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Sulazepam

Sulazepam is a benzodiazepine derivative. It is the thioamide derivative of diazepam. It is metabolised into diazepam, desmethyldiazepam and oxydiazepam[citation needed]. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines.[1][2] It was never marketed.

Sulazepam
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • 7-Chloro-1-methyl-5-phenyl-1,3-dihydro- 2H-1,4-benzodiazepine-2-thione
CAS Number
  • 2898-13-7 Y
PubChem CID
  • 17931
ChemSpider
  • 16935 Y
UNII
  • NZ779Q5S0W
KEGG
  • D05942 Y
CompTox Dashboard (EPA)
  • DTXSID1046267
Chemical and physical data
FormulaC16H13ClN2S
Molar mass300.80 g·mol−1
3D model (JSmol)
  • Interactive image
  • ClC1=CC=C(N(C)C(CN=C2C3=CC=CC=C3)=S)C2=C1
  • InChI=1S/C16H13ClN2S/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 Y
  • Key:MWGWTOPCKLQYEU-UHFFFAOYSA-N Y
  (verify)

Synthesis edit

 
Sulazepam synthesis:[3] U.S. Patent 3,141,890

Treatment of diazepam with phosphorus pentasulfide produces the corresponding thionamide, sulazepam.

See also edit

References edit

  1. ^ "sulazepam". psychotropics.dk. 2003. Retrieved 29 December 2008.
  2. ^ Golovenko NI, Zin'kovskii VG (September 1976). "[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]" [Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]. Biulleten' Eksperimental'noi Biologii I Meditsiny (in Russian). 82 (9): 1078–81. PMID 11012.
  3. ^ Archer GA, Sternbach LH (1964). "Quinazolines and 1,4-Benzodiazepines. XVI. Synthesis and Transformations of 5-Phenyl-1,4-benzodiazepine-2-thiones". The Journal of Organic Chemistry. 29: 231. doi:10.1021/jo01024a511.

sulazepam, benzodiazepine, derivative, thioamide, derivative, diazepam, metabolised, into, diazepam, desmethyldiazepam, oxydiazepam, citation, needed, sedative, muscle, relaxant, hypnotic, anticonvulsant, anxiolytic, properties, like, those, other, benzodiazep. Sulazepam is a benzodiazepine derivative It is the thioamide derivative of diazepam It is metabolised into diazepam desmethyldiazepam and oxydiazepam citation needed It has sedative muscle relaxant hypnotic anticonvulsant and anxiolytic properties like those of other benzodiazepines 1 2 It was never marketed SulazepamClinical dataATC codenoneLegal statusLegal statusCA Schedule IVIdentifiersIUPAC name 7 Chloro 1 methyl 5 phenyl 1 3 dihydro 2H 1 4 benzodiazepine 2 thioneCAS Number2898 13 7 YPubChem CID17931ChemSpider16935 YUNIINZ779Q5S0WKEGGD05942 YCompTox Dashboard EPA DTXSID1046267Chemical and physical dataFormulaC 16H 13Cl N 2SMolar mass300 80 g mol 13D model JSmol Interactive imageSMILES ClC1 CC C N C C CN C2C3 CC CC C3 S C2 C1InChI InChI 1S C16H13ClN2S c1 19 14 8 7 12 17 9 13 14 16 18 10 15 19 20 11 5 3 2 4 6 11 h2 9H 10H2 1H3 YKey MWGWTOPCKLQYEU UHFFFAOYSA N Y verify Synthesis edit nbsp Sulazepam synthesis 3 U S Patent 3 141 890Treatment of diazepam with phosphorus pentasulfide produces the corresponding thionamide sulazepam See also editUldazepamReferences edit sulazepam psychotropics dk 2003 Retrieved 29 December 2008 Golovenko NI Zin kovskii VG September 1976 Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice Biulleten Eksperimental noi Biologii I Meditsiny in Russian 82 9 1078 81 PMID 11012 Archer GA Sternbach LH 1964 Quinazolines and 1 4 Benzodiazepines XVI Synthesis and Transformations of 5 Phenyl 1 4 benzodiazepine 2 thiones The Journal of Organic Chemistry 29 231 doi 10 1021 jo01024a511 nbsp This sedative related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Sulazepam amp oldid 1124561230, wikipedia, wiki, book, books, library,

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