Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1gene.[5] Its gene product, as well as the gene itself, is commonly known as TIP47.
Mannose 6-phosphate receptors (MPRs) deliver lysosomalhydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[6]
The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[7] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000105355 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024197 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: M6PRBP1 mannose-6-phosphate receptor binding protein 1".
^Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6. Bibcode:2001Sci...292.1373C. doi:10.1126/science.1056791. PMID 11359012. S2CID 31343936.
^Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S (May 2009). "TIP47 functions in the biogenesis of lipid droplets" (PDF). J. Cell Biol. 185 (4): 641–55. doi:10.1083/jcb.200812042. PMC2711566. PMID 19451273.
^Ducharme NA, Bickel PE (March 2008). "Lipid droplets in lipogenesis and lipolysis". Endocrinology. 149 (3): 942–9. doi:10.1210/en.2007-1713. PMID 18202123.
^Brasaemle DL (December 2007). "Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis" (PDF). J. Lipid Res. 48 (12): 2547–59. doi:10.1194/jlr.R700014-JLR200. PMID 17878492. S2CID 38744670.
^Díaz, E; Pfeffer S R (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell. UNITED STATES. 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. ISSN 0092-8674. PMID 9590177. S2CID 17161071.
^Orsel, J G; Sincock P M; Krise J P; Pfeffer S R (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9047–51. Bibcode:2000PNAS...97.9047O. doi:10.1073/pnas.160251397. ISSN 0027-8424. PMC16819. PMID 10908666.
Further readingedit
Bohn H, Kraus W, Winckler W (1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodev. Biol. Med. 4 (5): 343–50. PMID 6856484.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Díaz E, Pfeffer SR (1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell. 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. PMID 9590177. S2CID 17161071.
Than NG, Sumegi B, Than GN, et al. (1999). "Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants". Eur. J. Biochem. 258 (2): 752–7. doi:10.1046/j.1432-1327.1998.2580752.x. PMID 9874244.
Than NG, Sumegi B, Than GN, et al. (1999). "Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein". Tumour Biol. 20 (4): 184–92. doi:10.1159/000030062. PMID 10393528. S2CID 46847947.
Krise JP, Sincock PM, Orsel JG, Pfeffer SR (2000). "Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking". J. Biol. Chem. 275 (33): 25188–93. doi:10.1074/jbc.M001138200. PMID 10829017.
Orsel JG, Sincock PM, Krise JP, Pfeffer SR (2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. Bibcode:2000PNAS...97.9047O. doi:10.1073/pnas.160251397. PMC16819. PMID 10908666.
Barbero P, Buell E, Zulley S, Pfeffer SR (2001). "TIP47 is not a component of lipid droplets". J. Biol. Chem. 276 (26): 24348–51. doi:10.1074/jbc.M102468200. PMID 11313361.
Carroll KS, Hanna J, Simon I, et al. (2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6. Bibcode:2001Sci...292.1373C. doi:10.1126/science.1056791. PMID 11359012. S2CID 31343936.
Hanna J, Carroll K, Pfeffer SR (2002). "Identification of residues in TIP47 essential for Rab9 binding". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7450–4. Bibcode:2002PNAS...99.7450H. doi:10.1073/pnas.112198799. PMC124251. PMID 12032303.
Miura S, Gan JW, Brzostowski J, et al. (2002). "Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium". J. Biol. Chem. 277 (35): 32253–7. doi:10.1074/jbc.M204410200. PMID 12077142.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Sincock PM, Ganley IG, Krise JP, et al. (2003). "Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport". Traffic. 4 (1): 18–25. doi:10.1034/j.1600-0854.2003.40104.x. PMID 12535272.
Than NG, Sumegi B, Bellyei S, et al. (2003). "Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells". Eur. J. Biochem. 270 (6): 1176–88. doi:10.1046/j.1432-1033.2003.03475.x. PMID 12631276.
Nair P, Schaub BE, Rohrer J (2003). "Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor". J. Biol. Chem. 278 (27): 24753–8. doi:10.1074/jbc.M300174200. PMID 12697764.
Blot G, Janvier K, Le Panse S, et al. (2003). "Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity". J. Virol. 77 (12): 6931–45. doi:10.1128/JVI.77.12.6931-6945.2003. PMC156179. PMID 12768012.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC442148. PMID 15231748.
Ganley IG, Carroll K, Bittova L, Pfeffer S (2005). "Rab9 GTPase regulates late endosome size and requires effector interaction for its stability". Mol. Biol. Cell. 15 (12): 5420–30. doi:10.1091/mbc.E04-08-0747. PMC532021. PMID 15456905.
perilipin, mannose, phosphate, receptor, binding, protein, m6prbp1, protein, which, humans, encoded, m6prbp1, gene, gene, product, well, gene, itself, commonly, known, tip47, plin3available, structurespdbortholog, search, pdbe, rcsblist, codes1sziidentifiersal. Mannose 6 phosphate receptor binding protein 1 M6PRBP1 is a protein which in humans is encoded by the M6PRBP1 gene 5 Its gene product as well as the gene itself is commonly known as TIP47 PLIN3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1SZIIdentifiersAliasesPLIN3 M6PRBP1 PP17 TIP47 perilipin 3External IDsOMIM 602702 MGI 1914155 HomoloGene 4247 GeneCards PLIN3Gene location Human Chr Chromosome 19 human 1 Band19p13 3Start4 838 341 bp 1 End4 867 694 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 DStart56 584 476 bp 2 End56 599 873 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbody of tongueinferior ganglion of vagus nervesuperior surface of tonguenipplejejunal mucosastromal cell of endometriumpericardiumepithelium of esophagusduodenumright adrenal glandTop expressed inintestinal villusileumyolk sacjejunummyocardium of ventricleduodenumlacrimal glandutricleright ventriclecardiac musclesMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding cadherin bindingCellular componentendosome lipid droplet Golgi apparatus endosome membrane membrane transport vesicle cytoplasm cytosolBiological processvesicle mediated transport transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1022666905EnsemblENSG00000105355ENSMUSG00000024197UniProtO60664Q9DBG5RefSeq mRNA NM 005817NM 001164189NM 001164194NM 025836RefSeq protein NP 001157661NP 001157666NP 005808NP 080112Location UCSC Chr 19 4 84 4 87 MbChr 17 56 58 56 6 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction editMannose 6 phosphate receptors MPRs deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex The protein encoded by this gene interacts with the cytoplasmic domains of both cation independent and cation dependent MPRs and is required for endosome to Golgi transport This protein also binds directly to the GTPase RAB9 RAB9A a member of the RAS oncogene family The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo 6 The mannose 6 phosphate receptor binding properties of TIP47 are disputed 7 despite the designation of M6PRBP1 as TIP47 s gene symbol TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets 8 TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family including perilipin and adipophilin 9 Interactions editM6PRBP1 has been shown to interact with both Mannose 6 phosphate receptors 10 11 References edit a b c GRCh38 Ensembl release 89 ENSG00000105355 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024197 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene M6PRBP1 mannose 6 phosphate receptor binding protein 1 Carroll KS Hanna J Simon I Krise J Barbero P Pfeffer SR May 2001 Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 Science 292 5520 1373 6 Bibcode 2001Sci 292 1373C doi 10 1126 science 1056791 PMID 11359012 S2CID 31343936 Bulankina AV Deggerich A Wenzel D Mutenda K Wittmann JG Rudolph MG Burger KN Honing S May 2009 TIP47 functions in the biogenesis of lipid droplets PDF J Cell Biol 185 4 641 55 doi 10 1083 jcb 200812042 PMC 2711566 PMID 19451273 Ducharme NA Bickel PE March 2008 Lipid droplets in lipogenesis and lipolysis Endocrinology 149 3 942 9 doi 10 1210 en 2007 1713 PMID 18202123 Brasaemle DL December 2007 Thematic review series adipocyte biology The perilipin family of structural lipid droplet proteins stabilization of lipid droplets and control of lipolysis PDF J Lipid Res 48 12 2547 59 doi 10 1194 jlr R700014 JLR200 PMID 17878492 S2CID 38744670 Diaz E Pfeffer S R May 1998 TIP47 a cargo selection device for mannose 6 phosphate receptor trafficking Cell UNITED STATES 93 3 433 43 doi 10 1016 S0092 8674 00 81171 X ISSN 0092 8674 PMID 9590177 S2CID 17161071 Orsel J G Sincock P M Krise J P Pfeffer S R August 2000 Recognition of the 300 kDa mannose 6 phosphate receptor cytoplasmic domain by 47 kDa tail interacting protein Proc Natl Acad Sci U S A UNITED STATES 97 16 9047 51 Bibcode 2000PNAS 97 9047O doi 10 1073 pnas 160251397 ISSN 0027 8424 PMC 16819 PMID 10908666 Further reading editBohn H Kraus W Winckler W 1983 Purification and characterization of two new soluble placental tissue proteins PP13 and PP17 Oncodev Biol Med 4 5 343 50 PMID 6856484 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Diaz E Pfeffer SR 1998 TIP47 a cargo selection device for mannose 6 phosphate receptor trafficking Cell 93 3 433 43 doi 10 1016 S0092 8674 00 81171 X PMID 9590177 S2CID 17161071 Than NG Sumegi B Than GN et al 1999 Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 PP17 variants Eur J Biochem 258 2 752 7 doi 10 1046 j 1432 1327 1998 2580752 x PMID 9874244 Than NG Sumegi B Than GN et al 1999 Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 PP17 homology with adipophilin and the mouse adipose differentiation related protein Tumour Biol 20 4 184 92 doi 10 1159 000030062 PMID 10393528 S2CID 46847947 Krise JP Sincock PM Orsel JG Pfeffer SR 2000 Quantitative analysis of TIP47 receptor cytoplasmic domain interactions implications for endosome to trans Golgi network trafficking J Biol Chem 275 33 25188 93 doi 10 1074 jbc M001138200 PMID 10829017 Orsel JG Sincock PM Krise JP Pfeffer SR 2000 Recognition of the 300 kDa mannose 6 phosphate receptor cytoplasmic domain by 47 kDa tail interacting protein Proc Natl Acad Sci U S A 97 16 9047 51 Bibcode 2000PNAS 97 9047O doi 10 1073 pnas 160251397 PMC 16819 PMID 10908666 Barbero P Buell E Zulley S Pfeffer SR 2001 TIP47 is not a component of lipid droplets J Biol Chem 276 26 24348 51 doi 10 1074 jbc M102468200 PMID 11313361 Carroll KS Hanna J Simon I et al 2001 Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 Science 292 5520 1373 6 Bibcode 2001Sci 292 1373C doi 10 1126 science 1056791 PMID 11359012 S2CID 31343936 Hanna J Carroll K Pfeffer SR 2002 Identification of residues in TIP47 essential for Rab9 binding Proc Natl Acad Sci U S A 99 11 7450 4 Bibcode 2002PNAS 99 7450H doi 10 1073 pnas 112198799 PMC 124251 PMID 12032303 Miura S Gan JW Brzostowski J et al 2002 Functional conservation for lipid storage droplet association among Perilipin ADRP and TIP47 PAT related proteins in mammals Drosophila and Dictyostelium J Biol Chem 277 35 32253 7 doi 10 1074 jbc M204410200 PMID 12077142 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Sincock PM Ganley IG Krise JP et al 2003 Self assembly is important for TIP47 function in mannose 6 phosphate receptor transport Traffic 4 1 18 25 doi 10 1034 j 1600 0854 2003 40104 x PMID 12535272 Than NG Sumegi B Bellyei S et al 2003 Lipid droplet and milk lipid globule membrane associated placental protein 17b PP17b is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells Eur J Biochem 270 6 1176 88 doi 10 1046 j 1432 1033 2003 03475 x PMID 12631276 Nair P Schaub BE Rohrer J 2003 Characterization of the endosomal sorting signal of the cation dependent mannose 6 phosphate receptor J Biol Chem 278 27 24753 8 doi 10 1074 jbc M300174200 PMID 12697764 Blot G Janvier K Le Panse S et al 2003 Targeting of the human immunodeficiency virus type 1 envelope to the trans Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity J Virol 77 12 6931 45 doi 10 1128 JVI 77 12 6931 6945 2003 PMC 156179 PMID 12768012 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Colland F Jacq X Trouplin V et al 2004 Functional proteomics mapping of a human signaling pathway Genome Res 14 7 1324 32 doi 10 1101 gr 2334104 PMC 442148 PMID 15231748 Ganley IG Carroll K Bittova L Pfeffer S 2005 Rab9 GTPase regulates late endosome size and requires effector interaction for its stability Mol Biol Cell 15 12 5420 30 doi 10 1091 mbc E04 08 0747 PMC 532021 PMID 15456905 External links editPLIN3 human gene location in the UCSC Genome Browser PLIN3 human gene details in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title Perilipin 3 amp oldid 1175143256, wikipedia, wiki, book, books, library,
