fbpx
Wikipedia

Tim Mitchison

April 12, 2024

Timothy John Mitchison FRS is a cell biologist and systems biologist and Hasib Sabbagh Professor of Systems Biology at Harvard Medical School in the United States.[6][7][8] He is known for his discovery, with Marc Kirschner, of dynamic instability in microtubules,[9][10] for studies of the mechanism of cell division, and for contributions to chemical biology.[11]

Tim Mitchison

FRS
Born
Timothy John Mitchison

1958 (age 65–66)[4]
Edinburgh
EducationHaberdashers' Aske's Boys' School
Alma materUniversity of Oxford (BA)
University of California, San Francisco (PhD)
SpouseChristine M. Field[5]
AwardsHaldane Lecture (2002)
Keith R. Porter Lecture (2013)
Scientific career
FieldsSystems biology
InstitutionsHarvard Medical School
National Institute for Medical Research
Marine Biological Laboratory[1]
ThesisStructure and Dynamics of Organized Microtubule Arrays (1984)
Doctoral advisorMarc Kirschner[2][3]
Notable studentsTony Hyman
Julie Theriot
Jason Swedlow
Inke Nathke
Katharina Ribbeck
Websitemitchison.hms.harvard.edu/people/timothy-mitchison

Education and early life edit

Mitchison was educated at Haberdashers' Aske's Boys' School and completed his Bachelor of Arts degree in Biochemistry at the University of Oxford where he was an undergraduate student of Merton College, Oxford, from 1976 to 1979. He moved to the University of California, San Francisco (UCSF) in 1979 for his PhD which was supervised by Marc Kirschner[12] and investigated the dynamic instability of microtubules.[12][13]

Career and research edit

Mitchison returned to the UK for postdoctoral research at the National Institute for Medical Research (NIMR) in London.[when?] In 1988 he returned to San Francisco where he was appointed assistant professor at UCSF.[14] In 1994 he wrote an opinion piece for the journal Chemistry & Biology titled "Towards a pharmacological genetics" which helped to launch the field of chemical genetics.[11] In 1997 he moved to Harvard University to become co-director of the Institute for Chemistry and Cell Biology at Harvard Medical School,[14] where he pioneered phenotype-based screening,[15] discovering the small molecule monastrol – the first small-molecule inhibitor of mitosis that does not target tubulin. Monastrol was shown to inhibit kinesin-5, a motor protein. In 2003 he became Deputy Chair of the newly formed Department of Systems Biology, chaired by Marc Kirschner.[16][17] He works on aspects of mesoscale biology[18] including the self-organization of the cytoskeleton[19][20] and of cytoplasm.[21][22] He collaborates extensively with Christine Field on the mechanism of cytokinesis.[23][24][25]

Awards and honors edit

Mitchison was elected Fellow of the Royal Society (FRS) in 1997 for “substantial contributions to the improvement of natural knowledge”[26] and served as president of the American Society for Cell Biology (ASCB) in 2010.[27] He was elected a member of the National Academy of Sciences of the United States in 2014[14] and delivered the Keith R. Porter Lecture in 2013.

Personal life edit

Mitchison is married to scientist Christine M. Field with whom he has two children.[7] Mitchison comes from a family of distinguished biologists; his father is Avrion Mitchison,[6] his uncles are Denis Mitchison[citation needed] and Murdoch Mitchison,[6] his great uncle was J.B.S. Haldane[6] and his great-grandfather John Scott Haldane. His grandparents were the politician Dick Mitchison[28] and the writer Naomi Mitchison (née Haldane).[28] His younger sister Hannah M. Mitchison is also a biologist.[29]

References edit

  1. ^ "Tim Mitchison (Harvard) Part 1: Self-organization of microtubule assemblies". Archived from the original on 13 December 2021 – via YouTube.
  2. ^ "Cell Biology Tree - Timothy J. Mitchison". academictree.org.
  3. ^ Mitchison, T. J. (2013). "A question of taste". Molecular Biology of the Cell. 24 (21): 3278–3280. doi:10.1091/mbc.e13-07-0410. ISSN 1059-1524. PMC 3814136. PMID 24174461.
  4. ^ "Profile" (PDF). ascb.org.
  5. ^ "Timothy Mitchison". Harvard Magazine. 1 November 2003. Retrieved 9 February 2019.
  6. ^ a b c d Wells, William (1997). "Tim Mitchison: Dynamic productivity". Current Biology. 7 (11): R666–R667. doi:10.1016/S0960-9822(06)00346-0. PMID 9382812.
  7. ^ a b "Timothy Mitchison". November 2003.
  8. ^ Ishihara, K.; Nguyen, P. A.; Wuhr, M.; Groen, A. C.; Field, C. M.; Mitchison, T. J. (2014). "Organization of early frog embryos by chemical waves emanating from centrosomes". Philosophical Transactions of the Royal Society B: Biological Sciences. 369 (1650): 20130454. doi:10.1098/rstb.2013.0454. ISSN 0962-8436. PMC 4113098. PMID 25047608.
  9. ^ Lewin, Ben (2007). . Archived from the original on 17 October 2013. Retrieved 9 February 2019.
  10. ^ "Milestone 14 : Nature Milestones in Cytoskeleton". Nature. Retrieved 9 February 2019.
  11. ^ a b Mitchison, T. J. (1994). "Towards a pharmacological genetics". Chemistry & Biology. 1 (1): 3–6. doi:10.1016/1074-5521(94)90034-5. ISSN 1074-5521. PMID 9383364.
  12. ^ a b Mitchison, Timothy John (1984). Structure and Dynamics of Organized Microtubule Arrays (PhD thesis). University of California, San Francisco. OCLC 1020493513. ProQuest 303337748.  
  13. ^ Mitchison, Tim; Kirschner, Marc (1984). "Dynamic instability of microtubule growth". Nature. 312 (5991): 237–242. Bibcode:1984Natur.312..237M. doi:10.1038/312237a0. ISSN 0028-0836. PMID 6504138. S2CID 30079133.
  14. ^ a b c "Timothy Mitchison". nasonline.org.
  15. ^ Mayer, T. U.; Kapoor, T. M.; Haggarty, S. J.; King, R. W.; Schreiber, S. L.; Mitchison, T. J. (29 October 1999). "Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen" (PDF). Science. 286 (5441): 971–974. doi:10.1126/science.286.5441.971. ISSN 0036-8075. PMID 10542155.
  16. ^ "HMS launches new department to study systems biology". Harvard Gazette. 25 September 2003. Retrieved 9 February 2019.
  17. ^ Check, Erika (2 October 2003). "Harvard heralds fresh take on systems biology". Nature. 425 (6957): 439. Bibcode:2003Natur.425..439C. doi:10.1038/425439a. ISSN 1476-4687. PMID 14523408.
  18. ^ Sear, Richard P.; Pagonabarraga, Ignacio; Flaus, Andrew (25 February 2015). "Life at the mesoscale: the self-organised cytoplasm and nucleoplasm". BMC Biophysics. 8 (1): 4. doi:10.1186/s13628-015-0018-6. ISSN 2046-1682. PMC 4374369. PMID 25815164.
  19. ^ Mitchison, T. J. (29 April 1992). "Self-organization of polymer-motor systems in the cytoskeleton". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 336 (1276): 99–106. Bibcode:1992RSPTB.336...99M. doi:10.1098/rstb.1992.0049. ISSN 0962-8436. PMID 1351302.
  20. ^ Ishihara, Keisuke; Nguyen, Phuong A.; Wühr, Martin; Groen, Aaron C.; Field, Christine M.; Mitchison, Timothy J. (5 September 2014). "Organization of early frog embryos by chemical waves emanating from centrosomes". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369 (1650): 20130454. doi:10.1098/rstb.2013.0454. ISSN 1471-2970. PMC 4113098. PMID 25047608.
  21. ^ Mitchison, Timothy J. (15 November 2010). "Remaining mysteries of the cytoplasm". Molecular Biology of the Cell. 21 (22): 3811–3812. doi:10.1091/mbc.E10-02-0084. ISSN 1939-4586. PMC 2982103. PMID 21079024.
  22. ^ Boke, Elvan; Ruer, Martine; Wühr, Martin; Coughlin, Margaret; Lemaitre, Regis; Gygi, Steven P.; Alberti, Simon; Drechsel, David; Hyman, Anthony A.; Mitchison, Timothy J. (28 July 2016). "Amyloid-like Self-Assembly of a Cellular Compartment". Cell. 166 (3): 637–650. doi:10.1016/j.cell.2016.06.051. ISSN 1097-4172. PMC 5082712. PMID 27471966.
  23. ^ Eggert, Ulrike S.; Mitchison, Timothy J.; Field, Christine M. (2006). "Animal Cytokinesis: From Parts List to Mechanisms". Annual Review of Biochemistry. 75 (1): 543–566. doi:10.1146/annurev.biochem.74.082803.133425. PMID 16756502.
  24. ^ Eggert, Ulrike S.; Kiger, Amy A.; Richter, Constance; Perlman, Zachary E.; Perrimon, Norbert; Mitchison, Timothy J.; Field, Christine M. (2004). "Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets". PLOS Biology. 2 (12): e379. doi:10.1371/journal.pbio.0020379. ISSN 1545-7885. PMC 528723. PMID 15547975.
  25. ^ Nguyen, Phuong A.; Groen, Aaron C.; Loose, Martin; Ishihara, Keisuke; Wühr, Martin; Field, Christine M.; Mitchison, Timothy J. (10 October 2014). "Spatial organization of cytokinesis signaling reconstituted in a cell-free system". Science. 346 (6206): 244–247. Bibcode:2014Sci...346..244N. doi:10.1126/science.1256773. ISSN 1095-9203. PMC 4281018. PMID 25301629.
  26. ^ Anon (1997). "Professor Timothy Mitchison FRS". royalsociety. London: Royal Society. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- at the Wayback Machine (archived 2016-11-11)
  27. ^ "ASCB Presidents". ASCB. Retrieved 9 February 2019.
  28. ^ a b "Obituary: Naomi Mitchison". The Independent. 13 January 1999. Archived from the original on 7 May 2022. Retrieved 9 February 2019.
  29. ^ Elmeshad, Sarah (2018). "Gene mutation identified in PCD, rare disease". Nature Middle East. doi:10.1038/nmiddleeast.2018.62. S2CID 90633419.

  This article incorporates text available under the CC BY 4.0 license.

April 12, 2024
mitchison, timothy, john, mitchison, cell, biologist, systems, biologist, hasib, sabbagh, professor, systems, biology, harvard, medical, school, united, states, known, discovery, with, marc, kirschner, dynamic, instability, microtubules, studies, mechanism, ce. Timothy John Mitchison FRS is a cell biologist and systems biologist and Hasib Sabbagh Professor of Systems Biology at Harvard Medical School in the United States 6 7 8 He is known for his discovery with Marc Kirschner of dynamic instability in microtubules 9 10 for studies of the mechanism of cell division and for contributions to chemical biology 11 Tim MitchisonFRSBornTimothy John Mitchison1958 age 65 66 4 EdinburghEducationHaberdashers Aske s Boys SchoolAlma materUniversity of Oxford BA University of California San Francisco PhD SpouseChristine M Field 5 AwardsHaldane Lecture 2002 Keith R Porter Lecture 2013 Scientific careerFieldsSystems biologyInstitutionsHarvard Medical SchoolNational Institute for Medical ResearchMarine Biological Laboratory 1 ThesisStructure and Dynamics of Organized Microtubule Arrays 1984 Doctoral advisorMarc Kirschner 2 3 Notable studentsTony Hyman Julie Theriot Jason Swedlow Inke Nathke Katharina RibbeckWebsitemitchison wbr hms wbr harvard wbr edu wbr people wbr timothy mitchison Contents 1 Education and early life 2 Career and research 2 1 Awards and honors 3 Personal life 4 ReferencesEducation and early life editMitchison was educated at Haberdashers Aske s Boys School and completed his Bachelor of Arts degree in Biochemistry at the University of Oxford where he was an undergraduate student of Merton College Oxford from 1976 to 1979 He moved to the University of California San Francisco UCSF in 1979 for his PhD which was supervised by Marc Kirschner 12 and investigated the dynamic instability of microtubules 12 13 Career and research editMitchison returned to the UK for postdoctoral research at the National Institute for Medical Research NIMR in London when In 1988 he returned to San Francisco where he was appointed assistant professor at UCSF 14 In 1994 he wrote an opinion piece for the journal Chemistry amp Biology titled Towards a pharmacological genetics which helped to launch the field of chemical genetics 11 In 1997 he moved to Harvard University to become co director of the Institute for Chemistry and Cell Biology at Harvard Medical School 14 where he pioneered phenotype based screening 15 discovering the small molecule monastrol the first small molecule inhibitor of mitosis that does not target tubulin Monastrol was shown to inhibit kinesin 5 a motor protein In 2003 he became Deputy Chair of the newly formed Department of Systems Biology chaired by Marc Kirschner 16 17 He works on aspects of mesoscale biology 18 including the self organization of the cytoskeleton 19 20 and of cytoplasm 21 22 He collaborates extensively with Christine Field on the mechanism of cytokinesis 23 24 25 Awards and honors edit Mitchison was elected Fellow of the Royal Society FRS in 1997 for substantial contributions to the improvement of natural knowledge 26 and served as president of the American Society for Cell Biology ASCB in 2010 27 He was elected a member of the National Academy of Sciences of the United States in 2014 14 and delivered the Keith R Porter Lecture in 2013 Personal life editMitchison is married to scientist Christine M Field with whom he has two children 7 Mitchison comes from a family of distinguished biologists his father is Avrion Mitchison 6 his uncles are Denis Mitchison citation needed and Murdoch Mitchison 6 his great uncle was J B S Haldane 6 and his great grandfather John Scott Haldane His grandparents were the politician Dick Mitchison 28 and the writer Naomi Mitchison nee Haldane 28 His younger sister Hannah M Mitchison is also a biologist 29 References edit Tim Mitchison Harvard Part 1 Self organization of microtubule assemblies Archived from the original on 13 December 2021 via YouTube Cell Biology Tree Timothy J Mitchison academictree org Mitchison T J 2013 A question of taste Molecular Biology of the Cell 24 21 3278 3280 doi 10 1091 mbc e13 07 0410 ISSN 1059 1524 PMC 3814136 PMID 24174461 Profile PDF ascb org Timothy Mitchison Harvard Magazine 1 November 2003 Retrieved 9 February 2019 a b c d Wells William 1997 Tim Mitchison Dynamic productivity Current Biology 7 11 R666 R667 doi 10 1016 S0960 9822 06 00346 0 PMID 9382812 a b Timothy Mitchison November 2003 Ishihara K Nguyen P A Wuhr M Groen A C Field C M Mitchison T J 2014 Organization of early frog embryos by chemical waves emanating from centrosomes Philosophical Transactions of the Royal Society B Biological Sciences 369 1650 20130454 doi 10 1098 rstb 2013 0454 ISSN 0962 8436 PMC 4113098 PMID 25047608 Lewin Ben 2007 Great Experiments Dynamic Instability of Microtubules Marc Kirschner and Tim Mitchison Archived from the original on 17 October 2013 Retrieved 9 February 2019 Milestone 14 Nature Milestones in Cytoskeleton Nature Retrieved 9 February 2019 a b Mitchison T J 1994 Towards a pharmacological genetics Chemistry amp Biology 1 1 3 6 doi 10 1016 1074 5521 94 90034 5 ISSN 1074 5521 PMID 9383364 a b Mitchison Timothy John 1984 Structure and Dynamics of Organized Microtubule Arrays PhD thesis University of California San Francisco OCLC 1020493513 ProQuest 303337748 nbsp Mitchison Tim Kirschner Marc 1984 Dynamic instability of microtubule growth Nature 312 5991 237 242 Bibcode 1984Natur 312 237M doi 10 1038 312237a0 ISSN 0028 0836 PMID 6504138 S2CID 30079133 a b c Timothy Mitchison nasonline org Mayer T U Kapoor T M Haggarty S J King R W Schreiber S L Mitchison T J 29 October 1999 Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype based screen PDF Science 286 5441 971 974 doi 10 1126 science 286 5441 971 ISSN 0036 8075 PMID 10542155 HMS launches new department to study systems biology Harvard Gazette 25 September 2003 Retrieved 9 February 2019 Check Erika 2 October 2003 Harvard heralds fresh take on systems biology Nature 425 6957 439 Bibcode 2003Natur 425 439C doi 10 1038 425439a ISSN 1476 4687 PMID 14523408 Sear Richard P Pagonabarraga Ignacio Flaus Andrew 25 February 2015 Life at the mesoscale the self organised cytoplasm and nucleoplasm BMC Biophysics 8 1 4 doi 10 1186 s13628 015 0018 6 ISSN 2046 1682 PMC 4374369 PMID 25815164 Mitchison T J 29 April 1992 Self organization of polymer motor systems in the cytoskeleton Philosophical Transactions of the Royal Society of London Series B Biological Sciences 336 1276 99 106 Bibcode 1992RSPTB 336 99M doi 10 1098 rstb 1992 0049 ISSN 0962 8436 PMID 1351302 Ishihara Keisuke Nguyen Phuong A Wuhr Martin Groen Aaron C Field Christine M Mitchison Timothy J 5 September 2014 Organization of early frog embryos by chemical waves emanating from centrosomes Philosophical Transactions of the Royal Society of London Series B Biological Sciences 369 1650 20130454 doi 10 1098 rstb 2013 0454 ISSN 1471 2970 PMC 4113098 PMID 25047608 Mitchison Timothy J 15 November 2010 Remaining mysteries of the cytoplasm Molecular Biology of the Cell 21 22 3811 3812 doi 10 1091 mbc E10 02 0084 ISSN 1939 4586 PMC 2982103 PMID 21079024 Boke Elvan Ruer Martine Wuhr Martin Coughlin Margaret Lemaitre Regis Gygi Steven P Alberti Simon Drechsel David Hyman Anthony A Mitchison Timothy J 28 July 2016 Amyloid like Self Assembly of a Cellular Compartment Cell 166 3 637 650 doi 10 1016 j cell 2016 06 051 ISSN 1097 4172 PMC 5082712 PMID 27471966 Eggert Ulrike S Mitchison Timothy J Field Christine M 2006 Animal Cytokinesis From Parts List to Mechanisms Annual Review of Biochemistry 75 1 543 566 doi 10 1146 annurev biochem 74 082803 133425 PMID 16756502 Eggert Ulrike S Kiger Amy A Richter Constance Perlman Zachary E Perrimon Norbert Mitchison Timothy J Field Christine M 2004 Parallel chemical genetic and genome wide RNAi screens identify cytokinesis inhibitors and targets PLOS Biology 2 12 e379 doi 10 1371 journal pbio 0020379 ISSN 1545 7885 PMC 528723 PMID 15547975 Nguyen Phuong A Groen Aaron C Loose Martin Ishihara Keisuke Wuhr Martin Field Christine M Mitchison Timothy J 10 October 2014 Spatial organization of cytokinesis signaling reconstituted in a cell free system Science 346 6206 244 247 Bibcode 2014Sci 346 244N doi 10 1126 science 1256773 ISSN 1095 9203 PMC 4281018 PMID 25301629 Anon 1997 Professor Timothy Mitchison FRS royalsociety London Royal Society One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies at the Wayback Machine archived 2016 11 11 ASCB Presidents ASCB Retrieved 9 February 2019 a b Obituary Naomi Mitchison The Independent 13 January 1999 Archived from the original on 7 May 2022 Retrieved 9 February 2019 Elmeshad Sarah 2018 Gene mutation identified in PCD rare disease Nature Middle East doi 10 1038 nmiddleeast 2018 62 S2CID 90633419 nbsp This article incorporates text available under the CC BY 4 0 license Retrieved from https en wikipedia org w index php title Tim Mitchison amp oldid 1187737132, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.