Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes[2][3] Some members of this family have been shown to facilitate protein sorting.
Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.
A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.)
An example of a sorting nexin domain structure can be seen here for SNX1:
Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1 (SNX1). NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.
ReferencesEdit
^Bravo J, Karathanassis D, Pacold CM, et al. (October 2001). "The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate". Mol. Cell. 8 (4): 829–39. doi:10.1016/S1097-2765(01)00372-0. PMID 11684018.
^Dixon JE, Worby CA (2002). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–931. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
^Worby CA, Dixon JE (2002). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
^ abcdFrost A, Unger VM, De Camilli P (April 2009). "The BAR domain superfamily: membrane-molding macromolecules". Cell. 137 (2): 191–196. doi:10.1016/j.cell.2009.04.010. PMC4832598. PMID 19379681.
^BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein, Pfam PF10456
sorting, nexin, large, group, proteins, that, localized, cytoplasm, have, potential, membrane, association, either, through, their, lipid, binding, domain, phospholipid, binding, motif, through, protein, protein, interactions, with, membrane, associated, prote. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid binding PX domain a phospholipid binding motif or through protein protein interactions with membrane associated protein complexes 2 3 Some members of this family have been shown to facilitate protein sorting PX domainStructure of the PX domain from p40 phox bound to phosphatidylinositol 3 phosphate 1 IdentifiersSymbolPXPfamPF00787InterProIPR001683SMARTPXPROSITEPDOC50195SCOP21h6h SCOPe SUPFAMOPM superfamily57OPM protein4on3Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summarySorting nexin N terminal domainIdentifiersSymbolSorting nexinPfamPF03700InterProIPR005329Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryVps5 C terminal like BAR domain IdentifiersSymbolVps5PfamPF09325InterProIPR015404Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summarySorting nexin C terminal domainIdentifiersSymbolNexin CPfamPF08628InterProIPR013937Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryWASP binding domain of Sorting nexin proteinIdentifiersSymbolBAR3 WASPPfamPF10456Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Family members 2 Structure 3 References 4 External linksFamily members EditIn humans sorting nexins are transcribed from the following genes Genes Domain CompositionN terminus Mid 1 Mid 2 Mid 3 C terminusSNX1 SNX2 Sorting nexin N PX BAR 4 Vps5 SNX4 SNX7 SNX8 SNX30 PX BAR 4 Vsp5 SNX5 SNX6 SNX32 PX BAR 4 SNX9 SNX18 SNX33 SH3 PX BAR 4 BAR 3 WASP bdg 5 SNX13 SNX14 SNX19 SNX25 PXA 6 RGS PX Nexin CSNX15 PX MIT 7 SNX17 SNX31 PX RA 8 FERM M 9 SNX23 kinesin motor SMAD FHA 10 PX SNX26 PX SH3 RhoGAPSNX27 PDZ PX FERM M 9 SNX28 PX SH3 SH3SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29 PX Structure EditSorting nexins either consist solely of a PX domain e g SNX3 or have a modular structure made up of the PX and additional domains A subgroup of sorting nexins comprising in humans SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 and SNX33 possess a BAR domain at their C terminus The BAR domain of SNXs 1 2 4 7 8 and 30 is classified by pfam as Vps5 C terminal like An example of a sorting nexin domain structure can be seen here for SNX1 NTD N terminal domain PX domain CTD C terminal BAR domain nbsp Schematic diagram of the 1D structures of a representative sorting nexin the sorting nexin 1 SNX1 NTD N terminal SNX domain PX PX domain CTD C terminal BAR domain References Edit Bravo J Karathanassis D Pacold CM et al October 2001 The crystal structure of the PX domain from p40 phox bound to phosphatidylinositol 3 phosphate Mol Cell 8 4 829 39 doi 10 1016 S1097 2765 01 00372 0 PMID 11684018 Dixon JE Worby CA 2002 Sorting out the cellular functions of sorting nexins Nat Rev Mol Cell Biol 3 12 919 931 doi 10 1038 nrm974 PMID 12461558 S2CID 36361630 Worby CA Dixon JE 2002 Sorting out the cellular functions of sorting nexins Nat Rev Mol Cell Biol 3 12 919 31 doi 10 1038 nrm974 PMID 12461558 S2CID 36361630 a b c d Frost A Unger VM De Camilli P April 2009 The BAR domain superfamily membrane molding macromolecules Cell 137 2 191 196 doi 10 1016 j cell 2009 04 010 PMC 4832598 PMID 19379681 BAR 3 WASP bdg WASP binding domain of Sorting nexin protein Pfam PF10456 PXA PXA domain Pfam PF02194 MIT MIT microtubule interacting and transport domain Pfam PF04212 RA Ras association RalGDS AF 6 domain Pfam PF00788 a b FERM M FERM central domain Pfam PF00373 SMAD FHA SMAD FHA domain InterPro IPR008984External links EditSorting Nexins at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Sorting nexin amp oldid 1072836020, wikipedia, wiki, book, books, library,
