TRPP subunits can be divided into two subcategories depending on structural similarity.
Polycystic Kidney Disease 1 (PKD1)-Like Groupedit
The first group, polycystic kidney disease 1 (PKD1)-like, contains polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal adhesive domains that are important for cell-cell contact.[1] This group of subunits also contain a large extracellular domain with numerous polycystin motifs. These motifs are of unknown function and are located between the S6 and S7 segments. The large intracellular C-terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex.[2]
Polycystic Kidney Disease 2 (PKD2)-Like Groupedit
This group of TRPP members (previously known as TRPP2-like) are: TRPP1 (previously known as TRPP2 or PKD2), TRPP2 (previously known as TRPP3 or PKDL2), and TRPP3 (previously known as TRPP5 or polycystin-L2).[3] Unlike the previous group, which contain 11 membrane-spanning segments, this group resemble other TRP channels, having 6 membrane-spanning segments with intracellular N- and C-termini. All of the members of this group contain a coiled coil region in their C-terminus involved in the interaction with the polycystin-1 group. TRPP1 and TRPP3 form constitutively active cation-selective ion channels that are permeable to calcium. TRPP2 has also been implicated in sour taste perception. Coupling of PKD1 and TRPP1 recruits TRPP1 to the membrane. Here, its activity is decreased and it suppresses the activation of G proteins by PKD1.[2]
Genesedit
Group 1: polycystic kidney disease 1 (PKD1) like proteins
"Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
"TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels.
April 09, 2024
trpp, transient, receptor, potential, polycystic, family, transient, receptor, potential, channels, which, when, mutated, cause, polycystic, kidney, disease, contents, subcategories, polycystic, kidney, disease, pkd1, like, group, polycystic, kidney, disease, . TRPP transient receptor potential polycystic is a family of transient receptor potential ion channels which when mutated can cause polycystic kidney disease Contents 1 Subcategories 1 1 Polycystic Kidney Disease 1 PKD1 Like Group 1 2 Polycystic Kidney Disease 2 PKD2 Like Group 2 Genes 3 See also 4 References 5 External linksSubcategories editTRPP subunits can be divided into two subcategories depending on structural similarity Polycystic Kidney Disease 1 PKD1 Like Group edit The first group polycystic kidney disease 1 PKD1 like contains polycystin 1 Previously known as TRPP1 PKDREJ PKD1L1 PKD1L2 and PKD1L3 Polycystin 1 contains numerous N terminal adhesive domains that are important for cell cell contact 1 This group of subunits also contain a large extracellular domain with numerous polycystin motifs These motifs are of unknown function and are located between the S6 and S7 segments The large intracellular C terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex 2 Polycystic Kidney Disease 2 PKD2 Like Group edit This group of TRPP members previously known as TRPP2 like are TRPP1 previously known as TRPP2 or PKD2 TRPP2 previously known as TRPP3 or PKDL2 and TRPP3 previously known as TRPP5 or polycystin L2 3 Unlike the previous group which contain 11 membrane spanning segments this group resemble other TRP channels having 6 membrane spanning segments with intracellular N and C termini All of the members of this group contain a coiled coil region in their C terminus involved in the interaction with the polycystin 1 group TRPP1 and TRPP3 form constitutively active cation selective ion channels that are permeable to calcium TRPP2 has also been implicated in sour taste perception Coupling of PKD1 and TRPP1 recruits TRPP1 to the membrane Here its activity is decreased and it suppresses the activation of G proteins by PKD1 2 Genes editGroup 1 polycystic kidney disease 1 PKD1 like proteins PKD1 PKD1 PKDREJ PKD1L1 PKD1L2 PKD1L3 Group 2 polycystic kidney disease 2 PKD2 like proteins TRPP1 PKD2 TRPP2 PKD2L1 TRPP3 PKD2L2See also editPolycystic kidney diseaseReferences edit Islam M S Transient Receptor Potential Channels Advances in Experimental Medicine and Biology Vol 704 ISBN 978 94 007 0264 6 a b Nilius B Owsianik G Voets T Peters JA 2007 Transient receptor potential cation channels in disease PDF Physiol Rev 87 1 165 217 doi 10 1152 physrev 00021 2006 PMID 17237345 Transient Receptor Potential Channels IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology External links editTRPP Cation Channels at the U S National Library of Medicine Medical Subject Headings MeSH Transient Receptor Potential Channels IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology TRIP Database a manually curated database of protein protein interactions for mammalian TRP channels Retrieved from https en wikipedia org w index php title TRPP amp oldid 1082981841, wikipedia, wiki, book, books, library,
