Good results were obtained in 21 of 35 patients treated in Germany.[4]
It is photoactivated at 652 nm[2] i.e. by red light.
Patients can remain photosensitive for several weeks after treatment.[2]
Referencesedit
^Lorenz KJ, Maier H (April 2008). "[Squamous cell carcinoma of the head and neck. Photodynamic therapy with Foscan]". Hno (in German). 56 (4): 402–409. doi:10.1007/s00106-007-1573-1. PMID 17516041.
^ abcO'Connor AE, Gallagher WM, Byrne AT (2009). "Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy". Photochemistry and Photobiology. 85 (5): 1053–1074. doi:10.1111/j.1751-1097.2009.00585.x. PMID 19682322. S2CID 205950773.
^. HighBeam. Archived from the original on 2012-11-04.
^Lorenz KJ, Maier H (December 2009). "Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients". European Archives of Oto-Rhino-Laryngology. 266 (12): 1937–1944. doi:10.1007/s00405-009-0947-2. PMID 19290535. S2CID 5892034.
Further readingedit
Marchal S, François A, Dumas D, Guillemin F, Bezdetnaya L (March 2007). "Relationship between subcellular localisation of Foscan and caspase activation in photosensitised MCF-7 cells". British Journal of Cancer. 96 (6): 944–51. doi:10.1038/sj.bjc.6603631. PMC2360096. PMID 17325708.
temoporfin, photosensitizer, based, chlorin, used, photodynamic, therapy, treatment, squamous, cell, carcinoma, head, neck, marketed, european, union, under, brand, name, foscan, food, drug, administration, declined, approve, foscan, 2000, approved, june, 2001. Temoporfin INN is a photosensitizer based on chlorin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck 1 2 It is marketed in the European Union under the brand name Foscan The U S Food and Drug Administration FDA declined to approve Foscan in 2000 The EU approved its use in June 2001 3 TemoporfinClinical dataAHFS Drugs comInternational Drug NamesLicense dataEU EMA by INNATC codeL01XD05 WHO Legal statusLegal statusIn general Prescription only IdentifiersIUPAC name 3 3 3 3 2 3 dihydroporphyrin 5 10 15 20 tetrayl tetraphenolCAS Number122341 38 2 YPubChem CID60751ChemSpider54754UNIIFU21S769PFKEGGD06066 YChEMBLChEMBL383675CompTox Dashboard EPA DTXSID7048619ECHA InfoCard100 152 970Chemical and physical dataFormulaC 44H 32N 4O 4Molar mass680 764 g mol 13D model JSmol Interactive imageSMILES C1CC2 NC1 C C3 CC C N3 C C4C CC N4 C C5C CC C2C6 CC CC C6 O N5 C7 CC CC C7 O C8 CC CC C8 O C9 CC CC C9 OInChI InChI 1S C44H32N4O4 c49 29 9 1 5 25 21 29 41 33 13 15 35 45 33 42 26 6 2 10 30 50 22 26 37 17 19 39 47 37 44 28 8 4 12 32 52 24 28 40 20 18 38 48 40 43 36 16 14 34 41 46 36 27 7 3 11 31 51 23 27 h1 17 19 21 24 46 47 49 52H 18 20H2 b41 33 41 34 42 35 42 37 43 36 43 38 44 39 44 40 Key LYPFDBRUNKHDGX LWQDQPMZSA N verify Good results were obtained in 21 of 35 patients treated in Germany 4 It is photoactivated at 652 nm 2 i e by red light Patients can remain photosensitive for several weeks after treatment 2 References edit Lorenz KJ Maier H April 2008 Squamous cell carcinoma of the head and neck Photodynamic therapy with Foscan Hno in German 56 4 402 409 doi 10 1007 s00106 007 1573 1 PMID 17516041 a b c O Connor AE Gallagher WM Byrne AT 2009 Porphyrin and nonporphyrin photosensitizers in oncology preclinical and clinical advances in photodynamic therapy Photochemistry and Photobiology 85 5 1053 1074 doi 10 1111 j 1751 1097 2009 00585 x PMID 19682322 S2CID 205950773 Foscan approval saves Scotia s skin HighBeam Archived from the original on 2012 11 04 Lorenz KJ Maier H December 2009 Photodynamic therapy with meta tetrahydroxyphenylchlorin Foscan in the management of squamous cell carcinoma of the head and neck experience with 35 patients European Archives of Oto Rhino Laryngology 266 12 1937 1944 doi 10 1007 s00405 009 0947 2 PMID 19290535 S2CID 5892034 Further reading editMarchal S Francois A Dumas D Guillemin F Bezdetnaya L March 2007 Relationship between subcellular localisation of Foscan and caspase activation in photosensitised MCF 7 cells British Journal of Cancer 96 6 944 51 doi 10 1038 sj bjc 6603631 PMC 2360096 PMID 17325708 nbsp This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Temoporfin amp oldid 1184105490, wikipedia, wiki, book, books, library,
