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W. Mark Saltzman

April 09, 2024

William Mark Saltzman was named the Goizueta Foundation Professor of Biomedical and Chemical Engineering at Yale University on July 1, 2002 and became the founding chair of Yale's Department of Biomedical Engineering in 2003.[1] Saltzman's research aims to promote new methods for drug delivery and develop new biotechnologies to combat human disease. A pioneer in the fields of biomaterials, nanobiotechnology, and tissue engineering, Saltzman has contributed to the design and implementation of a number of clinical technologies that have become essential to medical practice today.[2] His popular course Frontiers of Biomedical Engineering is available to everyone through Open Yale Courses.

W. Mark Saltzman
Born (1959-09-08) September 8, 1959 (age 64)
United States
NationalityAmerican
Alma materIowa State University
Massachusetts Institute of Technology
Scientific career
FieldsBiomedical Engineering
InstitutionsJohns Hopkins
Cornell University
Yale University
Doctoral advisorRobert S. Langer

Biography edit

Saltzman received a B.S. in Chemical Engineering in 1981 from Iowa State University, followed by a M.S. in Chemical Engineering in 1984 and a Ph.D. in Medical Engineering in 1987, both at the Massachusetts Institute of Technology.[3]

As a graduate student at the Massachusetts Institute of Technology (MIT), Saltzman built scaffolds that could be seeded with cells to sculpt new replacement tissues. He also created drug-impregnated implants from polymers that slowly and steadily release medicines for long periods—work that now helps patients in the form of GLIADEL, a chemotherapy-loaded polymer wafer that neurosurgeons implant in the brain to combat glioblastoma multiforme (GBM), one of the most aggressive types of malignant brain tumors.[4]

 
Discovering the Gliadel Wafer

He was appointed Assistant Professor of Chemical Engineering at Johns Hopkins University in 1987 and received a joint appointment in the Department of Biomedical Engineering at The Johns Hopkins School of Medicine in 1990. He was promoted to Associate Professor in 1992 and to Professor in 1995. In 1996, he moved to Cornell University, holding the first BP Amoco/H. Laurance Fuller Chair in Chemical Engineering.

He joined the faculty at Yale University, as the Goizueta Foundation Professor of Chemical and Biomedical Engineering, in July 2002 and became the first chair of Yale's Department of Biomedical Engineering in 2003. Since he arrived at Yale in 2002 to form the new department, he has seen his faculty group grow to 19 members. He hired slowly, knowing that each new person would have a significant effect on the overall department culture. Saltzman settled on four areas to excel in: imaging, biomolecular engineering, biomechanics, and systems biology. The department has developed largely as its founders envisioned—multidisciplinary, collegial, integrated with the medical school, and committed to undergraduate education.[5]

As of July 1, 2016, Saltzman serves as Head of Jonathan Edwards College at Yale University.[6]

Research edit

Saltzman's research focuses on developing the most economical, transportable and accessible methods for disease prevention and methods to more effectively deliver chemotherapy to the most aggressive forms of brain tumors. Dr. Saltzman's research interests include controlled drug delivery to the brain, polymers for supplementing or stimulating the immune system, cell interactions with polymers, and tissue engineering. He studies how to create safer and more effective medical and surgical therapy based on tissue engineering. Dr. Saltzman worked with an interdisciplinary team to develop what is now the standard of care for treating brain tumors.[7][8]

Awards and honors edit

 
Committed to Undergraduate Teaching
  • Sheffield Teaching Prize, Yale University (2009)
  • Paper selected as one of top 25 published over past 25 years in Biomaterials (2006)
  • Distinguished Lecturer Award, Biomedical Engineering Society (2004)
  • BP Amoco/H.Laurence Fuller Chair in Chemical Engineering at Cornell (2001)
  • Britton Chance Distinguished Lecturer in Engineering and Medicine, at the University of Pennsylvania (2000)
  • Professional Progress in Engineering Award from Iowa State University (2000)
  • Member, Surgery & Bioengineering Study Section (NIH) (1999)
  • Richard Tucker Excellence in Teaching Award (Cornell) (1999)
  • Fellow, American Institute for Medical and Biological Engineering (1997)
  • Controlled Release Society Young Investigator Award (1996)
  • Allan C. Davis Medal as Maryland's Outstanding Young Engineer (1995)
  • Distinguished Faculty Award for Excellence in Undergraduate Education (Johns Hopkins) (1995)
  • Camille and Henry Dreyfus Foundation Teacher-Scholar Award. (1990)

Works edit

Books

  • Drug Delivery: Engineering Principles for Drug Therapy, 2001, Published by Oxford University Press.[9]
  • Tissue Engineering: Engineering principles for the design of replacement organs and tissues, 2004, Published by Oxford University Press.
  • Biomedical Engineering: Bridging Medicine and Technology, Second Edition, 2015, Published by Cambridge University Press.

Selected Publications

  • McNeer, NA; Chin, JY; Schleifman, EB; Fields, RJ; Glazer, PM; Saltzman, WM (2011). "Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ human hematopoietic progenitors". Mol Ther. 19 (1): 172–80. doi:10.1038/mt.2010.200. PMC 3017438. PMID 20859257.
  • Zhou, J; Liu, J; Cheng, C. J; Patel, T. R; Weller, C. E; Piepmeier, J. M; Jiang, Z; Saltzman, W. M (2011). "Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery". Nature Materials. 11 (1): 82–90. doi:10.1038/nmat3187. PMC 4180913. PMID 22138789.
  • Babar, I. A; Cheng, C. J; Booth, C. J; Liang, X; Weidhaas, J. B; Saltzman, W. M; Slack, F. J (2012). "Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma". Proceedings of the National Academy of Sciences. 109 (26): E1695–E1704. doi:10.1073/pnas.1201516109. PMC 3387084. PMID 22685206.
 
SEM image of nanoparticles
  • Zhou, J; Patel, T. R; Sirianni, R. W; Strohbehn, G; Zheng, M. Q; Duong, N; Schafbauer, T; Huttner, A. J; Huang, Y; Carson, R. E; Zhang, Y; Sullivan Jr, D. J; Piepmeier, J. M; Saltzman, W. M (2013). "Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma". Proceedings of the National Academy of Sciences. 110 (29): 11751–11756. Bibcode:2013PNAS..11011751Z. doi:10.1073/pnas.1304504110. PMC 3718184. PMID 23818631.
  • Devalliere, J; Chang, W. G; Andrejecsk, J. W; Abrahimi, P; Cheng, C. J; Jane-Wit, D; Saltzman, W. M; Pober, J. S (2014). "Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation". The FASEB Journal. 28 (2): 908–922. doi:10.1096/fj.13-238527. PMC 3898640. PMID 24221087.
  • Weiser, J. R; Saltzman, W. M (2014). "Controlled release for local delivery of drugs: Barriers and models". Journal of Controlled Release. 190: 664–73. doi:10.1016/j.jconrel.2014.04.048. PMC 4142083. PMID 24801251.
  • Cheng, C. J; Bahal, R; Babar, I. A; Pincus, Z; Barrera, F; Liu, C; Svoronos, A; Braddock, D. T; Glazer, P. M; Engelman, D. M; Saltzman, W. M; Slack, F. J (2015). "MicroRNA silencing for cancer therapy targeted to the tumour microenvironment". Nature. 518 (7537): 107–10. Bibcode:2015Natur.518..107C. doi:10.1038/nature13905. PMC 4367962. PMID 25409146.
  • McNeer, N. A; Anandalingam, K; Fields, R. J; Caputo, C; Kopic, S; Gupta, A; Quijano, E; Polikoff, L; Kong, Y; Bahal, R; Geibel, J. P; Glazer, P. M; Saltzman, W. M; Egan, M. E (2015). "Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium". Nature Communications. 6: 6952. Bibcode:2015NatCo...6.6952M. doi:10.1038/ncomms7952. PMC 4480796. PMID 25914116.
  • Abrahimi, P; Chang, W. G; Kluger, M. S; Qyang, Y; Tellides, G; Saltzman, W. M; Pober, J. S (2015). "Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9". Circulation Research. 117 (2): 121–8. doi:10.1161/CIRCRESAHA.117.306290. PMC 4490936. PMID 25940550.

References edit

  1. ^ "W. Mark Saltzman of Yale Announced as 2014 Mines Medalist". PRWEB.
  2. ^ "Chair of biomedical engineering joins Institute of Medicine".
  3. ^ Yale University faculty page
  4. ^ "Chair of biomedical engineering joins Institute of Medicine".
  5. ^ Hoffman, Christopher. "Human body as machine: How Yale launched the Department of Biomedical Engineering".
  6. ^ "Next head of Jonathan Edwards College to be W. Mark Saltzman". 6 May 2016.
  7. ^ Saltzman, W. Mark; Olbricht, William L (2002). "Building drug delivery into tissue engineering design". Nature Reviews Drug Discovery. 1 (3): 177–186. doi:10.1038/nrd744. PMID 12120502. S2CID 9191634.
  8. ^ "W. Mark Saltzman, PHD". Yale University Biological and Biomedical Sciences Faculty.
  9. ^ "Yale Official Web Page".

April 09, 2024
mark, saltzman, william, mark, saltzman, named, goizueta, foundation, professor, biomedical, chemical, engineering, yale, university, july, 2002, became, founding, chair, yale, department, biomedical, engineering, 2003, saltzman, research, aims, promote, metho. William Mark Saltzman was named the Goizueta Foundation Professor of Biomedical and Chemical Engineering at Yale University on July 1 2002 and became the founding chair of Yale s Department of Biomedical Engineering in 2003 1 Saltzman s research aims to promote new methods for drug delivery and develop new biotechnologies to combat human disease A pioneer in the fields of biomaterials nanobiotechnology and tissue engineering Saltzman has contributed to the design and implementation of a number of clinical technologies that have become essential to medical practice today 2 His popular course Frontiers of Biomedical Engineering is available to everyone through Open Yale Courses W Mark SaltzmanBorn 1959 09 08 September 8 1959 age 64 United StatesNationalityAmericanAlma materIowa State UniversityMassachusetts Institute of TechnologyScientific careerFieldsBiomedical EngineeringInstitutionsJohns HopkinsCornell UniversityYale UniversityDoctoral advisorRobert S Langer Contents 1 Biography 2 Research 3 Awards and honors 4 Works 5 ReferencesBiography editSaltzman received a B S in Chemical Engineering in 1981 from Iowa State University followed by a M S in Chemical Engineering in 1984 and a Ph D in Medical Engineering in 1987 both at the Massachusetts Institute of Technology 3 As a graduate student at the Massachusetts Institute of Technology MIT Saltzman built scaffolds that could be seeded with cells to sculpt new replacement tissues He also created drug impregnated implants from polymers that slowly and steadily release medicines for long periods work that now helps patients in the form of GLIADEL a chemotherapy loaded polymer wafer that neurosurgeons implant in the brain to combat glioblastoma multiforme GBM one of the most aggressive types of malignant brain tumors 4 nbsp Discovering the Gliadel WaferHe was appointed Assistant Professor of Chemical Engineering at Johns Hopkins University in 1987 and received a joint appointment in the Department of Biomedical Engineering at The Johns Hopkins School of Medicine in 1990 He was promoted to Associate Professor in 1992 and to Professor in 1995 In 1996 he moved to Cornell University holding the first BP Amoco H Laurance Fuller Chair in Chemical Engineering He joined the faculty at Yale University as the Goizueta Foundation Professor of Chemical and Biomedical Engineering in July 2002 and became the first chair of Yale s Department of Biomedical Engineering in 2003 Since he arrived at Yale in 2002 to form the new department he has seen his faculty group grow to 19 members He hired slowly knowing that each new person would have a significant effect on the overall department culture Saltzman settled on four areas to excel in imaging biomolecular engineering biomechanics and systems biology The department has developed largely as its founders envisioned multidisciplinary collegial integrated with the medical school and committed to undergraduate education 5 As of July 1 2016 Saltzman serves as Head of Jonathan Edwards College at Yale University 6 Research editSaltzman s research focuses on developing the most economical transportable and accessible methods for disease prevention and methods to more effectively deliver chemotherapy to the most aggressive forms of brain tumors Dr Saltzman s research interests include controlled drug delivery to the brain polymers for supplementing or stimulating the immune system cell interactions with polymers and tissue engineering He studies how to create safer and more effective medical and surgical therapy based on tissue engineering Dr Saltzman worked with an interdisciplinary team to develop what is now the standard of care for treating brain tumors 7 8 Awards and honors editElected Member National Academy of Engineering 2018 Elected Member National Academy of Medicine formerly Institute of Medicine 2014 Mines Medalist South Dakota School of Mines 2014 Fellow National Academy of Inventors 2013 Fellow Biomedical Engineering Society 2010 nbsp Committed to Undergraduate TeachingSheffield Teaching Prize Yale University 2009 Paper selected as one of top 25 published over past 25 years in Biomaterials 2006 Distinguished Lecturer Award Biomedical Engineering Society 2004 BP Amoco H Laurence Fuller Chair in Chemical Engineering at Cornell 2001 Britton Chance Distinguished Lecturer in Engineering and Medicine at the University of Pennsylvania 2000 Professional Progress in Engineering Award from Iowa State University 2000 Member Surgery amp Bioengineering Study Section NIH 1999 Richard Tucker Excellence in Teaching Award Cornell 1999 Fellow American Institute for Medical and Biological Engineering 1997 Controlled Release Society Young Investigator Award 1996 Allan C Davis Medal as Maryland s Outstanding Young Engineer 1995 Distinguished Faculty Award for Excellence in Undergraduate Education Johns Hopkins 1995 Camille and Henry Dreyfus Foundation Teacher Scholar Award 1990 Works editBooks Drug Delivery Engineering Principles for Drug Therapy 2001 Published by Oxford University Press 9 Tissue Engineering Engineering principles for the design of replacement organs and tissues 2004 Published by Oxford University Press Biomedical Engineering Bridging Medicine and Technology Second Edition 2015 Published by Cambridge University Press Selected Publications McNeer NA Chin JY Schleifman EB Fields RJ Glazer PM Saltzman WM 2011 Nanoparticles deliver triplex forming PNAs for site specific genomic recombination in CD34 human hematopoietic progenitors Mol Ther 19 1 172 80 doi 10 1038 mt 2010 200 PMC 3017438 PMID 20859257 Zhou J Liu J Cheng C J Patel T R Weller C E Piepmeier J M Jiang Z Saltzman W M 2011 Biodegradable poly amine co ester terpolymers for targeted gene delivery Nature Materials 11 1 82 90 doi 10 1038 nmat3187 PMC 4180913 PMID 22138789 Babar I A Cheng C J Booth C J Liang X Weidhaas J B Saltzman W M Slack F J 2012 Nanoparticle based therapy in an in vivo microRNA 155 miR 155 dependent mouse model of lymphoma Proceedings of the National Academy of Sciences 109 26 E1695 E1704 doi 10 1073 pnas 1201516109 PMC 3387084 PMID 22685206 nbsp SEM image of nanoparticlesZhou J Patel T R Sirianni R W Strohbehn G Zheng M Q Duong N Schafbauer T Huttner A J Huang Y Carson R E Zhang Y Sullivan Jr D J Piepmeier J M Saltzman W M 2013 Highly penetrative drug loaded nanocarriers improve treatment of glioblastoma Proceedings of the National Academy of Sciences 110 29 11751 11756 Bibcode 2013PNAS 11011751Z doi 10 1073 pnas 1304504110 PMC 3718184 PMID 23818631 Devalliere J Chang W G Andrejecsk J W Abrahimi P Cheng C J Jane Wit D Saltzman W M Pober J S 2014 Sustained delivery of proangiogenic microRNA 132 by nanoparticle transfection improves endothelial cell transplantation The FASEB Journal 28 2 908 922 doi 10 1096 fj 13 238527 PMC 3898640 PMID 24221087 Weiser J R Saltzman W M 2014 Controlled release for local delivery of drugs Barriers and models Journal of Controlled Release 190 664 73 doi 10 1016 j jconrel 2014 04 048 PMC 4142083 PMID 24801251 Cheng C J Bahal R Babar I A Pincus Z Barrera F Liu C Svoronos A Braddock D T Glazer P M Engelman D M Saltzman W M Slack F J 2015 MicroRNA silencing for cancer therapy targeted to the tumour microenvironment Nature 518 7537 107 10 Bibcode 2015Natur 518 107C doi 10 1038 nature13905 PMC 4367962 PMID 25409146 McNeer N A Anandalingam K Fields R J Caputo C Kopic S Gupta A Quijano E Polikoff L Kong Y Bahal R Geibel J P Glazer P M Saltzman W M Egan M E 2015 Nanoparticles that deliver triplex forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium Nature Communications 6 6952 Bibcode 2015NatCo 6 6952M doi 10 1038 ncomms7952 PMC 4480796 PMID 25914116 Abrahimi P Chang W G Kluger M S Qyang Y Tellides G Saltzman W M Pober J S 2015 Efficient gene disruption in cultured primary human endothelial cells by CRISPR Cas9 Circulation Research 117 2 121 8 doi 10 1161 CIRCRESAHA 117 306290 PMC 4490936 PMID 25940550 References edit W Mark Saltzman of Yale Announced as 2014 Mines Medalist PRWEB Chair of biomedical engineering joins Institute of Medicine Yale University faculty page Chair of biomedical engineering joins Institute of Medicine Hoffman Christopher Human body as machine How Yale launched the Department of Biomedical Engineering Next head of Jonathan Edwards College to be W Mark Saltzman 6 May 2016 Saltzman W Mark Olbricht William L 2002 Building drug delivery into tissue engineering design Nature Reviews Drug Discovery 1 3 177 186 doi 10 1038 nrd744 PMID 12120502 S2CID 9191634 W Mark Saltzman PHD Yale University Biological and Biomedical Sciences Faculty Yale Official Web Page Retrieved from https en wikipedia org w index php title W Mark Saltzman amp oldid 1215950448, wikipedia, wiki, book, books, library,

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