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Wikipedia

Tubulin beta-4B chain

February 15, 2024

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.[5][6]

TUBB4B
Identifiers
AliasesTUBB4B, Beta2, TUBB2, TUBB2C, tubulin beta 4B class IVb, LCAEOD
External IDsOMIM: 602660 MGI: 1915472 HomoloGene: 68504 GeneCards: TUBB4B
Orthologs
SpeciesHumanMouse
Entrez

10383

227613

Ensembl

ENSG00000188229

ENSMUSG00000036752

UniProt

P68371

P68372

RefSeq (mRNA)

NM_006088

NM_146116

RefSeq (protein)

NP_006079

NP_666228

Location (UCSC)Chr 9: 137.24 – 137.24 MbChr 2: 25.11 – 25.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188229 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036752 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol. 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.
  6. ^ "Entrez Gene: TUBB2C tubulin, beta 2C".

Further reading edit

  • Burgoyne RD, Cambray-Deakin MA, Lewis SA, et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum". EMBO J. 7 (8): 2311–9. doi:10.1002/j.1460-2075.1988.tb03074.x. PMC 457095. PMID 2461292.
  • Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". J. Cell Biol. 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288.
  • Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
  • Szalay J, Bruno P, Bhati R, et al. (2001). "Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells". J. Histochem. Cytochem. 49 (1): 49–66. doi:10.1177/002215540104900106. PMID 11118478. S2CID 41666892.
  • Tarazona R, López-Lluch G, Galiani MD, et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". J. Immunol. 165 (12): 6776–82. doi:10.4049/jimmunol.165.12.6776. PMID 11120798.
  • Walss-Bass C, Xu K, David S, et al. (2003). "Occurrence of nuclear beta(II)-tubulin in cultured cells". Cell Tissue Res. 308 (2): 215–23. doi:10.1007/s00441-002-0539-6. PMID 12037579. S2CID 25518226.
  • Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
  • Dozier JH, Hiser L, Davis JA, et al. (2003). "β class II tubulin predominates in normal and tumor breast tissues". Breast Cancer Res. 5 (5): R157–69. doi:10.1186/bcr631. PMC 314434. PMID 12927047.
  • Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
  • Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
  • Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
  • Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.

External links edit


 

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

February 15, 2024
tubulin, beta, chain, formerly, known, tubulin, beta, chain, protein, that, humans, encoded, tubb4b, gene, tubb4bidentifiersaliasestubb4b, beta2, tubb2, tubb2c, tubulin, beta, class, lcaeodexternal, idsomim, 602660, 1915472, homologene, 68504, genecards, tubb4. Tubulin beta 4B chain formerly known as tubulin beta 2C chain is a protein that in humans is encoded by the TUBB4B gene 5 6 TUBB4BIdentifiersAliasesTUBB4B Beta2 TUBB2 TUBB2C tubulin beta 4B class IVb LCAEODExternal IDsOMIM 602660 MGI 1915472 HomoloGene 68504 GeneCards TUBB4BGene location Human Chr Chromosome 9 human 1 Band9q34 3Start137 241 287 bp 1 End137 243 707 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 A3Start25 112 172 bp 2 End25 114 714 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbronchial epithelial cellright uterine tubespinal gangliaorbitofrontal cortexBrodmann area 46superior vestibular nucleuspostcentral gyrusentorhinal cortexponsgumsTop expressed inspermatidtesticlespermatocytesecondary oocytehypothalamusesophagusbone marrowlenslipzone of skinMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding unfolded protein binding GTP binding structural constituent of cytoskeleton GTPase activity double stranded RNA binding MHC class I protein bindingCellular componentcytoplasm extracellular vesicle cytosol myelin sheath microtubule cytoskeleton extracellular exosome nucleus extracellular matrix extracellular region microtubule cytoskeleton azurophil granule lumenBiological processG2 M transition of mitotic cell cycle microtubule based process natural killer cell mediated cytotoxicity cytoskeleton organization neutrophil degranulation ciliary basal body plasma membrane docking regulation of G2 M transition of mitotic cell cycle microtubule cytoskeleton organization mitotic cell cycleSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez10383227613EnsemblENSG00000188229ENSMUSG00000036752UniProtP68371P68372RefSeq mRNA NM 006088NM 146116RefSeq protein NP 006079NP 666228Location UCSC Chr 9 137 24 137 24 MbChr 2 25 11 25 11 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000188229 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000036752 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lewis SA Gilmartin ME Hall JL Cowan NJ Jul 1985 Three expressed sequences within the human beta tubulin multigene family each define a distinct isotype J Mol Biol 182 1 11 20 doi 10 1016 0022 2836 85 90023 3 PMID 3999141 Entrez Gene TUBB2C tubulin beta 2C Further reading editBurgoyne RD Cambray Deakin MA Lewis SA et al 1989 Differential distribution of beta tubulin isotypes in cerebellum EMBO J 7 8 2311 9 doi 10 1002 j 1460 2075 1988 tb03074 x PMC 457095 PMID 2461292 Wang D Villasante A Lewis SA Cowan NJ 1987 The mammalian beta tubulin repertoire hematopoietic expression of a novel heterologous beta tubulin isotype J Cell Biol 103 5 1903 10 doi 10 1083 jcb 103 5 1903 PMC 2114403 PMID 3782288 Watts NR Sackett DL Ward RD et al 2000 HIV 1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings J Cell Biol 150 2 349 60 doi 10 1083 jcb 150 2 349 PMC 2180222 PMID 10908577 Szalay J Bruno P Bhati R et al 2001 Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells J Histochem Cytochem 49 1 49 66 doi 10 1177 002215540104900106 PMID 11118478 S2CID 41666892 Tarazona R Lopez Lluch G Galiani MD et al 2001 HLA B2702 77 83 83 77 peptide binds to beta tubulin on human NK cells and blocks their cytotoxic capacity J Immunol 165 12 6776 82 doi 10 4049 jimmunol 165 12 6776 PMID 11120798 Walss Bass C Xu K David S et al 2003 Occurrence of nuclear beta II tubulin in cultured cells Cell Tissue Res 308 2 215 23 doi 10 1007 s00441 002 0539 6 PMID 12037579 S2CID 25518226 Krebs DL Uren RT Metcalf D et al 2002 SOCS 6 Binds to Insulin Receptor Substrate 4 and Mice Lacking the SOCS 6 Gene Exhibit Mild Growth Retardation Mol Cell Biol 22 13 4567 78 doi 10 1128 MCB 22 13 4567 4578 2002 PMC 133908 PMID 12052866 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Chen D Wang M Zhou S Zhou Q 2004 HIV 1 Tat targets microtubules to induce apoptosis a process promoted by the pro apoptotic Bcl 2 relative Bim EMBO J 21 24 6801 10 doi 10 1093 emboj cdf683 PMC 139103 PMID 12486001 Dozier JH Hiser L Davis JA et al 2003 b class II tubulin predominates in normal and tumor breast tissues Breast Cancer Res 5 5 R157 69 doi 10 1186 bcr631 PMC 314434 PMID 12927047 Trinczek B Brajenovic M Ebneth A Drewes G 2004 MARK4 is a novel microtubule associated proteins microtubule affinity regulating kinase that binds to the cellular microtubule network and to centrosomes J Biol Chem 279 7 5915 23 doi 10 1074 jbc M304528200 PMID 14594945 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Navarro Lerida I Martinez Moreno M Roncal F et al 2004 Proteomic identification of brain proteins that interact with dynein light chain LC8 Proteomics 4 2 339 46 doi 10 1002 pmic 200300528 PMID 14760703 S2CID 8868600 Campbell GR Pasquier E Watkins J et al 2005 The glutamine rich region of the HIV 1 Tat protein is involved in T cell apoptosis J Biol Chem 279 46 48197 204 doi 10 1074 jbc M406195200 PMID 15331610 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 de Mareuil J Carre M Barbier P et al 2006 HIV 1 Tat protein enhances Microtubule polymerization Retrovirology 2 5 doi 10 1186 1742 4690 2 5 PMC 549075 PMID 15691386 Giacca M 2006 HIV 1 Tat apoptosis and the mitochondria a tubulin link Retrovirology 2 7 doi 10 1186 1742 4690 2 7 PMC 549042 PMID 15698476 Ahmed M Forsberg J Bergsten P 2005 Protein profiling of human pancreatic islets by two dimensional gel electrophoresis and mass spectrometry J Proteome Res 4 3 931 40 doi 10 1021 pr050024a PMID 15952740 External links editTUBB4B human gene location in the UCSC Genome Browser TUBB4B human gene details in the UCSC Genome Browser nbsp This article on a gene on human chromosome 9 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Tubulin beta 4B chain amp oldid 1187251003, wikipedia, wiki, book, books, library,

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