Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arises due to presence of renal cell carcinoma, and, more rarely, in connection with other malignant neoplasms, though the specific pathogenesis is currently unknown. It is named for Dr. Maurice Stauffer, a gastroenterologist at the Mayo Clinic in Rochester, MN. The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease; they instead reflect the presence of a paraneoplastic syndrome.[1]
Stauffer syndrome causes abnormal liver function tests, especially those that reflect the presence of cholestasis, i.e. abnormal bile flow. Hepatosplenomegaly may also be observed. The symptoms and signs resolve if the renal cell carcinoma (or another associated tumor) is successfully ablated. It is due to release of IL-6 from cancerous cell.[1]
Eponymedit
Maurice H. Stauffer, M.D., a gastroenterologist at the Mayo Clinic in Rochester, MN, first characterized this syndrome in 1961, with the original name of "nephrogenic hepatomegaly."[2][3]
Referencesedit
^ abJakse G, Madersbacher H (1978). "[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (author's transl)]". Wien Klin Wochenschr. 90 (8): 268–70. PMID 636440.
^Morla D, Alazemi S, Lichtstein D (July 2006). "Stauffer's Syndrome Variant with Cholestatic Jaundice A Case Report". J Gen Intern Med. 21 (7): C11–3. doi:10.1111/j.1525-1497.2006.00448.x. PMC1924715. PMID 16808761.
External linksedit
April 09, 2024
stauffer, syndrome, constellation, signs, symptoms, liver, dysfunction, that, arises, presence, renal, cell, carcinoma, more, rarely, connection, with, other, malignant, neoplasms, though, specific, pathogenesis, currently, unknown, named, maurice, stauffer, g. Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arises due to presence of renal cell carcinoma and more rarely in connection with other malignant neoplasms though the specific pathogenesis is currently unknown It is named for Dr Maurice Stauffer a gastroenterologist at the Mayo Clinic in Rochester MN The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease they instead reflect the presence of a paraneoplastic syndrome 1 Stauffer syndromeSpecialtyHepatologyStauffer syndrome causes abnormal liver function tests especially those that reflect the presence of cholestasis i e abnormal bile flow Hepatosplenomegaly may also be observed The symptoms and signs resolve if the renal cell carcinoma or another associated tumor is successfully ablated It is due to release of IL 6 from cancerous cell 1 Eponym editMaurice H Stauffer M D a gastroenterologist at the Mayo Clinic in Rochester MN first characterized this syndrome in 1961 with the original name of nephrogenic hepatomegaly 2 3 References edit a b Jakse G Madersbacher H 1978 Stauffer s syndrome Reversible hepatic dysfunction in renal cell carcinoma author s transl Wien Klin Wochenschr 90 8 268 70 PMID 636440 Stauffer MH 1961 Nephrogenic hepatomegaly Gastroenterology 40 694 Morla D Alazemi S Lichtstein D July 2006 Stauffer s Syndrome Variant with Cholestatic Jaundice A Case Report J Gen Intern Med 21 7 C11 3 doi 10 1111 j 1525 1497 2006 00448 x PMC 1924715 PMID 16808761 External links edit Retrieved from https en wikipedia org w index php title Stauffer syndrome amp oldid 1183746197, wikipedia, wiki, book, books, library,
