This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins.
Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis.
Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000152558 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000050912 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (Aug 2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death". Proc Natl Acad Sci U S A. 98 (17): 9778–83. Bibcode:2001PNAS...98.9778M. doi:10.1073/pnas.171322898. PMC55529. PMID 11481458.
^ ab"Entrez Gene: TMEM123 transmembrane protein 123".
Further readingedit
Dekker J, Rossen JW, Büller HA, Einerhand AW (2002). "The MUC family: an obituary". Trends Biochem. Sci. 27 (3): 126–31. doi:10.1016/S0968-0004(01)02052-7. PMID 11893509.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang C, Xu Y, Gu J, Schlossman SF (1998). "A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6290–5. Bibcode:1998PNAS...95.6290Z. doi:10.1073/pnas.95.11.6290. PMC27661. PMID 9600958.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
tmem123, porimin, protein, that, humans, encoded, gene, identifiersaliases, kct3, porimin, pormin, transmembrane, protein, 123external, idsomim, 606356, 1919179, homologene, 14177, genecards, gene, location, human, chromosome, human, band11q22, 2start102, end1. Porimin is a protein that in humans is encoded by the TMEM123 gene 5 6 TMEM123IdentifiersAliasesTMEM123 KCT3 PORIMIN PORMIN transmembrane protein 123External IDsOMIM 606356 MGI 1919179 HomoloGene 14177 GeneCards TMEM123Gene location Human Chr Chromosome 11 human 1 Band11q22 2Start102 396 332 bp 1 End102 470 384 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 A1Start7 764 042 bp 2 End7 794 334 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpalpebral conjunctivahuman penisgerminal epitheliumthymuslymph nodeganglionic eminencemonocyteendometriumbronchial epithelial cellbone marrow cellsTop expressed inspleenseminal vesiculasuperior surface of tongueconjunctival fornixcorneal stromabloodcarotid bodyadrenal glandascending aortasubmandibular glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding signaling receptor activityCellular componentintegral component of membrane membrane external side of plasma membrane cytoplasmic vesicleBiological processoncosis signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez11490871929EnsemblENSG00000152558ENSMUSG00000050912UniProtQ8N131Q91Z22RefSeq mRNA NM 052932NM 133739RefSeq protein NP 443164NP 598500Location UCSC Chr 11 102 4 102 47 MbChr 9 7 76 7 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain similar to a broadly defined category of proteins termed mucins Exposure of some cell types to anti PORIMIN pro oncosis receptor inducing membrane injury antibody crosslinks this protein on the cell surface and induces a type of cell death termed oncosis Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation This gene product is proposed to function as a cell surface receptor that mediates cell death 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000152558 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000050912 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ma F Zhang C Prasad KV Freeman GJ Schlossman SF Aug 2001 Molecular cloning of Porimin a novel cell surface receptor mediating oncotic cell death Proc Natl Acad Sci U S A 98 17 9778 83 Bibcode 2001PNAS 98 9778M doi 10 1073 pnas 171322898 PMC 55529 PMID 11481458 a b Entrez Gene TMEM123 transmembrane protein 123 Further reading editDekker J Rossen JW Buller HA Einerhand AW 2002 The MUC family an obituary Trends Biochem Sci 27 3 126 31 doi 10 1016 S0968 0004 01 02052 7 PMID 11893509 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Zhang C Xu Y Gu J Schlossman SF 1998 A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis Proc Natl Acad Sci U S A 95 11 6290 5 Bibcode 1998PNAS 95 6290Z doi 10 1073 pnas 95 11 6290 PMC 27661 PMID 9600958 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Bonkobara M Das A Takao J et al 2003 Identification of novel genes for secreted and membrane anchored proteins in human keratinocytes Br J Dermatol 148 4 654 64 doi 10 1046 j 1365 2133 2003 05244 x PMID 12752121 S2CID 21635573 Clark HF Gurney AL Abaya E et al 2003 The secreted protein discovery initiative SPDI a large scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Zhang Z Henzel WJ 2005 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Sci 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Otsuki T Ota T Nishikawa T et al 2007 Signal sequence and keyword trap in silico for selection of full length human cDNAs encoding secretion or membrane proteins from oligo capped cDNA libraries DNA Res 12 2 117 26 doi 10 1093 dnares 12 2 117 PMID 16303743 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TMEM123 amp oldid 1116604857, wikipedia, wiki, book, books, library,
