The variome is the whole set of genetic variations found in populations of species that have gone through a relatively short evolution change. For example, among humans, about 1 in every 1,200[citation needed]nucleotide bases differ. The size of human variome in terms of effective population size is claimed to be about 10,000 individuals. This variation rate is comparatively small compared to other species. For example, the effective population size of tigers which perhaps has the whole population size less than 10,000 in the wild is not much smaller than the human species indicating a much higher level of genetic diversity although they are close to extinction in the wild. In practice, the variome can be the sum of the single nucleotide polymorphisms (SNPs), indels, and structural variation (SV) of a population or species. The Human Variome Project seeks to compile this genetic variation data worldwide. Variomics is the study of variome and a branch of bioinformatics.
The human variome can be subdivided into smaller ethnicity specific variomes. Each variome can have a utility in terms of filtering out common ethnic specific variants in the analyses of cancer normal variants filtering for more efficient detection of somatic mutations that can be relevant to certain anti-cancer drugs. KoVariome is one such ethnic specific variome where the project uses the term variome to denote their identity and connection to the concept of the broader human variome. KoVariome founders have been affiliated with HVP since early days of HVP where Prof. Richard Cotton initiated various efforts to compile the human variome resources.
Etymology
The blend word 'variome' is from genetic variant (“a version of a gene that differs from other versions of the same gene which may or may not have an effect on human health”) and the suffix –ome (“the complete whole of a class of substances for a species or an individual”). ‘Variomics’ (which appeared in the literature before ‘variome’) was first coined by Professor Richard ‘Dick’ Cotton in 2002 to describe (“The systematic study of the effect of genetic variation on human health”). ‘Variome’ has since been most commonly used in reference to the ‘Human Variome Project’ founded four years in 2006 after ‘variomics’ was first coined.
Projects
There are a number of international project studying the human variome, including the International HapMap Project and the Human Variome Project (HVP).[1] The HapMap Project aims to identify and catalog genetic similarities and differences among humans. The HVP aims to collect data on all human genetic variation. The Korean Genome Project, which aims to collect all the East Asian ethnic Korean genetic variations has produced KoVariome that contains currently over 1,000 Korean whole genome variation information.[2]
^Vizzini, Casimiro (March 19, 2015). "The Human Variome Project: Global Coordination in Data Sharing". Science & Diplomacy. 4 (1).
^Jeon, Sungwon; Bhak, Youngjune; Choi, Yeonsong; Jeon, Yeonsu; Kim, Seunghoon; Jang, Jaeyoung; Jang, Jinho; Blazyte, Asta; Kim, Changjae; Kim, Yeonkyung; Shim, Jungae (2020-05-01). "Korean Genome Project: 1094 Korean personal genomes with clinical information". Science Advances. 6 (22): eaaz7835. Bibcode:2020SciA....6.7835J. doi:10.1126/sciadv.aaz7835. ISSN 2375-2548. PMC7385432. PMID 32766443.
References
Variome.net: Variome information portal site.
Human Variome Project
"Human Variome Project Set to Launch", May 12, 2006
What is the Human Variome Project?
Ring H, Kwok P, Cotton R (2006). "Human Variome Project: an international collaboration to catalogue human genetic variation". Pharmacogenomics. 7 (7): 969–72. doi:10.2217/14622416.7.7.969. PMID 17054407.
External links
Human Genome Variation Society
Omics.org General Omics topics
Variomics.net: The earliest variomics project site
PersonalGenome.net: openfree Personal Genome project home page (Free Genome project)
January 12, 2023
variome, variome, whole, genetic, variations, found, populations, species, that, have, gone, through, relatively, short, evolution, change, example, among, humans, about, every, citation, needed, nucleotide, bases, differ, size, human, variome, terms, effectiv. The variome is the whole set of genetic variations found in populations of species that have gone through a relatively short evolution change For example among humans about 1 in every 1 200 citation needed nucleotide bases differ The size of human variome in terms of effective population size is claimed to be about 10 000 individuals This variation rate is comparatively small compared to other species For example the effective population size of tigers which perhaps has the whole population size less than 10 000 in the wild is not much smaller than the human species indicating a much higher level of genetic diversity although they are close to extinction in the wild In practice the variome can be the sum of the single nucleotide polymorphisms SNPs indels and structural variation SV of a population or species The Human Variome Project seeks to compile this genetic variation data worldwide Variomics is the study of variome and a branch of bioinformatics Contents 1 Ethnic variomes 2 Etymology 3 Projects 4 See also 5 Notes 6 References 7 External linksEthnic variomes EditThe human variome can be subdivided into smaller ethnicity specific variomes Each variome can have a utility in terms of filtering out common ethnic specific variants in the analyses of cancer normal variants filtering for more efficient detection of somatic mutations that can be relevant to certain anti cancer drugs KoVariome is one such ethnic specific variome where the project uses the term variome to denote their identity and connection to the concept of the broader human variome KoVariome founders have been affiliated with HVP since early days of HVP where Prof Richard Cotton initiated various efforts to compile the human variome resources Etymology EditThe blend word variome is from genetic variant a version of a gene that differs from other versions of the same gene which may or may not have an effect on human health and the suffix ome the complete whole of a class of substances for a species or an individual Variomics which appeared in the literature before variome was first coined by Professor Richard Dick Cotton in 2002 to describe The systematic study of the effect of genetic variation on human health Variome has since been most commonly used in reference to the Human Variome Project founded four years in 2006 after variomics was first coined Projects EditThere are a number of international project studying the human variome including the International HapMap Project and the Human Variome Project HVP 1 The HapMap Project aims to identify and catalog genetic similarities and differences among humans The HVP aims to collect data on all human genetic variation The Korean Genome Project which aims to collect all the East Asian ethnic Korean genetic variations has produced KoVariome that contains currently over 1 000 Korean whole genome variation information 2 See also EditHuman Variome Project Single nucleotide polymorphism DNA sequence International HapMap Project OMIM OmicsNotes Edit Vizzini Casimiro March 19 2015 The Human Variome Project Global Coordination in Data Sharing Science amp Diplomacy 4 1 Jeon Sungwon Bhak Youngjune Choi Yeonsong Jeon Yeonsu Kim Seunghoon Jang Jaeyoung Jang Jinho Blazyte Asta Kim Changjae Kim Yeonkyung Shim Jungae 2020 05 01 Korean Genome Project 1094 Korean personal genomes with clinical information Science Advances 6 22 eaaz7835 Bibcode 2020SciA 6 7835J doi 10 1126 sciadv aaz7835 ISSN 2375 2548 PMC 7385432 PMID 32766443 References EditVariome net Variome information portal site Human Variome Project Human Variome Project Set to Launch May 12 2006 What is the Human Variome Project Ring H Kwok P Cotton R 2006 Human Variome Project an international collaboration to catalogue human genetic variation Pharmacogenomics 7 7 969 72 doi 10 2217 14622416 7 7 969 PMID 17054407 External links EditHuman Genome Variation Society Omics org General Omics topics Variomics net The earliest variomics project site PersonalGenome net openfree Personal Genome project home page Free Genome project Retrieved from https en wikipedia org w index php title Variome amp oldid 1066548518, wikipedia, wiki, book, books, library,
