TRPs, mammalian homologs of the Drosophilatransient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000092439 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027365 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7".
^ abRunnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. S2CID 21592843.
^Baldoli E, Maier JA (2012). "Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells". Angiogenesis. 15 (1): 47–57. doi:10.1007/s10456-011-9242-0. PMID 22183257. S2CID 16274084.
Further readingedit
Chubanov V, Gudermann T, Schlingmann KP (2005). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflügers Arch. 451 (1): 228–34. doi:10.1007/s00424-005-1470-y. PMID 16075242. S2CID 6037803.
Clapham DE, Julius D, Montell C, Schultz G (2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
Penner R, Fleig A (2007). "The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 313–28. doi:10.1007/978-3-540-34891-7_19. ISBN978-3-540-34889-4. PMC5663631. PMID 17217066.
trpm7, transient, receptor, potential, cation, channel, subfamily, member, also, known, human, gene, encoding, protein, same, name, identifiersaliases, alspdc, chak, chak1, ltrpc7, ltrpc, plik, transient, receptor, potential, cation, channel, subfamily, member. Transient receptor potential cation channel subfamily M member 7 also known as TRPM7 is a human gene encoding a protein of the same name TRPM7IdentifiersAliasesTRPM7 ALSPDC CHAK CHAK1 LTRPC7 LTrpC 7 TRP PLIK transient receptor potential cation channel subfamily M member 7External IDsOMIM 605692 MGI 1929996 HomoloGene 9774 GeneCards TRPM7Gene location Human Chr Chromosome 15 human 1 Band15q21 2Start50 552 473 bp 1 End50 686 797 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 F1Start126 633 485 bp 2 End126 718 150 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonsural nervegastric mucosaright lobe of liverstromal cell of endometriumbone marrow cellsislet of LangerhansmonocyterectumappendixTop expressed inmolarparotid glandsacculepineal glandatriumdermisirisseminal vesicularetinal pigment epitheliumectodermMore reference expression dataBioGPSn aGene ontologyMolecular functiontransferase activity nucleotide binding myosin binding metal ion binding kinase activity protein serine threonine kinase activity ion channel activity actin binding ATP binding calcium channel activityCellular componentintegral component of membrane membrane ruffle plasma membraneBiological processcellular magnesium ion homeostasis calcium dependent cell matrix adhesion programmed cell death phosphorylation actomyosin structure organization cation transport ion transport protein tetramerization protein phosphorylation calcium ion transmembrane transport protein autophosphorylation necroptosis calcium ion transport transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5482258800EnsemblENSG00000092439ENSMUSG00000027365UniProtQ96QT4Q923J1RefSeq mRNA NM 001301212NM 017672NM 001164325NM 021450RefSeq protein NP 001288141NP 060142NP 001157797NP 067425Location UCSC Chr 15 50 55 50 69 MbChr 2 126 63 126 72 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 Clinical relevance 4 See also 5 References 6 Further reading 7 External linksFunction editTRPs mammalian homologs of the Drosophila transient receptor potential trp protein are ion channels that are thought to mediate capacitative calcium entry into the cell TRP PLIK is a protein that is both an ion channel and a kinase As a channel it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium As a kinase it is capable of phosphorylating itself and other substrates The kinase activity is necessary for channel function as shown by its dependence on intracellular ATP and by the kinase mutants 5 Interactions editTRPM7 has been shown to interact with PLCB1 6 and PLCB2 6 Clinical relevance editDefects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells 7 See also editTRPMReferences edit a b c GRCh38 Ensembl release 89 ENSG00000092439 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027365 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene TRPM7 transient receptor potential cation channel subfamily M member 7 a b Runnels LW Yue L Clapham DE May 2002 The TRPM7 channel is inactivated by PIP 2 hydrolysis Nat Cell Biol 4 5 329 36 doi 10 1038 ncb781 PMID 11941371 S2CID 21592843 Baldoli E Maier JA 2012 Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells Angiogenesis 15 1 47 57 doi 10 1007 s10456 011 9242 0 PMID 22183257 S2CID 16274084 Further reading editChubanov V Gudermann T Schlingmann KP 2005 Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis Pflugers Arch 451 1 228 34 doi 10 1007 s00424 005 1470 y PMID 16075242 S2CID 6037803 Clapham DE Julius D Montell C Schultz G 2005 International Union of Pharmacology XLIX Nomenclature and structure function relationships of transient receptor potential channels Pharmacol Rev 57 4 427 50 doi 10 1124 pr 57 4 6 PMID 16382100 S2CID 17936350 Penner R Fleig A 2007 The Mg2 and Mg 2 nucleotide regulated channel kinase TRPM7 Transient Receptor Potential TRP Channels Handbook of Experimental Pharmacology Vol 179 pp 313 28 doi 10 1007 978 3 540 34891 7 19 ISBN 978 3 540 34889 4 PMC 5663631 PMID 17217066 External links editTRPM7 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TRPM7 amp oldid 1167764594, wikipedia, wiki, book, books, library,
