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Tohoku Medical Megabank Project

April 13, 2024

The Tohoku Medical Megabank Project is a national project in Japan, which started in 2012.[1] The mission of the Tohoku Medical Megabank (TMM) project is to carry out a long-term health survey in the Miyagi and Iwate prefectures, which were affected by the Great East Japan Earthquake, and provide the research infrastructure for the development of personalized medicine by establishing a biobank and conducting cohort studies.[2][3]

Tohoku Medical Megabank Project
Building of ToMMo at Tohoku Univ.
Commercial?No
Type of projectProspective cohort study
LocationSendai, Miyagi, JAPAN (ToMMo) and Shiwa-gun, Iwate, JAPAN (IMM)
Key peopleMasayuki Yamamoto (Executive Director, ToMMo) Makoto Sasaki (Executive Director, IMM)
Established2012

The TMM project is conducted by Tohoku University's Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University's Iwate Tohoku Medical Megabank Organization (IMM).

Projects edit

The following cohort studies and research projects are in progress or completed.

Prospective cohort studies edit

  • Community-based cohort.[1]

The study recruited over 80,000 participants, with 50,000 from Miyagi Prefecture and 30,000 from Iwate Prefecture.

  • Birth and Three-generation cohort.[1]

The study recruited over 70,000 participants, including over 23,000 newborns and their parents, siblings, grandparents, and extended family members.[3]

The project has been collecting various specimens, including peripheral and cord blood mononuclear cells, Buffy coat, plasma, serum, urine, breast milk, and saliva.[2]

  • Return of results to participants (including genomic information).[5]

Research projects edit

The project provides allele frequencies of SNVs (single nucleotide variants) and short INDELs (insertions/deletions) detected by short-read whole genome sequencing (WGS) analysis of 54,000 Japanese individuals, as well as allele frequencies of structural variants detected by long-read WGS analysis of 222 individuals.[7]

  • SNP array Genotyping.[6]

The project designed ethnic-specific SNP arrays optimized for the Japanese population and performed a series of GWAS analyses with the cohort samples.[8]

The project constructed a reference genome for Japanese by integrating de novo assemblies of three Japanese individuals.

Timeline edit

2013

  • Recruitment of TMM Community-Based Cohort starts.[1]
  • Recruitment of TMM Birth and Three-Generation Cohort Study starts.[1]

2014

  • Japanese genome reference panel (1KJPN), which shows variant allele frequency based on whole genome sequencing of 1,070 cohort participants, is released (draft version 2014, official version 2015).[13]
  • Japonica array, a SNP array optimized for Japanese population by taking advantage of 1KJPN haplotype information, is released.[14]

2015

  • A portal site of Japanese Multi Omics Reference Panel (jMorp), providing metabolome and proteome data from the cohort participants, is opened. As of 2022, jMorp covers metabolome, proteome, transcriptome, methylome, as well as genome reference panel.[15]

2016

  • Recruitment of TMM Community-Based Cohort is finished with over 80,000 participants.[1]

2017

  • Recruitment of TMM Birth and Three-Generation Cohort Study is finished with over 70,000 participants.[1]
  • The second followup survey starts.

2018

  • Japanese genome reference panel (3.5KJPNv2), which shows variant allele frequency based on whole genome sequencing of 3,554 cohort participants, is released (published in 2019).[16]

2019

  • Japanese reference genome (JG1) is released (published in 2021).[9]
  • Distribution of 67,000 TMM Community-Based Cohort samples data starts.
  • Japanese genome reference panel (4.7KJPN) is released.
  • Japonica array NEO, a SNP array optimized for Japanese population by taking advantage of 3.5KJPN haplotype information, is released (published in 2021).[17]

2020

  • Distribution of 54,000 SNP array data starts.
  • Distribution of TMM Birth and Three-Generation Cohort samples data starts.
  • Japanese genome reference panel (8.3KJPN) is released.
  • Japanese reference genome (JG2) is released.

2021

  • The third followup survey starts.
  • Japanese genome reference panel (14KJPN) is released.[18]
  • JSV1, a structural variation panel, which is constructed with long-read sequencing data, is released.[19]

2022

  • Whole genome sequencing of 50,000 cohort participants was finished.[20]
  • Japanese genome reference panel (38KJPN) is released.

2023

  • Whole genome sequencing of 69,000 cohort participants was finished.[21]
  • Japanese genome reference panel (54KJPN) is released. Data is available through the portal site, jMorp.

References edit

  1. ^ a b c d e f g Kuriyama, Shinichi; Yaegashi, Nobuo; Nagami, Fuji; Arai, Tomohiko; Kawaguchi, Yoshio; Osumi, Noriko; Sakaida, Masaki; Suzuki, Yoichi; Nakayama, Keiko; Hashizume, Hiroaki; Tamiya, Gen (2016). "The Tohoku Medical Megabank Project: Design and Mission". Journal of Epidemiology. 26 (9): 493–511. doi:10.2188/jea.JE20150268. PMC 5008970. PMID 27374138.
  2. ^ a b c Minegishi, Naoko; Nishijima, Ichiko; Nobukuni, Takahiro; Kudo, Hisaaki; Ishida, Noriko; Terakawa, Takahiro; Kumada, Kazuki; Yamashita, Riu; Katsuoka, Fumiki; Ogishima, Soichi; Suzuki, Kichiya (2019). "Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project". The Tohoku Journal of Experimental Medicine. 248 (1): 45–55. doi:10.1620/tjem.248.45. PMID 31130587. S2CID 167210746.
  3. ^ a b Kuriyama, Shinichi; Metoki, Hirohito; Kikuya, Masahiro; Obara, Taku; Ishikuro, Mami; Yamanaka, Chizuru; Nagai, Masato; Matsubara, Hiroko; Kobayashi, Tomoko; Sugawara, Junichi; Tamiya, Gen (2020-02-01). "Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective". International Journal of Epidemiology. 49 (1): 18–19m. doi:10.1093/ije/dyz169. ISSN 0300-5771. PMC 7124511. PMID 31504573.
  4. ^ Ogishima, Soichi; Nagaie, Satoshi; Mizuno, Satoshi; Ishiwata, Ryosuke; Iida, Keita; Shimokawa, Kazuro; Takai-Igarashi, Takako; Nakamura, Naoki; Nagase, Sachiko; Nakamura, Tomohiro; Tsuchiya, Naho (2021-12-10). "dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project". Human Genome Variation. 8 (1): 44. doi:10.1038/s41439-021-00175-5. ISSN 2054-345X. PMC 8660797. PMID 34887386.
  5. ^ Kawame, Hiroshi; Fukushima, Akimune; Fuse, Nobuo; Nagami, Fuji; Suzuki, Yoichi; Sakurai-Yageta, Mika; Yasuda, Jun; Yamaguchi-Kabata, Yumi; Kinoshita, Kengo; Ogishima, Soichi; Takai, Takako (January 2022). "The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project". Journal of Human Genetics. 67 (1): 9–17. doi:10.1038/s10038-021-00952-8. ISSN 1435-232X. PMID 34234266. S2CID 235768398.
  6. ^ a b Yasuda, Jun; Kinoshita, Kengo; Katsuoka, Fumiki; Danjoh, Inaho; Sakurai-Yageta, Mika; Motoike, Ikuko N.; Kuroki, Yoko; Saito, Sakae; Kojima, Kaname; Shirota, Matsuyuki; Saigusa, Daisuke (2019-02-01). "Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare". Journal of Biochemistry. 165 (2): 139–158. doi:10.1093/jb/mvy096. ISSN 1756-2651. PMID 30452759.
  7. ^ "jMorp". jmorp.megabank.tohoku.ac.jp. Retrieved 2024-03-12.
  8. ^ Sakurai-Yageta, Mika; Kumada, Kazuki; Gocho, Chinatsu; Makino, Satoshi; Uruno, Akira; Tadaka, Shu; Motoike, Ikuko N; Kimura, Masae; Ito, Shin; Otsuki, Akihito; Narita, Akira; Kudo, Hisaaki; Aoki, Yuichi; Danjoh, Inaho; Yasuda, Jun (2021-10-12). "Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs". The Journal of Biochemistry. 170 (3): 399–410. doi:10.1093/jb/mvab060. ISSN 0021-924X. PMC 8510329. PMID 34131746.
  9. ^ a b Takayama, Jun; Tadaka, Shu; Yano, Kenji; Katsuoka, Fumiki; Gocho, Chinatsu; Funayama, Takamitsu; Makino, Satoshi; Okamura, Yasunobu; Kikuchi, Atsuo; Sugimoto, Sachiyo; Kawashima, Junko (2021-01-11). "Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference". Nature Communications. 12 (1): 226. Bibcode:2021NatCo..12..226T. doi:10.1038/s41467-020-20146-8. ISSN 2041-1723. PMC 7801658. PMID 33431880.
  10. ^ a b Koshiba, Seizo; Motoike, Ikuko; Saigusa, Daisuke; Inoue, Jin; Shirota, Matsuyuki; Katoh, Yasutake; Katsuoka, Fumiki; Danjoh, Inaho; Hozawa, Atsushi; Kuriyama, Shinichi; Minegishi, Naoko (June 2018). "Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project". Genes to Cells: Devoted to Molecular & Cellular Mechanisms. 23 (6): 406–417. doi:10.1111/gtc.12588. ISSN 1365-2443. PMID 29701317. S2CID 21700516.
  11. ^ a b Furukawa, Ryohei; Hachiya, Tsuyoshi; Ohmomo, Hideki; Shiwa, Yuh; Ono, Kanako; Suzuki, Sadafumi; Satoh, Mamoru; Hitomi, Jiro; Sobue, Kenji; Shimizu, Atsushi (2016-05-19). "Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation". Scientific Reports. 6: 26424. Bibcode:2016NatSR...626424F. doi:10.1038/srep26424. ISSN 2045-2322. PMC 4872231. PMID 27192970.
  12. ^ Saito, Sakae; Aoki, Yuichi; Tamahara, Toru; Goto, Maki; Matsui, Hiroyuki; Kawashima, Junko; Danjoh, Inaho; Hozawa, Atsushi; Kuriyama, Shinichi; Suzuki, Yoichi; Fuse, Nobuo (2020). "Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project". Frontiers in Cellular and Infection Microbiology. 10: 604596. doi:10.3389/fcimb.2020.604596. ISSN 2235-2988. PMC 7878372. PMID 33585276.
  13. ^ Nagasaki, Masao; Yasuda, Jun; Katsuoka, Fumiki; Nariai, Naoki; Kojima, Kaname; Kawai, Yosuke; Yamaguchi-Kabata, Yumi; Yokozawa, Junji; Danjoh, Inaho; Saito, Sakae; Sato, Yukuto (2015-08-21). "Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals". Nature Communications. 6: 8018. Bibcode:2015NatCo...6.8018.. doi:10.1038/ncomms9018. ISSN 2041-1723. PMC 4560751. PMID 26292667.
  14. ^ Kawai, Yosuke; Mimori, Takahiro; Kojima, Kaname; Nariai, Naoki; Danjoh, Inaho; Saito, Rumiko; Yasuda, Jun; Yamamoto, Masayuki; Nagasaki, Masao (October 2015). "Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals". Journal of Human Genetics. 60 (10): 581–587. doi:10.1038/jhg.2015.68. ISSN 1434-5161. PMC 4635170. PMID 26108142.
  15. ^ Tadaka, Shu; Saigusa, Daisuke; Motoike, Ikuko N.; Inoue, Jin; Aoki, Yuichi; Shirota, Matsuyuki; Koshiba, Seizo; Yamamoto, Masayuki; Kinoshita, Kengo (2018-01-04). "jMorp: Japanese Multi Omics Reference Panel". Nucleic Acids Research. 46 (D1): D551–D557. doi:10.1093/nar/gkx978. ISSN 1362-4962. PMC 5753289. PMID 29069501.
  16. ^ Tadaka, Shu; Katsuoka, Fumiki; Ueki, Masao; Kojima, Kaname; Makino, Satoshi; Saito, Sakae; Otsuki, Akihito; Gocho, Chinatsu; Sakurai-Yageta, Mika; Danjoh, Inaho; Motoike, Ikuko N. (2019). "3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome". Human Genome Variation. 6: 28. doi:10.1038/s41439-019-0059-5. ISSN 2054-345X. PMC 6581902. PMID 31240104.
  17. ^ Sakurai-Yageta, Mika; Kumada, Kazuki; Gocho, Chinatsu; Makino, Satoshi; Uruno, Akira; Tadaka, Shu; Motoike, Ikuko N.; Kimura, Masae; Ito, Shin; Otsuki, Akihito; Narita, Akira (2021-10-12). "Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs". Journal of Biochemistry. 170 (3): 399–410. doi:10.1093/jb/mvab060. ISSN 1756-2651. PMC 8510329. PMID 34131746.
  18. ^ "Genome information for 14,000 people is now available -jMorp 2021 major update-｜ToMMo". ToMMo ｜ Tohoku Medical Megabank Organization (in Japanese). 2021-12-27. Retrieved 2022-07-01.
  19. ^ Otsuki, Akihito; Okamura, Yasunobu; Ishida, Noriko; Tadaka, Shu; Takayama, Jun; Kumada, Kazuki; Kawashima, Junko; Taguchi, Keiko; Minegishi, Naoko; Kuriyama, Shinichi; Tamiya, Gen; Kinoshita, Kengo; Katsuoka, Fumiki; Yamamoto, Masayuki (2022-09-20). "Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology". Communications Biology. 5 (1): 991. doi:10.1038/s42003-022-03953-1. ISSN 2399-3642. PMC 9489684. PMID 36127505.
  20. ^ "Completion of 50,000 Japanese whole genome sequence analysis and release of whole genome reference panel of 38,000 Japanese individuals (38KJPN)｜ToMMo". ToMMo ｜ Tohoku Medical Megabank Organization (in Japanese). 2022-07-19. Retrieved 2022-10-13.
  21. ^ "jMorp". jmorp.megabank.tohoku.ac.jp. Retrieved 2023-07-11.

External links edit

  • Tohoku Medical Megabank Organization
  • Iwate Tohoku Medical Megabank Organization
  • jMorp: Japanese Multi Omics Reference Panel
  • iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation.

April 13, 2024
tohoku, medical, megabank, project, national, project, japan, which, started, 2012, mission, tohoku, medical, megabank, project, carry, long, term, health, survey, miyagi, iwate, prefectures, which, were, affected, great, east, japan, earthquake, provide, rese. The Tohoku Medical Megabank Project is a national project in Japan which started in 2012 1 The mission of the Tohoku Medical Megabank TMM project is to carry out a long term health survey in the Miyagi and Iwate prefectures which were affected by the Great East Japan Earthquake and provide the research infrastructure for the development of personalized medicine by establishing a biobank and conducting cohort studies 2 3 Tohoku Medical Megabank ProjectBuilding of ToMMo at Tohoku Univ Commercial NoType of projectProspective cohort studyLocationSendai Miyagi JAPAN ToMMo and Shiwa gun Iwate JAPAN IMM Key peopleMasayuki Yamamoto Executive Director ToMMo Makoto Sasaki Executive Director IMM Established2012The TMM project is conducted by Tohoku University s Tohoku Medical Megabank Organization ToMMo and Iwate Medical University s Iwate Tohoku Medical Megabank Organization IMM Contents 1 Projects 1 1 Prospective cohort studies 1 2 Research projects 2 Timeline 3 References 4 External linksProjects editThe following cohort studies and research projects are in progress or completed Prospective cohort studies edit Community based cohort 1 The study recruited over 80 000 participants with 50 000 from Miyagi Prefecture and 30 000 from Iwate Prefecture Birth and Three generation cohort 1 The study recruited over 70 000 participants including over 23 000 newborns and their parents siblings grandparents and extended family members 3 Biobanking and database 2 4 The project has been collecting various specimens including peripheral and cord blood mononuclear cells Buffy coat plasma serum urine breast milk and saliva 2 Return of results to participants including genomic information 5 Research projects edit Whole genome sequencing with short read and long read technologies 6 The project provides allele frequencies of SNVs single nucleotide variants and short INDELs insertions deletions detected by short read whole genome sequencing WGS analysis of 54 000 Japanese individuals as well as allele frequencies of structural variants detected by long read WGS analysis of 222 individuals 7 SNP array Genotyping 6 The project designed ethnic specific SNP arrays optimized for the Japanese population and performed a series of GWAS analyses with the cohort samples 8 Construction of Japanese reference genome 9 The project constructed a reference genome for Japanese by integrating de novo assemblies of three Japanese individuals Plasma metabolome analysis with NMR and Mass spectrometry 10 Proteome analysis 10 Transcriptome analysis 11 Epigenome analysis 11 Oral Microbiome analysis 12 Timeline edit2013 Recruitment of TMM Community Based Cohort starts 1 Recruitment of TMM Birth and Three Generation Cohort Study starts 1 2014 Japanese genome reference panel 1KJPN which shows variant allele frequency based on whole genome sequencing of 1 070 cohort participants is released draft version 2014 official version 2015 13 Japonica array a SNP array optimized for Japanese population by taking advantage of 1KJPN haplotype information is released 14 2015 A portal site of Japanese Multi Omics Reference Panel jMorp providing metabolome and proteome data from the cohort participants is opened As of 2022 jMorp covers metabolome proteome transcriptome methylome as well as genome reference panel 15 2016 Recruitment of TMM Community Based Cohort is finished with over 80 000 participants 1 2017 Recruitment of TMM Birth and Three Generation Cohort Study is finished with over 70 000 participants 1 The second followup survey starts 2018 Japanese genome reference panel 3 5KJPNv2 which shows variant allele frequency based on whole genome sequencing of 3 554 cohort participants is released published in 2019 16 2019 Japanese reference genome JG1 is released published in 2021 9 Distribution of 67 000 TMM Community Based Cohort samples data starts Japanese genome reference panel 4 7KJPN is released Japonica array NEO a SNP array optimized for Japanese population by taking advantage of 3 5KJPN haplotype information is released published in 2021 17 2020 Distribution of 54 000 SNP array data starts Distribution of TMM Birth and Three Generation Cohort samples data starts Japanese genome reference panel 8 3KJPN is released Japanese reference genome JG2 is released 2021 The third followup survey starts Japanese genome reference panel 14KJPN is released 18 JSV1 a structural variation panel which is constructed with long read sequencing data is released 19 2022 Whole genome sequencing of 50 000 cohort participants was finished 20 Japanese genome reference panel 38KJPN is released 2023 Whole genome sequencing of 69 000 cohort participants was finished 21 Japanese genome reference panel 54KJPN is released Data is available through the portal site jMorp References edit a b c d e f g Kuriyama Shinichi Yaegashi Nobuo Nagami Fuji Arai Tomohiko Kawaguchi Yoshio Osumi Noriko Sakaida Masaki Suzuki Yoichi Nakayama Keiko Hashizume Hiroaki Tamiya Gen 2016 The Tohoku Medical Megabank Project Design and Mission Journal of Epidemiology 26 9 493 511 doi 10 2188 jea JE20150268 PMC 5008970 PMID 27374138 a b c Minegishi Naoko Nishijima Ichiko Nobukuni Takahiro Kudo Hisaaki Ishida Noriko Terakawa Takahiro Kumada Kazuki Yamashita Riu Katsuoka Fumiki Ogishima Soichi Suzuki Kichiya 2019 Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project The Tohoku Journal of Experimental Medicine 248 1 45 55 doi 10 1620 tjem 248 45 PMID 31130587 S2CID 167210746 a b Kuriyama Shinichi Metoki Hirohito Kikuya Masahiro Obara Taku Ishikuro Mami Yamanaka Chizuru Nagai Masato Matsubara Hiroko Kobayashi Tomoko Sugawara Junichi Tamiya Gen 2020 02 01 Cohort Profile Tohoku Medical Megabank Project Birth and Three Generation Cohort Study TMM BirThree Cohort Study rationale progress and perspective International Journal of Epidemiology 49 1 18 19m doi 10 1093 ije dyz169 ISSN 0300 5771 PMC 7124511 PMID 31504573 Ogishima Soichi Nagaie Satoshi Mizuno Satoshi Ishiwata Ryosuke Iida Keita Shimokawa Kazuro Takai Igarashi Takako Nakamura Naoki Nagase Sachiko Nakamura Tomohiro Tsuchiya Naho 2021 12 10 dbTMM an integrated database of large scale cohort genome and clinical data for the Tohoku Medical Megabank Project Human Genome Variation 8 1 44 doi 10 1038 s41439 021 00175 5 ISSN 2054 345X PMC 8660797 PMID 34887386 Kawame Hiroshi Fukushima Akimune Fuse Nobuo Nagami Fuji Suzuki Yoichi Sakurai Yageta Mika Yasuda Jun Yamaguchi Kabata Yumi Kinoshita Kengo Ogishima Soichi Takai Takako January 2022 The return of individual genomic results to research participants design and pilot study of Tohoku Medical Megabank Project Journal of Human Genetics 67 1 9 17 doi 10 1038 s10038 021 00952 8 ISSN 1435 232X PMID 34234266 S2CID 235768398 a b Yasuda Jun Kinoshita Kengo Katsuoka Fumiki Danjoh Inaho Sakurai Yageta Mika Motoike Ikuko N Kuroki Yoko Saito Sakae Kojima Kaname Shirota Matsuyuki Saigusa Daisuke 2019 02 01 Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare Journal of Biochemistry 165 2 139 158 doi 10 1093 jb mvy096 ISSN 1756 2651 PMID 30452759 jMorp jmorp megabank tohoku ac jp Retrieved 2024 03 12 Sakurai Yageta Mika Kumada Kazuki Gocho Chinatsu Makino Satoshi Uruno Akira Tadaka Shu Motoike Ikuko N Kimura Masae Ito Shin Otsuki Akihito Narita Akira Kudo Hisaaki Aoki Yuichi Danjoh Inaho Yasuda Jun 2021 10 12 Japonica Array NEO with increased genome wide coverage and abundant disease risk SNPs The Journal of Biochemistry 170 3 399 410 doi 10 1093 jb mvab060 ISSN 0021 924X PMC 8510329 PMID 34131746 a b Takayama Jun Tadaka Shu Yano Kenji Katsuoka Fumiki Gocho Chinatsu Funayama Takamitsu Makino Satoshi Okamura Yasunobu Kikuchi Atsuo Sugimoto Sachiyo Kawashima Junko 2021 01 11 Construction and integration of three de novo Japanese human genome assemblies toward a population specific reference Nature Communications 12 1 226 Bibcode 2021NatCo 12 226T doi 10 1038 s41467 020 20146 8 ISSN 2041 1723 PMC 7801658 PMID 33431880 a b Koshiba Seizo Motoike Ikuko Saigusa Daisuke Inoue Jin Shirota Matsuyuki Katoh Yasutake Katsuoka Fumiki Danjoh Inaho Hozawa Atsushi Kuriyama Shinichi Minegishi Naoko June 2018 Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project Genes to Cells Devoted to Molecular amp Cellular Mechanisms 23 6 406 417 doi 10 1111 gtc 12588 ISSN 1365 2443 PMID 29701317 S2CID 21700516 a b Furukawa Ryohei Hachiya Tsuyoshi Ohmomo Hideki Shiwa Yuh Ono Kanako Suzuki Sadafumi Satoh Mamoru Hitomi Jiro Sobue Kenji Shimizu Atsushi 2016 05 19 Intraindividual dynamics of transcriptome and genome wide stability of DNA methylation Scientific Reports 6 26424 Bibcode 2016NatSR 626424F doi 10 1038 srep26424 ISSN 2045 2322 PMC 4872231 PMID 27192970 Saito Sakae Aoki Yuichi Tamahara Toru Goto Maki Matsui Hiroyuki Kawashima Junko Danjoh Inaho Hozawa Atsushi Kuriyama Shinichi Suzuki Yoichi Fuse Nobuo 2020 Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project Frontiers in Cellular and Infection Microbiology 10 604596 doi 10 3389 fcimb 2020 604596 ISSN 2235 2988 PMC 7878372 PMID 33585276 Nagasaki Masao Yasuda Jun Katsuoka Fumiki Nariai Naoki Kojima Kaname Kawai Yosuke Yamaguchi Kabata Yumi Yokozawa Junji Danjoh Inaho Saito Sakae Sato Yukuto 2015 08 21 Rare variant discovery by deep whole genome sequencing of 1 070 Japanese individuals Nature Communications 6 8018 Bibcode 2015NatCo 6 8018 doi 10 1038 ncomms9018 ISSN 2041 1723 PMC 4560751 PMID 26292667 Kawai Yosuke Mimori Takahiro Kojima Kaname Nariai Naoki Danjoh Inaho Saito Rumiko Yasuda Jun Yamamoto Masayuki Nagasaki Masao October 2015 Japonica array improved genotype imputation by designing a population specific SNP array with 1070 Japanese individuals Journal of Human Genetics 60 10 581 587 doi 10 1038 jhg 2015 68 ISSN 1434 5161 PMC 4635170 PMID 26108142 Tadaka Shu Saigusa Daisuke Motoike Ikuko N Inoue Jin Aoki Yuichi Shirota Matsuyuki Koshiba Seizo Yamamoto Masayuki Kinoshita Kengo 2018 01 04 jMorp Japanese Multi Omics Reference Panel Nucleic Acids Research 46 D1 D551 D557 doi 10 1093 nar gkx978 ISSN 1362 4962 PMC 5753289 PMID 29069501 Tadaka Shu Katsuoka Fumiki Ueki Masao Kojima Kaname Makino Satoshi Saito Sakae Otsuki Akihito Gocho Chinatsu Sakurai Yageta Mika Danjoh Inaho Motoike Ikuko N 2019 3 5KJPNv2 an allele frequency panel of 3552 Japanese individuals including the X chromosome Human Genome Variation 6 28 doi 10 1038 s41439 019 0059 5 ISSN 2054 345X PMC 6581902 PMID 31240104 Sakurai Yageta Mika Kumada Kazuki Gocho Chinatsu Makino Satoshi Uruno Akira Tadaka Shu Motoike Ikuko N Kimura Masae Ito Shin Otsuki Akihito Narita Akira 2021 10 12 Japonica Array NEO with increased genome wide coverage and abundant disease risk SNPs Journal of Biochemistry 170 3 399 410 doi 10 1093 jb mvab060 ISSN 1756 2651 PMC 8510329 PMID 34131746 Genome information for 14 000 people is now available jMorp 2021 major update ToMMo ToMMo Tohoku Medical Megabank Organization in Japanese 2021 12 27 Retrieved 2022 07 01 Otsuki Akihito Okamura Yasunobu Ishida Noriko Tadaka Shu Takayama Jun Kumada Kazuki Kawashima Junko Taguchi Keiko Minegishi Naoko Kuriyama Shinichi Tamiya Gen Kinoshita Kengo Katsuoka Fumiki Yamamoto Masayuki 2022 09 20 Construction of a trio based structural variation panel utilizing activated T lymphocytes and long read sequencing technology Communications Biology 5 1 991 doi 10 1038 s42003 022 03953 1 ISSN 2399 3642 PMC 9489684 PMID 36127505 Completion of 50 000 Japanese whole genome sequence analysis and release of whole genome reference panel of 38 000 Japanese individuals 38KJPN ToMMo ToMMo Tohoku Medical Megabank Organization in Japanese 2022 07 19 Retrieved 2022 10 13 jMorp jmorp megabank tohoku ac jp Retrieved 2023 07 11 External links editTohoku Medical Megabank Organization Iwate Tohoku Medical Megabank Organization jMorp Japanese Multi Omics Reference Panel iMETHYL an integrative database of human DNA methylation gene expression and genomic variation Retrieved from https en wikipedia org w index php title Tohoku Medical Megabank Project amp oldid 1214504977, wikipedia, wiki, book, books, library,

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