the United States and Canadian Academy of Pathology (USCAP).[12] For one year from 1952 to 1953 he was the president of the American Association of Pathologists and Bacteriologists (AAPB).[3]

He was an acclaimed expert in photomicrography. "He personally made all photographic illustrations for his publications, using a home-made device",[3] which he described in a 1929 article in the Archives of Pathology.[13] He made photographs of Sir William Osler, as well as Osler's home, laboratory, and instruments.[14] Feldman made photographic portraits of many prominent physicians, especially pathologists, and medical researchers, including 14 Nobel Prize winners.[3] In 1972 the U.S. National Library of Medicine displayed his photographic portraits of pathologists in the U.S. National Library of Medicine.[1]

Feldman was given many awards and honors, including in 1946 the Pasteur Medal from the Pasteur Institute, in 1955 the Trudeau Medal from the National Tuberculosis Association, in 1957 the Distinguished Service Medal from the American College of Chest Physicians,[3] and in the Varrier-Jones Memorial Medal, a British honor awarded for research in tuberculosis.[15] He delivered in 1941 the John W. Bell Memorial Tuberculosis Lecture and in 1946 the Harben Lectures at the Royal Institute of Public Health and Hygiene. Colorado A&M (renamed from Colorado Agricultural College) gave him in 1945 an honorary D.Sc. and in 1950 made him an Honor Alumnus.[3] In 1951 Gerhard Domagk nominated Feldman for a Nobel Prize.[16]

In Colorado, Feldman married Esther Marsh Dickinson (1895–1932). Their daughter Esther Isabelle Feldman (1918–1960) married and had two children. William Hugh Feldman's second wife was Ruth Elaine Harrison. They had a son, William Harrison Feldman (born in 1938),[17] who married Diane V. Nemeczek in 1973.

Selected publications edit

Articles edit

  • Feldman, W. H. (1930). "The Pathogenicity for Dogs of Bacilli of Avian Tuberculosis". Journal of the American Veterinary Medical Association. 76: 399–419.
  • Feldman, William H.; Baggenstoss, Archie H. (July 1938). "The residual infectivity of the primary complex of tuberculosis". Am J Pathol. 14 (4): 473–490.3. PMC 1964987. PMID 19970404.
  • Feldman, W. H.; Hinshaw, H. C.; Mann, F. C. (1945). "Streptomycin in experimental tuberculosis". American Review of Tuberculosis. 52 (4): 269–298. doi:10.1164/art.1945.52.4.269 (inactive 31 January 2024).{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
  • Hinshaw, Corwin; Feldman, William H.; Pfuetze, Karl H. (November 30, 1946). "Treatment of Tuberculosis with Streptomycin: A Summary of Observations on One Hundred Cases". Journal of the American Medical Association. 132 (13): 778–782. doi:10.1001/jama.1946.02870480024007. PMID 21002442.
  • Feldman, William H.; Henshaw, H. Corwin (17 January 1948). "Streptomycin: A Valuable Anti-tuberculosis Agent". Br Med J. 1 (4541): 87–92. doi:10.1136/bmj.1.4541.87. PMC 2089248. PMID 18921002.
  • Van Patter, W.N.; Bargen, J.A.; Dockerty, M.B.; Feldman, W.H.; Mayo, C.W.; Waugh, J.M. (1954). "Regional enteritis". Gastroenterology. 26 (3): 347–450. doi:10.1016/S0016-5085(54)80024-2. PMID 13142217. (over 500 citations)
  • Feldman, W. H. (January 1955). "Recruitment and training of veterinary research pathologists". J Am Vet Med Assoc. 126 (934): 10–13. PMID 13221501.

Books edit

  • Feldman, William Hugh (1932). Neoplasms of Domesticated Animals. W. B. Saunders.
  • Feldman, William Hugh (1938). Avian Tuberculosis Infections. Williams & Wilkins.

References edit

  1. ^ a b c d "1941–1942 William H. Feldman USA (Scotland)". Hall of Presidents, Presidents of the International Academy of Pathology.
  2. ^ a b c Karlson, A. G. (January 1975). "William Hugh Feldman, DVM, 1892-1974". The American Journal of Pathology. 78 (1): 3–6. PMC 1915027. PMID 1089013.
  3. ^ a b c d e f g h i j k Saunders, L. Z. (1974). "William H. Feldman 1892–1974". Veterinary Pathology. 11 (3): 197–202. doi:10.1177/030098587401100301. PMID 4618701. S2CID 38775576.
  4. ^ "Review of Neoplasms of Domesticated Animals by William H. Feldman". British Medical Journal. 1 (3729): 1179–1183. 25 June 1932. PMC 2521221.
  5. ^ "Review of Neoplasms of Domesticated Animals by William Feldman". American Journal of Clinical Pathology. 2 (3): 275–276. 1 May 1932. doi:10.1093/ajcp/2.3.275a.
  6. ^ Coleman, Bernard S. (April 1939). "Review of Avian Tuberculosis Infections by William Feldman". American Journal of Public Health. 29: 393–394. doi:10.2105/AJPH.29.4.393.
  7. ^ Feldman WH; Hinshaw HC (1944). "Effects of streptomycin on experimental tuberculosis in guinea pigs". Proc. Staff Meet. Mayo Clin. 19: 593–599.
  8. ^ Schatz, Albert (1993). "The true story of the development of streptomycin". Actinomycetes. 4 (2): 27–39.
  9. ^ Woodruf, H. Boyd (January 2014). "Selman A. Waksman, Winner of the 1952 Nobel Prize for Physiology or Medicine". Appl Environ Microbiol. 80 (1): 2–8. Bibcode:2014ApEnM..80....2W. doi:10.1128/AEM.01143-13. PMC 3911012. PMID 24162573.
  10. ^ Woodruf, H. Boyd (January 2014). "Selman A. Waksman, Winner of the 1952 Nobel Prize for Physiology or Medicine". Appl Environ Microbiol. 80 (1): 2–8. Bibcode:2014ApEnM..80....2W. doi:10.1128/AEM.01143-13. PMC 3911012. PMID 24162573.
  11. ^ Long, Esmond, R. "Obituary. William Hugh Feldman, DVM., M.S. 1892-1974". ILSL - International Journal of Leprosy and Other Mycobacterial Diseases. 42 (3): 328–331.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  12. ^ "Past Presidents". USCAP. 30 March 2021.
  13. ^ Feldman, W. H. (1929). "A simple inexpensive photomicrographic apparatus". Archives of Pathology. 8: 78–80.
  14. ^ Photographs of Sir William Osler; his home; laboratory; memorial; old autopsy house; instruments (Housed at end of collection in Box 43) National Museum of Health and Medicine, Otis Historical Archives
  15. ^ "Award to Dr. Feldman, Veterans Administration, Government Services". Journal of the American Medical Association. 179 (5): 376. February 3, 1962. doi:10.1001/jama.1962.03050050066015.
  16. ^ "William H. Feldman". Nomination Archive, The Nobel Prize. April 2020.
  17. ^ "Ruth Feldman in 1940 census". ancestry.com.,

External links edit

  • Parmar, Arundhati (December 22, 2011). "The 50 best Mayo Clinic doctors. Ever". MedCity News, MinnPost.
  • Witte, Carmel (28 October 2016). "My Date with Dr. Feldman". Science Blog, San Diego Zoo Wildlife Alliance.

January 01, 1970
william, hugh, feldman, november, 1892, glasgow, scotland, january, 1974, rochester, minnesota, doctor, veterinary, medicine, known, world, renowned, achievement, distinct, fields, veterinary, pathology, chemotherapy, experimental, tuberculosis, also, made, im. William Hugh Feldman November 30 1892 Glasgow Scotland January 15 1974 Rochester Minnesota 1 was a doctor of veterinary medicine known for world renowned achievement in two distinct fields veterinary pathology and chemotherapy of experimental tuberculosis 2 He also made important contributions to the treatment of leprosy 3 Contents 1 Biography 2 Selected publications 2 1 Articles 2 2 Books 3 References 4 External linksBiography editIn 1894 he immigrated with his mother to the United States where they settled in a small frontier town in western Colorado There he grew up and graduated from high school At Colorado Agricultural College now named Colorado State University he matriculated in 1913 graduated with a D V M in 1917 joined the faculty in 1917 and received an M Sc in 1926 From 1917 to 1927 he taught laboratory classes in pathology and bacteriology and also directed the band at College Agricultural College with the exception of a leave of absence when in 1920 he studied pathology under Aldred Scott Warthin at the University of Michigan Medical School 3 In Rochester Minnesota from 1927 to 1944 Feldman was a veterinary research pathologist and an instructor of comparative pathology at the Mayo Foundation s Institute of Experimental Medicine In 1944 he became a professor of pathology in the Mayo Foundation Graduate School of the University of Minnesota 1 He retired from the Mayo Clinic and Mayo Foundation in 1957 to accept a position in Washington DC with the Veterans Administration as Chief of Laboratory Services Department of Surgery and Medicine where he took part in cooperative studies on mycobacterial infections and other projects of the tuberculosis service He resigned from this position in 1967 at age 75 returning to Rochester Minnesota where he continued to write and to pursue his avocation of photography 2 He expanded his M Sc thesis into a book with 410 pages In 1932 he published the book 3 Neoplasms of Domesticated Animals 4 which was the first of its kind published in the English language 5 and was acclaimed by reviewers in veterinary and medical journals all over the world 3 Feldman s second book Avian Tuberculosis Infections published in 1938 is a splendid contribution to the literature on tuberculosis 6 He was the author or co author of approximately 300 research papers 2 A 1944 paper by Feldman and H Corwin Hinshaw played an essential role in developing antibiotics to treat tuberculosis 7 Feldman at the Mayo Clinic suggested to Selman Waksman to search for antibiotics that could effectively treat tuberculosis Waksman was reluctant to do research on a potentially deadly bacterium such as Mycobacterium tuberculosis the causative pathogen of tuberculosis When Selman s student Albert Schatz learned about this he insisted that he should be allowed to work on an anti tuberculosis drug to which Waksman agreed Feldman gave Schatz H 37 the most virulent tuberculosis bacterial strain in humans 8 Under Waksman s direction Schatz isolated from the Rutgers Agriculture School s farm soil a Streptomyces griseus strain that produced an antibiotic 9 The culture differed little from Dr Waksman s many prior Actinomyces griseus isolations made over his many years of research but the presence of an antibiotic was new Dr Waksman and his student Schatz named it streptomycin A sample was given by Dr Waksman to the Mayo Clinic s expert researchers Drs William Feldman and Corwin Hinshaw who were specialists in tuberculosis studies and after testing it they reported that it was not toxic to various animals It was the first Rutgers antibiotic obtained that was not toxic to animals Therefore Schatz s culture was a very significant discovery 10 Dr Feldman was the first veterinarian in the United States to hold a chair of comparative pathology in a medical institution By the example he set he won respect among the medical profession for the previously overlooked extent to which veterinarians could contribute in scientific research projects 3 More than any other researcher he developed the field of comparative pathology of tuberculosis 11 For one year from 1941 to 1942 Feldman was the president of the International Association of Medical Museums renamed in 1955 the International Academy of Pathology 1 He was the first veterinarian to be honored with that presidency 3 For one year from 1941 to 1942 he was also the president of the United States and Canadian Academy of Pathology USCAP 12 For one year from 1952 to 1953 he was the president of the American Association of Pathologists and Bacteriologists AAPB 3 He was an acclaimed expert in photomicrography He personally made all photographic illustrations for his publications using a home made device 3 which he described in a 1929 article in the Archives of Pathology 13 He made photographs of Sir William Osler as well as Osler s home laboratory and instruments 14 Feldman made photographic portraits of many prominent physicians especially pathologists and medical researchers including 14 Nobel Prize winners 3 In 1972 the U S National Library of Medicine displayed his photographic portraits of pathologists in the U S National Library of Medicine 1 Feldman was given many awards and honors including in 1946 the Pasteur Medal from the Pasteur Institute in 1955 the Trudeau Medal from the National Tuberculosis Association in 1957 the Distinguished Service Medal from the American College of Chest Physicians 3 and in the Varrier Jones Memorial Medal a British honor awarded for research in tuberculosis 15 He delivered in 1941 the John W Bell Memorial Tuberculosis Lecture and in 1946 the Harben Lectures at the Royal Institute of Public Health and Hygiene Colorado A amp M renamed from Colorado Agricultural College gave him in 1945 an honorary D Sc and in 1950 made him an Honor Alumnus 3 In 1951 Gerhard Domagk nominated Feldman for a Nobel Prize 16 In Colorado Feldman married Esther Marsh Dickinson 1895 1932 Their daughter Esther Isabelle Feldman 1918 1960 married and had two children William Hugh Feldman s second wife was Ruth Elaine Harrison They had a son William Harrison Feldman born in 1938 17 who married Diane V Nemeczek in 1973 Selected publications editArticles edit Feldman W H 1930 The Pathogenicity for Dogs of Bacilli of Avian Tuberculosis Journal of the American Veterinary Medical Association 76 399 419 Feldman William H Baggenstoss Archie H July 1938 The residual infectivity of the primary complex of tuberculosis Am J Pathol 14 4 473 490 3 PMC 1964987 PMID 19970404 Feldman W H Hinshaw H C Mann F C 1945 Streptomycin in experimental tuberculosis American Review of Tuberculosis 52 4 269 298 doi 10 1164 art 1945 52 4 269 inactive 31 January 2024 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint DOI inactive as of January 2024 link Hinshaw Corwin Feldman William H Pfuetze Karl H November 30 1946 Treatment of Tuberculosis with Streptomycin A Summary of Observations on One Hundred Cases Journal of the American Medical Association 132 13 778 782 doi 10 1001 jama 1946 02870480024007 PMID 21002442 Feldman William H Henshaw H Corwin 17 January 1948 Streptomycin A Valuable Anti tuberculosis Agent Br Med J 1 4541 87 92 doi 10 1136 bmj 1 4541 87 PMC 2089248 PMID 18921002 Van Patter W N Bargen J A Dockerty M B Feldman W H Mayo C W Waugh J M 1954 Regional enteritis Gastroenterology 26 3 347 450 doi 10 1016 S0016 5085 54 80024 2 PMID 13142217 over 500 citations Feldman W H January 1955 Recruitment and training of veterinary research pathologists J Am Vet Med Assoc 126 934 10 13 PMID 13221501 Books edit Feldman William Hugh 1932 Neoplasms of Domesticated Animals W B Saunders Feldman William Hugh 1938 Avian Tuberculosis Infections Williams amp Wilkins References edit a b c d 1941 1942 William H Feldman USA Scotland Hall of Presidents Presidents of the International Academy of Pathology a b c Karlson A G January 1975 William Hugh Feldman DVM 1892 1974 The American Journal of Pathology 78 1 3 6 PMC 1915027 PMID 1089013 a b c d e f g h i j k Saunders L Z 1974 William H Feldman 1892 1974 Veterinary Pathology 11 3 197 202 doi 10 1177 030098587401100301 PMID 4618701 S2CID 38775576 Review of Neoplasms of Domesticated Animals by William H Feldman British Medical Journal 1 3729 1179 1183 25 June 1932 PMC 2521221 Review of Neoplasms of Domesticated Animals by William Feldman American Journal of Clinical Pathology 2 3 275 276 1 May 1932 doi 10 1093 ajcp 2 3 275a Coleman Bernard S April 1939 Review of Avian Tuberculosis Infections by William Feldman American Journal of Public Health 29 393 394 doi 10 2105 AJPH 29 4 393 Feldman WH Hinshaw HC 1944 Effects of streptomycin on experimental tuberculosis in guinea pigs Proc Staff Meet Mayo Clin 19 593 599 Schatz Albert 1993 The true story of the development of streptomycin Actinomycetes 4 2 27 39 Woodruf H Boyd January 2014 Selman A Waksman Winner of the 1952 Nobel Prize for Physiology or Medicine Appl Environ Microbiol 80 1 2 8 Bibcode 2014ApEnM 80 2W doi 10 1128 AEM 01143 13 PMC 3911012 PMID 24162573 Woodruf H Boyd January 2014 Selman A Waksman Winner of the 1952 Nobel Prize for Physiology or Medicine Appl Environ Microbiol 80 1 2 8 Bibcode 2014ApEnM 80 2W doi 10 1128 AEM 01143 13 PMC 3911012 PMID 24162573 Long Esmond R Obituary William Hugh Feldman DVM M S 1892 1974 ILSL International Journal of Leprosy and Other Mycobacterial Diseases 42 3 328 331 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Past Presidents USCAP 30 March 2021 Feldman W H 1929 A simple inexpensive photomicrographic apparatus Archives of Pathology 8 78 80 Photographs of Sir William Osler his home laboratory memorial old autopsy house instruments Housed at end of collection in Box 43 National Museum of Health and Medicine Otis Historical Archives Award to Dr Feldman Veterans Administration Government Services Journal of the American Medical Association 179 5 376 February 3 1962 doi 10 1001 jama 1962 03050050066015 William H Feldman Nomination Archive The Nobel Prize April 2020 Ruth Feldman in 1940 census ancestry com External links editParmar Arundhati December 22 2011 The 50 best Mayo Clinic doctors Ever MedCity News MinnPost Witte Carmel 28 October 2016 My Date with Dr Feldman Science Blog San Diego Zoo Wildlife Alliance Retrieved from https en wikipedia org w index php title William Hugh Feldman amp oldid 1202008937, wikipedia, wiki, book, books, library,

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