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Wikipedia

TGFB1I1

January 01, 1970

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene.[5][6] Often put together with and studied alongside TGFB1I1 is the mouse homologue HIC-5 ( Hydrogen Peroxide-Inducible Clone-5). As the name suggests, TGFB1I1 is an induced form of the larger family of TGFB1. Studies suggest TGFB1I1 plays a role in processes of cell growth, proliferation,[7] migration, differentiation[8] and senescence.[9] TGFB1I1 is most localized at focal adhesion complexes of cells,[5] although it may be found active in the cytosol, nucleus and cell membrane as well.[7][10][11]

TGFB1I1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTGFB1I1, ARA55, HIC-5, HIC5, TSC-5, transforming growth factor beta 1 induced transcript 1
External IDsOMIM: 602353 MGI: 102784 HomoloGene: 7572 GeneCards: TGFB1I1
Orthologs
SpeciesHumanMouse
Entrez

7041

21804

Ensembl

ENSG00000140682

ENSMUSG00000030782

UniProt

O43294

Q62219

RefSeq (mRNA)

NM_015927
NM_001042454
NM_001164719

NM_001289550
NM_001289551
NM_001289552
NM_001289553
NM_009365

RefSeq (protein)

NP_001035919
NP_001158191
NP_057011
NP_001158191.1
NP_057011.2

NP_001276479
NP_001276480
NP_001276481
NP_001276482

Location (UCSC)Chr 16: 31.47 – 31.48 MbChr 7: 127.85 – 127.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Functions edit

Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide.[9] During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein,[12][13] an androgen and glucocorticoid receptor co-activator,[10][14] a negative regulator of muscle differentiation,[8] and major player in the recovery of arterial media.[15][16]

Interactions edit

TGFB1I1 has been shown to interact with:

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140682 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030782 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, et al. (January 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". The Journal of Biological Chemistry. 273 (2): 1003–1014. doi:10.1074/jbc.273.2.1003. PMID 9422762.
  6. ^ Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (March 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". The Journal of Biological Chemistry. 274 (12): 8316–8321. doi:10.1074/jbc.274.12.8316. PMID 10075738.
  7. ^ a b Heitzer MD, DeFranco DB (July 2006). "Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells". Cancer Research. 66 (14): 7326–7333. doi:10.1158/0008-5472.can-05-2379. PMID 16849583.
  8. ^ a b Hu Y, Cascone PJ, Cheng L, Sun D, Nambu JR, Schwartz LM (August 1999). "Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation". Proceedings of the National Academy of Sciences of the United States of America. 96 (18): 10218–10223. Bibcode:1999PNAS...9610218H. doi:10.1073/pnas.96.18.10218. PMC 17869. PMID 10468589.
  9. ^ a b Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence". The Journal of Biological Chemistry. 269 (43): 26767–26774. doi:10.1016/S0021-9258(18)47085-8. PMID 7929412.
  10. ^ a b Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix". Molecular Biology of the Cell. 11 (6): 2007–2018. doi:10.1091/mbc.11.6.2007. PMC 14899. PMID 10848625.
  11. ^ Shibanuma M, Kim-Kaneyama JR, Ishino K, Sakamoto N, Hishiki T, Yamaguchi K, et al. (March 2003). "Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal". Molecular Biology of the Cell. 14 (3): 1158–1171. doi:10.1091/mbc.02-06-0099. PMC 151587. PMID 12631731.
  12. ^ Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. doi:10.1074/jbc.274.14.9847. PMID 10092676.
  13. ^ Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. doi:10.1242/jcs.112.2.181. PMID 9858471.
  14. ^ Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (March 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". The Journal of Biological Chemistry. 274 (12): 8316–8321. doi:10.1074/jbc.274.12.8316. PMID 10075738.
  15. ^ Ohanian J, Pieri M, Ohanian V (September 2015). "Non-receptor tyrosine kinases and the actin cytoskeleton in contractile vascular smooth muscle". The Journal of Physiology. 593 (17): 3807–3814. doi:10.1113/jphysiol.2014.284174. PMC 4575570. PMID 25433074.
  16. ^ Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A (2012). "Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders". Journal of Atherosclerosis and Thrombosis. 19 (7): 601–607. doi:10.5551/jat.10736. PMID 22472216.
  17. ^ a b Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". The Journal of Biological Chemistry. 277 (18): 15426–15431. doi:10.1074/jbc.M111218200. PMID 11856738.
  18. ^ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–10235. doi:10.1074/jbc.M111975200. PMID 11779876.
  19. ^ Carneiro AM, Ingram SL, Beaulieu JM, Sweeney A, Amara SG, Thomas SM, et al. (August 2002). "The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter". The Journal of Neuroscience. 22 (16): 7045–7054. doi:10.1523/JNEUROSCI.22-16-07045.2002. PMC 6757888. PMID 12177201.
  20. ^ Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". The Journal of Biological Chemistry. 276 (43): 39911–39918. doi:10.1074/jbc.M103510200. PMID 11546764.
  21. ^ a b Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. doi:10.1242/jcs.112.2.181. PMID 9858471.
  22. ^ Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–5345. doi:10.1128/MCB.21.16.5332-5345.2001. PMC 87257. PMID 11463817.
  23. ^ Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. doi:10.1074/jbc.274.14.9847. PMID 10092676.

Further reading edit

  • Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, et al. (December 2000). "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer". Journal of the Formosan Medical Association = Taiwan Yi Zhi. 99 (12): 885–894. PMID 11155740.
  • Heitzer MD, DeFranco DB (February 2007). "Hic-5/ARA55: a prostate stroma-specific AR coactivator". Steroids. 72 (2): 218–220. doi:10.1016/j.steroids.2006.11.010. PMID 17166536. S2CID 38796305.
  • Wilson SE, Lloyd SA (September 1991). "Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells". Investigative Ophthalmology & Visual Science. 32 (10): 2747–2756. PMID 1716619.
  • Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence". The Journal of Biological Chemistry. 269 (43): 26767–26774. doi:10.1016/S0021-9258(18)47085-8. PMID 7929412.
  • Shibanuma M, Mochizuki E, Maniwa R, Mashimo J, Nishiya N, Imai S, et al. (March 1997). "Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts". Molecular and Cellular Biology. 17 (3): 1224–1235. doi:10.1128/mcb.17.3.1224. PMC 231847. PMID 9032249.
  • Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K (October 1998). "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase". The Journal of Biological Chemistry. 273 (41): 26516–26521. doi:10.1074/jbc.273.41.26516. PMID 9756887.
  • Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. doi:10.1242/jcs.112.2.181. PMID 9858471.
  • Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. doi:10.1074/jbc.274.14.9847. PMID 10092676.
  • Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, et al. (May 1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling". The Journal of Cell Biology. 145 (4): 851–863. doi:10.1083/jcb.145.4.851. PMC 2133183. PMID 10330411.
  • Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH (December 1999). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–681. Bibcode:1999Natur.402..676L. doi:10.1038/45264. PMID 10604475. S2CID 2770368.
  • Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix". Molecular Biology of the Cell. 11 (6): 2007–2018. doi:10.1091/mbc.11.6.2007. PMC 14899. PMID 10848625.
  • Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, et al. (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–2639. doi:10.1182/blood.V97.9.2633. PMID 11313252.
  • Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–5345. doi:10.1128/MCB.21.16.5332-5345.2001. PMC 87257. PMID 11463817.
  • Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". The Journal of Biological Chemistry. 276 (43): 39911–39918. doi:10.1074/jbc.M103510200. PMID 11546764.
  • Ting HJ, Yeh S, Nishimura K, Chang C (January 2002). "Supervillin associates with androgen receptor and modulates its transcriptional activity". Proceedings of the National Academy of Sciences of the United States of America. 99 (2): 661–666. Bibcode:2002PNAS...99..661T. doi:10.1073/pnas.022469899. PMC 117362. PMID 11792840.
  • Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, et al. (April 2002). "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5". The Journal of Biological Chemistry. 277 (14): 12270–12274. doi:10.1074/jbc.M110291200. PMID 11805099.
  • Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". The Journal of Biological Chemistry. 277 (18): 15426–15431. doi:10.1074/jbc.M111218200. PMID 11856738.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
tgfb1i1, transforming, growth, factor, beta, induced, transcript, protein, protein, that, humans, encoded, gene, often, together, with, studied, alongside, mouse, homologue, hydrogen, peroxide, inducible, clone, name, suggests, induced, form, larger, family, t. Transforming growth factor beta 1 induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene 5 6 Often put together with and studied alongside TGFB1I1 is the mouse homologue HIC 5 Hydrogen Peroxide Inducible Clone 5 As the name suggests TGFB1I1 is an induced form of the larger family of TGFB1 Studies suggest TGFB1I1 plays a role in processes of cell growth proliferation 7 migration differentiation 8 and senescence 9 TGFB1I1 is most localized at focal adhesion complexes of cells 5 although it may be found active in the cytosol nucleus and cell membrane as well 7 10 11 TGFB1I1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1KLA 1KLC 1KLD 3KFD 4KV5IdentifiersAliasesTGFB1I1 ARA55 HIC 5 HIC5 TSC 5 transforming growth factor beta 1 induced transcript 1External IDsOMIM 602353 MGI 102784 HomoloGene 7572 GeneCards TGFB1I1Gene location Human Chr Chromosome 16 human 1 Band16p11 2Start31 471 585 bp 1 End31 477 960 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 F3Start127 845 984 bp 2 End127 854 871 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insaphenous veinmyometriumpopliteal arteryleft uterine tubethoracic aortaright coronary arteryascending aortaurethraseminal vesiculagastric mucosaTop expressed inascending aortaatriumexternal carotid arteryinternal carotid arterycalvariaaortic valvebelly cordcervixleft lungirisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionI SMAD binding transcription coactivator activity metal ion binding protein binding androgen receptor binding Roundabout binding transcription coregulator activityCellular componentcytoplasm focal adhesion nuclear matrix extracellular matrix intracellular anatomical structure cell junction cytoskeleton nucleus collagen containing extracellular matrix cytosol plasma membraneBiological processandrogen receptor signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation response to heat negative regulation of transforming growth factor beta receptor signaling pathway Wnt signaling pathway transcription by RNA polymerase II positive regulation of epithelial to mesenchymal transition ubiquitin dependent SMAD protein catabolic process positive regulation of transcription DNA templated cell adhesion negative regulation of cell population proliferation morphogenesis of embryonic epithelium epithelial cell differentiation cell fate commitment negative regulation of fat cell differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez704121804EnsemblENSG00000140682ENSMUSG00000030782UniProtO43294Q62219RefSeq mRNA NM 015927NM 001042454NM 001164719NM 001289550NM 001289551NM 001289552NM 001289553NM 009365RefSeq protein NP 001035919NP 001158191NP 057011NP 001158191 1NP 057011 2NP 001276479NP 001276480NP 001276481NP 001276482Location UCSC Chr 16 31 47 31 48 MbChr 7 127 85 127 85 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Functions 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunctions editTransforming growth factor beta 1 induced transcript 1 plays a role in a number of cell functions Originally TGFB1I1 was isolated as a senescence inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta 1 and hydrogen peroxide 9 During this TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein 12 13 an androgen and glucocorticoid receptor co activator 10 14 a negative regulator of muscle differentiation 8 and major player in the recovery of arterial media 15 16 Interactions editTGFB1I1 has been shown to interact with Androgen receptor 17 18 Dopamine transporter 19 Hsp27 20 PTK2B 5 17 21 PTK2 5 21 22 and PTPN12 23 See also editTranscription coregulatorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000140682 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000030782 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c d Matsuya M Sasaki H Aoto H Mitaka T Nagura K Ohba T et al January 1998 Cell adhesion kinase beta forms a complex with a new member Hic 5 of proteins localized at focal adhesions The Journal of Biological Chemistry 273 2 1003 1014 doi 10 1074 jbc 273 2 1003 PMID 9422762 Fujimoto N Yeh S Kang HY Inui S Chang HC Mizokami A Chang C March 1999 Cloning and characterization of androgen receptor coactivator ARA55 in human prostate The Journal of Biological Chemistry 274 12 8316 8321 doi 10 1074 jbc 274 12 8316 PMID 10075738 a b Heitzer MD DeFranco DB July 2006 Hic 5 ARA55 a LIM domain containing nuclear receptor coactivator expressed in prostate stromal cells Cancer Research 66 14 7326 7333 doi 10 1158 0008 5472 can 05 2379 PMID 16849583 a b Hu Y Cascone PJ Cheng L Sun D Nambu JR Schwartz LM August 1999 Lepidopteran DALP and its mammalian ortholog HIC 5 function as negative regulators of muscle differentiation Proceedings of the National Academy of Sciences of the United States of America 96 18 10218 10223 Bibcode 1999PNAS 9610218H doi 10 1073 pnas 96 18 10218 PMC 17869 PMID 10468589 a b Shibanuma M Mashimo J Kuroki T Nose K October 1994 Characterization of the TGF beta 1 inducible hic 5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence The Journal of Biological Chemistry 269 43 26767 26774 doi 10 1016 S0021 9258 18 47085 8 PMID 7929412 a b Yang L Guerrero J Hong H DeFranco DB Stallcup MR June 2000 Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator Hic 5 which localizes to both focal adhesions and the nuclear matrix Molecular Biology of the Cell 11 6 2007 2018 doi 10 1091 mbc 11 6 2007 PMC 14899 PMID 10848625 Shibanuma M Kim Kaneyama JR Ishino K Sakamoto N Hishiki T Yamaguchi K et al March 2003 Hic 5 communicates between focal adhesions and the nucleus through oxidant sensitive nuclear export signal Molecular Biology of the Cell 14 3 1158 1171 doi 10 1091 mbc 02 06 0099 PMC 151587 PMID 12631731 Nishiya N Iwabuchi Y Shibanuma M Cote JF Tremblay ML Nose K April 1999 Hic 5 a paxillin homologue binds to the protein tyrosine phosphatase PEST PTP PEST through its LIM 3 domain The Journal of Biological Chemistry 274 14 9847 9853 doi 10 1074 jbc 274 14 9847 PMID 10092676 Thomas SM Hagel M Turner CE January 1999 Characterization of a focal adhesion protein Hic 5 that shares extensive homology with paxillin Journal of Cell Science 112 Pt 2 2 181 190 doi 10 1242 jcs 112 2 181 PMID 9858471 Fujimoto N Yeh S Kang HY Inui S Chang HC Mizokami A Chang C March 1999 Cloning and characterization of androgen receptor coactivator ARA55 in human prostate The Journal of Biological Chemistry 274 12 8316 8321 doi 10 1074 jbc 274 12 8316 PMID 10075738 Ohanian J Pieri M Ohanian V September 2015 Non receptor tyrosine kinases and the actin cytoskeleton in contractile vascular smooth muscle The Journal of Physiology 593 17 3807 3814 doi 10 1113 jphysiol 2014 284174 PMC 4575570 PMID 25433074 Kim Kaneyama JR Lei XF Arita S Miyauchi A Miyazaki T Miyazaki A 2012 Hydrogen peroxide inducible clone 5 Hic 5 as a potential therapeutic target for vascular and other disorders Journal of Atherosclerosis and Thrombosis 19 7 601 607 doi 10 5551 jat 10736 PMID 22472216 a b Wang X Yang Y Guo X Sampson ER Hsu CL Tsai MY et al May 2002 Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator The Journal of Biological Chemistry 277 18 15426 15431 doi 10 1074 jbc M111218200 PMID 11856738 He B Minges JT Lee LW Wilson EM March 2002 The FXXLF motif mediates androgen receptor specific interactions with coregulators The Journal of Biological Chemistry 277 12 10226 10235 doi 10 1074 jbc M111975200 PMID 11779876 Carneiro AM Ingram SL Beaulieu JM Sweeney A Amara SG Thomas SM et al August 2002 The multiple LIM domain containing adaptor protein Hic 5 synaptically colocalizes and interacts with the dopamine transporter The Journal of Neuroscience 22 16 7045 7054 doi 10 1523 JNEUROSCI 22 16 07045 2002 PMC 6757888 PMID 12177201 Jia Y Ransom RF Shibanuma M Liu C Welsh MJ Smoyer WE October 2001 Identification and characterization of hic 5 ARA55 as an hsp27 binding protein The Journal of Biological Chemistry 276 43 39911 39918 doi 10 1074 jbc M103510200 PMID 11546764 a b Thomas SM Hagel M Turner CE January 1999 Characterization of a focal adhesion protein Hic 5 that shares extensive homology with paxillin Journal of Cell Science 112 Pt 2 2 181 190 doi 10 1242 jcs 112 2 181 PMID 9858471 Nishiya N Tachibana K Shibanuma M Mashimo JI Nose K August 2001 Hic 5 reduced cell spreading on fibronectin competitive effects between paxillin and Hic 5 through interaction with focal adhesion kinase Molecular and Cellular Biology 21 16 5332 5345 doi 10 1128 MCB 21 16 5332 5345 2001 PMC 87257 PMID 11463817 Nishiya N Iwabuchi Y Shibanuma M Cote JF Tremblay ML Nose K April 1999 Hic 5 a paxillin homologue binds to the protein tyrosine phosphatase PEST PTP PEST through its LIM 3 domain The Journal of Biological Chemistry 274 14 9847 9853 doi 10 1074 jbc 274 14 9847 PMID 10092676 Further reading editYeh S Sampson ER Lee DK Kim E Hsu CL Chen YL et al December 2000 Functional analysis of androgen receptor N terminal and ligand binding domain interacting coregulators in prostate cancer Journal of the Formosan Medical Association Taiwan Yi Zhi 99 12 885 894 PMID 11155740 Heitzer MD DeFranco DB February 2007 Hic 5 ARA55 a prostate stroma specific AR coactivator Steroids 72 2 218 220 doi 10 1016 j steroids 2006 11 010 PMID 17166536 S2CID 38796305 Wilson SE Lloyd SA September 1991 Epidermal growth factor and its receptor basic fibroblast growth factor transforming growth factor beta 1 and interleukin 1 alpha messenger RNA production in human corneal endothelial cells Investigative Ophthalmology amp Visual Science 32 10 2747 2756 PMID 1716619 Shibanuma M Mashimo J Kuroki T Nose K October 1994 Characterization of the TGF beta 1 inducible hic 5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence The Journal of Biological Chemistry 269 43 26767 26774 doi 10 1016 S0021 9258 18 47085 8 PMID 7929412 Shibanuma M Mochizuki E Maniwa R Mashimo J Nishiya N Imai S et al March 1997 Induction of senescence like phenotypes by forced expression of hic 5 which encodes a novel LIM motif protein in immortalized human fibroblasts Molecular and Cellular Biology 17 3 1224 1235 doi 10 1128 mcb 17 3 1224 PMC 231847 PMID 9032249 Fujita H Kamiguchi K Cho D Shibanuma M Morimoto C Tachibana K October 1998 Interaction of Hic 5 A senescence related protein with focal adhesion kinase The Journal of Biological Chemistry 273 41 26516 26521 doi 10 1074 jbc 273 41 26516 PMID 9756887 Thomas SM Hagel M Turner CE January 1999 Characterization of a focal adhesion protein Hic 5 that shares extensive homology with paxillin Journal of Cell Science 112 Pt 2 2 181 190 doi 10 1242 jcs 112 2 181 PMID 9858471 Nishiya N Iwabuchi Y Shibanuma M Cote JF Tremblay ML Nose K April 1999 Hic 5 a paxillin homologue binds to the protein tyrosine phosphatase PEST PTP PEST through its LIM 3 domain The Journal of Biological Chemistry 274 14 9847 9853 doi 10 1074 jbc 274 14 9847 PMID 10092676 Turner CE Brown MC Perrotta JA Riedy MC Nikolopoulos SN McDonald AR et al May 1999 Paxillin LD4 motif binds PAK and PIX through a novel 95 kD ankyrin repeat ARF GAP protein A role in cytoskeletal remodeling The Journal of Cell Biology 145 4 851 863 doi 10 1083 jcb 145 4 851 PMC 2133183 PMID 10330411 Liu S Thomas SM Woodside DG Rose DM Kiosses WB Pfaff M Ginsberg MH December 1999 Binding of paxillin to alpha4 integrins modifies integrin dependent biological responses Nature 402 6762 676 681 Bibcode 1999Natur 402 676L doi 10 1038 45264 PMID 10604475 S2CID 2770368 Yang L Guerrero J Hong H DeFranco DB Stallcup MR June 2000 Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator Hic 5 which localizes to both focal adhesions and the nuclear matrix Molecular Biology of the Cell 11 6 2007 2018 doi 10 1091 mbc 11 6 2007 PMC 14899 PMID 10848625 Oda A Ochs HD Lasky LA Spencer S Ozaki K Fujihara M et al May 2001 CrkL is an adapter for Wiskott Aldrich syndrome protein and Syk Blood 97 9 2633 2639 doi 10 1182 blood V97 9 2633 PMID 11313252 Nishiya N Tachibana K Shibanuma M Mashimo JI Nose K August 2001 Hic 5 reduced cell spreading on fibronectin competitive effects between paxillin and Hic 5 through interaction with focal adhesion kinase Molecular and Cellular Biology 21 16 5332 5345 doi 10 1128 MCB 21 16 5332 5345 2001 PMC 87257 PMID 11463817 Jia Y Ransom RF Shibanuma M Liu C Welsh MJ Smoyer WE October 2001 Identification and characterization of hic 5 ARA55 as an hsp27 binding protein The Journal of Biological Chemistry 276 43 39911 39918 doi 10 1074 jbc M103510200 PMID 11546764 Ting HJ Yeh S Nishimura K Chang C January 2002 Supervillin associates with androgen receptor and modulates its transcriptional activity Proceedings of the National Academy of Sciences of the United States of America 99 2 661 666 Bibcode 2002PNAS 99 661T doi 10 1073 pnas 022469899 PMC 117362 PMID 11792840 Denhez F Wilcox Adelman SA Baciu PC Saoncella S Lee S French B et al April 2002 Syndesmos a syndecan 4 cytoplasmic domain interactor binds to the focal adhesion adaptor proteins paxillin and Hic 5 The Journal of Biological Chemistry 277 14 12270 12274 doi 10 1074 jbc M110291200 PMID 11805099 Wang X Yang Y Guo X Sampson ER Hsu CL Tsai MY et al May 2002 Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator The Journal of Biological Chemistry 277 18 15426 15431 doi 10 1074 jbc M111218200 PMID 11856738 External links editTGFB1I1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH NURSA C148 This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title TGFB1I1 amp oldid 1191313440, wikipedia, wiki, book, books, library,

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