The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.
This gene is a member of the WNT gene family. It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000075290 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036961 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lako M, Strachan T, Curtis AR, Lindsay S (Sep 1996). "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24". Genomics. 35 (2): 386–8. doi:10.1006/geno.1996.0374. PMID 8661156.
^ ab"Entrez Gene: WNT8B wingless-type MMTV integration site family, member 8B".
Further readingedit
Katoh M, Katoh M (2007). "Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs". Int. J. Oncol. 30 (5): 1273–7. doi:10.3892/ijo.30.5.1273. PMID 17390031.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Saitoh T, Mine T, Katoh M (2002). "Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". Int. J. Oncol. 20 (5): 999–1003. doi:10.3892/ijo.20.5.999. PMID 11956596.
Saitoh T, Mine T, Katoh M (2002). "Up-regulation of WNT8B mRNA in human gastric cancer". Int. J. Oncol. 20 (2): 343–8. doi:10.3892/ijo.20.2.343. PMID 11788899.
Lako M, Lindsay S, Bullen P, et al. (1998). "A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain". Hum. Mol. Genet. 7 (5): 813–22. doi:10.1093/hmg/7.5.813. PMID 9536085.
Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC275763. PMID 8167409.
This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.
wnt8b, protein, protein, that, humans, encoded, gene, identifiersaliases, family, member, 8bexternal, idsomim, 601396, 109485, homologene, 2550, genecards, gene, location, human, chromosome, human, band10q24, 31start100, end100, gene, location, mouse, chromoso. Protein Wnt 8b is a protein that in humans is encoded by the WNT8B gene 5 6 WNT8BIdentifiersAliasesWNT8B Wnt family member 8BExternal IDsOMIM 601396 MGI 109485 HomoloGene 2550 GeneCards WNT8BGene location Human Chr Chromosome 10 human 1 Band10q24 31Start100 463 009 bp 1 End100 483 744 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 C3 19 37 98 cMStart44 481 911 bp 2 End44 502 712 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inkidneybody of pancreasrenal cortexliverurinary bladderprostateright adrenal glandmuscle of legmouthsalivary glandTop expressed incorneal epitheliumveinascending aortacorneal endotheliumaortic valvecorneal stromasurface ectodermrenal corpusclethymussuperior frontal gyrusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsignaling receptor binding frizzled binding receptor ligand activityCellular componentextracellular region extracellular spaceBiological processmulticellular organism development cellular response to retinoic acid cell fate commitment determination of dorsal identity response to estradiol gastrulation response to retinoic acid neuron differentiation signal transduction nervous system development beta catenin destruction complex disassembly Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez747922423EnsemblENSG00000075290ENSMUSG00000036961UniProtQ93098Q9WUD6RefSeq mRNA NM 003393NM 011720RefSeq protein NP 003384n aLocation UCSC Chr 10 100 46 100 48 MbChr 19 44 48 44 5 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe WNT gene family consists of structurally related genes that encode secreted signaling proteins These proteins have been implicated in oncogenesis and in several developmental processes including regulation of cell fate and patterning during embryogenesis This gene is a member of the WNT gene family It encodes a protein showing 95 86 and 71 amino acid identity to the mouse zebrafish and Xenopus Wnt8B proteins respectively The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000075290 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000036961 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lako M Strachan T Curtis AR Lindsay S Sep 1996 Isolation and characterization of WNT8B a novel human Wnt gene that maps to 10q24 Genomics 35 2 386 8 doi 10 1006 geno 1996 0374 PMID 8661156 a b Entrez Gene WNT8B wingless type MMTV integration site family member 8B Further reading editKatoh M Katoh M 2007 Conserved POU OCT and GATA binding sites in 5 flanking promoter region of mammalian WNT8B orthologs Int J Oncol 30 5 1273 7 doi 10 3892 ijo 30 5 1273 PMID 17390031 Deloukas P Earthrowl ME Grafham DV et al 2004 The DNA sequence and comparative analysis of human chromosome 10 Nature 429 6990 375 81 Bibcode 2004Natur 429 375D doi 10 1038 nature02462 PMID 15164054 Brandenberger R Wei H Zhang S et al 2005 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat Biotechnol 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Saitoh T Mine T Katoh M 2002 Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines up regulation of WNT8B mRNA by beta estradiol in MCF 7 cells and down regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells Int J Oncol 20 5 999 1003 doi 10 3892 ijo 20 5 999 PMID 11956596 Saitoh T Mine T Katoh M 2002 Up regulation of WNT8B mRNA in human gastric cancer Int J Oncol 20 2 343 8 doi 10 3892 ijo 20 2 343 PMID 11788899 Lako M Lindsay S Bullen P et al 1998 A novel mammalian wnt gene WNT8B shows brain restricted expression in early development with sharply delimited expression boundaries in the developing forebrain Hum Mol Genet 7 5 813 22 doi 10 1093 hmg 7 5 813 PMID 9536085 Smolich BD McMahon JA McMahon AP Papkoff J 1994 Wnt family proteins are secreted and associated with the cell surface Mol Biol Cell 4 12 1267 75 doi 10 1091 mbc 4 12 1267 PMC 275763 PMID 8167409 nbsp This article on a gene on human chromosome 10 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title WNT8B amp oldid 1115920587, wikipedia, wiki, book, books, library,
