A topogenic sequence is a collective term used for a peptide sequence present at nascent proteins essential for their insertion and orienting in cellular membranes. The sequences are also used to translocate proteins across various intracellular membranes,[1] and ensure they are transported to the correct organelle after synthesis.[2] The position of the sequence may be at the end, e.g. N-terminal signal sequence, or in mid parts of the nascent protein, e.g. stop-transfer anchor sequences and signal-anchor sequences.[3] If the sequence is at the end of the polypeptide, it is cleaved off after entering the ER-lumen (via a translocon) by a signal peptidase, and subsequently degraded.
As an example, the vast majority of all known complex plastid preproteins (an 'unactivated' protein) encoded in the nucleus possess a topogenic sequence.[2]
^Robinson, A; Austen, B (1 September 1987). "The role of topogenic sequences in the movement of proteins through membranes". Biochem. J. 246 (2): 249–261. doi:10.1042/bj2460249. PMC1148271. PMID 3318806.
topogenic, sequence, topogenic, sequence, collective, term, used, peptide, sequence, present, nascent, proteins, essential, their, insertion, orienting, cellular, membranes, sequences, also, used, translocate, proteins, across, various, intracellular, membrane. A topogenic sequence is a collective term used for a peptide sequence present at nascent proteins essential for their insertion and orienting in cellular membranes The sequences are also used to translocate proteins across various intracellular membranes 1 and ensure they are transported to the correct organelle after synthesis 2 The position of the sequence may be at the end e g N terminal signal sequence or in mid parts of the nascent protein e g stop transfer anchor sequences and signal anchor sequences 3 If the sequence is at the end of the polypeptide it is cleaved off after entering the ER lumen via a translocon by a signal peptidase and subsequently degraded As an example the vast majority of all known complex plastid preproteins an unactivated protein encoded in the nucleus possess a topogenic sequence 2 See also editProtein targeting Target peptide Translocon Signal peptideReferences edit Robinson A Austen B 1 September 1987 The role of topogenic sequences in the movement of proteins through membranes Biochem J 246 2 249 261 doi 10 1042 bj2460249 PMC 1148271 PMID 3318806 a b Gould Sven Waller R McFadden G June 2008 Plastid Evolution Annual Review of Plant Biology 59 491 517 doi 10 1146 annurev arplant 59 032607 092915 PMID 18315522 Lodish Harvey 2013 Molecular Cell Biology Macmillan Higher Education pp 587 588 ISBN 978 1 4292 3413 9 nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Topogenic sequence amp oldid 1150304704, wikipedia, wiki, book, books, library,
