The WNT gene family consists of structurally-related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates two transcript variants.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000111186 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030170 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". Int J Oncol. 19 (2): 347–51. doi:10.3892/ijo.19.2.347. PMID 11445850.
^ ab"Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B".
Further readingedit
Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC275763. PMID 8167409.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med. 10 (3): 345–9. doi:10.3892/ijmm.10.3.345. PMID 12165812.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Kanazawa A, Tsukada S, Sekine A, et al. (2005). "Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes". Am. J. Hum. Genet. 75 (5): 832–43. doi:10.1086/425340. PMC1182112. PMID 15386214.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Mangioni S, Viganò P, Lattuada D, et al. (2005). "Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor". J. Clin. Endocrinol. Metab. 90 (9): 5349–55. doi:10.1210/jc.2005-0272. PMID 15972578.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
wnt5b, protein, protein, that, humans, encoded, gene, identifiersaliases, family, member, 5bexternal, idsomim, 606361, 98959, homologene, 22530, genecards, gene, location, human, chromosome, human, band12p13, 33start1, end1, gene, location, mouse, chromosome, . Protein Wnt 5b is a protein that in humans is encoded by the WNT5B gene 5 6 WNT5BIdentifiersAliasesWNT5B Wnt family member 5BExternal IDsOMIM 606361 MGI 98959 HomoloGene 22530 GeneCards WNT5BGene location Human Chr Chromosome 12 human 1 Band12p13 33Start1 529 891 bp 1 End1 647 212 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 F1 6 56 86 cMStart119 409 492 bp 2 End119 521 308 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumperiodontal fiberprostateminor salivary glandpalpebral conjunctivatibiapituitary glandanterior pituitaryAchilles tendontibial nerveTop expressed inrenal corpuscleprimitive streakaortic valveadrenal medullainternal carotid arteryvas deferensconjunctival fornixexternal carotid arteryascending aortafossaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionfrizzled binding signaling receptor bindingCellular componentendocytic vesicle membrane endoplasmic reticulum lumen plasma membrane extracellular region cell surface Golgi lumen extracellular exosome extracellular space extracellular matrix collagen containing extracellular matrixBiological processcellular response to retinoic acid cell fate commitment chondrocyte differentiation positive regulation of cell migration wound healing multicellular organism development neuron differentiation positive regulation of fat cell differentiation fat cell differentiation negative regulation of canonical Wnt signaling pathway lens fiber cell development Wnt signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8102922419EnsemblENSG00000111186ENSMUSG00000030170UniProtQ9H1J7P22726RefSeq mRNA NM 030775NM 032642NM 001271757NM 001271758NM 009525RefSeq protein NP 110402NP 116031NP 001258686NP 001258687NP 033551Location UCSC Chr 12 1 53 1 65 MbChr 6 119 41 119 52 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe WNT gene family consists of structurally related genes that encode secreted signaling proteins These proteins have been implicated in oncogenesis and in several developmental processes including regulation of cell fate and patterning during embryogenesis This gene is a member of the WNT gene family It encodes a protein showing 94 and 80 amino acid identity to the mouse Wnt5b protein and the human WNT5A protein respectively Alternative splicing of this gene generates two transcript variants 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000111186 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000030170 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Saitoh T Katoh M Jul 2001 Molecular cloning and characterization of human WNT5B on chromosome 12p13 3 region Int J Oncol 19 2 347 51 doi 10 3892 ijo 19 2 347 PMID 11445850 a b Entrez Gene WNT5B wingless type MMTV integration site family member 5B Further reading editSmolich BD McMahon JA McMahon AP Papkoff J 1994 Wnt family proteins are secreted and associated with the cell surface Mol Biol Cell 4 12 1267 75 doi 10 1091 mbc 4 12 1267 PMC 275763 PMID 8167409 Tanaka K Okabayashi K Asashima M et al 2000 The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family Eur J Biochem 267 13 4300 11 doi 10 1046 j 1432 1033 2000 01478 x PMID 10866835 Saitoh T Katoh M 2003 Expression and regulation of WNT5A and WNT5B in human cancer up regulation of WNT5A by TNFalpha in MKN45 cells and up regulation of WNT5B by beta estradiol in MCF 7 cells Int J Mol Med 10 3 345 9 doi 10 3892 ijmm 10 3 345 PMID 12165812 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kanazawa A Tsukada S Sekine A et al 2005 Association of the Gene Encoding Wingless Type Mammary Tumor Virus Integration Site Family Member 5B WNT5B with Type 2 Diabetes Am J Hum Genet 75 5 832 43 doi 10 1086 425340 PMC 1182112 PMID 15386214 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Mangioni S Vigano P Lattuada D et al 2005 Overexpression of the Wnt5b gene in leiomyoma cells implications for a role of the Wnt signaling pathway in the uterine benign tumor J Clin Endocrinol Metab 90 9 5349 55 doi 10 1210 jc 2005 0272 PMID 15972578 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title WNT5B amp oldid 1142725850, wikipedia, wiki, book, books, library,
