The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, which are involved in the Wnt signaling pathway. It is overexpressed in cervical cancercell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line.[3] The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level.[1]
Role in Development
Wnt6 plays a role in the formation and maturation of different embryonic structures, namely the fetal heart, ventral body wall, and somite derived structures. Wnt6, through the canonical Wnt signaling pathway, inhibits the induction of cardiogenic mesoderm.[4] For this reason, Wnt6 inhibitors like Cerberus must be present to allow the cells to be induced.[4] Knockout models show that without Wnt6 the fetus develops an enlarged heart, while upregulating Wnt6 results in the heart being underdeveloped.[4] Several Wnts, including Wnt6, have shown to be involved in the formation of the ventral body wall and when inhibited result in birth defects such as failure of the wall to close, hypoplasia of the musculature, and other defects.[5] Following the formation of the somites from the Paraxial Mesoderm, the outermost cells of the somites undergo a mesenchymal to epithelial transition.[6] Wnt6 is expressed by the overlying ectoderm and promotes the production of Paraxis, which facilitates the transition.[6] While many structures will still form if Wnt6 is knocked out, the structures (ribs, vertebra, and muscles) are fused and not organized properly.[6] On the other hand, if Wnt6 is upregulated, muscle in the limbs and surrounding areas are decreased as the mesenchymal progenitor cells that migrate and become the muscle are locked in the somite as epithelial cells.[6]
Referencesedit
^ ab"Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2".
^Rankin J, Strachan T, Lako M, Lindsay S (1999). "Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization". Cytogenet. Cell Genet. 84 (1–2): 50–2. doi:10.1159/000015212. PMID 10343101. S2CID 19452847.
^Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
^ abcLavery, Danielle L.; Martin, Jennifer; Turnbull, Yvonne D.; Hoppler, Stefan (November 2008). "Wnt6 signaling regulates heart muscle development during organogenesis". Developmental Biology. 323 (2): 177–188. doi:10.1016/j.ydbio.2008.08.032. PMC2593796. PMID 18804460.
wnt6, wingless, type, mmtv, integration, site, family, member, also, known, human, gene, wingless, type, mmtv, integration, site, family, member, 6identifierssymbolncbi, gene7475hgnc12785omim604663refseqnm, 006522uniprotq9y6f9other, datalocuschr, q35search, fo. Wingless type MMTV integration site family member 6 also known as WNT6 is a human gene 1 2 wingless type MMTV integration site family member 6IdentifiersSymbolWNT6NCBI gene7475HGNC12785OMIM604663RefSeqNM 006522UniProtQ9Y6F9Other dataLocusChr 2 q35Search forStructuresSwiss modelDomainsInterPro The WNT gene family consists of structurally related genes that encode secreted signaling proteins These proteins have been implicated in oncogenesis and in several developmental processes including regulation of cell fate and patterning during embryogenesis This gene is a member of the WNT gene family which are involved in the Wnt signaling pathway It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member WNT10A in colorectal cancer cell line 3 The gene overexpression may play key roles in carcinogenesis This gene and the WNT10A gene are clustered in the chromosome 2q35 region The protein encoded by this gene is 97 identical to the mouse Wnt6 protein at the amino acid level 1 Role in DevelopmentWnt6 plays a role in the formation and maturation of different embryonic structures namely the fetal heart ventral body wall and somite derived structures Wnt6 through the canonical Wnt signaling pathway inhibits the induction of cardiogenic mesoderm 4 For this reason Wnt6 inhibitors like Cerberus must be present to allow the cells to be induced 4 Knockout models show that without Wnt6 the fetus develops an enlarged heart while upregulating Wnt6 results in the heart being underdeveloped 4 Several Wnts including Wnt6 have shown to be involved in the formation of the ventral body wall and when inhibited result in birth defects such as failure of the wall to close hypoplasia of the musculature and other defects 5 Following the formation of the somites from the Paraxial Mesoderm the outermost cells of the somites undergo a mesenchymal to epithelial transition 6 Wnt6 is expressed by the overlying ectoderm and promotes the production of Paraxis which facilitates the transition 6 While many structures will still form if Wnt6 is knocked out the structures ribs vertebra and muscles are fused and not organized properly 6 On the other hand if Wnt6 is upregulated muscle in the limbs and surrounding areas are decreased as the mesenchymal progenitor cells that migrate and become the muscle are locked in the somite as epithelial cells 6 References edit a b Entrez Gene WNT2 wingless type MMTV integration site family member 2 Rankin J Strachan T Lako M Lindsay S 1999 Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization Cytogenet Cell Genet 84 1 2 50 2 doi 10 1159 000015212 PMID 10343101 S2CID 19452847 Kirikoshi H Sekihara H Katoh M May 2001 WNT10A and WNT6 clustered in human chromosome 2q35 region with head to tail manner are strongly coexpressed in SW480 cells Biochem Biophys Res Commun 283 4 798 805 doi 10 1006 bbrc 2001 4855 PMID 11350055 a b c Lavery Danielle L Martin Jennifer Turnbull Yvonne D Hoppler Stefan November 2008 Wnt6 signaling regulates heart muscle development during organogenesis Developmental Biology 323 2 177 188 doi 10 1016 j ydbio 2008 08 032 PMC 2593796 PMID 18804460 Zhang Lingling Li Hanjun Yu Jian Cao Jingjing Chen Huihui Zhao Haixia March 2014 Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development Developmental Biology 387 1 64 72 doi 10 1016 j ydbio 2013 12 027 PMID 24394376 a b c d Schmidt Corina Stoeckelhuber Mechthild McKinnell Iain Putz Reinhard Christ Bodo Patel Ketan July 2004 Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation Developmental Biology 271 1 198 209 doi 10 1016 j ydbio 2004 03 016 PMID 15196961 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title WNT6 amp oldid 1028447479, wikipedia, wiki, book, books, library,
