The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.[5]
Interactionsedit
Structure specific recognition protein 1 has been shown to interact with NEK9.[6] SSRP1 further interacts with transcriptional activator p63.[7] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000149136 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027067 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: SSRP1 structure specific recognition protein 1".
^Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.
^Zeng SX, Dai MS, Keller DM, Lu H (15 Oct 2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC129072. PMID 12374749.
Further readingedit
Bruhn SL, Pil PM, Essigmann JM, Housman DE, Lippard SJ (1992). "Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin". Proc. Natl. Acad. Sci. U.S.A. 89 (6): 2307–11. Bibcode:1992PNAS...89.2307B. doi:10.1073/pnas.89.6.2307. PMC48646. PMID 1372440.
Toney JH, Donahue BA, Kellett PJ, Bruhn SL, Essigmann JM, Lippard SJ (1989). "Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8328–32. Bibcode:1989PNAS...86.8328T. doi:10.1073/pnas.86.21.8328. PMC298274. PMID 2530581.
Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". J. Immunol. 155 (9): 4330–8. doi:10.4049/jimmunol.155.9.4330. PMID 7594592.
Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D (1998). "FACT, a factor that facilitates transcript elongation through nucleosomes". Cell. 92 (1): 105–16. doi:10.1016/S0092-8674(00)80903-4. PMID 9489704. S2CID 11248520.
Dyer MA, Hayes PJ, Baron MH (1998). "The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene". Mol. Cell. Biol. 18 (5): 2617–28. doi:10.1128/MCB.18.5.2617. PMC110641. PMID 9566881.
LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
Kelley DE, Stokes DG, Perry RP (1999). "CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin". Chromosoma. 108 (1): 10–25. doi:10.1007/s004120050347. PMID 10199952. S2CID 12945778.
Spencer JA, Baron MH, Olson EN (1999). "Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1". J. Biol. Chem. 274 (22): 15686–93. doi:10.1074/jbc.274.22.15686. PMID 10336466.
Orphanides G, Wu WH, Lane WS, Hampsey M, Reinberg D (1999). "The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins". Nature. 400 (6741): 284–8. Bibcode:1999Natur.400..284O. doi:10.1038/22350. PMID 10421373. S2CID 4300397.
Wada T, Orphanides G, Hasegawa J, Kim DK, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H (2000). "FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH". Mol. Cell. 5 (6): 1067–72. doi:10.1016/S1097-2765(00)80272-5. PMID 10912001.
Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H (2001). "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1". Mol. Cell. 7 (2): 283–92. doi:10.1016/S1097-2765(01)00176-9. PMID 11239457.
Yarnell AT, Oh S, Reinberg D, Lippard SJ (2001). "Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin". J. Biol. Chem. 276 (28): 25736–41. doi:10.1074/jbc.M101208200. PMID 11344167.
Santoro P, De Andrea M, Migliaretti G, Trapani C, Landolfo S, Gariglio M (2002). "High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases". J. Rheumatol. 29 (1): 90–3. PMID 11824977.
Roig J, Mikhailov A, Belham C, Avruch J (2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC186374. PMID 12101123.
Zeng SX, Dai MS, Keller DM, Lu H (2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC129072. PMID 12374749.
Keller DM, Lu H (2003). "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex". J. Biol. Chem. 277 (51): 50206–13. doi:10.1074/jbc.M209820200. PMID 12393879.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC207616. PMID 14559993.
Tan BC, Lee SC (2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.
structure, specific, recognition, protein, fact, complex, subunit, ssrp1, also, known, structure, specific, recognition, protein, protein, that, humans, encoded, ssrp1, gene, ssrp1available, structurespdbortholog, search, pdbe, rcsblist, codes4ifsidentifiersal. FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene 5 SSRP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4IFSIdentifiersAliasesSSRP1 FACT FACT80 T160 Structure specific recognition protein 1External IDsOMIM 604328 MGI 107912 HomoloGene 110735 GeneCards SSRP1Gene location Human Chr Chromosome 11 human 1 Band11q12 1Start57 325 986 bp 1 End57 335 892 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 D 2 49 45 cMStart84 867 578 bp 2 End84 877 453 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencegastrocnemius muscleAchilles tendonislet of Langerhansbody of pancreasrectumanterior pituitaryright uterine tubebody of stomachleft uterine tubeTop expressed inotic placodesacculeabdominal wallmaxillary prominenceprimitive streaksomitehandureterganglionic eminencedermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding chromatin binding protein binding RNA binding DNA binding transcription factor activity RNA polymerase II specific nucleosome binding histone bindingCellular componentnucleolus nucleoplasm chromosome nucleus FACT complexBiological processDNA replication transcription elongation from RNA polymerase II promoter regulation of transcription DNA templated transcription by RNA polymerase II DNA repair transcription DNA templated cellular response to DNA damage stimulus regulation of signal transduction by p53 class mediator regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez674920833EnsemblENSG00000149136ENSMUSG00000027067UniProtQ08945Q08943RefSeq mRNA NM 003146NM 001136081NM 182990RefSeq protein NP 003137NP 001129553NP 892035Location UCSC Chr 11 57 33 57 34 MbChr 2 84 87 84 88 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction editThe protein encoded by this gene is a subunit of a heterodimer that along with SUPT16H forms chromatin transcriptional elongation factor FACT FACT interacts specifically with histones H2A H2B to effect nucleosome disassembly and transcription elongation FACT and cisplatin damaged DNA may be crucial to the anticancer mechanism of cisplatin This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin modified DNA This protein also functions as a co activator of the transcriptional activator p63 5 Interactions editStructure specific recognition protein 1 has been shown to interact with NEK9 6 SSRP1 further interacts with transcriptional activator p63 7 SSRP1 enhances the activity of full length p63 but it has no effect on the N terminus deleted p63 DeltaN p63 variant References edit a b c GRCh38 Ensembl release 89 ENSG00000149136 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027067 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene SSRP1 structure specific recognition protein 1 Tan BC Lee SC Mar 2004 Nek9 a novel FACT associated protein modulates interphase progression J Biol Chem 279 10 9321 30 doi 10 1074 jbc M311477200 PMID 14660563 Zeng SX Dai MS Keller DM Lu H 15 Oct 2002 SSRP1 functions as a co activator of the transcriptional activator p63 EMBO J 21 20 5487 97 doi 10 1093 emboj cdf540 PMC 129072 PMID 12374749 Further reading editBruhn SL Pil PM Essigmann JM Housman DE Lippard SJ 1992 Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin Proc Natl Acad Sci U S A 89 6 2307 11 Bibcode 1992PNAS 89 2307B doi 10 1073 pnas 89 6 2307 PMC 48646 PMID 1372440 Toney JH Donahue BA Kellett PJ Bruhn SL Essigmann JM Lippard SJ 1989 Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis diamminedichloroplatinum II Proc Natl Acad Sci U S A 86 21 8328 32 Bibcode 1989PNAS 86 8328T doi 10 1073 pnas 86 21 8328 PMC 298274 PMID 2530581 Nagulapalli S Pongubala JM Atchison ML 1995 Multiple proteins physically interact with PU 1 Transcriptional synergy with NF IL6 beta C EBP delta CRP3 J Immunol 155 9 4330 8 doi 10 4049 jimmunol 155 9 4330 PMID 7594592 Orphanides G LeRoy G Chang CH Luse DS Reinberg D 1998 FACT a factor that facilitates transcript elongation through nucleosomes Cell 92 1 105 16 doi 10 1016 S0092 8674 00 80903 4 PMID 9489704 S2CID 11248520 Dyer MA Hayes PJ Baron MH 1998 The HMG domain protein SSRP1 PREIIBF is involved in activation of the human embryonic beta like globin gene Mol Cell Biol 18 5 2617 28 doi 10 1128 MCB 18 5 2617 PMC 110641 PMID 9566881 LeRoy G Orphanides G Lane WS Reinberg D 1998 Requirement of RSF and FACT for transcription of chromatin templates in vitro Science 282 5395 1900 4 doi 10 1126 science 282 5395 1900 PMID 9836642 Kelley DE Stokes DG Perry RP 1999 CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase helicase like domain for proper association with chromatin Chromosoma 108 1 10 25 doi 10 1007 s004120050347 PMID 10199952 S2CID 12945778 Spencer JA Baron MH Olson EN 1999 Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1 J Biol Chem 274 22 15686 93 doi 10 1074 jbc 274 22 15686 PMID 10336466 Orphanides G Wu WH Lane WS Hampsey M Reinberg D 1999 The chromatin specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins Nature 400 6741 284 8 Bibcode 1999Natur 400 284O doi 10 1038 22350 PMID 10421373 S2CID 4300397 Wada T Orphanides G Hasegawa J Kim DK Shima D Yamaguchi Y Fukuda A Hisatake K Oh S Reinberg D Handa H 2000 FACT relieves DSIF NELF mediated inhibition of transcriptional elongation and reveals functional differences between P TEFb and TFIIH Mol Cell 5 6 1067 72 doi 10 1016 S1097 2765 00 80272 5 PMID 10912001 Keller DM Zeng X Wang Y Zhang QH Kapoor M Shu H Goodman R Lozano G Zhao Y Lu H 2001 A DNA damage induced p53 serine 392 kinase complex contains CK2 hSpt16 and SSRP1 Mol Cell 7 2 283 92 doi 10 1016 S1097 2765 01 00176 9 PMID 11239457 Yarnell AT Oh S Reinberg D Lippard SJ 2001 Interaction of FACT SSRP1 and the high mobility group HMG domain of SSRP1 with DNA damaged by the anticancer drug cisplatin J Biol Chem 276 28 25736 41 doi 10 1074 jbc M101208200 PMID 11344167 Santoro P De Andrea M Migliaretti G Trapani C Landolfo S Gariglio M 2002 High prevalence of autoantibodies against the nuclear high mobility group HMG protein SSRP1 in sera from patients with systemic lupus erythematosus but not other rheumatic diseases J Rheumatol 29 1 90 3 PMID 11824977 Roig J Mikhailov A Belham C Avruch J 2002 Nercc1 a mammalian NIMA family kinase binds the Ran GTPase and regulates mitotic progression Genes Dev 16 13 1640 58 doi 10 1101 gad 972202 PMC 186374 PMID 12101123 Zeng SX Dai MS Keller DM Lu H 2002 SSRP1 functions as a co activator of the transcriptional activator p63 EMBO J 21 20 5487 97 doi 10 1093 emboj cdf540 PMC 129072 PMID 12374749 Keller DM Lu H 2003 p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2 hSPT16 SSRP1 complex J Biol Chem 277 51 50206 13 doi 10 1074 jbc M209820200 PMID 12393879 Belotserkovskaya R Oh S Bondarenko VA Orphanides G Studitsky VM Reinberg D 2003 FACT facilitates transcription dependent nucleosome alteration Science 301 5636 1090 3 Bibcode 2003Sci 301 1090B doi 10 1126 science 1085703 PMID 12934006 S2CID 26667338 Li J Hawkins IC Harvey CD Jennings JL Link AJ Patton JG 2003 Regulation of alternative splicing by SRrp86 and its interacting proteins Mol Cell Biol 23 21 7437 47 doi 10 1128 MCB 23 21 7437 7447 2003 PMC 207616 PMID 14559993 Tan BC Lee SC 2004 Nek9 a novel FACT associated protein modulates interphase progression J Biol Chem 279 10 9321 30 doi 10 1074 jbc M311477200 PMID 14660563 External links editSSRP1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Structure specific recognition protein 1 amp oldid 1191702001, wikipedia, wiki, book, books, library,
