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Transrepression

January 01, 1970

In the field of molecular biology, transrepression is a process whereby one protein represses (i.e., inhibits) the activity of a second protein through a protein-protein interaction. Since this repression occurs between two different protein molecules (intermolecular), it is referred to as a trans-acting process.

The protein that is repressed is usually a transcription factor whose function is to up-regulate (i.e., increase) the rate of gene transcription. Hence the net result of transrepression is down regulation of gene transcription.

An example of transrepression is the ability of the glucocorticoid receptor to inhibit the transcriptional promoting activity of the AP-1 and NF-κB transcription factors.[1][2] In addition to transactivation, transrepression is an important pathway for the anti-inflammatory effects of glucocorticoids.[3][4] Other nuclear receptors such as LXR and PPAR have been demonstrated to also have the ability to transrepress the activity of other proteins.[5]

See also edit

References edit

  1. ^ Lucibello FC, Slater EP, Jooss KU, Beato M, Müller R (September 1990). "Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB". EMBO J. 9 (9): 2827–34. doi:10.1002/j.1460-2075.1990.tb07471.x. PMC 551994. PMID 2118106.
  2. ^ Lin, Cw; Nakane, M; Stashko, M; Falls, D; Kuk, J; Miller, L; Huang, R; Tyree, C; Miner, Jn; Rosen, J; Kym, Pr; Coghlan, Mj; Carter, G; Lane, Bc (Aug 2002). "trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-1benzopyrano3,4-fquinoline (A276575) and its four stereoisomers" (Free full text). Molecular Pharmacology. 62 (2): 297–303. doi:10.1124/mol.62.2.297. ISSN 0026-895X. PMID 12130681.
  3. ^ Pascual G, Glass CK (October 2006). "Nuclear receptors versus inflammation: mechanisms of transrepression". Trends Endocrinol. Metab. 17 (8): 321–7. doi:10.1016/j.tem.2006.08.005. PMID 16942889. S2CID 19612552.
  4. ^ Newton R, Holden NS (October 2007). "Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?". Mol. Pharmacol. 72 (4): 799–809. doi:10.1124/mol.107.038794. PMID 17622575. S2CID 52803631.
  5. ^ Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK (January 2007). "Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ". Mol. Cell. 25 (1): 57–70. doi:10.1016/j.molcel.2006.11.022. PMC 1850387. PMID 17218271.


 

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January 01, 1970
transrepression, field, molecular, biology, transrepression, process, whereby, protein, represses, inhibits, activity, second, protein, through, protein, protein, interaction, since, this, repression, occurs, between, different, protein, molecules, intermolecu. In the field of molecular biology transrepression is a process whereby one protein represses i e inhibits the activity of a second protein through a protein protein interaction Since this repression occurs between two different protein molecules intermolecular it is referred to as a trans acting process The protein that is repressed is usually a transcription factor whose function is to up regulate i e increase the rate of gene transcription Hence the net result of transrepression is down regulation of gene transcription An example of transrepression is the ability of the glucocorticoid receptor to inhibit the transcriptional promoting activity of the AP 1 and NF kB transcription factors 1 2 In addition to transactivation transrepression is an important pathway for the anti inflammatory effects of glucocorticoids 3 4 Other nuclear receptors such as LXR and PPAR have been demonstrated to also have the ability to transrepress the activity of other proteins 5 See also editSelective glucocorticoid receptor agonistReferences edit Lucibello FC Slater EP Jooss KU Beato M Muller R September 1990 Mutual transrepression of Fos and the glucocorticoid receptor involvement of a functional domain in Fos which is absent in FosB EMBO J 9 9 2827 34 doi 10 1002 j 1460 2075 1990 tb07471 x PMC 551994 PMID 2118106 Lin Cw Nakane M Stashko M Falls D Kuk J Miller L Huang R Tyree C Miner Jn Rosen J Kym Pr Coghlan Mj Carter G Lane Bc Aug 2002 trans Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2 5 dihydro 9 hydroxy 10 methoxy 2 2 4 trimethyl 5 1 methylcyclohexen 3 y1 1H 1benzopyrano3 4 fquinoline A276575 and its four stereoisomers Free full text Molecular Pharmacology 62 2 297 303 doi 10 1124 mol 62 2 297 ISSN 0026 895X PMID 12130681 Pascual G Glass CK October 2006 Nuclear receptors versus inflammation mechanisms of transrepression Trends Endocrinol Metab 17 8 321 7 doi 10 1016 j tem 2006 08 005 PMID 16942889 S2CID 19612552 Newton R Holden NS October 2007 Separating transrepression and transactivation a distressing divorce for the glucocorticoid receptor Mol Pharmacol 72 4 799 809 doi 10 1124 mol 107 038794 PMID 17622575 S2CID 52803631 Ghisletti S Huang W Ogawa S Pascual G Lin ME Willson TM Rosenfeld MG Glass CK January 2007 Parallel SUMOylation dependent pathways mediate gene and signal specific transrepression by LXRs and PPARg Mol Cell 25 1 57 70 doi 10 1016 j molcel 2006 11 022 PMC 1850387 PMID 17218271 nbsp This molecular biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Transrepression amp oldid 1136834182, wikipedia, wiki, book, books, library,

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