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Wikipedia

MAP3K8

December 15, 2023

Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.[5][6][7]

MAP3K8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, AURA2, mitogen-activated protein kinase kinase kinase 8, Tpl2
External IDsOMIM: 191195 MGI: 1346878 HomoloGene: 3812 GeneCards: MAP3K8
Orthologs
SpeciesHumanMouse
Entrez

1326

26410

Ensembl

ENSG00000107968

ENSMUSG00000024235

UniProt

P41279

Q07174

RefSeq (mRNA)

NM_001244134
NM_005204
NM_001320961

NM_007746

RefSeq (protein)

NP_001231063
NP_001307890
NP_005195

NP_031772

Location (UCSC)Chr 10: 30.43 – 30.46 MbChr 18: 4.33 – 4.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine-specific protein kinase family. This kinase can activate ERK1, ERK2 and p38 MAP kinases.[8][9] This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1). This gene may also start transcription at a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.[7] In mice, the gene is known as TPL2 and is a tumor-suppressor gene whose absence contributes to the development and progression of cancer.[10] However, it functions in other organs as a oncogene, promoting cancer.[11]

Interactions edit

MAP3K8 has been shown to interact with AKT1,[12] CHUK,[13] NFKB2,[14] NFKB1,[14][15] C22orf25[16] and TNIP2.[17]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107968 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024235 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T (Aug 1991). "Structure and transforming potential of the human cot oncogene encoding a putative protein kinase". Molecular and Cellular Biology. 11 (8): 4088–96. doi:10.1128/mcb.11.8.4088. PMC 361219. PMID 2072910.
  6. ^ Chan AM, Chedid M, McGovern ES, Popescu NC, Miki T, Aaronson SA (May 1993). "Expression cDNA cloning of a serine kinase transforming gene". Oncogene. 8 (5): 1329–33. PMID 8479752.
  7. ^ a b "Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8".
  8. ^ Arthur JS, Ley SC (Sep 2013). "Mitogen-activated protein kinases in innate immunity". Nature Reviews Immunology. 13 (9): 679–92. doi:10.1038/nri3495. PMID 23954936. S2CID 12049695.
  9. ^ Pattison MJ, Mitchell O, Flynn HR, Chen CS, Yang HT, Ben-Addi H, Boeing S, Snijders AP, Ley SC (Sep 2016). "TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase". Biochemical Journal. 473 (18): 2845–61. doi:10.1042/BCJ20160502. PMC 5095906. PMID 27402796.
  10. ^ DeCicco-Skinner, Kathleen (2011). "Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis". Oncogene. 30 (4): 389–97. doi:10.1038/onc.2010.447. PMC 3460638. PMID 20935675.
  11. ^ DeCicco-Skinner, Kathleen (2011). "Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis". Oncogene. 30 (4): 389–97. doi:10.1038/onc.2010.447. PMC 3460638. PMID 20935675.
  12. ^ Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (Aug 2002). "Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription". Molecular and Cellular Biology. 22 (16): 5962–74. doi:10.1128/MCB.22.16.5962-5974.2002. PMC 133991. PMID 12138205.
  13. ^ Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC (Feb 1999). "The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases". Immunity. 10 (2): 271–80. doi:10.1016/S1074-7613(00)80027-8. PMID 10072079.
  14. ^ a b Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  15. ^ Belich MP, Salmerón A, Johnston LH, Ley SC (Jan 1999). "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105". Nature. 397 (6717): 363–8. doi:10.1038/16946. PMID 9950430. S2CID 4391108.
  16. ^ . Archived from the original on 2006-05-06. Retrieved 2012-05-08.
  17. ^ Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC (Jun 2004). "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability". Molecular and Cellular Biology. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.

Further reading edit

  • Aoki M, Akiyama T, Miyoshi J, Toyoshima K (Sep 1991). "Identification and characterization of protein products of the cot oncogene with serine kinase activity". Oncogene. 6 (9): 1515–9. PMID 1833717.
  • Aoki M, Hamada F, Sugimoto T, Sumida S, Akiyama T, Toyoshima K (Oct 1993). "The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation". The Journal of Biological Chemistry. 268 (30): 22723–32. doi:10.1016/S0021-9258(18)41587-6. PMID 8226782.
  • Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP, Ley SC (Feb 1996). "Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase". The EMBO Journal. 15 (4): 817–26. doi:10.1002/j.1460-2075.1996.tb00417.x. PMC 450280. PMID 8631303.
  • Ballester A, Tobeña R, Lisbona C, Calvo V, Alemany S (Aug 1997). "Cot kinase regulation of IL-2 production in Jurkat T cells". Journal of Immunology. 159 (4): 1613–8. PMID 9257820.
  • Ballester A, Velasco A, Tobeña R, Alemany S (Jun 1998). "Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner". The Journal of Biological Chemistry. 273 (23): 14099–106. doi:10.1074/jbc.273.23.14099. PMID 9603908.
  • Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WC (Oct 1998). "Molecular determinants of NF-kappaB-inducing kinase action". Molecular and Cellular Biology. 18 (10): 5899–907. doi:10.1128/mcb.18.10.5899. PMC 109176. PMID 9742107.
  • Belich MP, Salmerón A, Johnston LH, Ley SC (Jan 1999). "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105". Nature. 397 (6717): 363–8. doi:10.1038/16946. PMID 9950430. S2CID 4391108.
  • Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC (Feb 1999). "The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases". Immunity. 10 (2): 271–80. doi:10.1016/S1074-7613(00)80027-8. PMID 10072079.
  • Chiariello M, Marinissen MJ, Gutkind JS (Mar 2000). "Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation". Molecular and Cellular Biology. 20 (5): 1747–58. doi:10.1128/MCB.20.5.1747-1758.2000. PMC 85357. PMID 10669751.
  • Sánchez-Góngora E, Lisbona C, de Gregorio R, Ballester A, Calvo V, Pérez-Jurado L, Alemany S (Oct 2000). "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation". The Journal of Biological Chemistry. 275 (40): 31379–86. doi:10.1074/jbc.M000382200. PMID 10896655.
  • Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E (May 2001). "Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". The Journal of Biological Chemistry. 276 (18): 14602–6. doi:10.1074/jbc.C100103200. PMID 11278268.
  • Eliopoulos AG, Davies C, Blake SS, Murray P, Najafipour S, Tsichlis PN, Young LS (May 2002). "The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2". Journal of Virology. 76 (9): 4567–79. doi:10.1128/JVI.76.9.4567-4579.2002. PMC 155061. PMID 11932422.
  • Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (Aug 2002). "Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription". Molecular and Cellular Biology. 22 (16): 5962–74. doi:10.1128/MCB.22.16.5962-5974.2002. PMC 133991. PMID 12138205.
  • Waterfield MR, Zhang M, Norman LP, Sun SC (Mar 2003). "NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase". Molecular Cell. 11 (3): 685–94. doi:10.1016/S1097-2765(03)00070-4. PMID 12667451.
  • Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y (Nov 2003). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". The Journal of Biological Chemistry. 278 (47): 47089–97. doi:10.1074/jbc.M306002200. PMID 12975377.
  • Gándara ML, López P, Hernando R, Castaño JG, Alemany S (Oct 2003). "The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity". Molecular and Cellular Biology. 23 (20): 7377–90. doi:10.1128/MCB.23.20.7377-7390.2003. PMC 230324. PMID 14517305.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.

December 15, 2023
map3k8, mitogen, activated, protein, kinase, kinase, kinase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4y83, 4y85identifiersaliases, estf, mekk8, tpl2, aura2, mitogen, activated, protein, kinase, kinase. Mitogen activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene 5 6 7 MAP3K8Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4Y83 4Y85IdentifiersAliasesMAP3K8 COT EST ESTF MEKK8 TPL2 Tpl 2 c COT AURA2 mitogen activated protein kinase kinase kinase 8 Tpl2External IDsOMIM 191195 MGI 1346878 HomoloGene 3812 GeneCards MAP3K8Gene location Human Chr Chromosome 10 human 1 Band10p11 23Start30 434 021 bp 1 End30 461 833 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 A1 18 2 73 cMStart4 331 327 bp 2 End4 353 015 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastric mucosaupper lobe of left lungleft uterine tubegerminal epitheliummonocyteAchilles tendontibial nerveright lunggallbladderparietal pleuraTop expressed insacculelipotic placodespleenhair folliclesubcutaneous adipose tissueesophagusbloodbelly cordskin of backMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein binding ATP binding magnesium ion binding MAP kinase kinase kinase activity protein serine threonine kinase activityCellular componentcytosol cytoplasmBiological processphosphorylation immune system process T cell costimulation stress activated MAPK cascade cell cycle signal transduction protein phosphorylation regulation of mitotic cell cycle stress activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process interleukin 1 mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez132626410EnsemblENSG00000107968ENSMUSG00000024235UniProtP41279Q07174RefSeq mRNA NM 001244134NM 005204NM 001320961NM 007746RefSeq protein NP 001231063NP 001307890NP 005195NP 031772Location UCSC Chr 10 30 43 30 46 MbChr 18 4 33 4 35 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThe gene was identified by its oncogenic transforming activity in cells The encoded protein is a member of the serine threonine specific protein kinase family This kinase can activate ERK1 ERK2 and p38 MAP kinases 8 9 This kinase was shown to activate IkappaB kinases and thus induce the nuclear production of NF kappaB This kinase was also found to promote the production of TNF alpha and IL 2 during T lymphocyte activation Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF kappaB1 p105 NFKB1 This gene may also start transcription at a downstream in frame translation start codon and thus produce an isoform containing a shorter N terminus The shorter isoform has been shown to display weaker transforming activity 7 In mice the gene is known as TPL2 and is a tumor suppressor gene whose absence contributes to the development and progression of cancer 10 However it functions in other organs as a oncogene promoting cancer 11 Interactions editMAP3K8 has been shown to interact with AKT1 12 CHUK 13 NFKB2 14 NFKB1 14 15 C22orf25 16 and TNIP2 17 References edit a b c GRCh38 Ensembl release 89 ENSG00000107968 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024235 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Miyoshi J Higashi T Mukai H Ohuchi T Kakunaga T Aug 1991 Structure and transforming potential of the human cot oncogene encoding a putative protein kinase Molecular and Cellular Biology 11 8 4088 96 doi 10 1128 mcb 11 8 4088 PMC 361219 PMID 2072910 Chan AM Chedid M McGovern ES Popescu NC Miki T Aaronson SA May 1993 Expression cDNA cloning of a serine kinase transforming gene Oncogene 8 5 1329 33 PMID 8479752 a b Entrez Gene MAP3K8 mitogen activated protein kinase kinase kinase 8 Arthur JS Ley SC Sep 2013 Mitogen activated protein kinases in innate immunity Nature Reviews Immunology 13 9 679 92 doi 10 1038 nri3495 PMID 23954936 S2CID 12049695 Pattison MJ Mitchell O Flynn HR Chen CS Yang HT Ben Addi H Boeing S Snijders AP Ley SC Sep 2016 TLR and TNF R1 activation of the MKK3 MKK6 p38a axis in macrophages is mediated by TPL 2 kinase Biochemical Journal 473 18 2845 61 doi 10 1042 BCJ20160502 PMC 5095906 PMID 27402796 DeCicco Skinner Kathleen 2011 Loss of tumor progression locus 2 tpl2 enhances tumorigenesis and inflammation in two stage skin carcinogenesis Oncogene 30 4 389 97 doi 10 1038 onc 2010 447 PMC 3460638 PMID 20935675 DeCicco Skinner Kathleen 2011 Loss of tumor progression locus 2 tpl2 enhances tumorigenesis and inflammation in two stage skin carcinogenesis Oncogene 30 4 389 97 doi 10 1038 onc 2010 447 PMC 3460638 PMID 20935675 Kane LP Mollenauer MN Xu Z Turck CW Weiss A Aug 2002 Akt dependent phosphorylation specifically regulates Cot induction of NF kappa B dependent transcription Molecular and Cellular Biology 22 16 5962 74 doi 10 1128 MCB 22 16 5962 5974 2002 PMC 133991 PMID 12138205 Lin X Cunningham ET Mu Y Geleziunas R Greene WC Feb 1999 The proto oncogene Cot kinase participates in CD3 CD28 induction of NF kappaB acting through the NF kappaB inducing kinase and IkappaB kinases Immunity 10 2 271 80 doi 10 1016 S1074 7613 00 80027 8 PMID 10072079 a b Bouwmeester T Bauch A Ruffner H Angrand PO Bergamini G Croughton K Cruciat C Eberhard D Gagneur J Ghidelli S Hopf C Huhse B Mangano R Michon AM Schirle M Schlegl J Schwab M Stein MA Bauer A Casari G Drewes G Gavin AC Jackson DB Joberty G Neubauer G Rick J Kuster B Superti Furga G Feb 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nature Cell Biology 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Belich MP Salmeron A Johnston LH Ley SC Jan 1999 TPL 2 kinase regulates the proteolysis of the NF kappaB inhibitory protein NF kappaB1 p105 Nature 397 6717 363 8 doi 10 1038 16946 PMID 9950430 S2CID 4391108 Molecular Interaction Database Archived from the original on 2006 05 06 Retrieved 2012 05 08 Lang V Symons A Watton SJ Janzen J Soneji Y Beinke S Howell S Ley SC Jun 2004 ABIN 2 forms a ternary complex with TPL 2 and NF kappa B1 p105 and is essential for TPL 2 protein stability Molecular and Cellular Biology 24 12 5235 48 doi 10 1128 MCB 24 12 5235 5248 2004 PMC 419892 PMID 15169888 Further reading editAoki M Akiyama T Miyoshi J Toyoshima K Sep 1991 Identification and characterization of protein products of the cot oncogene with serine kinase activity Oncogene 6 9 1515 9 PMID 1833717 Aoki M Hamada F Sugimoto T Sumida S Akiyama T Toyoshima K Oct 1993 The human cot proto oncogene encodes two protein serine threonine kinases with different transforming activities by alternative initiation of translation The Journal of Biological Chemistry 268 30 22723 32 doi 10 1016 S0021 9258 18 41587 6 PMID 8226782 Salmeron A Ahmad TB Carlile GW Pappin D Narsimhan RP Ley SC Feb 1996 Activation of MEK 1 and SEK 1 by Tpl 2 proto oncoprotein a novel MAP kinase kinase kinase The EMBO Journal 15 4 817 26 doi 10 1002 j 1460 2075 1996 tb00417 x PMC 450280 PMID 8631303 Ballester A Tobena R Lisbona C Calvo V Alemany S Aug 1997 Cot kinase regulation of IL 2 production in Jurkat T cells Journal of Immunology 159 4 1613 8 PMID 9257820 Ballester A Velasco A Tobena R Alemany S Jun 1998 Cot kinase activates tumor necrosis factor alpha gene expression in a cyclosporin A resistant manner The Journal of Biological Chemistry 273 23 14099 106 doi 10 1074 jbc 273 23 14099 PMID 9603908 Lin X Mu Y Cunningham ET Marcu KB Geleziunas R Greene WC Oct 1998 Molecular determinants of NF kappaB inducing kinase action Molecular and Cellular Biology 18 10 5899 907 doi 10 1128 mcb 18 10 5899 PMC 109176 PMID 9742107 Belich MP Salmeron A Johnston LH Ley SC Jan 1999 TPL 2 kinase regulates the proteolysis of the NF kappaB inhibitory protein NF kappaB1 p105 Nature 397 6717 363 8 doi 10 1038 16946 PMID 9950430 S2CID 4391108 Lin X Cunningham ET Mu Y Geleziunas R Greene WC Feb 1999 The proto oncogene Cot kinase participates in CD3 CD28 induction of NF kappaB acting through the NF kappaB inducing kinase and IkappaB kinases Immunity 10 2 271 80 doi 10 1016 S1074 7613 00 80027 8 PMID 10072079 Chiariello M Marinissen MJ Gutkind JS Mar 2000 Multiple mitogen activated protein kinase signaling pathways connect the cot oncoprotein to the c jun promoter and to cellular transformation Molecular and Cellular Biology 20 5 1747 58 doi 10 1128 MCB 20 5 1747 1758 2000 PMC 85357 PMID 10669751 Sanchez Gongora E Lisbona C de Gregorio R Ballester A Calvo V Perez Jurado L Alemany S Oct 2000 COT kinase proto oncogene expression in T cells implication of the JNK SAPK signal transduction pathway in COT promoter activation The Journal of Biological Chemistry 275 40 31379 86 doi 10 1074 jbc M000382200 PMID 10896655 Luftig MA Cahir McFarland E Mosialos G Kieff E May 2001 Effects of the NIK aly mutation on NF kappaB activation by the Epstein Barr virus latent infection membrane protein lymphotoxin beta receptor and CD40 The Journal of Biological Chemistry 276 18 14602 6 doi 10 1074 jbc C100103200 PMID 11278268 Eliopoulos AG Davies C Blake SS Murray P Najafipour S Tsichlis PN Young LS May 2002 The oncogenic protein kinase Tpl 2 Cot contributes to Epstein Barr virus encoded latent infection membrane protein 1 induced NF kappaB signaling downstream of TRAF2 Journal of Virology 76 9 4567 79 doi 10 1128 JVI 76 9 4567 4579 2002 PMC 155061 PMID 11932422 Kane LP Mollenauer MN Xu Z Turck CW Weiss A Aug 2002 Akt dependent phosphorylation specifically regulates Cot induction of NF kappa B dependent transcription Molecular and Cellular Biology 22 16 5962 74 doi 10 1128 MCB 22 16 5962 5974 2002 PMC 133991 PMID 12138205 Waterfield MR Zhang M Norman LP Sun SC Mar 2003 NF kappaB1 p105 regulates lipopolysaccharide stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase Molecular Cell 11 3 685 94 doi 10 1016 S1097 2765 03 00070 4 PMID 12667451 Channavajhala PL Wu L Cuozzo JW Hall JP Liu W Lin LL Zhang Y Nov 2003 Identification of a novel human kinase supporter of Ras hKSR 2 that functions as a negative regulator of Cot Tpl2 signaling The Journal of Biological Chemistry 278 47 47089 97 doi 10 1074 jbc M306002200 PMID 12975377 Gandara ML Lopez P Hernando R Castano JG Alemany S Oct 2003 The COOH terminal domain of wild type Cot regulates its stability and kinase specific activity Molecular and Cellular Biology 23 20 7377 90 doi 10 1128 MCB 23 20 7377 7390 2003 PMC 230324 PMID 14517305 Bouwmeester T Bauch A Ruffner H Angrand PO Bergamini G Croughton K Cruciat C Eberhard D Gagneur J Ghidelli S Hopf C Huhse B Mangano R Michon AM Schirle M Schlegl J Schwab M Stein MA Bauer A Casari G Drewes G Gavin AC Jackson DB Joberty G Neubauer G Rick J Kuster B Superti Furga G Feb 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nature Cell Biology 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Portal nbsp Biology Retrieved from https en wikipedia org w index php title MAP3K8 amp oldid 1126406722, wikipedia, wiki, book, books, library,

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