In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.[9]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM[7]
^Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, et al. (November 2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". International Journal of Molecular Sciences. 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC4264187. PMID 25391046.
^Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A (January 2018). "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLOS Computational Biology. 14 (1): e1005945. Bibcode:2018PLSCB..14E5945I. doi:10.1371/journal.pcbi.1005945. PMC5783396. PMID 29324768.
Further readingedit
Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. Bibcode:2001PNAS...98.8966B. doi:10.1073/pnas.151105198. PMC55357. PMID 11459929.
taar8, trace, amine, associated, receptor, protein, that, humans, encoded, gene, humans, only, trace, amine, associated, receptor, that, known, coupled, identifiersaliases, gpr102, tar5, trar5, trace, amine, associated, receptor, 8external, idsomim, 606927, 26. Trace amine associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene 5 6 7 In humans TAAR8 is the only trace amine associated receptor that is known to be Gi o coupled 8 TAAR8IdentifiersAliasesTAAR8 GPR102 TA5 TAR5 TRAR5 TaR 5 TaR 8 trace amine associated receptor 8External IDsOMIM 606927 MGI 2685995 HomoloGene 77586 GeneCards TAAR8Gene location Human Chr Chromosome 6 human 1 Band6q23 2Start132 552 693 bp 1 End132 553 721 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 A4Start23 967 158 bp 2 End23 968 192 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreasfemale reproductive systemorgan systemmaterial anatomical entitykidneyrenal cortexvaginaislet of Langerhanstibial nerven aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontrace amine receptor activity G protein coupled receptor activity signal transducer activityCellular componentplasma membrane membrane integral component of membraneBiological processG protein coupled receptor signaling pathway signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez83551382348EnsemblENSG00000146385ENSMUSG00000100186UniProtQ969N4Q5QD06RefSeq mRNA NM 053278NM 001010837RefSeq protein NP 444508NP 001010837Location UCSC Chr 6 132 55 132 55 MbChr 10 23 97 23 97 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseIn humans molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors 9 G protein coupled receptors GPCRs or GPRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins supplied by OMIM 7 See also editTrace amine associated receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000146385 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000100186 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lee DK Nguyen T Lynch KR Cheng R Vanti WB Arkhitko O et al September 2001 Discovery and mapping of ten novel G protein coupled receptor genes Gene 275 1 83 91 doi 10 1016 S0378 1119 01 00651 5 PMID 11574155 Lindemann L Ebeling M Kratochwil NA Bunzow JR Grandy DK Hoener MC March 2005 Trace amine associated receptors form structurally and functionally distinct subfamilies of novel G protein coupled receptors Genomics 85 3 372 85 doi 10 1016 j ygeno 2004 11 010 PMID 15718104 a b Entrez Gene TAAR8 trace amine associated receptor 8 Muhlhaus J Dinter J Nurnberg D Rehders M Depke M Golchert J et al November 2014 Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile International Journal of Molecular Sciences 15 11 20638 55 doi 10 3390 ijms151120638 PMC 4264187 PMID 25391046 Izquierdo C Gomez Tamayo JC Nebel JC Pardo L Gonzalez A January 2018 Identifying human diamine sensors for death related putrescine and cadaverine molecules PLOS Computational Biology 14 1 e1005945 Bibcode 2018PLSCB 14E5945I doi 10 1371 journal pcbi 1005945 PMC 5783396 PMID 29324768 Further reading editBorowsky B Adham N Jones KA Raddatz R Artymyshyn R Ogozalek KL et al July 2001 Trace amines identification of a family of mammalian G protein coupled receptors Proceedings of the National Academy of Sciences of the United States of America 98 16 8966 71 Bibcode 2001PNAS 98 8966B doi 10 1073 pnas 151105198 PMC 55357 PMID 11459929 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TAAR8 amp oldid 1187412848, wikipedia, wiki, book, books, library,
