TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed the activin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.[2][3] In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.[4] The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.[5]
Unlike the Type I and II receptors which are kinases, TGFBR3 has a Zona pellucida-like domain. Its core domain binds TGF-beta family ligands and its heparan sulfate chains bind bFGF. It acts as a reservoir of ligand for TGF-beta receptors.[6][7]
^. Archived from the original on 2011-05-25. Retrieved 2006-07-01.
^Fliesler SJ, Kisselev OG (26 December 2007). Signal Transduction in the Retina. CRC Press. pp. 273–. ISBN978-1-4200-0716-9.
^Thiriet M (14 December 2011). Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer Science & Business Media. pp. 666–. ISBN978-1-4614-1991-4.
^Wrana JL, Attisano L, Cárcamo J, et al. (December 1992). "TGF beta signals through a heteromeric protein kinase receptor complex". Cell. 71 (6): 1003–14. doi:10.1016/0092-8674(92)90395-S. PMID 1333888. S2CID 54397586.
^Huse, M; Muir, TW; Xu, L; Chen, YG; Kuriyan, J; Massagué, J (September 2001). "The TGF beta receptor activation process: an inhibitor- to substrate-binding switch". Molecular Cell. 8 (3): 671–82. doi:10.1016/S1097-2765(01)00332-X. PMID 11583628.
^Andres JL, Stanley K, et al. (1989). "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta". J. Cell Biol. 109 (6 (Pt 1)): 3137–3145. doi:10.1083/jcb.109.6.3137. PMC2115961. PMID 2592419.
^Andres JL, DeFalcis D, et al. (1992). "Binding of two growth factor families to separate domains of the proteoglycan betaglycan". J. Biol. Chem. 267 (9): 5927–5930. doi:10.1016/S0021-9258(18)42643-9. PMID 1556106.
beta, receptor, family, also, beta, receptor, tgfβ, signaling, pathway, transforming, growth, factor, beta, tgfβ, receptors, family, serine, threonine, kinase, receptors, involved, beta, signaling, pathway, these, receptors, bind, growth, factor, cytokine, sig. See also TGF beta receptor and TGFb signaling pathway The transforming growth factor beta TGFb receptors are a family of serine threonine kinase receptors involved in TGF beta signaling pathway These receptors bind growth factor and cytokine signaling proteins in the TGF beta family such as TGFbs TGFb1 TGFb2 TGFb3 bone morphogenetic proteins BMPs growth differentiation factors GDFs activin and inhibin myostatin anti Mullerian hormone AMH and NODAL 1 Ser Thr protein kinase TGFB receptorIdentifiersSymbolTGFb receptorInterProIPR000333SCOP21B6C SCOPe SUPFAMMembranome1216 Contents 1 TGFb family receptors 1 1 Type I 1 2 Type II 1 3 Type III 2 ReferencesTGFb family receptors editTGFb family receptors are grouped into three types type I type II and type III There are seven type I receptors termed the activin like receptors ALK1 7 five type II receptors and one type III receptor for a total of 13 TGFb superfamily receptors 2 3 In the transduction pathway ligand bound type II receptors activate type I receptors by phosphorylation which then autophosphorylate and bind SMAD 4 The Type I receptors have a glycine serine GS or TTSGSGSG repeat motif of around 30 AA a target of type II activity At least three and perhaps four to five of the serines and threonines in the GS domain must be phosphorylated to fully activate TbetaR 1 5 Type I edit Transforming growth factor beta type I GS motifIdentifiersSymbolTGF beta GSPfamPF08515InterProIPR003605Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryALK1 ACVRL1 ALK2 ACVR1A ALK3 BMPR1A ALK4 ACVR1B ALK5 TGFbR1 ALK6 BMPR1B ALK7 ACVR1C Type II edit TGFbR2 BMPR2 ACVR2A ACVR2B AMHR2 AMHR Type III edit Unlike the Type I and II receptors which are kinases TGFBR3 has a Zona pellucida like domain Its core domain binds TGF beta family ligands and its heparan sulfate chains bind bFGF It acts as a reservoir of ligand for TGF beta receptors 6 7 TGFbR3 b glycan References edit Prosite Documentation PDOC00223 Archived from the original on 2011 05 25 Retrieved 2006 07 01 Fliesler SJ Kisselev OG 26 December 2007 Signal Transduction in the Retina CRC Press pp 273 ISBN 978 1 4200 0716 9 Thiriet M 14 December 2011 Signaling at the Cell Surface in the Circulatory and Ventilatory Systems Springer Science amp Business Media pp 666 ISBN 978 1 4614 1991 4 Wrana JL Attisano L Carcamo J et al December 1992 TGF beta signals through a heteromeric protein kinase receptor complex Cell 71 6 1003 14 doi 10 1016 0092 8674 92 90395 S PMID 1333888 S2CID 54397586 Huse M Muir TW Xu L Chen YG Kuriyan J Massague J September 2001 The TGF beta receptor activation process an inhibitor to substrate binding switch Molecular Cell 8 3 671 82 doi 10 1016 S1097 2765 01 00332 X PMID 11583628 Andres JL Stanley K et al 1989 Membrane anchored and soluble forms of betaglycan a polymorphic proteoglycan that binds transforming growth factor beta J Cell Biol 109 6 Pt 1 3137 3145 doi 10 1083 jcb 109 6 3137 PMC 2115961 PMID 2592419 Andres JL DeFalcis D et al 1992 Binding of two growth factor families to separate domains of the proteoglycan betaglycan J Biol Chem 267 9 5927 5930 doi 10 1016 S0021 9258 18 42643 9 PMID 1556106 Portal nbsp Biology nbsp This article about a biochemical receptor is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TGF beta receptor family amp oldid 1187422983, wikipedia, wiki, book, books, library,
