Translin is a DNA-binding protein that in humans is encoded by the TSNgene.[5][6][7] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[8][9][10]
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000211460 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026374 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (July 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". International Immunology. 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.
^Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (July 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
^Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q (August 2009). "C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation". Science. 325 (5941): 750–3. Bibcode:2009Sci...325..750L. doi:10.1126/science.1176325. PMC2855623. PMID 19661431.
^Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H (June 2011). "Structure of C3PO and mechanism of human RISC activation". Nature Structural & Molecular Biology. 18 (6): 650–7. doi:10.1038/nsmb.2032. PMC3109212. PMID 21552258.
^Ha M, Kim VN (August 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649. S2CID 205495632.
^Hasegawa T, Isobe K (August 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta (BBA) - General Subjects. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.
Further readingedit
Aoki K, Suzuki K, Sugano T, Tasaka T, Nakahara K, Kuge O, Omori A, Kasai M (June 1995). "A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations". Nature Genetics. 10 (2): 167–74. doi:10.1038/ng0695-167. PMID 7663511. S2CID 9678546.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Aoki K, Nakahara K, Ikegawa C, Seto M, Takahashi T, Minowada J, Strominger JL, Maziarz RT, Kasai M (April 1994). "Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family". Oncogene. 9 (4): 1109–15. PMID 8134113.
Aoki K, Ishida R, Kasai M (January 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters. 401 (2–3): 109–12. doi:10.1016/S0014-5793(96)01444-5. PMID 9013868. S2CID 46704829.
Kasai M, Matsuzaki T, Katayanagi K, Omori A, Maziarz RT, Strominger JL, Aoki K, Suzuki K (April 1997). "The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome". The Journal of Biological Chemistry. 272 (17): 11402–7. doi:10.1074/jbc.272.17.11402. PMID 9111049.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hasegawa T, Isobe K (August 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta (BBA) - General Subjects. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.
Badge RM, Yardley J, Jeffreys AJ, Armour JA (May 2000). "Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination". Human Molecular Genetics. 9 (8): 1239–44. doi:10.1093/hmg/9.8.1239. PMID 10767349.
Hosaka T, Kanoe H, Nakayama T, Murakami H, Yamamoto H, Nakamata T, Tsuboyama T, Oka M, Kasai M, Sasaki MS, Nakamura T, Toguchida J (November 2000). "Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6)". Oncogene. 19 (50): 5821–5. doi:10.1038/sj.onc.1203943. hdl:2433/150205. PMID 11126370.
Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (April 2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". The Journal of Biological Chemistry. 276 (16): 13256–63. doi:10.1074/jbc.M009707200. PMID 11278549.
Lee SP, Fuior E, Lewis MS, Han MK (November 2001). "Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide". Biochemistry. 40 (46): 14081–8. doi:10.1021/bi010302t. PMID 11705401.
Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (January 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science. 115 (Pt 1): 207–16. doi:10.1242/jcs.115.1.207. hdl:11693/24740. PMID 11801738.
Han MK, Lin P, Paek D, Harvey JJ, Fuior E, Knutson JR (March 2002). "Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer". Biochemistry. 41 (10): 3468–76. doi:10.1021/bi015901e. PMID 11876655.
Sengupta K, Rao BJ (December 2002). "Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions". Biochemistry. 41 (51): 15315–26. doi:10.1021/bi026378m. PMID 12484770.
Li K, Wang L, Cheng J, Lu YY, Zhang LX, Mu JS, Hong Y, Liu Y, Duan HJ, Wang G, Li L, Chen JM (February 2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus". World Journal of Gastroenterology. 9 (2): 300–3. doi:10.3748/wjg.v9.i2.300. PMC4611333. PMID 12532453.
Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB (March 2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation". The Journal of Biological Chemistry. 279 (13): 12605–14. doi:10.1074/jbc.M313133200. PMID 14711818.
External linksedit
Overview of all the structural information available in the PDB for UniProt: Q15631 (Human Translin) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q62348 (Mouse Translin) at the PDBe-KB.
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
translin, binding, protein, that, humans, encoded, gene, together, with, translin, associated, factor, translin, forms, component, promoter, risc, c3po, complex, which, facilitates, endonucleolytic, cleavage, passenger, strand, during, microrna, loading, into,. Translin is a DNA binding protein that in humans is encoded by the TSN gene 5 6 7 Together with translin associated factor X translin forms the component 3 of promoter of RISC C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA induced silencing complex RISC 8 9 10 TSNAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1J1J 3PJA 3QB5 4WYVIdentifiersAliasesTSN BCLF 1 C3PO RCHF1 REHF 1 TBRBP TRSLN translinExternal IDsOMIM 600575 MGI 109263 HomoloGene 3397 GeneCards TSNGene location Human Chr Chromosome 2 human 1 Band2q14 3Start121 737 103 bp 1 End121 767 853 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 E2 3Start118 222 508 bp 2 End118 239 469 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocyteoptic nerveganglionic eminencethoracic diaphragmgerminal epitheliumislet of Langerhanssuperficial temporal arteryhair folliclehuman penisendometriumTop expressed intrigeminal ganglionrenal corpuscleprimitive streakmedullary collecting ductneural tubePaneth cellsuperior cervical ganglionbarrel cortexciliary bodysexually immature organismMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding nuclease activity endonuclease activity sequence specific DNA binding protein binding mRNA binding hydrolase activity RNA binding single stranded DNA binding identical protein binding endoribonuclease activity protein containing complex bindingCellular componentcytoplasm cytosol nucleusBiological processDNA recombination nucleic acid phosphodiester bond hydrolysis RNA metabolic process RNA phosphodiester bond hydrolysis endonucleolytic production of siRNA involved in RNA interferenceSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez724722099EnsemblENSG00000211460ENSMUSG00000026374UniProtQ15631Q62348RefSeq mRNA NM 001261401NM 004622NM 011650RefSeq protein NP 001248330NP 004613NP 035780Location UCSC Chr 2 121 74 121 77 MbChr 1 118 22 118 24 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction editThis gene encodes a DNA binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations Translin polypeptides form a multimeric structure that is responsible for its DNA binding activity Recombination associated motifs and translin binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms 7 Interactions editTranslin has been shown to interact with PPP1R15A 11 References edit a b c GRCh38 Ensembl release 89 ENSG00000211460 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026374 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kasai M Aoki K Matsuo Y Minowada J Maziarz RT Strominger JL July 1994 Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T ALL patients with t 8 14 q24 q11 and t 1 14 p32 q11 International Immunology 6 7 1017 25 doi 10 1093 intimm 6 7 1017 PMID 7947454 Aoki K Inazawa J Takahashi T Nakahara K Kasai M July 1997 Genomic structure and chromosomal localization of the gene encoding translin a recombination hotspot binding protein Genomics 43 2 237 41 doi 10 1006 geno 1997 4796 PMID 9244443 a b Entrez Gene TSN translin Liu Y Ye X Jiang F Liang C Chen D Peng J Kinch LN Grishin NV Liu Q August 2009 C3PO an endoribonuclease that promotes RNAi by facilitating RISC activation Science 325 5941 750 3 Bibcode 2009Sci 325 750L doi 10 1126 science 1176325 PMC 2855623 PMID 19661431 Ye X Huang N Liu Y Paroo Z Huerta C Li P Chen S Liu Q Zhang H June 2011 Structure of C3PO and mechanism of human RISC activation Nature Structural amp Molecular Biology 18 6 650 7 doi 10 1038 nsmb 2032 PMC 3109212 PMID 21552258 Ha M Kim VN August 2014 Regulation of microRNA biogenesis Nature Reviews Molecular Cell Biology 15 8 509 24 doi 10 1038 nrm3838 PMID 25027649 S2CID 205495632 Hasegawa T Isobe K August 1999 Evidence for the interaction between Translin and GADD34 in mammalian cells Biochimica et Biophysica Acta BBA General Subjects 1428 2 3 161 8 doi 10 1016 s0304 4165 99 00060 4 PMID 10434033 Further reading editAoki K Suzuki K Sugano T Tasaka T Nakahara K Kuge O Omori A Kasai M June 1995 A novel gene Translin encodes a recombination hotspot binding protein associated with chromosomal translocations Nature Genetics 10 2 167 74 doi 10 1038 ng0695 167 PMID 7663511 S2CID 9678546 Maruyama K Sugano S January 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Aoki K Nakahara K Ikegawa C Seto M Takahashi T Minowada J Strominger JL Maziarz RT Kasai M April 1994 Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl 2 and the immunoglobulin DH gene family Oncogene 9 4 1109 15 PMID 8134113 Aoki K Ishida R Kasai M January 1997 Isolation and characterization of a cDNA encoding a Translin like protein TRAX FEBS Letters 401 2 3 109 12 doi 10 1016 S0014 5793 96 01444 5 PMID 9013868 S2CID 46704829 Kasai M Matsuzaki T Katayanagi K Omori A Maziarz RT Strominger JL Aoki K Suzuki K April 1997 The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome The Journal of Biological Chemistry 272 17 11402 7 doi 10 1074 jbc 272 17 11402 PMID 9111049 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S October 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Hasegawa T Isobe K August 1999 Evidence for the interaction between Translin and GADD34 in mammalian cells Biochimica et Biophysica Acta BBA General Subjects 1428 2 3 161 8 doi 10 1016 s0304 4165 99 00060 4 PMID 10434033 Badge RM Yardley J Jeffreys AJ Armour JA May 2000 Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination Human Molecular Genetics 9 8 1239 44 doi 10 1093 hmg 9 8 1239 PMID 10767349 Hosaka T Kanoe H Nakayama T Murakami H Yamamoto H Nakamata T Tsuboyama T Oka M Kasai M Sasaki MS Nakamura T Toguchida J November 2000 Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t 12 6 Oncogene 19 50 5821 5 doi 10 1038 sj onc 1203943 hdl 2433 150205 PMID 11126370 Chennathukuzhi VM Kurihara Y Bray JD Hecht NB April 2001 Trax translin associated factor X a primarily cytoplasmic protein inhibits the binding of TB RBP translin to RNA The Journal of Biological Chemistry 276 16 13256 63 doi 10 1074 jbc M009707200 PMID 11278549 Lee SP Fuior E Lewis MS Han MK November 2001 Analytical ultracentrifugation studies of translin analysis of protein DNA interactions using a single stranded fluorogenic oligonucleotide Biochemistry 40 46 14081 8 doi 10 1021 bi010302t PMID 11705401 Erdemir T Bilican B Oncel D Goding CR Yavuzer U January 2002 DNA damage dependent interaction of the nuclear matrix protein C1D with Translin associated factor X TRAX Journal of Cell Science 115 Pt 1 207 16 doi 10 1242 jcs 115 1 207 hdl 11693 24740 PMID 11801738 Han MK Lin P Paek D Harvey JJ Fuior E Knutson JR March 2002 Fluorescence studies of pyrene maleimide labeled translin excimer fluorescence indicates subunits associate in a tail to tail configuration to form octamer Biochemistry 41 10 3468 76 doi 10 1021 bi015901e PMID 11876655 Sengupta K Rao BJ December 2002 Translin binding to DNA recruitment through DNA ends and consequent conformational transitions Biochemistry 41 51 15315 26 doi 10 1021 bi026378m PMID 12484770 Li K Wang L Cheng J Lu YY Zhang LX Mu JS Hong Y Liu Y Duan HJ Wang G Li L Chen JM February 2003 Interaction between hepatitis C virus core protein and translin protein a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus World Journal of Gastroenterology 9 2 300 3 doi 10 3748 wjg v9 i2 300 PMC 4611333 PMID 12532453 Yang S Cho YS Chennathukuzhi VM Underkoffler LA Loomes K Hecht NB March 2004 Translin associated factor X is post transcriptionally regulated by its partner protein TB RBP and both are essential for normal cell proliferation The Journal of Biological Chemistry 279 13 12605 14 doi 10 1074 jbc M313133200 PMID 14711818 External links editOverview of all the structural information available in the PDB for UniProt Q15631 Human Translin at the PDBe KB Overview of all the structural information available in the PDB for UniProt Q62348 Mouse Translin at the PDBe KB nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Translin amp oldid 1174319489, wikipedia, wiki, book, books, library,
