Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2Bgene.[5][6]
^Nayler O, Cap C, Stamm S (October 1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.
^Hofmann, Yvonne; Wirth Brunhilde (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. ISSN 0964-6906. PMID 12165565.
Further readingedit
Matsuo N, Ogawa S, Imai Y, et al. (1996). "Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation". J. Biol. Chem. 270 (47): 28216–22. doi:10.1074/jbc.270.47.28216. PMID 7499316.
Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
Beil B, Screaton G, Stamm S (1997). "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing". DNA Cell Biol. 16 (6): 679–90. doi:10.1089/dna.1997.16.679. PMID 9212162.
Imai Y, Matsuo N, Ogawa S, et al. (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Res. Mol. Brain Res. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
Tacke R, Tohyama M, Ogawa S, Manley JL (1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
Nayler O, Cap C, Stamm S (1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC26846. PMID 10339552.
Lai MC, Lin RI, Huang SY, et al. (2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". J. Biol. Chem. 275 (11): 7950–7. doi:10.1074/jbc.275.11.7950. PMID 10713112.
Venables JP, Elliott DJ, Makarova OV, et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet. 9 (5): 685–94. doi:10.1093/hmg/9.5.685. PMID 10749975.
Helmken C, Wirth B (2001). "Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy". Hum. Genet. 107 (6): 554–8. doi:10.1007/s004390000409. PMID 11153908. S2CID 30528707.
Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. doi:10.1093/hmg/11.5.577. PMID 11875052.
Hofmann Y, Wirth B (2003). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. PMID 12165565.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochim. Biophys. Acta. 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
El Yazidi-Belkoura I, Adriaenssens E, Dollé L, et al. (2003). "Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells". J. Biol. Chem. 278 (19): 16952–6. doi:10.1074/jbc.M300631200. PMID 12604596.
Jiang Z, Tang H, Havlioglu N, et al. (2003). "Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta". J. Biol. Chem. 278 (21): 18997–9007. doi:10.1074/jbc.M301800200. PMC2140226. PMID 12649279.
Chen X, Guo L, Lin W, Xu P (2004). "Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern". Cell Biol. Int. 27 (6): 491–6. doi:10.1016/S1065-6995(03)00072-6. PMID 12798777. S2CID 44758770.
Helmken C, Hofmann Y, Schoenen F, et al. (2004). "Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1". Hum. Genet. 114 (1): 11–21. doi:10.1007/s00439-003-1025-2. PMID 14520560. S2CID 19872246.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC207616. PMID 14559993.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
tra2b, transformer, protein, homolog, beta, also, known, previously, known, splicing, factor, arginine, serine, rich, transformer, homolog, drosophila, sfrs10, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, code. Transformer 2 protein homolog beta also known as TRA2B previously known as splicing factor arginine serine rich 10 transformer 2 homolog Drosophila SFRS10 is a protein that in humans is encoded by the TRA2B gene 5 6 TRA2BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2CQC 2KXN 2RRA 2RRBIdentifiersAliasesTRA2B Htra2 beta PPP1R156 SFRS10 SRFS10 TRA2 BETA TRAN2B transformer 2 beta homolog Drosophila transformer 2 beta homologExternal IDsOMIM 602719 MGI 106016 HomoloGene 20965 GeneCards TRA2BGene location Human Chr Chromosome 3 human 1 Band3q27 2Start185 914 558 bp 1 End185 938 103 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 B1 16 13 18 cMStart22 063 299 bp 2 End22 084 755 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingerminal epitheliumparietal pleuraembryovisceral pleuraendothelial cellganglionic eminenceamniotic fluidtibiapalpebral conjunctivahair follicleTop expressed inyolk sacspermatocytemorulaesophaguslipspermatidsuperior frontal gyrusneural tubethymusstomachMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleic acid binding mRNA binding protein binding poly purine tract binding RNA binding protein domain specific binding pre mRNA binding identical protein bindingCellular componentnucleus nuclear inner membrane nucleoplasm spliceosomal complex ribonucleoprotein complexBiological processRNA splicing via transesterification reactions RNA splicing cerebral cortex regionalization mRNA processing negative regulation of mRNA splicing via spliceosome embryonic brain development mRNA splicing via spliceosome positive regulation of mRNA splicing via spliceosome regulation of alternative mRNA splicing via spliceosome regulation of RNA splicing protein complex oligomerization cellular response to glucose stimulusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez643420462EnsemblENSG00000136527ENSMUSG00000022858UniProtP62995P62996RefSeq mRNA NM 001243879NM 004593NM 009186NM 001330554NM 001330555RefSeq protein NP 001230808NP 004584NP 001317483NP 001317484NP 033212Location UCSC Chr 3 185 91 185 94 MbChr 16 22 06 22 08 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editTRA2B has been shown to interact with RBMX 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000136527 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022858 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene SFRS10 splicing factor arginine serine rich 10 transformer 2 homolog Drosophila Nayler O Cap C Stamm S October 1998 Human transformer 2 beta gene SFRS10 complete nucleotide sequence chromosomal localization and generation of a tissue specific isoform Genomics 53 2 191 202 doi 10 1006 geno 1998 5471 PMID 9790768 Hofmann Yvonne Wirth Brunhilde Aug 2002 hnRNP G promotes exon 7 inclusion of survival motor neuron SMN via direct interaction with Htra2 beta1 Hum Mol Genet 11 17 2037 49 doi 10 1093 hmg 11 17 2037 ISSN 0964 6906 PMID 12165565 Further reading editMatsuo N Ogawa S Imai Y et al 1996 Cloning of a novel RNA binding polypeptide RA301 induced by hypoxia reoxygenation J Biol Chem 270 47 28216 22 doi 10 1074 jbc 270 47 28216 PMID 7499316 Lennon G Auffray C Polymeropoulos M Soares MB 1996 The I M A G E Consortium an integrated molecular analysis of genomes and their expression Genomics 33 1 151 2 doi 10 1006 geno 1996 0177 PMID 8617505 Beil B Screaton G Stamm S 1997 Molecular cloning of htra2 beta 1 and htra2 beta 2 two human homologs of tra 2 generated by alternative splicing DNA Cell Biol 16 6 679 90 doi 10 1089 dna 1997 16 679 PMID 9212162 Imai Y Matsuo N Ogawa S et al 1998 Cloning of a gene YT521 for a novel RNA splicing related protein induced by hypoxia reoxygenation Brain Res Mol Brain Res 53 1 2 33 40 doi 10 1016 S0169 328X 97 00262 3 PMID 9473574 Tacke R Tohyama M Ogawa S Manley JL 1998 Human Tra2 proteins are sequence specific activators of pre mRNA splicing Cell 93 1 139 48 doi 10 1016 S0092 8674 00 81153 8 PMID 9546399 S2CID 15384749 Nayler O Cap C Stamm S 1998 Human transformer 2 beta gene SFRS10 complete nucleotide sequence chromosomal localization and generation of a tissue specific isoform Genomics 53 2 191 202 doi 10 1006 geno 1998 5471 PMID 9790768 Eldridge AG Li Y Sharp PA Blencowe BJ 1999 The SRm160 300 splicing coactivator is required for exon enhancer function Proc Natl Acad Sci U S A 96 11 6125 30 Bibcode 1999PNAS 96 6125E doi 10 1073 pnas 96 11 6125 PMC 26846 PMID 10339552 Lai MC Lin RI Huang SY et al 2000 A human importin beta family protein transportin SR2 interacts with the phosphorylated RS domain of SR proteins J Biol Chem 275 11 7950 7 doi 10 1074 jbc 275 11 7950 PMID 10713112 Venables JP Elliott DJ Makarova OV et al 2000 RBMY a probable human spermatogenesis factor and other hnRNP G proteins interact with Tra2beta and affect splicing Hum Mol Genet 9 5 685 94 doi 10 1093 hmg 9 5 685 PMID 10749975 Helmken C Wirth B 2001 Exclusion of Htra2 beta1 an up regulator of full length SMN2 transcript as a modifying gene for spinal muscular atrophy Hum Genet 107 6 554 8 doi 10 1007 s004390000409 PMID 11153908 S2CID 30528707 Young PJ DiDonato CJ Hu D et al 2002 SRp30c dependent stimulation of survival motor neuron SMN exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1 Hum Mol Genet 11 5 577 87 doi 10 1093 hmg 11 5 577 PMID 11875052 Hofmann Y Wirth B 2003 hnRNP G promotes exon 7 inclusion of survival motor neuron SMN via direct interaction with Htra2 beta1 Hum Mol Genet 11 17 2037 49 doi 10 1093 hmg 11 17 2037 PMID 12165565 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Tran Q Coleman TP Roesser JR 2003 Human transformer 2beta and SRp55 interact with a calcitonin specific splice enhancer Biochim Biophys Acta 1625 2 141 52 doi 10 1016 S0167 4781 02 00600 0 PMID 12531473 El Yazidi Belkoura I Adriaenssens E Dolle L et al 2003 Tumor necrosis factor receptor associated death domain protein is involved in the neurotrophin receptor mediated antiapoptotic activity of nerve growth factor in breast cancer cells J Biol Chem 278 19 16952 6 doi 10 1074 jbc M300631200 PMID 12604596 Jiang Z Tang H Havlioglu N et al 2003 Mutations in tau gene exon 10 associated with FTDP 17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta J Biol Chem 278 21 18997 9007 doi 10 1074 jbc M301800200 PMC 2140226 PMID 12649279 Chen X Guo L Lin W Xu P 2004 Expression of Tra2beta isoforms is developmentally regulated in a tissue and temporal specific pattern Cell Biol Int 27 6 491 6 doi 10 1016 S1065 6995 03 00072 6 PMID 12798777 S2CID 44758770 Helmken C Hofmann Y Schoenen F et al 2004 Evidence for a modifying pathway in SMA discordant families reduced SMN level decreases the amount of its interacting partners and Htra2 beta1 Hum Genet 114 1 11 21 doi 10 1007 s00439 003 1025 2 PMID 14520560 S2CID 19872246 Li J Hawkins IC Harvey CD et al 2003 Regulation of alternative splicing by SRrp86 and its interacting proteins Mol Cell Biol 23 21 7437 47 doi 10 1128 MCB 23 21 7437 7447 2003 PMC 207616 PMID 14559993 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TRA2B amp oldid 1142699410, wikipedia, wiki, book, books, library,
