This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000104723 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000118664 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^MacGrogan D, Levy A, Bova GS, Isaacs WB, Bookstein R (Sep 1996). "Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22". Genomics. 35 (1): 55–65. doi:10.1006/geno.1996.0322. PMID 8661104.
^Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi:10.1073/pnas.96.7.3928. PMC22397. PMID 10097140.
Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells". Placenta. 19 (7): 483–8. doi:10.1016/S0143-4004(98)91041-4. PMID 9778121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Mol. Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Pils D, Horak P, Gleiss A, et al. (2006). "Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival". Cancer. 104 (11): 2417–29. doi:10.1002/cncr.21538. PMID 16270321. S2CID 26030376.
Guervós MA, Marcos CA, Hermsen M, et al. (2007). "Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas". Cell. Oncol. 29 (4): 327–34. doi:10.1155/2007/635962. PMC4618212. PMID 17641416.
This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.
tusc3, tumor, suppressor, candidate, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4m8g, 4m90, 4m91, 4m92identifiersaliases, d8s1992, mrt22, mrt7, ost3a, tumor, suppressor, candidate, magt2, slc58a2externa. Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene 5 6 7 TUSC3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4M8G 4M90 4M91 4M92IdentifiersAliasesTUSC3 D8S1992 M33 MRT22 MRT7 N33 OST3A tumor suppressor candidate 3 MagT2 SLC58A2External IDsOMIM 601385 MGI 1933134 HomoloGene 6937 GeneCards TUSC3Gene location Human Chr Chromosome 8 human 1 Band8p22Start15 417 215 bp 1 End15 766 649 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 A4Start39 472 999 bp 2 End39 619 367 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumbronchial epithelial cellanterior pituitaryleft adrenal glandganglionic eminencecorpus epididymisright uterine tubesmooth muscle tissueplacentaperiodontal fibern aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmagnesium ion transmembrane transporter activity dolichyl diphosphooligosaccharide protein glycotransferase activityCellular componentintegral component of membrane oligosaccharyltransferase complex plasma membrane integral component of plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane mitochondrionBiological processprotein N linked glycosylation magnesium ion transport cognition transmembrane transport magnesium ion transmembrane transport protein glycosylation protein N linked glycosylation via asparagineSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez799180286EnsemblENSG00000104723ENSMUSG00000118664UniProtQ13454Q8BTV1RefSeq mRNA NM 006765NM 178234NM 001356429NM 030254NM 001357304NM 001357305NM 001357306RefSeq protein NP 006756NP 839952NP 001343358NP 084530NP 001344233NP 001344234NP 001344235Location UCSC Chr 8 15 42 15 77 MbChr 8 39 47 39 62 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is a candidate tumor suppressor gene It is located within a deleted region of a metastatic prostate cancer The gene is expressed in most nonlymphoid human tissues including prostate lung liver and colon Expression was also detected in many epithelial tumor cell lines Two transcript variants encoding distinct isoforms have been identified for this gene 7 References Edit a b c GRCh38 Ensembl release 89 ENSG00000104723 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000118664 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine MacGrogan D Levy A Bova GS Isaacs WB Bookstein R Sep 1996 Structure and methylation associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22 Genomics 35 1 55 65 doi 10 1006 geno 1996 0322 PMID 8661104 Ishii H Baffa R Numata SI Murakumo Y Rattan S Inoue H Mori M Fidanza V Alder H Croce CM May 1999 The FEZ1 gene at chromosome 8p22 encodes a leucine zipper protein and its expression is altered in multiple human tumors Proc Natl Acad Sci U S A 96 7 3928 33 Bibcode 1999PNAS 96 3928I doi 10 1073 pnas 96 7 3928 PMC 22397 PMID 10097140 a b Entrez Gene TUSC3 tumor suppressor candidate 3 Further reading EditPak BJ Park H Chang ER et al 1998 Differential display analysis of oxygen mediated changes in gene expression in first trimester human trophoblast cells Placenta 19 7 483 8 doi 10 1016 S0143 4004 98 91041 4 PMID 9778121 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kelleher DJ Karaoglu D Mandon EC Gilmore R 2003 Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties Mol Cell 12 1 101 11 doi 10 1016 S1097 2765 03 00243 0 PMID 12887896 Anderson NL Polanski M Pieper R et al 2004 The human plasma proteome a nonredundant list developed by combination of four separate sources Mol Cell Proteomics 3 4 311 26 doi 10 1074 mcp M300127 MCP200 PMID 14718574 Colland F Jacq X Trouplin V et al 2004 Functional proteomics mapping of a human signaling pathway Genome Res 14 7 1324 32 doi 10 1101 gr 2334104 PMC 442148 PMID 15231748 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Shibatani T David LL McCormack AL et al 2005 Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61 TRAP and two potential new subunits Biochemistry 44 16 5982 92 doi 10 1021 bi047328f PMID 15835887 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Pils D Horak P Gleiss A et al 2006 Five genes from chromosomal band 8p22 are significantly down regulated in ovarian carcinoma N33 and EFA6R have a potential impact on overall survival Cancer 104 11 2417 29 doi 10 1002 cncr 21538 PMID 16270321 S2CID 26030376 Guervos MA Marcos CA Hermsen M et al 2007 Deletions of N33 STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas Cell Oncol 29 4 327 34 doi 10 1155 2007 635962 PMC 4618212 PMID 17641416 This article on a gene on human chromosome 8 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TUSC3 amp oldid 1170104404, wikipedia, wiki, book, books, library,
