This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternative splicing has been identified, with observed variation resulting in the presence or absence of domains. In addition, splicing occurs in the 5' UTR but transcripts including these variations have not been described completely.[7]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025497 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
^Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.
^ ab"Entrez Gene: MUCDHL mucin and cadherin-like".
Goldberg M, Wei M, Tycko B, et al. (2002). "Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys". Am. J. Physiol. Renal Physiol. 283 (3): F454–63. doi:10.1152/ajprenal.00012.2002. PMID 12167596. S2CID 615952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Goldberg M, Wei M, Yuan L, et al. (2003). "Biallelic expression of HRAS and MUCDHL in human and mouse". Hum. Genet. 112 (4): 334–42. doi:10.1007/s00439-003-0907-7. PMID 12589428. S2CID 1143721.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
mupcdh, mucin, cadherin, like, protein, protein, that, humans, encoded, gene, cdhr5identifiersaliasescdhr5, pcdh, mucdhl, mlpcdh, cadherin, related, family, member, 5external, idsomim, 606839, 1919290, homologene, 69345, genecards, cdhr5gene, location, human, . Mucin and cadherin like protein is a protein that in humans is encoded by the MUPCDH gene 5 6 7 CDHR5IdentifiersAliasesCDHR5 MU PCDH MUCDHL MUPCDH MLPCDH cadherin related family member 5External IDsOMIM 606839 MGI 1919290 HomoloGene 69345 GeneCards CDHR5Gene location Human Chr Chromosome 11 human 1 Band11p15 5Start616 577 bp 1 End626 078 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 F5Start140 848 996 bp 2 End140 856 699 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed induodenumrectumright lobe of liverkidneygallbladdersural nerveappendixrenal cortexislet of LangerhansstomachTop expressed induodenumlarge intestinecolonjejunumcrypt of lieberkuhn of small intestineileumleft colonkidneyproximal tubuleyolk sacMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding beta catenin binding protein binding cell adhesion molecule bindingCellular componentintegral component of membrane spanning component of plasma membrane brush border membrane clathrin coated pit plasma membrane extracellular exosome membrane cell projection microvillus membrane apical plasma membraneBiological processcell adhesion regulation of microvillus length homophilic cell adhesion via plasma membrane adhesion molecules intermicrovillar adhesion cell differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5384172040EnsemblENSG00000099834ENSG00000273572ENSMUSG00000025497UniProtQ9HBB8Q8VHF2RefSeq mRNA NM 001171968NM 017717NM 021924NM 031264NM 031265NM 001114322NM 028069RefSeq protein NP 001165439NP 068743NP 112554NP 001107794NP 082345Location UCSC Chr 11 0 62 0 63 MbChr 7 140 85 140 86 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene is a novel mucin like gene that is a member of the cadherin superfamily While encoding nonpolymorphic tandem repeats rich in proline serine and threonine similar to mucin proteins the gene also contains sequence encoding calcium binding motifs found in all cadherins The role of the hybrid extracellular region and the specific function of this protein have not yet been determined Alternative splicing has been identified with observed variation resulting in the presence or absence of domains In addition splicing occurs in the 5 UTR but transcripts including these variations have not been described completely 7 References edit a b c ENSG00000273572 GRCh38 Ensembl release 89 ENSG00000099834 ENSG00000273572 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025497 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Paris MJ Williams BR Jan 2001 Characterization of a 500 kb contig spanning the region between c Ha Ras and MUC2 on chromosome 11p15 5 Genomics 69 2 196 202 doi 10 1006 geno 2000 6339 PMID 11031102 Goldberg M Peshkovsky C Shifteh A Al Awqati Q Sep 2000 mu Protocadherin a novel developmentally regulated protocadherin with mucin like domains J Biol Chem 275 32 24622 9 doi 10 1074 jbc M000234200 PMID 10801787 S2CID 42493271 a b Entrez Gene MUCDHL mucin and cadherin like Further reading editYagi T Takeichi M 2000 Cadherin superfamily genes functions genomic organization and neurologic diversity Genes Dev 14 10 1169 80 doi 10 1101 gad 14 10 1169 PMID 10817752 S2CID 44844497 Goldberg M Wei M Tycko B et al 2002 Identification and expression analysis of the human mu protocadherin gene in fetal and adult kidneys Am J Physiol Renal Physiol 283 3 F454 63 doi 10 1152 ajprenal 00012 2002 PMID 12167596 S2CID 615952 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Goldberg M Wei M Yuan L et al 2003 Biallelic expression of HRAS and MUCDHL in human and mouse Hum Genet 112 4 334 42 doi 10 1007 s00439 003 0907 7 PMID 12589428 S2CID 1143721 Clark HF Gurney AL Abaya E et al 2003 The Secreted Protein Discovery Initiative SPDI a Large Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins A Bioinformatics Assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 S2CID 21903526 Liu T Qian WJ Gritsenko MA et al 2006 Human Plasma N Glycoproteome Analysis by Immunoaffinity Subtraction Hydrazide Chemistry and Mass Spectrometry J Proteome Res 4 6 2070 80 doi 10 1021 pr0502065 PMC 1850943 PMID 16335952 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MUPCDH amp oldid 1181810490, wikipedia, wiki, book, books, library,
