This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000095587 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025013 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Scott IC, Blitz IL, Pappano WN, et al. (1999). "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis". Dev. Biol. 213 (2): 283–300. doi:10.1006/dbio.1999.9383. PMID 10479448.
Reynolds SD, Zhang D, Puzas JE, et al. (2000). "Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues". Gene. 248 (1–2): 233–43. doi:10.1016/S0378-1119(00)00114-1. PMID 10806368.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures". J. Biol. Chem. 276 (25): 22537–43. doi:10.1074/jbc.M102352200. PMID 11313359.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.
tll2, tolloid, like, protein, protein, that, humans, encoded, gene, identifiersaliases, tolloid, like, 2external, idsomim, 606743, 1346044, homologene, 56545, genecards, gene, location, human, chromosome, human, band10q24, 1start96, end96, gene, location, mous. Tolloid like protein 2 is a protein that in humans is encoded by the TLL2 gene 5 6 TLL2IdentifiersAliasesTLL2 tolloid like 2External IDsOMIM 606743 MGI 1346044 HomoloGene 56545 GeneCards TLL2Gene location Human Chr Chromosome 10 human 1 Band10q24 1Start96 364 608 bp 1 End96 513 926 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 19 C3Start41 071 192 bp 2 End41 195 274 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inleft ventricleBrodmann area 23right ventriclemiddle temporal gyrusprefrontal cortexatriumislet of LangerhansBrodmann area 9striated muscle tissueinferior olivary nucleusTop expressed inesophagusstria vascularismesencephalonovaryMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding zinc ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding serine type endopeptidase activityCellular componentextracellular regionBiological processmulticellular organism development cell differentiation extracellular matrix disassembly negative regulation of skeletal muscle tissue growth proteolysisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez709324087EnsemblENSG00000095587ENSMUSG00000025013UniProtQ9Y6L7Q9WVM6RefSeq mRNA NM 012465NM 011904RefSeq protein NP 036597NP 036034Location UCSC Chr 10 96 36 96 51 MbChr 19 41 07 41 2 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes an astacin like zinc dependent metalloprotease and is a subfamily member of the metzincin family Unlike other family members a similar protein in mice does not cleave procollagen C propeptides or chordin 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000095587 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025013 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Scott IC Clark TG Takahara K Hoffman GG Eddy RL Haley LL Shows TB Greenspan DS Oct 1999 Assignment of TLL1 and TLL2 which encode human BMP 1 Tolloid related metalloproteases to chromosomes 4q32 q33 and 10q23 q24 and assignment of murine Tll2 to chromosome 19 Cytogenet Cell Genet 86 1 64 5 doi 10 1159 000015412 PMID 10516436 S2CID 42081614 a b Entrez Gene TLL2 tolloid like 2 Further reading editNagase T Ishikawa K Suyama M et al 1999 Prediction of the coding sequences of unidentified human genes XIII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 6 1 63 70 doi 10 1093 dnares 6 1 63 PMID 10231032 Scott IC Blitz IL Pappano WN et al 1999 Mammalian BMP 1 Tolloid related metalloproteinases including novel family member mammalian Tolloid like 2 have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis Dev Biol 213 2 283 300 doi 10 1006 dbio 1999 9383 PMID 10479448 Reynolds SD Zhang D Puzas JE et al 2000 Cloning of the chick BMP1 Tolloid cDNA and expression in skeletal tissues Gene 248 1 2 233 43 doi 10 1016 S0378 1119 00 00114 1 PMID 10806368 Hartley JL Temple GF Brasch MA 2001 DNA Cloning Using In Vitro Site Specific Recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Uzel MI Scott IC Babakhanlou Chase H et al 2001 Multiple bone morphogenetic protein 1 related mammalian metalloproteinases process pro lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures J Biol Chem 276 25 22537 43 doi 10 1074 jbc M102352200 PMID 11313359 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Deloukas P Earthrowl ME Grafham DV et al 2004 The DNA sequence and comparative analysis of human chromosome 10 Nature 429 6990 375 81 Bibcode 2004Natur 429 375D doi 10 1038 nature02462 PMID 15164054 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 nbsp This article on a gene on human chromosome 10 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TLL2 amp oldid 1116602803, wikipedia, wiki, book, books, library,
