This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitinmoiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000101557 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047879 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
^ ab"Entrez Gene: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)".
^Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH (Feb 2009). "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation". J. Biol. Chem. 284 (9): 5742–52. doi:10.1074/jbc.M808507200. PMC2645827. PMID 19106094.
Further readingedit
Wilson SM, Bhattacharyya B, Rachel RA, Coppola V, Tessarollo L, Householder DB, Fletcher CF, Miller RJ, Copeland NG, Jenkins NA (2002). "Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease". Nature Genetics. 32 (3): 420–425. doi:10.1038/ng1006. PMID 12368914. S2CID 23542012.
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
Deshpande KL, Seubert PH, Tillman DM, Farkas WR, Katze JR (1996). "Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit". Arch. Biochem. Biophys. 326 (1): 1–7. doi:10.1006/abbi.1996.0039. PMID 8579355.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution". Genomics. 83 (3): 493–501. doi:10.1016/j.ygeno.2003.08.017. PMID 14962675.
Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y (2005). "Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14". EMBO J. 24 (21): 3747–56. doi:10.1038/sj.emboj.7600832. PMC1276716. PMID 16211010.
Shinji S, Naito Z, Ishiwata S, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, Seya T, Matsuda A, Katsuta M, Tajiri T (2006). "Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases". Oncol. Rep. 15 (3): 539–43. doi:10.3892/or.15.3.539. PMID 16465409.
Crimmins S, Jin Y, Wheeler C, Huffman AK, Chapman C, Dobrunz LE, Levey A, Roth KA, Wilson JA, Wilson SM (2006). "Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14". J. Neurosci. 26 (44): 11423–31. doi:10.1523/JNEUROSCI.3600-06.2006. PMC6674543. PMID 17079671.
External linksedit
Overview of all the structural information available in the PDB for UniProt: P54578 (Ubiquitin carboxyl-terminal hydrolase 14) at the PDBe-KB.
This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.
usp14, ubiquitin, specific, protease, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2ayn, 2ayoidentifiersaliases, ubiquitin, specific, peptidase, ubp6external, idsomim, 607274, 1928898, homologene, 3780, ge. Ubiquitin specific protease 14 is an enzyme that in humans is encoded by the USP14 gene 5 6 USP14Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2AYN 2AYOIdentifiersAliasesUSP14 TGT ubiquitin specific peptidase 14 Ubp6External IDsOMIM 607274 MGI 1928898 HomoloGene 3780 GeneCards USP14Gene location Human Chr Chromosome 18 human 1 Band18p11 32Start158 383 bp 1 End214 629 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 A1 18 4 91 cMStart9 993 066 bp 2 End10 045 119 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytetibialis anterior muscledeltoid muscleponsthoracic diaphragmspongy bonetrigeminal ganglionspinal gangliasuperior vestibular nucleusbiceps brachiiTop expressed indorsomedial hypothalamic nucleusventromedial nucleusmammillary bodylateral hypothalamussuperior frontal gyrusmaxillary prominenceventral tegmental areaparaventricular nucleus of hypothalamusarcuate nucleusmorulaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncysteine type peptidase activity proteasome binding peptidase activity protein binding thiol dependent deubiquitinase cysteine type endopeptidase activity endopeptidase inhibitor activity hydrolase activity tRNA guanylyltransferase activityCellular componentmembrane plasma membrane synapse cell surface proteasome complex extracellular exosome cytoplasm cytosol cytoplasmic vesicle nucleusBiological processregulation of proteasomal protein catabolic process regulation of chemotaxis ubiquitin dependent protein catabolic process proteolysis negative regulation of ER associated ubiquitin dependent protein catabolic process chemical synaptic transmission negative regulation of endopeptidase activity protein deubiquitination immune system process innate immune response tRNA 5 end processingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez909759025EnsemblENSG00000101557ENSMUSG00000047879UniProtP54578Q9JMA1RefSeq mRNA NM 005151NM 001037334NM 001038589NM 021522NM 001360884RefSeq protein NP 001032411NP 005142NP 001033678NP 067497NP 001347813Location UCSC Chr 18 0 16 0 21 MbChr 18 9 99 10 05 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the ubiquitin specific processing UBP family of proteases that is a deubiquitinating enzyme DUB with His and Cys domains This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin fused precursors and ubiquitinylated proteins Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age Alternate transcriptional splice variants encoding different isoforms have been characterized 6 Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editUSP14 has been shown to interact with CXCR4 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000101557 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000047879 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Puente XS Sanchez LM Overall CM Lopez Otin C Jul 2003 Human and mouse proteases a comparative genomic approach Nat Rev Genet 4 7 544 58 doi 10 1038 nrg1111 PMID 12838346 S2CID 2856065 a b Entrez Gene USP14 ubiquitin specific peptidase 14 tRNA guanine transglycosylase Mines MA Goodwin JS Limbird LE Cui FF Fan GH Feb 2009 Deubiquitination of CXCR4 by USP14 is critical for both CXCL12 induced CXCR4 degradation and chemotaxis but not ERK activation J Biol Chem 284 9 5742 52 doi 10 1074 jbc M808507200 PMC 2645827 PMID 19106094 Further reading editWilson SM Bhattacharyya B Rachel RA Coppola V Tessarollo L Householder DB Fletcher CF Miller RJ Copeland NG Jenkins NA 2002 Synaptic defects in ataxia mice result from a mutation in Usp14 encoding a ubiquitin specific protease Nature Genetics 32 3 420 425 doi 10 1038 ng1006 PMID 12368914 S2CID 23542012 D Andrea A Pellman D 1999 Deubiquitinating enzymes a new class of biological regulators Crit Rev Biochem Mol Biol 33 5 337 52 doi 10 1080 10409239891204251 PMID 9827704 Deshpande KL Seubert PH Tillman DM Farkas WR Katze JR 1996 Cloning and characterization of cDNA encoding the rabbit tRNA guanine transglycosylase 60 kilodalton subunit Arch Biochem Biophys 326 1 1 7 doi 10 1006 abbi 1996 0039 PMID 8579355 Reuter TY Medhurst AL Waisfisz Q Zhi Y Herterich S Hoehn H Gross HJ Joenje H Hoatlin ME Mathew CG Huber PA 2003 Yeast two hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation cell signaling oxidative metabolism and cellular transport Exp Cell Res 289 2 211 21 doi 10 1016 S0014 4827 03 00261 1 PMID 14499622 Dennehey BK Gutches DG McConkey EH Krauter KS 2004 Inversion duplication and changes in gene context are associated with human chromosome 18 evolution Genomics 83 3 493 501 doi 10 1016 j ygeno 2003 08 017 PMID 14962675 Hu M Li P Song L Jeffrey PD Chenova TA Wilkinson KD Cohen RE Shi Y 2005 Structure and mechanisms of the proteasome associated deubiquitinating enzyme USP14 EMBO J 24 21 3747 56 doi 10 1038 sj emboj 7600832 PMC 1276716 PMID 16211010 Shinji S Naito Z Ishiwata S Ishiwata T Tanaka N Furukawa K Suzuki H Seya T Matsuda A Katsuta M Tajiri T 2006 Ubiquitin specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases Oncol Rep 15 3 539 43 doi 10 3892 or 15 3 539 PMID 16465409 Crimmins S Jin Y Wheeler C Huffman AK Chapman C Dobrunz LE Levey A Roth KA Wilson JA Wilson SM 2006 Transgenic rescue of ataxia mice with neuronal specific expression of ubiquitin specific protease 14 J Neurosci 26 44 11423 31 doi 10 1523 JNEUROSCI 3600 06 2006 PMC 6674543 PMID 17079671 External links editOverview of all the structural information available in the PDB for UniProt P54578 Ubiquitin carboxyl terminal hydrolase 14 at the PDBe KB nbsp This article on a gene on human chromosome 18 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title USP14 amp oldid 1142789562, wikipedia, wiki, book, books, library,
