Unsaturated chondroitin disaccharide hydrolase (EC 3.2.1.180, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic namebeta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hydrolase.[1][2] This enzyme catalyses the following chemical reaction
The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides.
Referencesedit
^Maruyama Y, Nakamichi Y, Itoh T, Mikami B, Hashimoto W, Murata K (July 2009). "Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan". J. Biol. Chem. 284 (27): 18059–69. doi:10.1074/jbc.M109.005660. PMC2709336. PMID 19416976.
^Nakamichi Y, Maruyama Y, Mikami B, Hashimoto W, Murata K (February 2011). "Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups". J. Biol. Chem. 286 (8): 6262–71. doi:10.1074/jbc.M110.182618. PMC3057837. PMID 21147778.
External linksedit
Unsaturated+chondroitin+disaccharide+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
unsaturated, chondroitin, disaccharide, hydrolase, unsaturated, glucuronyl, hydrolase, enzyme, with, systematic, name, beta, deoxy, delta4, glcap, beta, galnac6s, hydrolase, this, enzyme, catalyses, following, chemical, reactionidentifiersec, 180databasesinten. Unsaturated chondroitin disaccharide hydrolase EC 3 2 1 180 UGL unsaturated glucuronyl hydrolase is an enzyme with systematic name beta D 4 deoxy Delta4 GlcAp 1 gt 3 beta D GalNAc6S hydrolase 1 2 This enzyme catalyses the following chemical reactionUnsaturated chondroitin disaccharide hydrolaseIdentifiersEC no 3 2 1 180DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins beta D 4 deoxy Delta4 GlcAp 1 gt 3 beta D GalNAc6S H2O displaystyle rightleftharpoons 5 dehydro 4 deoxy D glucuronate N acetyl beta D galactosamine 6 O sulfateThe enzyme releases 4 deoxy 4 5 didehydro D glucuronic acid or 4 deoxy 4 5 didehydro L iduronic acid from chondroitin disaccharides hyaluronan disaccharides and heparin disaccharides References edit Maruyama Y Nakamichi Y Itoh T Mikami B Hashimoto W Murata K July 2009 Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan J Biol Chem 284 27 18059 69 doi 10 1074 jbc M109 005660 PMC 2709336 PMID 19416976 Nakamichi Y Maruyama Y Mikami B Hashimoto W Murata K February 2011 Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups J Biol Chem 286 8 6262 71 doi 10 1074 jbc M110 182618 PMC 3057837 PMID 21147778 External links editUnsaturated chondroitin disaccharide hydrolase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title Unsaturated chondroitin disaccharide hydrolase amp oldid 1172365062, wikipedia, wiki, book, books, library,
