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Wikipedia

TCP protein domain

March 04, 2024

In molecular biology, the protein domain TCP is actually a family of transcription factors named after: teosinte branched 1 (tb1, Zea mays (Maize)),[1] cycloidea (cyc) (Antirrhinum majus) (Garden snapdragon)[2] and PCF in rice (Oryza sativa).[3]

TCP
Identifiers
SymbolTCP
PfamPF03634
InterProIPR005333
PROSITEPDOC00610
SCOP21grl / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Function edit

Members of the TCP protein domain family appear to be involved in cell proliferation. It may also have a role in signalling pathways since it has three phosphorylation sites. The TCP domain is necessary for specific binding to promoter elements of the Proliferating cell nuclear antigen (PCNA) gene and also in DNA binding.[2]

Evolution edit

This family of transcription factors are exclusive to vascular plants. They can be divided into two groups, TCP-C and TCP-P, that appear to have separated following an early gene duplication event.[4] This duplication event may have led to functional divergence and it has been proposed that the TCP-P subfamily are transcriptional repressors, while the TPC-C subfamily are transcription activators.[5]

Structure edit

The TCP proteins code for structurally related proteins implicated in the evolution of key morphological traits.[2] However, the biochemical function of CYC and TB1 proteins remains to be demonstrated. One of the conserved regions is predicted to form a non-canonical basic-Helix-Loop-Helix (bHLH) structure. This domain is also found in two rice DNA-binding proteins, PCF1 and PCF2, where it has been shown to be involved in DNA-binding and dimerization.

References edit

  1. ^ Finlayson SA (May 2007). "Arabidopsis Teosinte Branched1-like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1". Plant Cell Physiol. 48 (5): 667–77. doi:10.1093/pcp/pcm044. PMID 17452340.
  2. ^ a b c Cubas P, Lauter N, Doebley J, Coen E (April 1999). "The TCP domain: a motif found in proteins regulating plant growth and development". Plant J. 18 (2): 215–22. doi:10.1046/j.1365-313x.1999.00444.x. PMID 10363373.
  3. ^ Kosugi S, Ohashi Y (May 2002). "DNA binding and dimerization specificity and potential targets for the TCP protein family". Plant J. 30 (3): 337–48. doi:10.1046/j.1365-313x.2002.01294.x. PMID 12000681.
  4. ^ Navaud O, Dabos P, Carnus E, Tremousaygue D, Hervé C (July 2007). "TCP transcription factors predate the emergence of land plants". J. Mol. Evol. 65 (1): 23–33. Bibcode:2007JMolE..65...23N. doi:10.1007/s00239-006-0174-z. PMID 17568984. S2CID 2961858.
  5. ^ Li C, Potuschak T, Colón-Carmona A, Gutiérrez RA, Doerner P (September 2005). "Arabidopsis TCP20 links regulation of growth and cell division control pathways". Proc. Natl. Acad. Sci. U.S.A. 102 (36): 12978–83. Bibcode:2005PNAS..10212978L. doi:10.1073/pnas.0504039102. PMC 1200278. PMID 16123132.
This article incorporates text from the public domain Pfam and InterPro: IPR005333

External links edit

  • TCP family at PlantTFDB: Plant Transcription Factor Database

March 04, 2024
protein, domain, molecular, biology, protein, domain, actually, family, transcription, factors, named, after, teosinte, branched, mays, maize, cycloidea, antirrhinum, majus, garden, snapdragon, rice, oryza, sativa, tcpidentifierssymboltcppfampf03634interproipr. In molecular biology the protein domain TCP is actually a family of transcription factors named after teosinte branched 1 tb1 Zea mays Maize 1 cycloidea cyc Antirrhinum majus Garden snapdragon 2 and PCF in rice Oryza sativa 3 TCPIdentifiersSymbolTCPPfamPF03634InterProIPR005333PROSITEPDOC00610SCOP21grl SCOPe SUPFAMAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Function 2 Evolution 3 Structure 4 References 5 External linksFunction editMembers of the TCP protein domain family appear to be involved in cell proliferation It may also have a role in signalling pathways since it has three phosphorylation sites The TCP domain is necessary for specific binding to promoter elements of the Proliferating cell nuclear antigen PCNA gene and also in DNA binding 2 Evolution editThis family of transcription factors are exclusive to vascular plants They can be divided into two groups TCP C and TCP P that appear to have separated following an early gene duplication event 4 This duplication event may have led to functional divergence and it has been proposed that the TCP P subfamily are transcriptional repressors while the TPC C subfamily are transcription activators 5 Structure editThe TCP proteins code for structurally related proteins implicated in the evolution of key morphological traits 2 However the biochemical function of CYC and TB1 proteins remains to be demonstrated One of the conserved regions is predicted to form a non canonical basic Helix Loop Helix bHLH structure This domain is also found in two rice DNA binding proteins PCF1 and PCF2 where it has been shown to be involved in DNA binding and dimerization References edit Finlayson SA May 2007 Arabidopsis Teosinte Branched1 like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1 Plant Cell Physiol 48 5 667 77 doi 10 1093 pcp pcm044 PMID 17452340 a b c Cubas P Lauter N Doebley J Coen E April 1999 The TCP domain a motif found in proteins regulating plant growth and development Plant J 18 2 215 22 doi 10 1046 j 1365 313x 1999 00444 x PMID 10363373 Kosugi S Ohashi Y May 2002 DNA binding and dimerization specificity and potential targets for the TCP protein family Plant J 30 3 337 48 doi 10 1046 j 1365 313x 2002 01294 x PMID 12000681 Navaud O Dabos P Carnus E Tremousaygue D Herve C July 2007 TCP transcription factors predate the emergence of land plants J Mol Evol 65 1 23 33 Bibcode 2007JMolE 65 23N doi 10 1007 s00239 006 0174 z PMID 17568984 S2CID 2961858 Li C Potuschak T Colon Carmona A Gutierrez RA Doerner P September 2005 Arabidopsis TCP20 links regulation of growth and cell division control pathways Proc Natl Acad Sci U S A 102 36 12978 83 Bibcode 2005PNAS 10212978L doi 10 1073 pnas 0504039102 PMC 1200278 PMID 16123132 This article incorporates text from the public domain Pfam and InterPro IPR005333External links editTCP family at PlantTFDB Plant Transcription Factor Database Retrieved from https en wikipedia org w index php title TCP protein domain amp oldid 1187551823, wikipedia, wiki, book, books, library,

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