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Sudden acquired retinal degeneration syndrome

January 01, 1970

Sudden acquired retinal degeneration syndrome (SARDS) is a disease in dogs causing sudden blindness. It can occur in any breed, but female dogs may be predisposed.[1] Approximately 4000 cases are seen in the United States annually.[2]

Characteristics edit

Symptoms include sudden permanent blindness, but may occur more slowly over several days, weeks or months,[3] dilated pupils. Pupillary light reflexes are usually reduced but present; the slow phase mediated by melanopsin in retinal ganglion cells is retained. Other symptoms commonly seen are similar to those seen with Cushing's disease and include increased water consumption and urination, weight gain, confusion, restlessness, behavioral changes and lethargy. These symptoms may develop over a few months preceding the onset of SARDS.[4] Clinical signs and disease progression vary markedly among individual animals, depending on the number and type of hormones that are increased, the degree of hormone elevation, and the age of the dog.[5]

Some owners notice a more obvious "eye shine" in photographs due to the dilated pupils and retinal atrophy creating what is described as a "hyper-reflective tapetum".

Causes edit

The cause of SARDS is considered to be idiopathic and the veterinary community is divided as to its cause, but the most common hypotheses on the causes of the disease possibly include autoimmune disease, or exposure to toxins. Autoimmune disease as a cause is controversial because some studies have supported the presence of antiretinal autoantibodies in dogs with SARDS,[6][7] but others have failed to show a link.[8] Despite similar symptoms and blood test results to Cushing's disease, evaluation of dogs with SARDS did not reveal any tumors in the pituitary or adrenal glands,[9] and recent work has indicated significant differences in the clinical and laboratory test parameters between the two diseases.[10]

Diagnosis edit

Examination with an ophthalmoscope will initially show no changes, but in a few months atrophy of the retina will resemble the appearance of progressive retinal atrophy. Pathologically, there is a loss of the rod and cone cells followed by degeneration of other layers of the retina. The retinal degeneration appears to be related to apoptosis of these cells.[11] SARDS must be distinguished from other causes of sudden blindness that have no visible pathology, including retrobulbar optic neuritis, a tumor at the optic chiasm, or other central nervous system diseases. Electroretinography is useful to definitively diagnose SARDS.[12]

Treatment edit

While there is no unilateral treatment for SARDS[13] researchers at the Iowa State University led by Dr. Siniša Grozdanić, ISU Veterinary Ophthalmologist have successfully restored vision in two dogs who have been in 2007 successfully treated through an experimental treatment by intravenous immunoglobin (IVIg). "Although the dogs won't be catching any Frisbees, they can navigate and not bump into objects,", Dr. Grozdanić notes.[14]

Various immunosuppressive treatment regimens have been tried, but are not consistently effective.[13][15] Treatment regimens with adrenal steroids and thyroid hormones have been proposed, but as of 2016 no controlled, peer reviewed studies had investigated the effectiveness of such treatments.[13]

References edit

  1. ^ Cullen C, Grahn B (2002). "DIAGNOSTIC OPHTHALMOLOGY: What are your clinical diagnosis, lesion localization, and differential diagnoses?". Can Vet J. 43 (9): 729–30. PMC 339566. PMID 12240536.
  2. ^ "Some blind dogs may get chance to see again". DVM. Advanstar Communications: 1S. July 2007.
  3. ^ "Sudden Acquired Retinal Degeneration (SARD)". The Merck Veterinary Manual. 2006. Retrieved 2007-03-11.
  4. ^ Ofri, Ron (2006). "Examination of the Blind Animal" (PDF). Proceedings of the 31st World Congress of the World Small Animal Veterinary Association. Retrieved 2007-03-11.
  5. ^ Carter RT, Bentley E, Oliver JW, et al.: Elevations in adrenal sex hormones in canine sudden acquired retinal degeneration syndrome (SARDS) [abstract]. Proc Am Coll Vet Ophthalmol:9:40, 2003.
  6. ^ Braus, Barbara K.; Hauck, Stefanie M.; Amann, Barbara; Heinrich, Christine; Fritsche, Jens; Köstlin, Roberto; Deeg, Cornelia A. (July 2008). "Neuron-specific enolase antibodies in patients with sudden acquired retinal degeneration syndrome". Veterinary Immunology and Immunopathology. 124 (1–2): 177–183. doi:10.1016/j.vetimm.2008.02.020. PMID 18405980.
  7. ^ Bellhorn, R. W.; Murphy, C. J.; Thirkill, C. E. (February 1988). "Anti-retinal immunoglobulins in canine ocular diseases". Seminars in Veterinary Medicine and Surgery (Small Animal). 3 (1): 28–32. ISSN 0882-0511. PMID 3363244.
  8. ^ Keller R, Kania S, Hendrix D, Ward D, Abrams K (2006). "Evaluation of canine serum for the presence of antiretinal autoantibodies in sudden acquired retinal degeneration syndrome". Veterinary Ophthalmology. 9 (3): 195–200. doi:10.1111/j.1463-5224.2006.00466.x. PMID 16634935.
  9. ^ Gilmour M, Cardenas M, Blaik M, Bahr R, McGinnis J (2006). "Evaluation of a comparative pathogenesis between cancer-associated retinopathy in humans and sudden acquired retinal degeneration syndrome in dogs via diagnostic imaging and western blot analysis". Am J Vet Res. 67 (5): 877–81. doi:10.2460/ajvr.67.5.877. PMID 16649924.
  10. ^ Oh, Annie; Foster, Melanie L.; Williams, Jonathan G.; Zheng, Chaowen; Ru, Hongyu; Lunn, Katharine F.; Mowat, Freya M. (2019-03-12). "Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary-dependent hyperadrenocorticism in dogs". Veterinary Ophthalmology. 22 (6): 842–858. doi:10.1111/vop.12661. PMID 30864251. S2CID 76666023.
  11. ^ Miller P, Galbreath E, Kehren J, Steinberg H, Dubielzig R (1998). "Photoreceptor cell death by apoptosis in dogs with sudden acquired retinal degeneration syndrome". Am J Vet Res. 59 (2): 149–52. PMID 9492927.
  12. ^ Gilger, Brian C. (2006). (PDF). Proceedings of the North American Veterinary Conference. Archived from the original (PDF) on 2007-09-29. Retrieved 2007-03-11.
  13. ^ a b c Komáromy, AM; Abrams, KL; Heckenlively, JR; Lundy, SK; Maggs, DJ; Leeth, CM; MohanKumar, PS; Petersen-Jones, SM; Serreze, DV; van der Woerdt, A (July 2016). "Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy" (PDF). Veterinary Ophthalmology. 19 (4): 319–31. doi:10.1111/vop.12291. hdl:2027.42/122446. PMID 26096588.
  14. ^ "Blind dogs can see after new ISU treatment for a sudden onset blinding disease • News Service • Iowa State University". www.news.iastate.edu. Retrieved 2021-09-15.
  15. ^ Young, Whitney M.; Oh, Annie; Williams, Jonathan G.; Foster, Melanie L.; Miller, William W.; Lunn, Katharine F.; Mowat, Freya M. (November 2018). "Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study". Veterinary Ophthalmology. 21 (6): 565–576. doi:10.1111/vop.12545. PMID 29383824. S2CID 23927483.

January 01, 1970
sudden, acquired, retinal, degeneration, syndrome, sards, disease, dogs, causing, sudden, blindness, occur, breed, female, dogs, predisposed, approximately, 4000, cases, seen, united, states, annually, contents, characteristics, causes, diagnosis, treatment, r. Sudden acquired retinal degeneration syndrome SARDS is a disease in dogs causing sudden blindness It can occur in any breed but female dogs may be predisposed 1 Approximately 4000 cases are seen in the United States annually 2 Contents 1 Characteristics 2 Causes 3 Diagnosis 4 Treatment 5 ReferencesCharacteristics editSymptoms include sudden permanent blindness but may occur more slowly over several days weeks or months 3 dilated pupils Pupillary light reflexes are usually reduced but present the slow phase mediated by melanopsin in retinal ganglion cells is retained Other symptoms commonly seen are similar to those seen with Cushing s disease and include increased water consumption and urination weight gain confusion restlessness behavioral changes and lethargy These symptoms may develop over a few months preceding the onset of SARDS 4 Clinical signs and disease progression vary markedly among individual animals depending on the number and type of hormones that are increased the degree of hormone elevation and the age of the dog 5 Some owners notice a more obvious eye shine in photographs due to the dilated pupils and retinal atrophy creating what is described as a hyper reflective tapetum Causes editThe cause of SARDS is considered to be idiopathic and the veterinary community is divided as to its cause but the most common hypotheses on the causes of the disease possibly include autoimmune disease or exposure to toxins Autoimmune disease as a cause is controversial because some studies have supported the presence of antiretinal autoantibodies in dogs with SARDS 6 7 but others have failed to show a link 8 Despite similar symptoms and blood test results to Cushing s disease evaluation of dogs with SARDS did not reveal any tumors in the pituitary or adrenal glands 9 and recent work has indicated significant differences in the clinical and laboratory test parameters between the two diseases 10 Diagnosis editExamination with an ophthalmoscope will initially show no changes but in a few months atrophy of the retina will resemble the appearance of progressive retinal atrophy Pathologically there is a loss of the rod and cone cells followed by degeneration of other layers of the retina The retinal degeneration appears to be related to apoptosis of these cells 11 SARDS must be distinguished from other causes of sudden blindness that have no visible pathology including retrobulbar optic neuritis a tumor at the optic chiasm or other central nervous system diseases Electroretinography is useful to definitively diagnose SARDS 12 Treatment editWhile there is no unilateral treatment for SARDS 13 researchers at the Iowa State University led by Dr Sinisa Grozdanic ISU Veterinary Ophthalmologist have successfully restored vision in two dogs who have been in 2007 successfully treated through an experimental treatment by intravenous immunoglobin IVIg Although the dogs won t be catching any Frisbees they can navigate and not bump into objects Dr Grozdanic notes 14 Various immunosuppressive treatment regimens have been tried but are not consistently effective 13 15 Treatment regimens with adrenal steroids and thyroid hormones have been proposed but as of 2016 no controlled peer reviewed studies had investigated the effectiveness of such treatments 13 References edit Cullen C Grahn B 2002 DIAGNOSTIC OPHTHALMOLOGY What are your clinical diagnosis lesion localization and differential diagnoses Can Vet J 43 9 729 30 PMC 339566 PMID 12240536 Some blind dogs may get chance to see again DVM Advanstar Communications 1S July 2007 Sudden Acquired Retinal Degeneration SARD The Merck Veterinary Manual 2006 Retrieved 2007 03 11 Ofri Ron 2006 Examination of the Blind Animal PDF Proceedings of the 31st World Congress of the World Small Animal Veterinary Association Retrieved 2007 03 11 Carter RT Bentley E Oliver JW et al Elevations in adrenal sex hormones in canine sudden acquired retinal degeneration syndrome SARDS abstract Proc Am Coll Vet Ophthalmol 9 40 2003 Braus Barbara K Hauck Stefanie M Amann Barbara Heinrich Christine Fritsche Jens Kostlin Roberto Deeg Cornelia A July 2008 Neuron specific enolase antibodies in patients with sudden acquired retinal degeneration syndrome Veterinary Immunology and Immunopathology 124 1 2 177 183 doi 10 1016 j vetimm 2008 02 020 PMID 18405980 Bellhorn R W Murphy C J Thirkill C E February 1988 Anti retinal immunoglobulins in canine ocular diseases Seminars in Veterinary Medicine and Surgery Small Animal 3 1 28 32 ISSN 0882 0511 PMID 3363244 Keller R Kania S Hendrix D Ward D Abrams K 2006 Evaluation of canine serum for the presence of antiretinal autoantibodies in sudden acquired retinal degeneration syndrome Veterinary Ophthalmology 9 3 195 200 doi 10 1111 j 1463 5224 2006 00466 x PMID 16634935 Gilmour M Cardenas M Blaik M Bahr R McGinnis J 2006 Evaluation of a comparative pathogenesis between cancer associated retinopathy in humans and sudden acquired retinal degeneration syndrome in dogs via diagnostic imaging and western blot analysis Am J Vet Res 67 5 877 81 doi 10 2460 ajvr 67 5 877 PMID 16649924 Oh Annie Foster Melanie L Williams Jonathan G Zheng Chaowen Ru Hongyu Lunn Katharine F Mowat Freya M 2019 03 12 Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary dependent hyperadrenocorticism in dogs Veterinary Ophthalmology 22 6 842 858 doi 10 1111 vop 12661 PMID 30864251 S2CID 76666023 Miller P Galbreath E Kehren J Steinberg H Dubielzig R 1998 Photoreceptor cell death by apoptosis in dogs with sudden acquired retinal degeneration syndrome Am J Vet Res 59 2 149 52 PMID 9492927 Gilger Brian C 2006 Diagnosis and Treatment of Ocular Fundus Disorders of Geriatric Dogs PDF Proceedings of the North American Veterinary Conference Archived from the original PDF on 2007 09 29 Retrieved 2007 03 11 a b c Komaromy AM Abrams KL Heckenlively JR Lundy SK Maggs DJ Leeth CM MohanKumar PS Petersen Jones SM Serreze DV van der Woerdt A July 2016 Sudden acquired retinal degeneration syndrome SARDS a review and proposed strategies toward a better understanding of pathogenesis early diagnosis and therapy PDF Veterinary Ophthalmology 19 4 319 31 doi 10 1111 vop 12291 hdl 2027 42 122446 PMID 26096588 Blind dogs can see after new ISU treatment for a sudden onset blinding disease News Service Iowa State University www news iastate edu Retrieved 2021 09 15 Young Whitney M Oh Annie Williams Jonathan G Foster Melanie L Miller William W Lunn Katharine F Mowat Freya M November 2018 Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs a prospective open label pilot study Veterinary Ophthalmology 21 6 565 576 doi 10 1111 vop 12545 PMID 29383824 S2CID 23927483 Retrieved from https en wikipedia org w index php title Sudden acquired retinal degeneration syndrome amp oldid 1170442012, wikipedia, wiki, book, books, library,

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