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Cholera vaccine

February 01, 2023

A cholera vaccine is a vaccine that is effective at preventing cholera.[8] For the first six months after vaccination it provides about 85 percent protection, which decreases to 50 percent or 62 percent during the first year.[8][9][10] After two years the level of protection decreases to less than 50 percent.[8] When enough of the population is immunized, it may protect those who have not been immunized (known as herd immunity).[8]

Cholera vaccine
Vaccine description
TargetVibrio cholerae
Vaccine typeInactivated
Clinical data
Trade namesDukoral, Vaxchora, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Legal status
Legal status
Identifiers
DrugBank
  • DB11643 Y
  • DB14443 Y
ChemSpider
  • none
UNII
  • V9G528E9E0
 NY (what is this?)  (verify)

The World Health Organization (WHO) recommends the use of cholera vaccines in combination with other measures among those at high risk.[8] With the oral vaccine, two or three doses are typically recommended.[8] The duration of protection is two years in adults and six months in children aged 2–5 years.[8] A single dose vaccine is available for those traveling to an area where cholera is common.[11][12][13] In 2010, in some countries an injectable cholera vaccine was available.[8][9]

The available types of oral vaccine are generally safe.[8] Mild abdominal pain or diarrhea may occur.[8] They are safe in pregnancy and in those with poor immune function.[8] They are licensed for use in more than 60 countries.[8] In countries where the disease is common, the vaccine appears to be cost effective.[8]

The first cholera vaccines were developed in the late 1900s.[14] They were the first widely used vaccine that was made in a laboratory.[14] Oral cholera vaccines were first introduced in the 1990s.[8] It is on the World Health Organization's List of Essential Medicines.[15][16]

Medical use

In the late twentieth century, oral cholera vaccines started to be used on a massive scale, with millions of vaccinations taking place, as a tool to control cholera outbreaks in addition to the traditional interventions of improving safe water supplies, sanitation, handwashing, and other means of improving hygiene.[17] The Dukoral monovalent vaccine from Sweden, which combines formalin, heat-killed whole cells of Vibrio cholerae O1, and a recombinant cholera toxin B subunit, was licensed in 1991, mainly for travellers. Out of a million doses sold during the following decade, 63 negative side effects were reported.[8] The Shanchol/mORCVAX bivalent vaccine, which combines the O1 and O139 serogroups, was originally licensed in Vietnam in 1997 and given in 20 million doses to children in Vietnam during the following decade.[8] As of 2010, Vietnam continued to incorporate oral cholera vaccination in its public health programme, administering the vaccination through targeted mass vaccination of school-aged children in cholera endemic regions.[8]

The cholera vaccine is widely used by backpackers and persons visiting locations where there is a high risk of cholera infection. However, since it does not provide 100 percent immunity from the disease, food hygiene precautions are also recommended when visiting an area where there is a high risk of becoming infected with cholera. Although the protection observed has been described as "moderate", herd immunity can multiply the effectiveness of vaccination. Dukoral has been licensed for children two years of age and older, Shanchol for children one year of age and older. The administration of the vaccine to adults confers additional indirect protection (herd immunity) to children.

The World Health Organization (WHO) recommends both preventive and reactive use of the vaccine, making the following key statements:[18]

WHO recommends that current available cholera vaccines be used as complements to traditional control and preventive measures in areas where the disease is endemic and should be considered in areas at risk for outbreaks. Vaccination should not disrupt the provision of other high priority health interventions to control or prevent cholera outbreaks.... Reactive vaccination might be considered in view of limiting the extent of large prolonged outbreaks, provided the local infrastructure allows it, and an in-depth analysis of past cholera data and identification of a defined target area have been performed.

The WHO as of late 2013 established a revolving stockpile of two million OCV doses.[19] The supply is increasing to six million as a South Korean companies has gone into production (2016), the old production not being able to handle WHO demand in Haiti and Sudan for 2015, nor prior years. GAVI Alliance donated $115 million to help pay for expansions.[20][21]

Oral

 
Dukoral: vial of inactivated vaccine with packet of sodium bicarbonate buffer.

The oral vaccines are generally of two forms: inactivated and attenuated.[citation needed]

Inactivated oral vaccines provide protection in 52 percent of cases the first year following vaccination and in 62 percent of cases the second year.[10] Two variants of the inactivated oral vaccine currently are in use: WC-rBS and BivWC. WC-rBS (marketed as "Dukoral") is a monovalent inactivated vaccine containing killed whole cells of V. cholerae O1 plus additional recombinant cholera toxin B subunit. BivWC (marketed as "Shanchol" and "mORCVAX") is a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139. mORCVAX is only available in Vietnam.[citation needed]

Bacterial strains of both Inaba and Ogawa serotypes and of El Tor and Classical biotypes are included in the vaccine. Dukoral is taken orally with bicarbonate buffer, which protects the antigens from the gastric acid. The vaccine acts by inducing antibodies against both the bacterial components and CTB. The antibacterial intestinal antibodies prevent the bacteria from attaching to the intestinal wall, thereby impeding colonisation of V. cholerae O1. The anti-toxin intestinal antibodies prevent the cholera toxin from binding to the intestinal mucosal surface, thereby preventing the toxin-mediated diarrhoeal symptoms.[22]

A live, attenuated oral vaccine (CVD 103-HgR or Vaxchora), derived from a serogroup O1 classical Inaba strain, was approved by the US FDA in 2016.[11][23][12]

Injectable

Although rarely in use, the injected cholera vaccines are effective for people living where cholera is common. They offer some degree of protection for up to two years after a single shot, and for three to four years with annual booster. They reduce the risk of death from cholera by 50 percent in the first year after vaccination.[9]

Side effects

Both of the available types of oral vaccine are generally safe.[8] Mild abdominal pain or diarrhea may occur.[8] They are safe in pregnancy and in those with poor immune function.[8] They are licensed for use in more than 60 countries.[8] In countries where the disease is common, the vaccine appears to be cost effective.[8]

History of development

 
Cholera vaccinations by a Guinean nurse using a jet injector in Ziguinchor, Senegal, 1973

The first cholera vaccines were developed in the late 19th century. There were several pioneers in the development of the vaccine:

  • The first known attempt at a cholera vaccine was made by Louis Pasteur and it was aimed at preventing cholera in chickens.[24] This was the first widely used vaccine that was made in a laboratory.[14] Unfortunately, later use showed this early cholera vaccine to be ineffective.[25]
  • In 1884, Spanish physician Jaume Ferran i Clua developed a live vaccine he had isolated from cholera patients in Marseilles, and used it that on over 30,000 individuals in Valencia during that year's epidemic. However, his vaccine and inoculation was rather controversial and was rejected by his peers and several investigation commissions.[26][27][28]
  • In 1892, Waldemar Haffkine developed an effective vaccine with less severe side effects, later testing it on more than 40,000 people in the Calcutta area from 1893 to 1896.[29] His vaccine was accepted by the medical community, and is credited as the first effective human cholera vaccine.[26][27][28][30]
  • Finally, in 1896, Wilhelm Kolle introduced a heat-killed vaccine that was significantly easier to prepare than Haffkine's, using it on a large scale in Japan in 1902.[31]

Oral cholera vaccines were first introduced in the 1990s.[8]

Society and culture

Legal status

In 2016, the U.S. Food and Drug Administration (FDA) approved Vaxchora,[13][12][23] a single-dose oral vaccine to prevent cholera for travelers. As of June 2016, Vaxchora was the only FDA-approved vaccine for the prevention of cholera.[23]

Economics

The cost to immunize against cholera is between US$0.10 and US$4.00 per vaccination.[32]

The Vaxchora vaccine can cost more than US$250.[33]

References

  1. ^ "Summary for ARTG Entry:94483 Dukoral oral inactivated cholera vaccine liquid vial and buffer granules sachet". Therapeutic Goods Administration (TGA). Retrieved 30 July 2020.
  2. ^ "Dukoral Product information". Health Canada. 25 April 2012. Retrieved 30 July 2020.
  3. ^ "Dukoral suspension and effervescent granules for oral suspension, Cholera vaccine (inactivated, oral) - Summary of Product Characteristics (SmPC)". (emc). 7 December 2015. Retrieved 30 July 2020.
  4. ^ "Vaxchora- cholera vaccine, live, oral kit". DailyMed. 24 October 2018. Retrieved 30 July 2020.
  5. ^ "Vaxchora- cholera vaccine, live, oral kit". DailyMed. Retrieved 30 July 2020.
  6. ^ "Eukoral EPAR". European Medicines Agency (EMA). Retrieved 30 July 2020.
  7. ^ "Vaxchora EPAR". European Medicines Agency (EMA). 30 January 2020. Retrieved 30 July 2020.
  8. ^ a b c d e f g h i j k l m n o p q r s t u v w "Cholera vaccines: WHO position paper – August 2017". Relevé Épidémiologique Hebdomadaire. 92 (34): 477–98. August 2017. hdl:10665/258764. PMID 28845659.
  9. ^ a b c Graves PM, Deeks JJ, Demicheli V, Jefferson T (August 2010). "Vaccines for preventing cholera: killed whole cell or other subunit vaccines (injected)". The Cochrane Database of Systematic Reviews. 2019 (8): CD000974. doi:10.1002/14651858.CD000974.pub2. PMC 6532721. PMID 20687062.
  10. ^ a b Sinclair D, Abba K, Zaman K, Qadri F, Graves PM (March 2011). "Oral vaccines for preventing cholera". The Cochrane Database of Systematic Reviews. 2011 (3): CD008603. doi:10.1002/14651858.CD008603.pub2. PMC 6532691. PMID 21412922.
  11. ^ a b "Vaxchora (Cholera vaccine, Live, Oral)". U.S. Food and Drug Administration. (PDF) from the original on 1 March 2017. Retrieved 15 March 2017.
  12. ^ a b c "Vaxchora approval letter" (PDF). U.S. Food and Drug Administration. 10 June 2016. Archived from the original (PDF) on 22 July 2017. Retrieved 30 July 2020.   This article incorporates text from this source, which is in the public domain.
  13. ^ a b "Vaxchora". U.S. Food and Drug Administration (FDA). 1 September 2019. Retrieved 28 December 2019.
  14. ^ a b c Stanberry LR (2009). Vaccines for biodefense and emerging and neglected diseases (1st ed.). Amsterdam: Academic. p. 870. ISBN 9780080919027. from the original on 8 September 2017.
  15. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  16. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  17. ^ Harris JB, LaRocque RC, Qadri F, Ryan ET, Calderwood SB (June 2012). "Cholera". Lancet. 379 (9835): 2466–2476. doi:10.1016/s0140-6736(12)60436-x. PMC 3761070. PMID 22748592.
  18. ^ Oral cholera vaccines in mass immunization campaigns: guidance for planning and use (PDF). World Health Organization. 2010. ISBN 9789241500432. (PDF) from the original on 3 September 2014.
  19. ^ . World Health Organization. Archived from the original on 12 December 2013. Retrieved 18 December 2013.
  20. ^ "WHO Doubles Global Supply of Cholera Vaccine". NBC News. from the original on 8 January 2016. Retrieved 9 January 2016.
  21. ^ . The Task Force on Global Health. Archived from the original on 16 December 2013. Retrieved 18 December 2013.
  22. ^ (PDF). Dukoral. Archived from the original (PDF) on 22 August 2016. Retrieved 8 May 2013.
  23. ^ a b c "FDA approves vaccine to prevent cholera for travelers" (Press release). U.S. Food and Drug Administration (FDA). 10 June 2016. from the original on 18 December 2016.   This article incorporates text from this source, which is in the public domain.
  24. ^ Barranco, Caroline (28 September 2020). "The first live attenuated vaccines". Nature Research.
  25. ^ Dorsey, T.A.; Harshfield, G. S. (1 May 1959). "Studies on Control of Fowl Cholera". Agricultural Experiment Station Technical Bulletins (1939-2011).
  26. ^ a b Bornside, George H. (1 October 1982). "Waldemar Haffkine's Cholera Vaccines and the Ferran-Haffkine Priority Dispute". Journal of the History of Medicine and Allied Sciences. XXXVII (4): 399–422. doi:10.1093/jhmas/XXXVII.4.399. ISSN 0022-5045. PMID 6759570.
  27. ^ a b Bornside, George H. (1981). "Jaime Ferran and Preventive Inoculation Against Cholera". Bulletin of the History of Medicine. 55 (4): 516–532. ISSN 0007-5140. JSTOR 44441415. PMID 7039738.
  28. ^ a b Hawgood, Barbara J. (February 2007). "Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India". Journal of Medical Biography. 15 (1): 9–19. doi:10.1258/j.jmb.2007.05-59. ISSN 0967-7720. PMID 17356724. S2CID 42075270.
  29. ^ Hanhart J (2017). Un illustre inconnu. Une biographie du docteur Waldemar Mordekhaï Haffkine. Paris: Lichma. ISBN 978-2-912553-84-3.
  30. ^ "Waldemar Haffkine: The vaccine pioneer the world forgot". BBC News. 11 December 2020. Retrieved 20 January 2021.
  31. ^ Artenstein AW (2009). Vaccines: A Biography (1 ed.). New York City: Springer Science & Business Media. pp. 89–92. ISBN 9780080919027. from the original on 8 September 2017.
  32. ^ Martin S, Lopez AL, Bellos A, Deen J, Ali M, Alberti K, et al. (December 2014). "Post-licensure deployment of oral cholera vaccines: a systematic review". Bulletin of the World Health Organization. 92 (12): 881–93. doi:10.2471/blt.14.139949. PMC 4264394. PMID 25552772.
  33. ^ "New Cholera Vaccine for Adult Travelers". Medscape. 17 April 2017. from the original on 8 September 2017. Retrieved 20 August 2017. This vaccine can cost more than $250, and travelers may have to pay out of pocket if their insurance does not cover travel vaccines

Further reading

  • World Health Organization (2010). The immunological basis for immunization series: module 14: cholera. World Health Organization (WHO). hdl:10665/44367. ISBN 9789241599740.
  • Ramsay M, ed. (2013). "Chapter 14: Cholera". Immunisation against infectious disease. Public Health England.
  • Centers for Disease Control and Prevention (2017). "Cholera". CDC Yellow Book 2020: Health Information for International Travel. New York: Oxford University Press.
  • Cholera and enterotoxigenic escherichia coli (ETEC) travellers' diarrhea vaccine: Canadian Immunization Guide. Health Canada (Report).

External links

February 01, 2023
cholera, vaccine, cholera, vaccine, vaccine, that, effective, preventing, cholera, first, months, after, vaccination, provides, about, percent, protection, which, decreases, percent, percent, during, first, year, after, years, level, protection, decreases, les. A cholera vaccine is a vaccine that is effective at preventing cholera 8 For the first six months after vaccination it provides about 85 percent protection which decreases to 50 percent or 62 percent during the first year 8 9 10 After two years the level of protection decreases to less than 50 percent 8 When enough of the population is immunized it may protect those who have not been immunized known as herd immunity 8 Cholera vaccineVaccine descriptionTargetVibrio choleraeVaccine typeInactivatedClinical dataTrade namesDukoral Vaxchora othersAHFS Drugs comMicromedex Detailed Consumer InformationATC codeJ07AE01 WHO J07AE02 WHO J07AE51 WHO Legal statusLegal statusAU S4 Prescription only 1 CA only Schedule D 2 UK POM Prescription only 3 US only 4 5 EU Rx only 6 7 IdentifiersDrugBankDB11643 YDB14443 YChemSpidernoneUNIIV9G528E9E0 N Y what is this verify The World Health Organization WHO recommends the use of cholera vaccines in combination with other measures among those at high risk 8 With the oral vaccine two or three doses are typically recommended 8 The duration of protection is two years in adults and six months in children aged 2 5 years 8 A single dose vaccine is available for those traveling to an area where cholera is common 11 12 13 In 2010 in some countries an injectable cholera vaccine was available 8 9 The available types of oral vaccine are generally safe 8 Mild abdominal pain or diarrhea may occur 8 They are safe in pregnancy and in those with poor immune function 8 They are licensed for use in more than 60 countries 8 In countries where the disease is common the vaccine appears to be cost effective 8 The first cholera vaccines were developed in the late 1900s 14 They were the first widely used vaccine that was made in a laboratory 14 Oral cholera vaccines were first introduced in the 1990s 8 It is on the World Health Organization s List of Essential Medicines 15 16 Contents 1 Medical use 1 1 Oral 1 2 Injectable 2 Side effects 3 History of development 4 Society and culture 4 1 Legal status 4 2 Economics 5 References 6 Further reading 7 External linksMedical use EditIn the late twentieth century oral cholera vaccines started to be used on a massive scale with millions of vaccinations taking place as a tool to control cholera outbreaks in addition to the traditional interventions of improving safe water supplies sanitation handwashing and other means of improving hygiene 17 The Dukoral monovalent vaccine from Sweden which combines formalin heat killed whole cells of Vibrio cholerae O1 and a recombinant cholera toxin B subunit was licensed in 1991 mainly for travellers Out of a million doses sold during the following decade 63 negative side effects were reported 8 The Shanchol mORCVAX bivalent vaccine which combines the O1 and O139 serogroups was originally licensed in Vietnam in 1997 and given in 20 million doses to children in Vietnam during the following decade 8 As of 2010 update Vietnam continued to incorporate oral cholera vaccination in its public health programme administering the vaccination through targeted mass vaccination of school aged children in cholera endemic regions 8 The cholera vaccine is widely used by backpackers and persons visiting locations where there is a high risk of cholera infection However since it does not provide 100 percent immunity from the disease food hygiene precautions are also recommended when visiting an area where there is a high risk of becoming infected with cholera Although the protection observed has been described as moderate herd immunity can multiply the effectiveness of vaccination Dukoral has been licensed for children two years of age and older Shanchol for children one year of age and older The administration of the vaccine to adults confers additional indirect protection herd immunity to children The World Health Organization WHO recommends both preventive and reactive use of the vaccine making the following key statements 18 WHO recommends that current available cholera vaccines be used as complements to traditional control and preventive measures in areas where the disease is endemic and should be considered in areas at risk for outbreaks Vaccination should not disrupt the provision of other high priority health interventions to control or prevent cholera outbreaks Reactive vaccination might be considered in view of limiting the extent of large prolonged outbreaks provided the local infrastructure allows it and an in depth analysis of past cholera data and identification of a defined target area have been performed The WHO as of late 2013 established a revolving stockpile of two million OCV doses 19 The supply is increasing to six million as a South Korean companies has gone into production 2016 the old production not being able to handle WHO demand in Haiti and Sudan for 2015 nor prior years GAVI Alliance donated 115 million to help pay for expansions 20 21 Oral Edit Dukoral vial of inactivated vaccine with packet of sodium bicarbonate buffer The oral vaccines are generally of two forms inactivated and attenuated citation needed Inactivated oral vaccines provide protection in 52 percent of cases the first year following vaccination and in 62 percent of cases the second year 10 Two variants of the inactivated oral vaccine currently are in use WC rBS and BivWC WC rBS marketed as Dukoral is a monovalent inactivated vaccine containing killed whole cells of V cholerae O1 plus additional recombinant cholera toxin B subunit BivWC marketed as Shanchol and mORCVAX is a bivalent inactivated vaccine containing killed whole cells of V cholerae O1 and V cholerae O139 mORCVAX is only available in Vietnam citation needed Bacterial strains of both Inaba and Ogawa serotypes and of El Tor and Classical biotypes are included in the vaccine Dukoral is taken orally with bicarbonate buffer which protects the antigens from the gastric acid The vaccine acts by inducing antibodies against both the bacterial components and CTB The antibacterial intestinal antibodies prevent the bacteria from attaching to the intestinal wall thereby impeding colonisation of V cholerae O1 The anti toxin intestinal antibodies prevent the cholera toxin from binding to the intestinal mucosal surface thereby preventing the toxin mediated diarrhoeal symptoms 22 A live attenuated oral vaccine CVD 103 HgR or Vaxchora derived from a serogroup O1 classical Inaba strain was approved by the US FDA in 2016 11 23 12 Injectable Edit Although rarely in use the injected cholera vaccines are effective for people living where cholera is common They offer some degree of protection for up to two years after a single shot and for three to four years with annual booster They reduce the risk of death from cholera by 50 percent in the first year after vaccination 9 Side effects EditBoth of the available types of oral vaccine are generally safe 8 Mild abdominal pain or diarrhea may occur 8 They are safe in pregnancy and in those with poor immune function 8 They are licensed for use in more than 60 countries 8 In countries where the disease is common the vaccine appears to be cost effective 8 History of development Edit Cholera vaccinations by a Guinean nurse using a jet injector in Ziguinchor Senegal 1973 The first cholera vaccines were developed in the late 19th century There were several pioneers in the development of the vaccine The first known attempt at a cholera vaccine was made by Louis Pasteur and it was aimed at preventing cholera in chickens 24 This was the first widely used vaccine that was made in a laboratory 14 Unfortunately later use showed this early cholera vaccine to be ineffective 25 In 1884 Spanish physician Jaume Ferran i Clua developed a live vaccine he had isolated from cholera patients in Marseilles and used it that on over 30 000 individuals in Valencia during that year s epidemic However his vaccine and inoculation was rather controversial and was rejected by his peers and several investigation commissions 26 27 28 In 1892 Waldemar Haffkine developed an effective vaccine with less severe side effects later testing it on more than 40 000 people in the Calcutta area from 1893 to 1896 29 His vaccine was accepted by the medical community and is credited as the first effective human cholera vaccine 26 27 28 30 Finally in 1896 Wilhelm Kolle introduced a heat killed vaccine that was significantly easier to prepare than Haffkine s using it on a large scale in Japan in 1902 31 Oral cholera vaccines were first introduced in the 1990s 8 Society and culture EditLegal status Edit In 2016 the U S Food and Drug Administration FDA approved Vaxchora 13 12 23 a single dose oral vaccine to prevent cholera for travelers As of June 2016 update Vaxchora was the only FDA approved vaccine for the prevention of cholera 23 Economics Edit The cost to immunize against cholera is between US 0 10 and US 4 00 per vaccination 32 The Vaxchora vaccine can cost more than US 250 33 References Edit Summary for ARTG Entry 94483 Dukoral oral inactivated cholera vaccine liquid vial and buffer granules sachet Therapeutic Goods Administration TGA Retrieved 30 July 2020 Dukoral Product information Health Canada 25 April 2012 Retrieved 30 July 2020 Dukoral suspension and effervescent granules for oral suspension Cholera vaccine inactivated oral Summary of Product Characteristics SmPC emc 7 December 2015 Retrieved 30 July 2020 Vaxchora cholera vaccine live oral kit DailyMed 24 October 2018 Retrieved 30 July 2020 Vaxchora cholera vaccine live oral kit DailyMed Retrieved 30 July 2020 Eukoral EPAR European Medicines Agency EMA Retrieved 30 July 2020 Vaxchora EPAR European Medicines Agency EMA 30 January 2020 Retrieved 30 July 2020 a b c d e f g h i j k l m n o p q r s t u v w Cholera vaccines WHO position paper August 2017 Releve Epidemiologique Hebdomadaire 92 34 477 98 August 2017 hdl 10665 258764 PMID 28845659 a b c Graves PM Deeks JJ Demicheli V Jefferson T August 2010 Vaccines for preventing cholera killed whole cell or other subunit vaccines injected The Cochrane Database of Systematic Reviews 2019 8 CD000974 doi 10 1002 14651858 CD000974 pub2 PMC 6532721 PMID 20687062 a b Sinclair D Abba K Zaman K Qadri F Graves PM March 2011 Oral vaccines for preventing cholera The Cochrane Database of Systematic Reviews 2011 3 CD008603 doi 10 1002 14651858 CD008603 pub2 PMC 6532691 PMID 21412922 a b Vaxchora Cholera vaccine Live Oral U S Food and Drug Administration Archived PDF from the original on 1 March 2017 Retrieved 15 March 2017 a b c Vaxchora approval letter PDF U S Food and Drug Administration 10 June 2016 Archived from the original PDF on 22 July 2017 Retrieved 30 July 2020 This article incorporates text from this source which is in the public domain a b Vaxchora U S Food and Drug Administration FDA 1 September 2019 Retrieved 28 December 2019 a b c Stanberry LR 2009 Vaccines for biodefense and emerging and neglected diseases 1st ed Amsterdam Academic p 870 ISBN 9780080919027 Archived from the original on 8 September 2017 World Health Organization 2019 World Health Organization model list of essential medicines 21st list 2019 Geneva World Health Organization hdl 10665 325771 WHO MVP EMP IAU 2019 06 License CC BY NC SA 3 0 IGO World Health Organization 2021 World Health Organization model list of essential medicines 22nd list 2021 Geneva World Health Organization hdl 10665 345533 WHO MHP HPS EML 2021 02 Harris JB LaRocque RC Qadri F Ryan ET Calderwood SB June 2012 Cholera Lancet 379 9835 2466 2476 doi 10 1016 s0140 6736 12 60436 x PMC 3761070 PMID 22748592 Oral cholera vaccines in mass immunization campaigns guidance for planning and use PDF World Health Organization 2010 ISBN 9789241500432 Archived PDF from the original on 3 September 2014 Oral cholera vaccine stockpile World Health Organization Archived from the original on 12 December 2013 Retrieved 18 December 2013 WHO Doubles Global Supply of Cholera Vaccine NBC News Archived from the original on 8 January 2016 Retrieved 9 January 2016 GAVI Board Approves Support to Expand Oral Cholera Vaccine Stockpile The Task Force on Global Health Archived from the original on 16 December 2013 Retrieved 18 December 2013 Dukoral Canadian Product Monograph Part III Consumer Information PDF Dukoral Archived from the original PDF on 22 August 2016 Retrieved 8 May 2013 a b c FDA approves vaccine to prevent cholera for travelers Press release U S Food and Drug Administration FDA 10 June 2016 Archived from the original on 18 December 2016 This article incorporates text from this source which is in the public domain Barranco Caroline 28 September 2020 The first live attenuated vaccines Nature Research Dorsey T A Harshfield G S 1 May 1959 Studies on Control of Fowl Cholera Agricultural Experiment Station Technical Bulletins 1939 2011 a b Bornside George H 1 October 1982 Waldemar Haffkine s Cholera Vaccines and the Ferran Haffkine Priority Dispute Journal of the History of Medicine and Allied Sciences XXXVII 4 399 422 doi 10 1093 jhmas XXXVII 4 399 ISSN 0022 5045 PMID 6759570 a b Bornside George H 1981 Jaime Ferran and Preventive Inoculation Against Cholera Bulletin of the History of Medicine 55 4 516 532 ISSN 0007 5140 JSTOR 44441415 PMID 7039738 a b Hawgood Barbara J February 2007 Waldemar Mordecai Haffkine CIE 1860 1930 prophylactic vaccination against cholera and bubonic plague in British India Journal of Medical Biography 15 1 9 19 doi 10 1258 j jmb 2007 05 59 ISSN 0967 7720 PMID 17356724 S2CID 42075270 Hanhart J 2017 Un illustre inconnu Une biographie du docteur Waldemar Mordekhai Haffkine Paris Lichma ISBN 978 2 912553 84 3 Waldemar Haffkine The vaccine pioneer the world forgot BBC News 11 December 2020 Retrieved 20 January 2021 Artenstein AW 2009 Vaccines A Biography 1 ed New York City Springer Science amp Business Media pp 89 92 ISBN 9780080919027 Archived from the original on 8 September 2017 Martin S Lopez AL Bellos A Deen J Ali M Alberti K et al December 2014 Post licensure deployment of oral cholera vaccines a systematic review Bulletin of the World Health Organization 92 12 881 93 doi 10 2471 blt 14 139949 PMC 4264394 PMID 25552772 New Cholera Vaccine for Adult Travelers Medscape 17 April 2017 Archived from the original on 8 September 2017 Retrieved 20 August 2017 This vaccine can cost more than 250 and travelers may have to pay out of pocket if their insurance does not cover travel vaccinesFurther reading EditWorld Health Organization 2010 The immunological basis for immunization series module 14 cholera World Health Organization WHO hdl 10665 44367 ISBN 9789241599740 Ramsay M ed 2013 Chapter 14 Cholera Immunisation against infectious disease Public Health England Centers for Disease Control and Prevention 2017 Cholera CDC Yellow Book 2020 Health Information for International Travel New York Oxford University Press Cholera and enterotoxigenic escherichia coli ETEC travellers diarrhea vaccine Canadian Immunization Guide Health Canada Report External links Edit Cholera Vaccine Information Statement U S Centers for Disease Control and Prevention CDC October 2019 Cholera Vaccines at the US National Library of Medicine Medical Subject Headings MeSH Portal Medicine Retrieved from https en wikipedia org w index php title Cholera vaccine amp oldid 1136141130, wikipedia, wiki, book, books, library,

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