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Wikipedia

Visinin-like protein 1

April 12, 2024

Visinin-like protein 1 is a protein that in humans is encoded by the VSNL1 gene.[5][6][7]

VSNL1
Identifiers
AliasesVSNL1, HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1, visinin like 1
External IDsOMIM: 600817 MGI: 1349453 HomoloGene: 2542 GeneCards: VSNL1
Orthologs
SpeciesHumanMouse
Entrez

7447

26950

Ensembl

ENSG00000163032

ENSMUSG00000054459

UniProt

P62760

P62761

RefSeq (mRNA)

NM_003385

NM_012038
NM_001378929

RefSeq (protein)

NP_003376
NP_001353732
NP_001353733
NP_001353734
NP_001353735

NP_036168
NP_001365858

Location (UCSC)Chr 2: 17.54 – 17.66 MbChr 12: 11.38 – 11.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins.[8]

The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.[7]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163032 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054459 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Polymeropoulos MH, Ide S, Soares MB, Lennon GG (Feb 1996). "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1". Genomics. 29 (1): 273–5. doi:10.1006/geno.1995.1244. PMID 8530085.
  6. ^ Kose A, Ito A, Saito N, Tanaka C (Oct 1990). "Electron microscopic localization of gamma- and beta II-subspecies of protein kinase C in rat hippocampus". Brain Res. 518 (1–2): 209–17. doi:10.1016/0006-8993(90)90974-G. hdl:20.500.14094/D2001395. PMID 2202488. S2CID 54401066.
  7. ^ a b "Entrez Gene: VSNL1 visinin-like 1".
  8. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading edit

  • Kuno T, Kajimoto Y, Hashimoto T, et al. (1992). "cDNA cloning of a neural visinin-like Ca(2+)-binding protein". Biochem. Biophys. Res. Commun. 184 (3): 1219–25. doi:10.1016/S0006-291X(05)80012-9. PMID 1375457.
  • Lenz SE, Braunewell KH, Weise C, et al. (1996). "The neuronal EF-hand Ca(2+)-binding protein VILIP: interaction with cell membrane and actin-based cytoskeleton". Biochem. Biophys. Res. Commun. 225 (3): 1078–83. doi:10.1006/bbrc.1996.1298. PMID 8780737.
  • Braunewell KH, Spilker C, Behnisch T, Gundelfinger ED (1997). "The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity". J. Neurochem. 68 (5): 2129–39. doi:10.1046/j.1471-4159.1997.68052129.x. PMID 9109541. S2CID 29894577.
  • Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Seq. 9 (3): 171–6. doi:10.3109/10425179809072192. PMID 10520747.
  • Bernstein HG, Baumann B, Danos P, et al. (2000). "Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain". J. Neurocytol. 28 (8): 655–62. doi:10.1023/A:1007056731551. PMID 10851344. S2CID 7944931.
  • Braunewell KH, Brackmann M, Schaupp M, et al. (2001). "Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones". J. Neurochem. 78 (6): 1277–86. doi:10.1046/j.1471-4159.2001.00506.x. PMID 11579136. S2CID 41831236.
  • Schnurra I, Bernstein HG, Riederer P, Braunewell KH (2002). "The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease?". Neurobiol. Dis. 8 (5): 900–9. doi:10.1006/nbdi.2001.0432. PMID 11592857. S2CID 45639709.
  • Bernstein HG, Braunewell KH, Spilker C, et al. (2002). "Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia". NeuroReport. 13 (4): 393–6. doi:10.1097/00001756-200203250-00006. PMID 11930147. S2CID 22907782.
  • Spilker C, Dresbach T, Braunewell KH (2002). "Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons". J. Neurosci. 22 (17): 7331–9. doi:10.1523/JNEUROSCI.22-17-07331.2002. PMC 6757958. PMID 12196554.
  • Lin L, Braunewell KH, Gundelfinger ED, Anand R (2002). "Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1". Biochem. Biophys. Res. Commun. 296 (4): 827–32. doi:10.1016/S0006-291X(02)00943-9. PMID 12200122.
  • Lin L, Jeanclos EM, Treuil M, et al. (2003). "The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor". J. Biol. Chem. 277 (44): 41872–8. doi:10.1074/jbc.M206857200. PMID 12202488.
  • Spilker C, Gundelfinger ED, Braunewell KH (2002). "Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function". Biochim. Biophys. Acta. 1600 (1–2): 118–27. doi:10.1016/s1570-9639(02)00452-1. PMID 12445467.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Braunewell KH, Brackmann M, Manahan-Vaughan D (2003). "Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?". Neuropharmacology. 44 (6): 707–15. doi:10.1016/S0028-3908(03)00051-0. PMID 12681369. S2CID 20047130.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gonzalez Guerrico AM, Jaffer ZM, Page RE, et al. (2005). "Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells". Oncogene. 24 (14): 2307–16. doi:10.1038/sj.onc.1208476. PMID 15735716.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Jheng FF, Wang L, Lee L, Chang LS (2007). "Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins". Protein J. 25 (4): 250–6. doi:10.1007/s10930-006-9008-5. PMID 16703469. S2CID 29486237.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
 

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

April 12, 2024
visinin, like, protein, protein, that, humans, encoded, vsnl1, gene, vsnl1identifiersaliasesvsnl1, hlp3, hpcal3, huvisl1, vilip, vilip, visinin, like, 1external, idsomim, 600817, 1349453, homologene, 2542, genecards, vsnl1gene, location, human, chromosome, hum. Visinin like protein 1 is a protein that in humans is encoded by the VSNL1 gene 5 6 7 VSNL1IdentifiersAliasesVSNL1 HLP3 HPCAL3 HUVISL1 VILIP VILIP 1 visinin like 1External IDsOMIM 600817 MGI 1349453 HomoloGene 2542 GeneCards VSNL1Gene location Human Chr Chromosome 2 human 1 Band2p24 2Start17 539 126 bp 1 End17 657 018 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 12 A1 1Start11 375 243 bp 2 End11 486 614 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmiddle temporal gyrusBrodmann area 23orbitofrontal cortexponssuperior frontal gyrusendothelial cellBrodmann area 10Brodmann area 46occipital lobefrontal poleTop expressed inprimary motor cortexsuperior colliculuspontine nucleiventral tegmental areamammillary bodymedial dorsal nucleuslateral hypothalamusmedial geniculate nucleuscerebellar vermisprefrontal cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding protein binding metal ion bindingCellular componentcytosol membraneBiological processpositive regulation of exocytosis positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of insulin secretionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez744726950EnsemblENSG00000163032ENSMUSG00000054459UniProtP62760P62761RefSeq mRNA NM 003385NM 012038NM 001378929RefSeq protein NP 003376NP 001353732NP 001353733NP 001353734NP 001353735NP 036168NP 001365858Location UCSC Chr 2 17 54 17 66 MbChr 12 11 38 11 49 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is a member of the visinin recoverin subfamily of neuronal calcium sensor proteins 8 The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase Alternatively spliced transcript variants have been observed but their full length nature has not been determined 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000163032 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000054459 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Polymeropoulos MH Ide S Soares MB Lennon GG Feb 1996 Sequence characterization and genetic mapping of the human VSNL1 gene a homologue of the rat visinin like peptide RNVP1 Genomics 29 1 273 5 doi 10 1006 geno 1995 1244 PMID 8530085 Kose A Ito A Saito N Tanaka C Oct 1990 Electron microscopic localization of gamma and beta II subspecies of protein kinase C in rat hippocampus Brain Res 518 1 2 209 17 doi 10 1016 0006 8993 90 90974 G hdl 20 500 14094 D2001395 PMID 2202488 S2CID 54401066 a b Entrez Gene VSNL1 visinin like 1 Burgoyne RD 2007 Neuronal calcium sensor proteins generating diversity in neuronal Ca2 signalling Nat Rev Neurosci 8 3 182 193 doi 10 1038 nrn2093 PMC 1887812 PMID 17311005 Further reading editKuno T Kajimoto Y Hashimoto T et al 1992 cDNA cloning of a neural visinin like Ca 2 binding protein Biochem Biophys Res Commun 184 3 1219 25 doi 10 1016 S0006 291X 05 80012 9 PMID 1375457 Lenz SE Braunewell KH Weise C et al 1996 The neuronal EF hand Ca 2 binding protein VILIP interaction with cell membrane and actin based cytoskeleton Biochem Biophys Res Commun 225 3 1078 83 doi 10 1006 bbrc 1996 1298 PMID 8780737 Braunewell KH Spilker C Behnisch T Gundelfinger ED 1997 The neuronal calcium sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells amino terminal myristoylation determines functional activity J Neurochem 68 5 2129 39 doi 10 1046 j 1471 4159 1997 68052129 x PMID 9109541 S2CID 29894577 Kobayashi M Sakai E Furuta Y Takamatsu K 1999 Isolation of two human cDNAs HLP3 and HLP4 homologous to the neuron specific calcium binding protein genes DNA Seq 9 3 171 6 doi 10 3109 10425179809072192 PMID 10520747 Bernstein HG Baumann B Danos P et al 2000 Regional and cellular distribution of neural visinin like protein immunoreactivities VILIP 1 and VILIP 3 in human brain J Neurocytol 28 8 655 62 doi 10 1023 A 1007056731551 PMID 10851344 S2CID 7944931 Braunewell KH Brackmann M Schaupp M et al 2001 Intracellular neuronal calcium sensor NCS protein VILIP 1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones J Neurochem 78 6 1277 86 doi 10 1046 j 1471 4159 2001 00506 x PMID 11579136 S2CID 41831236 Schnurra I Bernstein HG Riederer P Braunewell KH 2002 The neuronal calcium sensor protein VILIP 1 is associated with amyloid plaques and extracellular tangles in Alzheimer s disease and promotes cell death and tau phosphorylation in vitro a link between calcium sensors and Alzheimer s disease Neurobiol Dis 8 5 900 9 doi 10 1006 nbdi 2001 0432 PMID 11592857 S2CID 45639709 Bernstein HG Braunewell KH Spilker C et al 2002 Hippocampal expression of the calcium sensor protein visinin like protein 1 in schizophrenia NeuroReport 13 4 393 6 doi 10 1097 00001756 200203250 00006 PMID 11930147 S2CID 22907782 Spilker C Dresbach T Braunewell KH 2002 Reversible translocation and activity dependent localization of the calcium myristoyl switch protein VILIP 1 to different membrane compartments in living hippocampal neurons J Neurosci 22 17 7331 9 doi 10 1523 JNEUROSCI 22 17 07331 2002 PMC 6757958 PMID 12196554 Lin L Braunewell KH Gundelfinger ED Anand R 2002 Functional analysis of calcium binding EF hand motifs of visinin like protein 1 Biochem Biophys Res Commun 296 4 827 32 doi 10 1016 S0006 291X 02 00943 9 PMID 12200122 Lin L Jeanclos EM Treuil M et al 2003 The calcium sensor protein visinin like protein 1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor J Biol Chem 277 44 41872 8 doi 10 1074 jbc M206857200 PMID 12202488 Spilker C Gundelfinger ED Braunewell KH 2002 Evidence for different functional properties of the neuronal calcium sensor proteins VILIP 1 and VILIP 3 from subcellular localization to cellular function Biochim Biophys Acta 1600 1 2 118 27 doi 10 1016 s1570 9639 02 00452 1 PMID 12445467 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Braunewell KH Brackmann M Manahan Vaughan D 2003 Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP 1 in vitro and in vivo implications for mGlu receptor dependent hippocampal plasticity Neuropharmacology 44 6 707 15 doi 10 1016 S0028 3908 03 00051 0 PMID 12681369 S2CID 20047130 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Gonzalez Guerrico AM Jaffer ZM Page RE et al 2005 Visinin like protein 1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells Oncogene 24 14 2307 16 doi 10 1038 sj onc 1208476 PMID 15735716 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Jheng FF Wang L Lee L Chang LS 2007 Functional contribution of Ca2 and Mg2 to the intermolecular interaction of visinin like proteins Protein J 25 4 250 6 doi 10 1007 s10930 006 9008 5 PMID 16703469 S2CID 29486237 Lim J Hao T Shaw C et al 2006 A protein protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration Cell 125 4 801 14 doi 10 1016 j cell 2006 03 032 PMID 16713569 S2CID 13709685 nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Visinin like protein 1 amp oldid 1195810696, wikipedia, wiki, book, books, library,

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