The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1gene.[5][6] TR2 is a member of the nuclear receptor family of transcription factors.
^ abcGRCh38: Ensembl release 89: ENSG00000120798 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005897 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
^Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
^Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. S2CID 24134119.
^Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
^Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
^ abFranco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. S2CID 19487189.
^ abFranco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.
Further readingedit
Chang C, Kokontis J (Sep 1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis". Biochemical and Biophysical Research Communications. 155 (2): 971–7. doi:10.1016/S0006-291X(88)80591-6. PMID 3421977.
Lin DL, Wu SQ, Chang C (Apr 1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily". Endocrine. 8 (2): 123–34. doi:10.1385/ENDO:8:2:123. PMID 9704569. S2CID 23712655.
Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
Lee CH, Chinpaisal C, Wei LN (Nov 1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Molecular and Cellular Biology. 18 (11): 6745–55. doi:10.1128/mcb.18.11.6745. PMC109258. PMID 9774688.
Yu Z, Lee CH, Chinpaisal C, Wei LN (Oct 1998). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2". The Journal of Endocrinology. 159 (1): 53–60. doi:10.1677/joe.0.1590053. PMID 9795341.
Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.
Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC126089. PMID 12093744.
Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. S2CID 19487189.
Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. S2CID 24134119.
Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
Lin YL, Wang YH, Lee HJ (Nov 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
testicular, receptor, testicular, receptor, also, known, nr2c1, nuclear, receptor, subfamily, group, member, protein, that, humans, encoded, nr2c1, gene, member, nuclear, receptor, family, transcription, factors, nr2c1identifiersaliasesnr2c1, nuclear, receptor. The testicular receptor 2 TR2 also known as NR2C1 nuclear receptor subfamily 2 group C member 1 is protein that in humans is encoded by the NR2C1 gene 5 6 TR2 is a member of the nuclear receptor family of transcription factors NR2C1IdentifiersAliasesNR2C1 TR2 Testicular receptor 2 nuclear receptor subfamily 2 group C member 1External IDsOMIM 601529 MGI 1352465 HomoloGene 55731 GeneCards NR2C1Gene location Human Chr Chromosome 12 human 1 Band12q22Start95 020 229 bp 1 End95 073 628 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 C2 10 48 81 cMStart93 983 885 bp 2 End94 033 073 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incerebellar hemisphereleft lobe of thyroid glandright lungtibial nervesural nerveright lobe of thyroid glandright lobe of livergastric mucosacanal of the cervixright uterine tubeTop expressed inspermatidspermatocyteseminal vesiculacorneal stromamale urethrasecondary oocyteseminiferous tubulewall of urinary bladdermucosa of urinary bladderleft lobe of liverMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsequence specific DNA binding protein homodimerization activity DNA binding transcription factor activity zinc ion binding histone deacetylase binding metal ion binding RNA polymerase II cis regulatory region sequence specific DNA binding steroid hormone receptor activity DNA binding transcription repressor activity RNA polymerase II specific protein binding DNA binding DNA binding transcription factor activity RNA polymerase II specific signaling receptor activityCellular componentPML body nucleoplasm nucleusBiological processregulation of transcription DNA templated negative regulation of transcription by RNA polymerase II transcription DNA templated positive regulation of retinoic acid receptor signaling pathway transcription initiation from RNA polymerase II promoter negative regulation of transcription DNA templated steroid hormone mediated signaling pathway signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez718122025EnsemblENSG00000120798ENSMUSG00000005897UniProtP13056Q505F1RefSeq mRNA NM 001032287NM 001127362NM 003297NM 011629RefSeq protein NP 001027458NP 001120834NP 003288NP 003288 2NP 035759Location UCSC Chr 12 95 02 95 07 MbChr 10 93 98 94 03 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 See also 3 References 4 Further readingInteractions editTesticular receptor 2 has been shown to interact with Androgen receptor 7 Estrogen receptor alpha 8 HDAC3 9 10 11 and HDAC4 10 11 See also editTesticular receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000120798 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000005897 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene NR2C1 nuclear receptor subfamily 2 group C member 1 Chang C Kokontis J Acakpo Satchivi L Liao S Takeda H Chang Y Dec 1989 Molecular cloning of new human TR2 receptors a class of steroid receptor with multiple ligand binding domains Biochemical and Biophysical Research Communications 165 2 735 41 doi 10 1016 S0006 291X 89 80028 2 PMID 2597158 Mu X Chang C Oct 2003 TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC 3 The Prostate 57 2 129 33 doi 10 1002 pros 10282 PMID 12949936 S2CID 24134119 Hu YC Shyr CR Che W Mu XM Kim E Chang C Sep 2002 Suppression of estrogen receptor mediated transcription and cell growth by interaction with TR2 orphan receptor The Journal of Biological Chemistry 277 37 33571 9 doi 10 1074 jbc M203531200 PMID 12093804 Li G Franco PJ Wei LN Oct 2003 Identification of histone deacetylase 3 domains that interact with the orphan nuclear receptor TR2 Biochemical and Biophysical Research Communications 310 2 384 90 doi 10 1016 j bbrc 2003 08 145 PMID 14521922 a b Franco PJ Li G Wei LN Aug 2003 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase Molecular and Cellular Endocrinology 206 1 2 1 12 doi 10 1016 S0303 7207 03 00254 5 PMID 12943985 S2CID 19487189 a b Franco PJ Farooqui M Seto E Wei LN Aug 2001 The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases Molecular Endocrinology 15 8 1318 28 doi 10 1210 mend 15 8 0682 PMID 11463856 Further reading editChang C Kokontis J Sep 1988 Identification of a new member of the steroid receptor super family by cloning and sequence analysis Biochemical and Biophysical Research Communications 155 2 971 7 doi 10 1016 S0006 291X 88 80591 6 PMID 3421977 Lin DL Wu SQ Chang C Apr 1998 The genomic structure and chromosomal location of the human TR2 orphan receptor a member of the steroid receptor superfamily Endocrine 8 2 123 34 doi 10 1385 ENDO 8 2 123 PMID 9704569 S2CID 23712655 Lee CH Chinpaisal C Wei LN Sep 1998 A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4 The Journal of Biological Chemistry 273 39 25209 15 doi 10 1074 jbc 273 39 25209 PMID 9737983 Lee CH Chinpaisal C Wei LN Nov 1998 Cloning and characterization of mouse RIP140 a corepressor for nuclear orphan receptor TR2 Molecular and Cellular Biology 18 11 6745 55 doi 10 1128 mcb 18 11 6745 PMC 109258 PMID 9774688 Yu Z Lee CH Chinpaisal C Wei LN Oct 1998 A constitutive nuclear localization signal from the second zinc finger of orphan nuclear receptor TR2 The Journal of Endocrinology 159 1 53 60 doi 10 1677 joe 0 1590053 PMID 9795341 Franco PJ Farooqui M Seto E Wei LN Aug 2001 The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases Molecular Endocrinology 15 8 1318 28 doi 10 1210 mend 15 8 0682 PMID 11463856 Tanabe O Katsuoka F Campbell AD Song W Yamamoto M Tanimoto K Engel JD Jul 2002 An embryonic fetal beta type globin gene repressor contains a nuclear receptor TR2 TR4 heterodimer The EMBO Journal 21 13 3434 42 doi 10 1093 emboj cdf340 PMC 126089 PMID 12093744 Hu YC Shyr CR Che W Mu XM Kim E Chang C Sep 2002 Suppression of estrogen receptor mediated transcription and cell growth by interaction with TR2 orphan receptor The Journal of Biological Chemistry 277 37 33571 9 doi 10 1074 jbc M203531200 PMID 12093804 Inui S Lee YF Chang E Shyr CR Chang C Feb 2003 Differential and bi directional regulation between TR2 TR4 orphan nuclear receptors and a specific ligand mediated peroxisome proliferator activated receptor alpha in human HaCaT keratinocytes Journal of Dermatological Science 31 1 65 71 doi 10 1016 S0923 1811 02 00152 4 PMID 12615366 Franco PJ Li G Wei LN Aug 2003 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase Molecular and Cellular Endocrinology 206 1 2 1 12 doi 10 1016 S0303 7207 03 00254 5 PMID 12943985 S2CID 19487189 Mu X Chang C Oct 2003 TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC 3 The Prostate 57 2 129 33 doi 10 1002 pros 10282 PMID 12949936 S2CID 24134119 Li G Franco PJ Wei LN Oct 2003 Identification of histone deacetylase 3 domains that interact with the orphan nuclear receptor TR2 Biochemical and Biophysical Research Communications 310 2 384 90 doi 10 1016 j bbrc 2003 08 145 PMID 14521922 Lin YL Wang YH Lee HJ Nov 2006 Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1 A Biochemical and Biophysical Research Communications 350 2 430 6 doi 10 1016 j bbrc 2006 09 061 PMID 17010934 nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Testicular receptor 2 amp oldid 1100514395, wikipedia, wiki, book, books, library,
