Tankyrase 2

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.^[5]

TNKS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y0I, 3KR7, 3KR8, 3MHJ, 3MHK, 3P0N, 3P0P, 3P0Q, 3TWQ, 3TWR, 3TWS, 3TWT, 3TWU, 3TWV, 3TWW, 3TWX, 3U9H, 3U9Y, 3UA9, 3W51, 4AVU, 4AVW, 4BFP, 4BJ9, 4BJB, 4BJC, 4BS4, 4BU3, 4BU5, 4BU6, 4BU7, 4BU8, 4BU9, 4BUA, 4BUD, 4BUE, 4BUF, 4BUI, 4BUS, 4BUT, 4BUU, 4BUV, 4BUW, 4BUX, 4BUY, 4HKI, 4HKK, 4HKN, 4HL5, 4HLF, 4HLG, 4HLH, 4HLK, 4HLM, 4HMH, 4HYF, 4IUE, 4J1Z, 4J21, 4J22, 4J3L, 4J3M, 4KZL, 4KZQ, 4KZU, 4L09, 4L0B, 4L0I, 4L0S, 4L0T, 4L0V, 4L10, 4L2F, 4L2G, 4L2K, 4L31, 4L32, 4L33, 4L34, 4M7B, 4PML, 4PNL, 4PNM, 4PNN, 4PNQ, 4PNR, 4PNS, 4PNT, 4TJU, 4TJW, 4TJY, 4TK0, 4TK5, 4TKF, 4TKG, 4TKI, 4UVL, 4UVN, 4UVO, 4UVP, 4UVS, 4UVT, 4UVU, 4UVV, 4UVW, 4UVX, 4UVY, 4UVZ, 4UX4, 4W5I, 5AKU, 5AKW, 5AL1, 5AL2, 5AL3, 5AL4, 5AL5, 5C5P, 5C5Q, 5C5R, 5ADT, 5ADS, 5ADQ, 5AEH, 5ADR, 4Z68, 5BXU, 4UI5, 4UFY, 4UI7, 4UI3, 4UI4, 4UFU, 4UHG, 4UI6, 5BXO, 4UI8
Identifiers
Aliases	TNKS2, ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6, tankyrase 2
External IDs	OMIM: 607128 MGI: 1921743 HomoloGene: 11890 GeneCards: TNKS2
Gene location (Human) Chr. Chromosome 10 (human)^[1] Band 10q23.32 Start 91,798,426 bp^[1] End 91,865,475 bp^[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)^[2] Band 19|19 C2 Start 36,811,632 bp^[2] End 36,870,877 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte triceps brachii muscle superior surface of tongue body of tongue superficial temporal artery placenta Region I of hippocampus proper trigeminal ganglion caput epididymis seminal vesicula Top expressed in primitive streak renal corpuscle aortic valve medullary collecting duct ascending aorta retinal pigment epithelium urothelium ciliary body maxillary prominence cumulus cell More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity metal ion binding protein binding enzyme binding NAD+ ADP-ribosyltransferase activity protein ADP-ribosylase activity Cellular component cytoplasm cytosol Golgi apparatus pericentriolar material nuclear envelope membrane Golgi membrane chromosome telomere perinuclear region of cytoplasm nucleus Biological process protein auto-ADP-ribosylation protein ADP-ribosylation positive regulation of telomere capping multicellular organism growth regulation of multicellular organism growth positive regulation of canonical Wnt signaling pathway protein polyubiquitination positive regulation of telomere maintenance via telomerase protein localization to chromosome, telomeric region negative regulation of telomere maintenance via telomere lengthening Wnt signaling pathway protein poly-ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80351 74493 Ensembl ENSG00000107854 ENSMUSG00000024811 UniProt Q9H2K2 Q3UES3 RefSeq (mRNA) NM_025235 NM_001163635 RefSeq (protein) NP_079511 NP_001157107 Location (UCSC) Chr 10: 91.8 – 91.87 Mb Chr 19: 36.81 – 36.87 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TNKS2 has been shown to interact with GRB14,^[6] TERF1^[7][8][9] and Cystinyl aminopeptidase.^[8][9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000107854 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024811 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2".
6. Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.
7. Cook, Brandoch D; Dynek Jasmin N; Chang William; Shostak Grigoriy; Smith Susan (January 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. United States. 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745.
8. Chi, N W; Lodish H F (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. UNITED STATES. 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
9. Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. England. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774.
10. Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. United States. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.

Further reading

• Monz D, Munnia A, Comtesse N, et al. (2001). "Novel tankyrase-related gene detected with meningioma-specific sera". Clin. Cancer Res. 7 (1): 113–9. PMID 11205898.
• Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563.
• Kuimov AN, Kuprash DV, Petrov VN, et al. (2001). "Cloning and characterization of TNKL, a member of tankyrase gene family". Genes Immun. 2 (1): 52–5. doi:10.1038/sj.gene.6363722. PMID 11294570.
• Kaminker PG, Kim SH, Taylor RD, et al. (2001). "TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression". J. Biol. Chem. 276 (38): 35891–9. doi:10.1074/jbc.M105968200. PMID 11454873.
• Cook BD, Dynek JN, Chang W, et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. PMC 134233. PMID 11739745.
• Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. PMC 1222327. PMID 11802774.
• Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J. Biol. Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Deng Z, Atanasiu C, Zhao K, et al. (2005). "Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1". J. Virol. 79 (8): 4640–50. doi:10.1128/JVI.79.8.4640-4650.2005. PMC 1069541. PMID 15795250.
• Sidorova N, Zavalishina L, Kurchashova S, et al. (2006). "Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue". Cell Tissue Res. 323 (1): 137–45. doi:10.1007/s00441-005-0053-8. PMID 16151859. S2CID 21992320.