TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,[2] but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil.[3][4][5][6][7][8] Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin,[9] but it failed to produce stimulant effects in animals,[10] and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5-Methyl-MDA.
^Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). from the original on 2023-08-27. Retrieved 2023-08-27.
^"EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA" (PDF). (PDF) from the original on 2020-11-08. Retrieved 2019-12-08.
^Nycz JE, Pazdziorek T, Malecki G, Szala M (September 2016). "Identification and derivatization of selected cathinones by spectroscopic studies". Forensic Science International. 266: 416–426. doi:10.1016/j.forsciint.2016.06.034. PMID 27423024.
^Yanini A, Esteve-Turrillas FA, de la Guardia M, Armenta S (November 2018). "Ion mobility spectrometry and high resolution mass-spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances". Journal of Chromatography A. 1574: 91–100. doi:10.1016/j.chroma.2018.09.006. PMID 30220430. S2CID 52281842.
^Wille SM, Richeval C, Nachon-Phanithavong M, Gaulier JM, Di Fazio V, Humbert L, et al. (March 2018). "Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population". Drug Testing and Analysis. 10 (3): 539–547. doi:10.1002/dta.2232. PMID 28640970.
^Błażewicz A, Bednarek E, Popławska M, Olech N, Sitkowski J, Kozerski L (July 2019). "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone". Forensic Toxicol. 37 (2): 288–307. doi:10.1007/s11419-018-00463-w.
^Göl E, Çok I (January 2019). "New psychoactive substances in Turkey: Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara, Turkey". Forensic Science International. 294: 113–123. doi:10.1016/j.forsciint.2018.11.003. PMID 30502695. S2CID 56176934.
^Boff B, Silveira Filho J, Nonemacher K, Schroeder SD, Arbo MD (24 October 2019). "New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study". Forensic Science International. 306: 110002. doi:10.1016/j.forsciint.2019.110002. PMID 31864775. S2CID 208415740.
^Eshleman AJ, Nagarajan S, Wolfrum KM, Reed JF, Swanson TL, Nilsen A, et al. (March 2019). "Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology. 236 (3): 939–952. doi:10.1007/s00213-018-5059-5. PMC6500773. PMID 30397775.
^Gatch MB, Dolan SB, Forster MJ (June 2019). "Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats". Drug and Alcohol Dependence. 199: 50–58. doi:10.1016/j.drugalcdep.2019.02.016. PMC6534427. PMID 30986635.
April 17, 2024
substituted, cathinone, derivative, which, been, sold, designer, drug, first, identified, forensic, laboratory, hungary, 2015, subsequently, been, found, numerous, other, countries, around, world, including, spain, belgium, poland, turkey, brazil, pharmacologi. TH PVP is a substituted cathinone derivative which has been sold as a designer drug It was first identified by a forensic laboratory in Hungary in 2015 2 but has subsequently been found in numerous other countries around the world including Spain Belgium Poland Turkey and Brazil 3 4 5 6 7 8 Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin 9 but it failed to produce stimulant effects in animals 10 and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5 Methyl MDA TH PVPClinical dataATC codeNoneLegal statusLegal statusBR Class F2 Prohibited psychotropics 1 CA Schedule I DE NpSG Industrial and scientific use only UK Under Psychoactive Substances ActIdentifiersIUPAC name 2 pyrrolidin 1 yl 1 5 6 7 8 tetrahydronaphthalen 2 yl pentan 1 oneCAS Number2304915 07 7 YPubChem CID132989549ChemSpider82954253UNIIS5MU9GV87CChemical and physical dataFormulaC 19H 27N OMolar mass285 431 g mol 13D model JSmol Interactive imageSMILES CCCC C O C1 CC2 C CCCC2 C C1 N3CCCC3InChI InChI 1S C19H27NO c1 2 7 18 20 12 5 6 13 20 19 21 17 11 10 15 8 3 4 9 16 15 14 17 h10 11 14 18H 2 9 12 13H2 1H3Key MMIKQWIZKBYLKZ UHFFFAOYSA NSee also edit4 Et PVP 6 APT EDMA Indapyrophenidone Naphyrone O 2390References edit Anvisa 2023 07 24 RDC Nº 804 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 804 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 2023 07 25 Archived from the original on 2023 08 27 Retrieved 2023 08 27 EMCDDA Europol 2015 Annual Report on the implementation of Council Decision 2005 387 JHA PDF Archived PDF from the original on 2020 11 08 Retrieved 2019 12 08 Nycz JE Pazdziorek T Malecki G Szala M September 2016 Identification and derivatization of selected cathinones by spectroscopic studies Forensic Science International 266 416 426 doi 10 1016 j forsciint 2016 06 034 PMID 27423024 Yanini A Esteve Turrillas FA de la Guardia M Armenta S November 2018 Ion mobility spectrometry and high resolution mass spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances Journal of Chromatography A 1574 91 100 doi 10 1016 j chroma 2018 09 006 PMID 30220430 S2CID 52281842 Wille SM Richeval C Nachon Phanithavong M Gaulier JM Di Fazio V Humbert L et al March 2018 Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population Drug Testing and Analysis 10 3 539 547 doi 10 1002 dta 2232 PMID 28640970 Blazewicz A Bednarek E Poplawska M Olech N Sitkowski J Kozerski L July 2019 Identification and structural characterization of synthetic cathinones N propylcathinone 2 4 dimethylmethcathinone 2 4 dimethylethcathinone 2 4 dimethyl a pyrrolidinopropiophenone 4 bromo a pyrrolidinopropiophenone 1 2 3 dihydro 1H inden 5 yl 2 pyrrolidin 1 yl hexan 1 one and 2 4 dimethylisocathinone Forensic Toxicol 37 2 288 307 doi 10 1007 s11419 018 00463 w Gol E Cok I January 2019 New psychoactive substances in Turkey Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara Turkey Forensic Science International 294 113 123 doi 10 1016 j forsciint 2018 11 003 PMID 30502695 S2CID 56176934 Boff B Silveira Filho J Nonemacher K Schroeder SD Arbo MD 24 October 2019 New psychoactive substances NPS prevalence over LSD in blotter seized in State of Santa Catarina Brazil a six year retrospective study Forensic Science International 306 110002 doi 10 1016 j forsciint 2019 110002 PMID 31864775 S2CID 208415740 Eshleman AJ Nagarajan S Wolfrum KM Reed JF Swanson TL Nilsen A et al March 2019 Structure activity relationships of bath salt components substituted cathinones and benzofurans at biogenic amine transporters Psychopharmacology 236 3 939 952 doi 10 1007 s00213 018 5059 5 PMC 6500773 PMID 30397775 Gatch MB Dolan SB Forster MJ June 2019 Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats Drug and Alcohol Dependence 199 50 58 doi 10 1016 j drugalcdep 2019 02 016 PMC 6534427 PMID 30986635 Retrieved from https en wikipedia org w index php title TH PVP amp oldid 1206083768, wikipedia, wiki, book, books, library,
