trpv3, drug, which, acts, selective, antagonist, trpv3, calcium, channel, analgesic, effects, animal, studies, against, both, neuropathic, pain, normal, pain, responses, identifiersiupac, name, hydroxy, pyridin, methyl, methyl, trifluoromethyl, pyridin, cyclob. TRPV3 74a is a drug which acts as a selective antagonist for the TRPV3 calcium channel It has analgesic effects in animal studies against both neuropathic pain and normal pain responses 1 2 TRPV3 74aIdentifiersIUPAC name 3 S hydroxy pyridin 2 yl methyl 1 methyl 3 4 trifluoromethyl pyridin 2 yl cyclobutan 1 olCAS Number1432051 63 2PubChem CID71554840ChemSpider58922619ChEMBLChEMBL3828340Chemical and physical dataFormulaC 17H 17F 3N 2O 2Molar mass338 330 g mol 13D model JSmol Interactive imageSMILES C C 1 C C C H C2 CC CC N2 O C3 CC C F F F CC N3 C1 OInChI InChI 1S C17H17F3N2O2 c1 15 24 9 16 10 15 14 23 12 4 2 3 6 21 12 13 8 11 5 7 22 13 17 18 19 20 h2 8 14 23 24H 9 10H2 1H3 t14 15 16 m1 s1Key MTJXDHFAWXGXIN QQFBHYJXSA NReferences edit Gomtsyan A Schmidt RG Bayburt EK Gfesser GA Voight EA Daanen JF et al May 2016 Synthesis and Pharmacology of Pyridin 2 yl methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists Journal of Medicinal Chemistry 59 10 4926 47 doi 10 1021 acs jmedchem 6b00287 PMID 27077528 Kocienski P February 2017 Synthesis of a TRPV3 Antagonist Synfacts 13 2 123 doi 10 1055 s 0036 1589889 S2CID 100058677 nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TRPV3 74a amp oldid 1182786208, wikipedia, wiki, book, books, library,
